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1 Size-exclusion chromatography revealed that oligomeric (125)I-PrP(Sc) were transported from the inte
2 llmarks of Alzheimer's disease (AD), soluble oligomeric Abeta has been hypothesized to be responsible
3 ilarly, intracerebroventricular infusions of oligomeric Abeta produced less microgliosis in mAPP(-/-)
6 proteins in human brain extract that bind to oligomeric Abeta1-42 (oAbeta1-42) and/or monomeric Abeta
9 15M S.A. candidate directly interacted with oligomeric Abeta42, as shown by coimmunoprecipitation an
10 omatic behaviours characterised by ultrafast oligomeric action chunks that correlated with deficient
13 ha-synuclein combinations using monomeric or oligomeric alpha-synuclein (MalphaSyn or OalphaSyn, resp
14 different alpha-synuclein SNPs and salivary oligomeric alpha-synuclein could be a potential diagnost
15 y, the further study was shown that salivary oligomeric alpha-synuclein in PD patients significantly
17 lucosylsphingosine triggers the formation of oligomeric alpha-synuclein species capable of templating
18 d using a highly sensitive Luminex assay and oligomeric alpha-synuclein was quantified by the combina
21 we found that in vitro delivery of exogenous oligomeric alphaSyn but not monomeric alphaSyn was causi
22 Here, we found an abnormal accumulation of oligomeric alphaSyn species in AD brains by custom ELISA
24 PP carboxylterminal fragments (APP-CTFs) and oligomeric amyloid beta (oAbeta) but no histological evi
28 mical and genetic evidence implicate soluble oligomeric amyloid-beta (Abetao) in triggering Alzheimer
29 elucidates our understanding of the soluble oligomeric amyloid-beta-Abetao-binding cellular prion pr
34 ion of total phenols, flavonoids, monomeric, oligomeric and polymeric flavanols, and color intensity
35 y at longer residence times, suggesting that oligomeric and polymeric species play an important role
36 sequential appearance of the same series of oligomeric and protofibrillar intermediates, the earlies
38 re we simulate the recognition of monomeric, oligomeric, and fibril amyloid-beta (Abeta) by three hom
39 lative channel forming ability of monomeric, oligomeric, and fibrillar forms of both Abeta(1-40) and
40 body, permits us to unambiguously assign the oligomeric arrangement of sGP and compare its structure
41 1 and pro-BMP-9 structures, but reveal a new oligomeric arrangement, with a domain-swapped, cross-arm
44 uronal cells to different types of misfolded oligomeric assemblies is directly related to the extent
45 t Abeta1-40, formed in the presence of SST14 oligomeric assemblies of 50 to 60 kDa that were visualiz
46 e pathologies of Alzheimer disease (AD), and oligomeric assemblies of each protein are localized to s
48 their DNA target sites, they form different oligomeric assemblies ranging from monomers, dimers, tet
54 nus, a 32-aa region near the C-terminal homo-oligomeric assembly domain, and portions of an interveni
58 tion on the MOM nucleates the assembly of an oligomeric Bax pore that is enlarged by alpha9 dimerizat
59 elevated glucose, as found in MetS/T2DM, and oligomeric beta-amyloid (Abeta) peptide, thought to be a
60 and a PAO show that low molecular weight and oligomeric carboxylic acids are kinetically equivalent a
61 se studies support a mechanism where complex oligomeric catalysts both racemize the starting material
63 exasaccharide isomers that interact with the oligomeric chemokine Monocyte Chemoattractant Protein-1
66 de evidence of cooperative insertion of homo-oligomeric complexes and demonstrate the possibility to
67 n of the receptor was present within dimeric/oligomeric complexes and that increased expression level
68 monomer and little is known about how higher oligomeric complexes assemble on effector proteins and i
70 phospholipid phosphatidic acid (PA) to form oligomeric complexes that permeabilize PA-containing mem
72 factors, such as transcription factors, form oligomeric complexes with structural symmetry that bind
73 ps regulate the size and stability of hetero-oligomeric complexes, indicating that terminal sHSP regi
80 their reactivity with at least two different oligomeric conformers from Alzheimer's, Parkinson and/or
81 ta-sheet secondary structure of pathological oligomeric conformers, characteristic of many neurodegen
82 ctroscopic studies provided insight into the oligomeric Cu-ligand complexes, which evolve during the
83 le precursors, and it relies on the fourfold oligomeric cyclization reaction of resorcinol with 2,3-d
84 king double helix of two right-handed coiled oligomeric defensin fibrils, the assembly of which is de
86 e Ru-S bond in Ohki-Tatsumi complexes breaks oligomeric DIBAL-H structures into their more reactive m
88 riavidus metallidurans BPHs disclosed a homo-oligomeric double-ring architecture in which the active
89 the soluble poly(ethylene oxide)-like linear oligomeric electrolyte breakdown products that are obser
90 Our work adds to evidence that the toxic oligomeric entities in protein aggregation diseases cont
91 physiological conditions consistent with the oligomeric filaments reported from in vitro experiments.
92 ydrolase that cleaves chitosan polymers into oligomeric fingerprints, ultrahigh-performance liquid ch
95 e blends, on the extraction of anthocyanins, oligomeric flavanols and polymeric flavanols from wither
96 at least a low-molecular weight coiled-coil oligomeric form and an amyloid fiber form involving the
97 t the structures of the low-molecular weight oligomeric form and the dynamics of their transitions to
100 nal and biochemical data, we investigate the oligomeric formation of HerA and detail the mechanism of
101 monoclonals are able to detect pathological oligomeric forms in different human neurodegenerative di
102 both in vitro and in vivo that nonfibrillar, oligomeric forms of Abeta are able to interact with the
103 t of the brain, whereas "bad" receptors bind oligomeric forms of Abeta that are largely responsible f
104 Mounting evidence indicates that soluble oligomeric forms of amyloid proteins linked to neurodege
106 of an antibody recognizing the toxic soluble oligomeric forms of different and unrelated amyloid spec
107 ent application of subtoxic doses of soluble oligomeric forms of human amyloid-beta (oAbeta) and Tau
108 d Psb28 proteins additionally associate with oligomeric forms of PSII and with PSII-PSI supercomplexe
110 and linker segments that stabilize different oligomeric forms such as tetramers, ULFs, and mature fil
111 dimer, tetramer, hexamer/octamer, and higher oligomeric forms that may be important determinants in d
115 peronin research, especially with the hetero-oligomeric forms, is to establish an efficient recombina
120 ompare this to a monomeric unit excised from oligomeric FP, which is also dysfunctional in bacterioly
121 ntrast, overexpression of a related secreted oligomeric glycoprotein, Nell2, which lacks only the T3R
124 eplication by interacting with the conserved oligomeric Golgi (COG) tethering complex, a major coordi
128 ) spectroscopy to refine the structure of an oligomeric integral membrane protein, Anabaena sensory r
134 the exceptions greater than 15 A are at homo-oligomeric interfaces, 19% arise from family structural
136 frared spectroscopy to spectrally resolve an oligomeric intermediate during the aggregation of the hu
137 esents the free energy cost of refolding the oligomeric intermediate into the structure of the amyloi
138 underpinnings for the higher toxicity of the oligomeric intermediates of amyloidogenic peptides, comp
139 g the structural aspects of the formation of oligomeric intermediates of beta2m and their subsequent
142 general approach to discrete collections of oligomeric macrocyclic depsipeptides using an oligomeriz
144 the exonic region of the gene for cartilage oligomeric matrix protein (COMP) leads to pseudoachondro
149 t cells to separate the perception of chitin oligomeric microbe-associated molecular patterns from th
150 predicted active site residues validate the oligomeric model and determined that each of the tested
152 arbon without Ag present, and the spectra of oligomeric molecular layers were completely consistent w
154 pyrroloindolines are an interesting class of oligomeric natural products that consist of multiple cyc
155 sa type III secretion system (T3SS), and its oligomeric nature allows for multiple complex binding an
157 ext of the virion, confirms the pH-sensitive oligomeric nature of the glycoprotein, indicating that t
159 d-beta (Abeta) peptide, particularly soluble oligomeric (oAbeta), considered a proximal neurotoxin an
161 ophores, coupled with either ethylene glycol oligomeric or polymeric diamines to yield bis-sulfonamid
162 ns have been identified that bind monomeric, oligomeric, or fibrillar forms of amyloid-beta (Abeta).
163 signal allowed for the determination of the oligomeric order and for obtaining long-range DEER dista
164 eir counterparts from seed plants, including oligomeric organization-PpSBPase is a dimer, and PpFBPas
165 ructural characterization of the full-length oligomeric p53 is challenging because of its complex arc
167 obility of the emitting entity, the specific oligomeric pathways undertaken by various proteins durin
171 alysis towards the synthesis of six distinct oligomeric polypyrroloindoline natural products: hodgkin
172 nt and filters the dynamics of the extracted oligomeric population based on arrival time between two
173 cently solved the first atomic model for Bax oligomeric pores at the membranes using computational ap
174 le monomers, perforin can self-assemble into oligomeric pores of 10-20 nm inner diameter in the membr
175 from the mitochondria to the cytosol via Bax oligomeric pores, a process which is required for apopto
176 ucturally diverse temporarily functional low-oligomeric pores, which mimic integral membrane protein
179 the structures of amyloid fibrils and their oligomeric precursors and of the mechanisms by which the
181 ata indicated that Abeta(1-42) assemblies in oligomeric preparations form voltage-independent, non-se
184 oped for separating the homologous series of oligomeric proanthocyanidins and the simultaneous assess
185 late manufacturing process on the content of oligomeric proanthocyanidins and their antioxidant capac
187 ns (B4 dimer, tetramer (TT) and fractions of oligomeric procyanidins), and the influence of several c
189 trategy for the computational design of homo-oligomeric protein assemblies with binding functionality
190 showed that the crRNA is stretched along an oligomeric protein assembly, leading us to ask how crRNA
192 y of interdomain signaling is challenging in oligomeric proteins is the difficulty in characterizing
195 -Wt induces the formation of beta-sheet-rich oligomeric protofibrils, which are important for adhesio
199 c sites, we used highly homologous, but homo-oligomeric, rho1 receptors that are contrastingly insens
200 30 monomers interact and assemble into large oligomeric ring complexes with different numbers of mono
203 for days) results in the formation of large oligomeric side-products that are difficult to break dow
204 glycerol mixed with 1.1 nm sized polyhedral oligomeric silsesquioxane (POSS) molecules using dielect
206 by a full agonist plus GTPgammaS reduced the oligomeric size of Gi1 without affecting that of the rec
212 H2-, -OCH2CH3, and -CH2CH3 contained in both oligomeric species and lithium semicarbonates ROCO2Li, R
213 synuclein (alphaS) self-assembles into small oligomeric species and subsequently into amyloid fibrils
214 periments that showed that MceA forms a homo-oligomeric species at the mitochondrial outer membrane d
215 ifamycin SV exert their effect by binding to oligomeric species both in solution and in gas phase.
217 it is not possible to characterize different oligomeric species by ensemble methods, especially the d
223 lecular weight (MW) complexes toward smaller oligomeric species that are competent to undergo ERAD.
225 tness) that tracks the mobility of different oligomeric species within live cell nuclear architecture
226 l amyloids, including the intermediate toxic oligomeric species, which can be sequestered in vivo in
230 , lack of regulation by the FRP, a different oligomeric state (monomer compared to dimer for OCP1) an
231 protonation state, (2) solvent exposure, (3) oligomeric state (the number of protein chains and thus
233 ltracentrifugation experiments to study VanS oligomeric state and conformation in the absence and pre
234 al position in human physiology, the in vivo oligomeric state and conformation of insulin in its stor
236 the UPR transducers entails changes in their oligomeric state and is easily corrupted by overexpressi
237 ity of information on the monomer structure, oligomeric state and locations of unreliable/flexible lo
238 escribed as a copper-binding protein and its oligomeric state as being monomeric, dimeric, and/or mul
239 ing of four residue types, and find that the oligomeric state at a given temperature depends on the s
240 ption factor relies on the modulation of its oligomeric state by 5'-deoxyadenosylcobalamin and light.
243 show that the CRD is involved in both higher oligomeric state formation and electron transfer to the
244 Nocardia farcinica, the determination of the oligomeric state in solution with small angle x-ray scat
246 theoretical basis for understanding how the oligomeric state of a transcriptional regulator influenc
247 ingle-molecule photobleaching to analyze the oligomeric state of an endoplasmic reticulum (ER) reside
248 ve mass spectrometry are used to analyze the oligomeric state of different soluble and full-length Fe
250 ns between FtsZ protofilaments, and that the oligomeric state of FtsA may influence FtsZ higher-order
251 ts has been used to successfully measure the oligomeric state of proteins at the plasma membrane, in
252 el was supported by in vitro analysis of the oligomeric state of TatA variants containing charge-inve
253 ing the internal translation site change the oligomeric state of the endolysin and reduce lytic activ
256 the two PSI-LHCI isomers and changes in the oligomeric state of the PSI-LHCI supercomplex, accompani
258 This dimer arrangement is different from any oligomeric state previously described, and it forms as a
259 quantify parameters including SHR mobility, oligomeric state, and association with SCR using a combi
260 r, PutAs vary widely in domain architecture, oligomeric state, and quaternary structure, and these va
261 ate information on the identity, solubility, oligomeric state, overall structure, and stability, as w
269 her work supports the formation of an active oligomeric state: (i) AUC data demonstrate the presence
270 visiae via several approaches to examine its oligomeric states and determine the effects of active si
271 rom different organisms to populate multiple oligomeric states in the presence of metal ions, e.g. Fe
277 l transitions between monomeric, dimeric and oligomeric states visualized by quantitative FRET analys
278 es the ability of K-Ras to exist in multiple oligomeric states whose population can be altered by int
286 ogy, and the ability to generate custom homo-oligomeric structures could enable new approaches to pro
287 two terminal residues strongly stabilize the oligomeric structures for Abeta42 relative to Abeta40, a
288 EBNA1 dimers can assemble into higher-order oligomeric structures important for diverse functions of
289 hese data support the influence of transient oligomeric structures on substrate accommodation and cat
290 the hypothesis that Abeta peptides can form oligomeric structures resembling cylindrins and beta-bar
291 nd NMR measurements for the determination of oligomeric structures would be widely applicable to memb
293 nd GrpEL2 associate with mtHsp70 as a hetero-oligomeric subcomplex and regulate mtHsp70 function.
296 ransgenic mouse model promoted insoluble and oligomeric tau accumulation leading to a physiological d
298 nally, CyP40 ameliorated silver-positive and oligomeric tau species in a mouse model of tau accumulat
299 ing of the allosteric regulator RuBP induces oligomeric transitions to the bacterial activase, it mer
300 uctural restraints for solving structures of oligomeric transmembrane domains (TMDs) of cell surface
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