ライフサイエンスコーパス: oligodendrocyte precursor

1 differentiation defects of miR-219-deficient oligodendrocyte precursors.

2 elin-specific genes and increased numbers of oligodendrocyte precursors.

3 favored in more lineage-restricted neuronal-oligodendrocyte precursors.

4 ation and the generation of motor neuron and oligodendrocyte precursors.

5 n cfy embryos due to an apparent decrease in oligodendrocyte precursors.

6 crophage accumulation, and the appearance of oligodendrocyte precursors.

7 halic ventricular zone subsequently generate oligodendrocyte precursors.

8 ogenitor cell cultures promotes formation of oligodendrocyte precursors.

9 ately prior to, and during the appearance of oligodendrocyte precursors.

10 ikely to influence the initial appearance of oligodendrocyte precursors.

11 ted migration of SVZ-derived progenitors and oligodendrocyte precursors.

12 ighly specific, because NGF had no effect on oligodendrocyte precursors and astrocytes.

13 n the developing brain include maturation of oligodendrocyte precursors and genetically programmed ch

14 oxidative cell death in primary cultures of oligodendrocyte precursors and immature fetal cortical n

15 MRP2/KLHL1 is expressed in oligodendrocyte precursors and mature OLGs, and its expr

16 receptors in ischaemia leads to the death of oligodendrocyte precursors and the loss of myelin.

17 or both the initial dispersal of spinal cord oligodendrocyte precursors and their subsequent developm

18 During development, the earliest oligodendrocyte precursors appear in the metencephalic v

19 Most remarkably, a normal number of oligodendrocyte precursors are formed at day 12 of mouse

20 Oligodendrocyte precursors are found only at low density

21 s a sequential model in which motoneuron and oligodendrocyte precursors are sequentially generated in

22 e embryonic CNS, recent studies suggest that oligodendrocyte precursors arise in a discrete ventral l

23 In the chick metencephalon, oligodendrocyte precursors arise in distinct domains of

24 Spinal cord oligodendrocyte precursors arise in the ventral ventricu

25 s required for the appearance of spinal cord oligodendrocyte precursors as neutralization of Shh sign

26 receptor 2 is localized in oligodendrocytes, oligodendrocyte precursors, astrocytes and macrophages/m

27 early 60% loss in astrocytes and 50% loss in oligodendrocyte precursors at birth.

28 quired for initiating the differentiation of oligodendrocyte precursors but has to be down-regulated

29 inoic acid and artificial polysialylation of oligodendrocyte precursors by a bacterial polysialyltran

30 recursors, a function that is antagonized in oligodendrocyte precursors by Olig2.

31 t-mediated activation of Notch1 receptors on oligodendrocyte precursors by the ligand Jagged1 induces

32 a (PDGFRalpha), the earliest known marker of oligodendrocyte precursors, by several days.

33 Ectopic oligodendrocyte precursors can be induced by sonic hedge

34 The oligodendrocyte precursor cell (OPC) arises from the sub

35 the proliferation and differentiation of the oligodendrocyte precursor cell (OPC) as well as the spat

36 Temple and Raff previously showed that an oligodendrocyte precursor cell (OPC) can divide a maximu

37 ceptor induced excitotoxicity contributes to oligodendrocyte precursor cell (OPC) damage and hypomyel

38 functional states of Wnt activity determine oligodendrocyte precursor cell (OPC) differentiation and

39 or GABAergic interneuron production, repress oligodendrocyte precursor cell (OPC) formation by acting

40 ons contain hyaluronan deposits that inhibit oligodendrocyte precursor cell (OPC) maturation.

41 ein (BMP) signaling, such as Noggin, promote oligodendrocyte precursor cell (OPC) production after hy

42 Gpr56-knockout mice manifest with decreased oligodendrocyte precursor cell (OPC) proliferation and d

43 NG2 cells in the SVZ and RMS expressed the oligodendrocyte precursor cell antigen platelet-derived

44 hin the nervous system, including defects in oligodendrocyte precursor cell development and a partial

45 -gamma is a positive regulator of endogenous oligodendrocyte precursor cell differentiation and remye

46 y, we identified novel molecules involved in oligodendrocyte precursor cell differentiation and valid

47 Specifically, exogenous CCL19 abolished oligodendrocyte precursor cell differentiation observed

48 an enrichment of proliferative pathways and oligodendrocyte precursor cell gene expression profile i

49 regulated expression of GPR17 in Oli-neu, an oligodendrocyte precursor cell line, making these cells

50 We have identified an oligodendrocyte precursor cell line, termed G144, that s

51 velopment, may also be active in controlling oligodendrocyte precursor cell migration in MS, and henc

52 ple sclerosis lesions are thought to inhibit oligodendrocyte precursor cell migration, limiting their

53 xons or do intrinsic properties of different oligodendrocyte precursor cell populations affect length

54 tate-methyltransferase (Gamt) did not affect oligodendrocyte precursor cell recruitment, but resulted

55 This conditioned media also enhanced oligodendrocyte precursor cell survival, maturation and

56 signaling contributes to the decision of an oligodendrocyte precursor cell to differentiate-both dur

57 NG2-expressing oligodendrocyte precursor cells (NG2 cells) are exposed

58 Synaptic signaling to NG2-expressing oligodendrocyte precursor cells (NG2 cells) could be key

59 adult CNS contains an abundant population of oligodendrocyte precursor cells (NG2(+) cells) that gene

60 bipotential oligodendrocyte-type-2 astrocyte/oligodendrocyte precursor cells (O-2A/OPCs).

61 ansmembrane proteoglycan NG2 is expressed by oligodendrocyte precursor cells (OPC), which migrate to

62 in reminiscent of neural stem cells (NSC) or oligodendrocyte precursor cells (OPC).

63 yelin is dependent on the differentiation of oligodendrocyte precursor cells (OPCs) and oligodendrocy

64 type 1 to type 2 status, elevated numbers of oligodendrocyte precursor cells (OPCs) and oligodendrocy

65 Oligodendrocyte precursor cells (OPCs) are generated fro

66 Oligodendrocyte precursor cells (OPCs) are lineage-restr

67 Other studies showed that oligodendrocyte precursor cells (OPCs) are responsible f

68 ventral spinal cord, motor neurons (MNs) and oligodendrocyte precursor cells (OPCs) are sequentially

69 Oligodendrocyte precursor cells (OPCs) are the major sou

70 Oligodendrocyte precursor cells (OPCs) are thought to ma

71 We and others have shown that oligodendrocyte precursor cells (OPCs) can also be the c

72 , it was demonstrated that lineage-committed oligodendrocyte precursor cells (OPCs) can be converted

73 Oligodendrocyte precursor cells (OPCs) can be differenti

74 We showed previously that purified rat oligodendrocyte precursor cells (OPCs) can be induced by

75 We previously showed that oligodendrocyte precursor cells (OPCs) can be transforme

76 hereas induced expression of Nkx2.2 in early oligodendrocyte precursor cells (OPCs) causes precocious

77 The appearance of oligodendrocyte precursor cells (OPCs) correlates with t

78 and transplantation of adult rat spinal cord oligodendrocyte precursor cells (OPCs) could enhance rem

79 Remyelination may fail because oligodendrocyte precursor cells (OPCs) do not completely

80 ll-intrinsic timer helps control when rodent oligodendrocyte precursor cells (OPCs) exit the cell cyc

81 In the mammalian CNS, oligodendrocyte precursor cells (OPCs) express most neur

82 Oligodendrocyte precursor cells (OPCs) express NMDA rece

83 Oligodendrocyte precursor cells (OPCs) express receptors

84 ansplantation of neural stem cells (NSCs) or oligodendrocyte precursor cells (OPCs) has been used to

85 Oligodendrocyte precursor cells (OPCs) have extraordinar

86 t hypoxia activates the ISR in primary mouse oligodendrocyte precursor cells (OPCs) in vitro and that

87 lly identified as a proliferative signal for oligodendrocyte precursor cells (OPCs) in vitro.

88 Jagged signalling via Notch receptors on oligodendrocyte precursor cells (OPCs) inhibits their di

89 Transplantation of oligodendrocyte precursor cells (OPCs) is a promising po

90 Adult oligodendrocyte precursor cells (OPCs) make up around 5-

91 rocytes are initially specified, after which oligodendrocyte precursor cells (OPCs) migrate and proli

92 cultured and exposed to media conditioned by oligodendrocyte precursor cells (OPCs) or differentiated

93 Oligodendrocyte precursor cells (OPCs) persist in substa

94 They differentiate from oligodendrocyte precursor cells (OPCs) that are produced

95 the central nervous system and develop from oligodendrocyte precursor cells (OPCs) that must first m

96 f which represent a continuum from Pdgfra(+) oligodendrocyte precursor cells (OPCs) to distinct matur

97 Sox8 is known to be expressed in oligodendrocyte precursor cells (OPCs) together with oth

98 e absence of Gsx2 expression, an increase in oligodendrocyte precursor cells (OPCs) with a concomitan

99 Oligodendrocyte precursor cells (OPCs), a major glial ce

100 yeloid cells, meningeal cells, proliferating oligodendrocyte precursor cells (OPCs), and a dense extr

101 aberrant growth prior to malignancy only in oligodendrocyte precursor cells (OPCs), but not in any o

102 ive AMPARs by recording from rat optic nerve oligodendrocyte precursor cells (OPCs), known to express

103 They develop from oligodendrocyte precursor cells (OPCs), most of which di

104 us examined the functional roles of CSPGs on oligodendrocyte precursor cells (OPCs), oligodendrocytes

105 xclusively expressed in oligodendrocytes and oligodendrocyte precursor cells (OPCs), which migrate co

106 e a novel role in white matter by modulating oligodendrocyte precursor cells (OPCs).

107 demyelination, as were numbers of CXCR4+NG2+ oligodendrocyte precursor cells (OPCs).

108 upport the survival and proliferation of rat oligodendrocyte precursor cells (OPCs).

109 ation program in existing or newly recruited oligodendrocyte precursor cells (OPCs).

110 ta receptors may mediate the effect of TH on oligodendrocyte precursor cells (OPCs).

111 lso expressed by some glial cells, including oligodendrocyte precursor cells (OPCs).

112 re postmitotic and derive from proliferative oligodendrocyte precursor cells (OPCs).

113 of functionally mature oligodendrocytes from oligodendrocyte precursor cells (OPCs).

114 factor-2, a guidance factor for migration of oligodendrocyte precursor cells (OPCs).

115 nhibited the differentiation of purified rat oligodendrocyte precursor cells (OPCs).

116 wild-type controls, as was proliferation of oligodendrocyte precursor cells (OPCs).

117 -length LINGO-1 inhibited differentiation of oligodendrocyte precursor cells (OPCs).

118 ression and function of REST in neonatal rat oligodendrocyte precursor cells (OPCs).

119 al differentiation-promoting effect of TH on oligodendrocyte precursor cells (OPCs): unlike wild-type

120 Oligodendrocyte precursor cells (OPCs; PDGFRalpha+) prod

121 ral spinal OLIG2-expressing progenitors, pre-oligodendrocyte precursor cells (pre-OPCs) and OPCs from

122 c MS lesions and that Notch1 is activated in oligodendrocyte precursor cells (see the related article

123 1 was significantly decreased in spinal cord oligodendrocyte precursor cells after onset of EAE, and

124 reduced remyelination, and increased loss of oligodendrocyte precursor cells and mature oligodendrocy

125 ances in our understanding of the biology of oligodendrocyte precursor cells and of the stage-depende

126 mbination with MCSF, increased the number of oligodendrocyte precursor cells and promoted remyelinati

127 In vitro and in vivo experiments in oligodendrocyte precursor cells and zebrafish were perfo

128 ation vulnerable to PVWMI and P5 when rodent oligodendrocyte precursor cells are more vulnerable to e

129 Oligodendrocyte precursor cells are the primary source o

130 termine a window of opportunity during which oligodendrocyte precursor cells can successfully differe

131 pression of the helix-loop-helix gene Id4 in oligodendrocyte precursor cells decreases in vivo and in

132 Oligodendrocyte precursor cells differentiate into matur

133 We also show that oligodendrocyte precursor cells display sensitivity to t

134 -1, a secreted protein that repels migrating oligodendrocyte precursor cells during neural developmen

135 In mice that lacked RXR-gamma, adult oligodendrocyte precursor cells efficiently repopulated

136 Motor neuron and oligodendrocyte precursor cells express Olig genes, whic

137 The alpha1B-AR is also expressed in NG2 oligodendrocyte precursor cells in both neonatal cell cu

138 ) and retinoic acid (RA) induce purified rat oligodendrocyte precursor cells in culture to stop divis

139 nterestingly, despite a normal production of oligodendrocyte precursor cells in the double mutants, o

140 ast to multiple observations indicating that oligodendrocyte precursor cells in the embryonic day 14

141 ne fumarate can stimulate differentiation of oligodendrocyte precursor cells in vitro, in animal mode

142 usly differentiating OLs generated from pure oligodendrocyte precursor cells in vitro.

143 During development, oligodendrocyte precursor cells integrate environmental

144 this compound induces the differentiation of oligodendrocyte precursor cells into mature oligodendroc

145 factors that inhibit the differentiation of oligodendrocyte precursor cells into myelinating oligode

146 Moreover, proliferation of oligodendrocyte precursor cells is altered by mutant hun

147 An intracellular timer in oligodendrocyte precursor cells is thought to help contr

148 udies demonstrated that the proliferation of oligodendrocyte precursor cells isolated from the develo

149 Oligodendrocyte precursor cells may differentiate into a

150 Seeding of oligodendrocyte precursor cells on these axons results i

151 NG2 cells, also known as oligodendrocyte precursor cells or polydendrocytes, whic

152 r glial fibrillary acidic protein (GFAP) and oligodendrocyte precursor cells positive for NG2 proteog

153 Here we show that most oligodendrocyte precursor cells purified from postnatal

154 nt mode of inheritance, in vitro analysis in oligodendrocyte precursor cells showed that mutant prote

155 art of the normal timer that determines when oligodendrocyte precursor cells stop dividing and differ

156 ived mediators influenced differentiation of oligodendrocyte precursor cells through a crosstalk with

157 glia/macrophage to lesions nor a failure for oligodendrocyte precursor cells to differentiate and rem

158 itical in regulating the transition of adult oligodendrocyte precursor cells to mature OLs that is es

159 hat certain extracellular signals can induce oligodendrocyte precursor cells to revert to multipotent

160 possible reason is the lack of migration of oligodendrocyte precursor cells to the lesion.

161 NLGN3 is cleaved from both neurons and oligodendrocyte precursor cells via the ADAM10 sheddase.

162 Migration and density of oligodendrocyte precursor cells were normal; however, a

163 ntracellular timer that helps determine when oligodendrocyte precursor cells withdraw from the cell c

164 efault of the resident stem/precursor cells (oligodendrocyte precursor cells) to differentiate into m

165 s system remyelination is mainly mediated by oligodendrocyte precursor cells, although subventricular

166 matter, apoptosis and arrested maturation of oligodendrocyte precursor cells, and hypomyelination.

167 ally infected neural stem cells, astrocytes, oligodendrocyte precursor cells, and microglia, whereas

168 ol cells, including normal human astrocytes, oligodendrocyte precursor cells, and primary explant cul

169 resses inflammation, attenuates apoptosis of oligodendrocyte precursor cells, and promotes myelinatio

170 Unlike oligodendrocyte precursor cells, APCs do not differentia

171 her obvious impairment in the recruitment of oligodendrocyte precursor cells, astrocytes, or reactive

172 domains VI and V of netrin-1 repel migrating oligodendrocyte precursor cells, but lack the chemoattra

173 We show that TNFR2 drives differentiation of oligodendrocyte precursor cells, but not proliferation o

174 nes, chemokines and growth factors, act upon oligodendrocyte precursor cells, causing their activatio

175 In contrast to oligodendrocyte precursor cells, microglia formed only w

176 entative populations of neurons, astrocytes, oligodendrocyte precursor cells, newly formed oligodendr

177 G2(+) glia, also known as polydendrocytes or oligodendrocyte precursor cells, represent a new entity

178 erating the correct numbers of WM but not GM oligodendrocyte precursor cells, whereas during astrocyt

179 ls in the postnatal SVZ but are likely to be oligodendrocyte precursor cells.

180 proliferation and inhibits the migration of oligodendrocyte precursor cells.

181 eptor thus serves as a phenotypic marker for oligodendrocyte precursor cells.

182 e they likely exert their influence on early oligodendrocyte precursor cells.

183 Similar results were obtained with oligodendrocyte precursor cells.

184 y neurons as well as in oligodendrocytes and oligodendrocyte precursor cells.

185 ransformation following differentiation into oligodendrocyte precursor cells.

186 ues extends this active role by showing that oligodendrocyte precursors cells (OPCs) in the hippocamp

187 the proliferation of Sox2 stem cells and NG2 oligodendrocyte precursors cells originating in the SVZ

188 Human oligodendrocytes precursor cells (OPCs) were stimulated

189 on of in vitro analyses, we demonstrate that oligodendrocyte precursors closely regulate their number

190 n the affected brains may be process-bearing oligodendrocyte precursors containing unsulfated GC or a

191 tion causes a tumor phenotypic shift from an oligodendrocyte precursor-correlated proneural toward an

192 nally, blockage of these miRNA activities in oligodendrocyte precursor culture and knockdown of miR-2

193 bB2 is not necessary for the early stages of oligodendrocyte precursor development, but is essential

194 as specific to Schwann cells, as deletion in oligodendrocyte precursors did not impair myelin formati

195 This decrease may help control when oligodendrocyte precursors differentiate.

196 tes both cell proliferation and migration in oligodendrocyte precursors during development.

197 eath in mice, despite an initial increase of oligodendrocyte precursors during early development.

198 essed in zones of neuroepithelium from which oligodendrocyte precursors emerge, as well as in the pre

199 The inhibition of oligodendrocyte precursor emergence in the absence of Sh

200 essed at the ventral ventricular zone during oligodendrocyte precursors emigration, and, in vitro, ne

201 his density-dependent feedback inhibition of oligodendrocyte precursor expansion may play a primary r

202 Oligodendrocyte precursors express the netrin receptors

203 in the spinal cord of netrin-1 mutant mice, oligodendrocyte precursors failed to disperse from the v

204 loping chick neural tube, Zfp488 can promote oligodendrocyte precursor formation upon Notch activatio

205 of Cell Stem Cell, Piao et al. (2015) derive oligodendrocyte precursors from human embryonic stem cel

206 These data indicate the initial dispersal of oligodendrocyte precursors from their localized origin i

207 distinct types of morphologically identical oligodendrocyte precursor glial cells (OPCs) in situ in

208 tion of Shh signaling after the emergence of oligodendrocyte precursors had no effect on the appearan

209 While oligodendrocyte precursors have previously been localize

210 In contrast, Ascl1 expressing oligodendrocyte precursors in gray matter already coexpr

211 t a dose-dependent increase in the number of oligodendrocyte precursors in response to Shh.

212 Ascl1 also broadly marks oligodendrocyte precursors in subcortical gray and white

213 tion factor, transiently labels neuronal and oligodendrocyte precursors in the adult brain.

214 ping studies that cast NG2-glia as dedicated oligodendrocyte precursors in the healthy adult CNS-thou

215 These "NG2 cells" descend from oligodendrocyte precursors in the perinatal CNS and cont

216 lling evidence for a second dorsal origin of oligodendrocyte precursors in the spinal cord and hindbr

217 significant reduction in the number of p27+ oligodendrocyte precursors in the transgenic mice suppor

218 Myocilin also affects differentiation of oligodendrocyte precursors in vitro.

219 ition to primary cultures of differentiating oligodendrocyte precursors increases levels of tested ma

220 Oligodendrocyte precursors initially arise in restricted

221 Oligodendrocyte precursors injected into presumptive whi

222 at population of presumptive white matter by oligodendrocyte precursors is dependent on localized exp

223 that spontaneous myelin repair by endogenous oligodendrocyte precursors is much more robust than prev

224 What regulates this initial localization of oligodendrocyte precursors is unclear.

225 euroblasts, but DCX(+) cells coexpressed the oligodendrocyte precursor marker Olig2, suggesting cauti

226 During development oligodendrocyte precursors mature through a series of st

227 gram of cell proliferation during which many oligodendrocyte precursors, microglia, and some astrocyt

228 In the absence of viable axons, oligodendrocyte precursors migrated along the length of

229 Knockout mice show increased rates of oligodendrocyte precursor migration along the optic nerv

230 C antibody or netrin 1 dramatically inhibits oligodendrocyte precursor migration from the ventral ven

231 lice preparations, CXCL1 inhibited embryonic oligodendrocyte precursor migration, and widespread disp

232 erosis lesions, have the capacity to inhibit oligodendrocyte precursor migration, identifying netrin-

233 Signaling through CXCR2, CXCL1 inhibited oligodendrocyte precursor migration.

234 merits of the GRP cell vs. the motor neuron-oligodendrocyte precursor (MNOP) cell hypothesis.

235 h nondifferentiated and differentiated mouse oligodendrocyte precursor (mOP) cells in vitro.

236 e of demyelinated lesions is the presence of oligodendrocyte precursors (OLPs) blocked at a premyelin

237 They are descended from oligodendrocyte precursors (OLPs) in the perinatal CNS,

238 neurons (MNs), before switching abruptly to oligodendrocyte precursors (OLPs).

239 surface binding of IgG or IgM antibodies to oligodendrocyte precursor (OPC)-derived cell lines was s

240 y results in defects in the morphogenesis of oligodendrocyte precursors (OPCs) and CNS hypomyelinatio

241 During development, spinal cord oligodendrocyte precursors (OPCs) originate from the ven

242 expressed by motor neurons postnatally, and oligodendrocyte precursors (OPCs), as previously reporte

243 Oligodendrocyte precursors (OPs) continue to proliferate

244 sequentially generate motoneurons (MNs) and oligodendrocyte precursors (OPs).

245 mitotic oligodendrocytes but is not found in oligodendrocyte precursors or astrocytes.

246 In the spinal cord, oligodendrocyte precursors originate at the ventral midl

247 Neuronal (TUBB3) and oligodendrocyte precursor (PLP) markers were down-regula

248 Oligodendrocyte precursors (pre-OLs; O4(+)O1(-)) predomi

249 , supplemented cholesterol directly supports oligodendrocyte precursor proliferation and differentiat

250 hown previously to promote remyelination and oligodendrocyte precursor proliferation in a murine mode

251 n along the optic nerve and reduced rates of oligodendrocyte precursor proliferation in different reg

252 ne-alpha (GRO-alpha) is a potent promoter of oligodendrocyte precursor proliferation.

253 In purified cultures of oligodendrocyte precursors, Shh promotes cell survival a

254 Oligodendrocyte precursors subsequently disperse through

255 The addition of large numbers of oligodendrocyte precursors substantially reduces precurs

256 differentiation of NCAM- or ST8SIA2-negative oligodendrocyte precursors suggested an underlying cell-

257 osum, Ascl1 defines a ventral layer of early oligodendrocyte precursors that do not yet express other

258 In spinal cord, oligodendrocyte precursors that give rise to myelin-form

259 Following Brg1 deletion in oligodendrocyte precursors, these cells showed normal su

260 responsible for the localized appearance of oligodendrocyte precursors throughout the CNS, irrespect

261 oliferative response of immature spinal cord oligodendrocyte precursors to their major mitogen, plate

262 For example, mammalian oligodendrocyte precursors typically proliferate for app

263 perimental animals the appearance of ectopic oligodendrocyte precursors was correlated with local flo

264 tage 10-12 dorsal chick spinal cord, Mab O4+ oligodendrocyte precursors were induced both in vivo by

265 ing in the early appearance of metencephalic oligodendrocyte precursors, while in vitro studies sugge

266 dicate that NG2+ cells in the normal CNS are oligodendrocyte precursors with restricted lineage poten

267 nately controlled biophysical interaction of oligodendrocyte precursors within an axonal niche leadin