ライフサイエンスコーパス: oligodendroglial

1 e that, in the mature CNS, a fraction of the oligodendroglial 155 kDa isoform of neurofascin (NF-155)

2 s, these lesions were accompanied by pTDP-43 oligodendroglial aggregates.

3 Survivin up-regulation was also found in oligodendroglial and astrocytic cultures infected with J

4 Astrocytic, oligodendroglial and mixed gliomas are the commonest gli

5 ne expression profile enriched for synaptic, oligodendroglial- and schizophrenia-related genes.

6 trocytic reactivity, attenuated neuronal and oligodendroglial apoptosis and reduced the production of

7 dicate a role for glutamate as a mediator of oligodendroglial apoptosis in traumatic SCI.

8 n up-regulation associated with neuronal and oligodendroglial apoptosis, glial scar formation and mic

9 the extent of myelin loss, the frequency of oligodendroglial apoptosis, or CNS recruitment of macrop

10 ry occurrence, following T antigen-triggered oligodendroglial apoptosis.

11 We have used bipotent postnatal cortical oligodendroglial-astroglial progenitor cells (O-2As) to

12 body and T cell-mediated immune responses to oligodendroglial autoantigens transaldolase (TAL) and my

13 mmon progenitor to determine neuronal versus oligodendroglial cell fate acquisition.

14 with concurrent suppression of neuronal and oligodendroglial cell fates.

15 nes sufficient to destroy the myelin-forming oligodendroglial cell in vitro.

16 thermore, knockdown of Zfp488 via RNAi in an oligodendroglial cell line leads to the downregulation o

17 growth factor (PDGF) was investigated in the oligodendroglial cell lines CG4 and CEINGE clone 3, usin

18 erestingly, activation of LXRs also promotes oligodendroglial cell maturation and remyelination after

19 Directed neuronal, astroglial, and oligodendroglial cell migrations comprise a prominent fe

20 ggest that alphavbeta3 integrin may regulate oligodendroglial cell proliferation and that both downre

21 y in EAE, whereas the low level of Mn-SOD in oligodendroglial cells and axons may increase their vuln

22 onist-induced trafficking of native GPR17 in oligodendroglial cells and may have implications for bot

23 but synapses from axons onto myelin-forming oligodendroglial cells are not required.

24 ing differentiation of rat, mouse, and human oligodendroglial cells both in vivo and in vitro.

25 There was also a variable loss of oligodendroglial cells in the cerebral peduncle.

26 osis of injured, phosphatidylserine-exposing oligodendroglial cells is abrogated in the absence of AT

27 suggest that voltage-gated Ca(2+) influx in oligodendroglial cells is critical for normal myelinatio

28 st that Ca(2+) influx mediated by L-VGCCs in oligodendroglial cells is necessary for normal remyelina

29 their precursors rather than in neuronal or oligodendroglial cells is responsible for the reduction

30 and a significant reduction in RIP-positive oligodendroglial cells were detected at day 7 post-injur

31 ally depends on the successful generation of oligodendroglial cells, a therapeutic need that is curre

32 , HLA-A2-transfected, but not control MO3.13 oligodendroglial cells, expressing high levels of endoge

33 Tau-immunoreactive and Gallyas-positive oligodendroglial coiled bodies (similar to CBD and PSP),

34 Gallyas-positive neuropil threads and oligodendroglial coiled bodies were also observed.

35 ggest that S1P could be a part of the neuron-oligodendroglial communication network regulating OPC mi

36 Clinical protocols to treat oligodendroglial-containing tumors, brain lymphoma or pr

37 terferon-gamma (IFNG) on highly purified rat oligodendroglial cultures at different developmental sta

38 d gliosis as well as the frequency of glial (oligodendroglial) cytoplasmic inclusions (GCIs) and neur

39 pic examination suggest that the increase in oligodendroglial density is not a consequence of atrophy

40 ein levels showed dynamic alterations during oligodendroglial development and following oxidative str

41 Scribble is expressed throughout oligodendroglial development and is up-regulated in matu

42 ts suggest that the C5aR may be a marker for oligodendroglial differentiation and play a role in olig

43 p2 gene encodes one such potent inhibitor of oligodendroglial differentiation and this study sheds li

44 A minority of tumours with oligodendroglial differentiation are chemosensitive and

45 absence of Brg1 points to a contribution to oligodendroglial differentiation but also shows that the

46 TLR4 results in an overall reduction of the oligodendroglial differentiation capacity, thereby contr

47 hibit, TCF7l2 signaling to overcome arrested oligodendroglial differentiation in multiple sclerosis a

48 O-2A progenitor cells undergo progressive oligodendroglial differentiation when cultured in serum-

49 des both instructive and inhibitory cues for oligodendroglial differentiation, depending on the devel

50 at beta-catenin is dispensable for postnatal oligodendroglial differentiation, that Apc one-allele de

51 and astroglial differentiation and inhibited oligodendroglial differentiation, whereas 100 ng/ml BMP2

52 rmacological compounds potentially promoting oligodendroglial differentiation.

53 HLH cooperation can serve as a mechanism for oligodendroglial differentiation.

54 to astrocytes with concurrent suppression of oligodendroglial differentiation.

55 accumulation of p57kip2 resulted in blocked oligodendroglial differentiation.

56 we investigated whether ENV protein affects oligodendroglial differentiation.

57 Degeneration of oligodendroglial distal processes has been identified as

58 all examined in light of the hypothesis that oligodendroglial dysfunction and even death, with subseq

59 age, 1p loss of heterozygosity, presence of oligodendroglial elements, and MGMT promoter methylation

60 Deletion experiments indicated that an oligodendroglial enhancer located in the region from -6

61 yelinating stage are controversial, although oligodendroglial excitability is potentially important f

62 he fate of these multipotent cells toward an oligodendroglial fate-a subgroup myelinated up to 52% (m

63 tamic acid decarboxylase 65), as well as the oligodendroglial gene encoding CNPase (2',3' cyclic nucl

64 Thus, neuronal and oligodendroglial gene products are present in a subset o

65 The neuronal and oligodendroglial genes expressed in ex vivo bone marrow

66 q13-15 and expression of both astrocytic and oligodendroglial genes.

67 l care of adult patients with astrocytic and oligodendroglial gliomas, including glioblastomas.

68 ctivity-dependent glutamate release enhances oligodendroglial glucose uptake and glycolytic support o

69 Following induction with myelin oligodendroglial glycoprotein (MOG) peptide 35-55 in CFA

70 transgenic, or retrogenic, models of myelin oligodendroglial glycoprotein (MOG)-induced experimental

71 their immunomodulatory properties in myelin oligodendroglial glycoprotein-induced experimental aller

72 odified grade, 1p/19q codeletion status, and oligodendroglial histology for the 586 HGGs analyzed by

73 gnosis, endothelial proliferation, necrosis, oligodendroglial histology, treatment center, and chromo

74 findings in early MS lesions, where a marked oligodendroglial histone deacetylation was observed.

75 e absence of a correlation between increased oligodendroglial infection and the extent of demyelinati

76 cerebral white matter lesions with prominent oligodendroglial injury and loss, a disorder termed peri

77 lation of the biophysical elements of axonal-oligodendroglial interactions.

78 d individual genes typically associated with oligodendroglial lineage (e.g., proteolipid protein and

79 ous polyposis coli (Apc) and its role in the oligodendroglial lineage are poorly understood.

80 pressing cells in the astroglial but not the oligodendroglial lineage are the essential source of rea

81 ulate beta-catenin-mediated Wnt signaling in oligodendroglial lineage cells, and that APC regulates o

82 gnate receptor (PDGF-alphaR) is expressed on oligodendroglial lineage cells, such cells are considere

83 that N-acetylaspartate is expressed also by oligodendroglial lineage cells.

84 t signaling in early postnatal but not adult oligodendroglial lineage cells.

85 as a direct transcriptional repressor of the oligodendroglial lineage determinant Olig2.

86 noreactive APC is transiently induced in the oligodendroglial lineage during both normal myelination

87 erentiation of cells already committed to an oligodendroglial lineage during development.

88 ghts toward the cell of origin, highlighting oligodendroglial lineage genes, and reveals unexpected m

89 t PEDF to the medium enhanced expressions of oligodendroglial lineage markers (NG2 and PDGFralpha) an

90 GFAP:GFP- SVZ neural precursors coexpressing oligodendroglial lineage markers and transcription facto

91 Collectively, our data suggest that oligodendroglial lineage NMDARs are neither required for

92 romotes the elaboration of both neuronal and oligodendroglial lineage species and inhibits the effect

93 pregulated in a time-dependent manner in the oligodendroglial lineage within the lesion.

94 ich had been thought to be restricted to the oligodendroglial lineage, also unexpectedly gave rise to

95 and the relationship of synantocytes to the oligodendroglial lineage, in particular, remains controv

96 ired for timely postnatal development of the oligodendroglial lineage, nor significant participants i

97 system to conditionally ablate APC from the oligodendroglial lineage, we determined that APC enhance

98 s that Hdac3 interacts with p300 to activate oligodendroglial lineage-specific genes, while suppressi

99 ion but no defects in the development of the oligodendroglial lineage.

100 tipotent adult neural progenitor cells to an oligodendroglial lineage.

101 to commit to the astrocytic rather than the oligodendroglial lineage.

102 munoreactive for rip antibody, suggesting an oligodendroglial lineage.

103 is a Wnt effector induced transiently in the oligodendroglial lineage.

104 atter (WM) by delaying the maturation of the oligodendroglial lineage.

105 th concurrent suppression of the neuronal or oligodendroglial lineages, or both.

106 roxide production, mitochondrial injury, and oligodendroglial loss occurred in fetal brains exhibitin

107 140a(+) cells revealed overexpression of the oligodendroglial marker CD9, suggesting that CD9(+)/CD14

108 oth beta-tubulin- (neuronal marker) and O4- (oligodendroglial marker) immunoreactive cells and reduce

109 ransplantation into adult brain, neuronal or oligodendroglial markers segregated into distinct nonove

110 nside the CC lining started to express other oligodendroglial markers such as CNPase, RIP, and APC.

111 ker was the transcription factor SOX1; early oligodendroglial markers were chondroitin sulfate proteo

112 n and double-immunostained for ubiquitin and oligodendroglial markers, but not glial fibrillary acidi

113 ividing cells expressed mature astrocyte and oligodendroglial markers.

114 ro studies revealed that 5hmC is lost during oligodendroglial maturation but not microglial activatio

115 coupled receptor that has been identified as oligodendroglial maturation inhibitor because its stimul

116 ic effects of glutathione depletion and that oligodendroglial maturation is associated with decreased

117 Although oligodendroglial maturation of classical OL progenitor c

118 oles for axoglial interactions in regulating oligodendroglial maturation.

119 hic lateral sclerosis, suggesting a role for oligodendroglial MCT1 in pathogenesis.

120 emaphorin 3A and 3F, already known to direct oligodendroglial migration in development, may also be a

121 For example, genetic ablation of key oligodendroglial molecules abrogates the oligodendrocyte

122 These results suggest that oligodendroglial myelination is not only important for m

123 WHO 2000 grading criteria for high-grade oligodendroglial neoplasms [anaplastic oligoastrocytoma

124 Oligodendroglial neoplasms are a subgroup of gliomas wit

125 p12-15, and 10q22-26 and p53 mutation in 100 oligodendroglial neoplasms diagnosed at a single treatme

126 genotype and histological growth patterns of oligodendroglial neoplasms in association with MR imagin

127 These findings demonstrate that oligodendroglial neoplasms usually have loss of 1p and 1

128 Oligodendroglial neoplasms with the -1p/-19q genotype ar

129 ach to aid diagnosis and prognostication for oligodendroglial neoplasms.

130 ults suggest that trans interactions between oligodendroglial NF-155 and axonal ligands result in cro

131 Pharmacological studies have suggested that oligodendroglial NMDA glutamate receptors (NMDARs) media

132 Here we show that the stimulation of oligodendroglial NMDA receptors mobilizes glucose transp

133 ve deletion of NR3A, a modulatory subunit of oligodendroglial NMDARs, did not alter the course of MOG

134 We found that selective ablation of oligodendroglial NR1 did not alter the clinical severity

135 re there significant differences between the oligodendroglial NR1 KO and non-KO mice in numbers of ax

136 human MS, by timed conditional disruption of oligodendroglial NR1, an essential subunit of functional

137 rentiation by cultured EZCs without altering oligodendroglial or neuronal differentiation.

138 issues and cell lines of both astrocytic and oligodendroglial origin.

139 tamate homeostasis contributes to axonal and oligodendroglial pathology in MS.

140 he source of a small number of cells with an oligodendroglial phenotype during postnatal development

141 The oligodendroglial phenotype was highly associated with lo

142 fferentiation into neuronal, astroglial, and oligodendroglial phenotypes.

143 differentiation of cells with astroglial and oligodendroglial phenotypes.

144 nduced by K-RAS and AKT and compared them to oligodendroglial platelet-derived growth factor B-induce

145 ed microRNA (miR) delivery method to control oligodendroglial precursor cell (OPC) differentiation th

146 due to dysregulation of ganglioside-mediated oligodendroglial precursor cell proliferation.

147 iating NSCs resulted in maturation-resistant oligodendroglial precursor cells (OPC), a cell populatio

148 receptors mediate hypoxic-ischemic injury to oligodendroglial precursor cells (OPCs) in a model of PV

149 The ability to isolate oligodendroglial precursor cells (OPCs) provides a power

150 resent in close proximity to TLR4-expressing oligodendroglial precursor cells adjacent to multiple sc

151 Human and rat oligodendroglial precursor cells expressed TLR4, and the

152 NV receptor, Toll-like receptor 4 (TLR4), on oligodendroglial precursor cells in human brain tissue a

153 Differentiation of oligodendroglial precursor cells is crucial for central

154 Cultured primary oligodendroglial precursor cells were stimulated with EN

155 ogenic effect on normal neural precursor and oligodendroglial precursor cells, the putative cellular

156 lt of activation and recruitment of resident oligodendroglial precursor cells.

157 , resulting from both transgene induction in oligodendroglial precursors and the birth of new cells.

158 ode in late embryogenesis, and astrocyte and oligodendroglial precursors fail to appear.

159 riatal cells were mature oligodendrocytes or oligodendroglial precursors that were intrinsic to the s

160 of fetal astrocytes and, to a lesser extent, oligodendroglial precursors.

161 before the establishment of interneurons and oligodendroglial precursors.

162 enerated cells expressing Sox10, a marker of oligodendroglial precursors.

163 Nodal proteins and migrating oligodendroglial processes are no longer juxtaposed, and

164 +-dependent detachment and disintegration of oligodendroglial processes in the white matter of mice e

165 sion complex at the extremities of migrating oligodendroglial processes promotes process convergence

166 /kainate receptors, and preventing injury to oligodendroglial processes required the blocking of NMDA

167 ro, demonstrating that enhanced expansion of oligodendroglial processes requires signaling by extrace

168 broad zones within gaps between neighbouring oligodendroglial processes, and then are condensed into

169 Axons ensheathed by oligodendroglial processes, but not yet myelinated, were

170 partic acid) receptors located on peripheral oligodendroglial processes.

171 ormation but allow wrapping of some axons by oligodendroglial processes.

172 Oligodendroglial production within these clones is stimu

173 etermined that APC enhances proliferation of oligodendroglial progenitor cells (OPCs) and is essentia

174 Previous studies have shown that oligodendroglial progenitor cells (OPCs) can give rise t

175 rn mouse CNS is restricted to NG2-expressing oligodendroglial progenitor cells and oligodendrocytes.

176 Further, while oligodendroglial progenitor cells derived from cortical

177 hanced survival and maturation of newly born oligodendroglial progenitor cells in the normal corpus c

178 into lineage-restricted progenitors such as oligodendroglial progenitors (OPs).

179 (and LacZ-transfected), magnetically labeled oligodendroglial progenitors can be readily detected in

180 ive inflammatory microglia, and NG2 positive oligodendroglial progenitors in the hypoperfused corpus

181 ophin-3 (NT-3), primary cultures of cortical oligodendroglial progenitors were responsive to PDGF but

182 stage-specific IFNG-induced cytotoxicity in oligodendroglial progenitors.

183 otype, and BDNF exerts distinct effects upon oligodendroglial proliferation, differentiation, and mye

184 identified as an actin cytoskeleton-related oligodendroglial protein in the rat central nervous syst

185 the normal corpus callosum, and accelerated oligodendroglial regeneration in lysolecithin-induced co

186 ions correlated with a dramatic reduction of oligodendroglial repopulation in the demyelinated lesion

187 Interruption of oligodendroglial signaling to axons in Shiverer mutant m

188 endence of both axonal Robo1 positioning and oligodendroglial Slit2 production on cell-type-specific

189 indicate that myelinated axons require local oligodendroglial support.

190 nti-proliferative, astroglial-inductive, and oligodendroglial-suppressive effects of BMP2.

191 au and CBD-tau strains induce astroglial and oligodendroglial tau inclusions, recapitulating the dive

192 Here we demonstrate that oligodendroglial TNFR2 is a key mediator of tmTNF-depend

193 gamma signaling was associated with enhanced oligodendroglial tropism and delayed virus clearance.

194 We sequenced the CIC gene on 127 oligodendroglial tumors (109 with the 1p19q codeletion)

195 Remarkably, 9 of 10 murine oligodendroglial tumors (from p53+/- or ink4a/arf+/- ani

196 ificant associations of rs55705857 were with oligodendroglial tumors and gliomas with mutant IDH1 or

197 supplement 1p/19q prognostic information in oligodendroglial tumors and screen out cases that would

198 the potential to develop both astrocytic and oligodendroglial tumors given loss of p19(Arf), and that

199 g knowledge of the molecular pathogenesis of oligodendroglial tumors has spurred translational resear

200 Astrocytic and oligodendroglial tumors represent the two most common gr

201 Oligodendroglial tumors showed frequent loss of heterozy

202 ult patients with newly diagnosed anaplastic oligodendroglial tumors were randomly assigned to either

203 H mutational status identified patients with oligodendroglial tumors who did (and did not) benefit fr

204 Patients with 1p/19q codeleted anaplastic oligodendroglial tumors who participated in RTOG (Radiat

205 CIC gene is frequently mutated in oligodendroglial tumors with 1p19q codeletion.

206 ith IDH1-mutated and IDH2-mutated tumors and oligodendroglial tumors, albeit the specific mechanism o

207 genetic events differ between astrocytic and oligodendroglial tumors, but all tumors have an initiall

208 mor tissues and between GBMs and lower-grade oligodendroglial tumors.

209 of OLIG markers to augment identification of oligodendroglial tumors.

210 rvival with chemotherapy is not explained by oligodendroglial tumors.

211 also be the cell of origin for experimental oligodendroglial tumors.

212 vincristine (PCV) chemotherapy in anaplastic oligodendroglial tumors.

213 f RT increases both OS and PFS in anaplastic oligodendroglial tumors.

214 differ between grade-matched astrocytic and oligodendroglial tumors.

215 This study identified a group of oligodendroglial tumours with intact 1p/19q displaying d

216 The roles of oligodendroglial voltage-activated Na(+) channels (Nav)