ライフサイエンスコーパス: oligonucleotide

1 adical thiol-ene coupling of a substrate and oligonucleotide.

2 as the mRNA and siRNA or nuclear diffusible oligonucleotide.

3 cture of any TIA protein RRM in complex with oligonucleotide.

4 promoter DNA, and a de novo synthesized RNA oligonucleotide.

5 owing co-delivery with a single-stranded DNA oligonucleotide.

6 need for labelling of either probe or target oligonucleotide.

7 nly induced by chemically modified antisense oligonucleotides.

8 rs for sequence-specific detection of target oligonucleotides.

9 they both cleave simple single-stranded DNA oligonucleotides.

10 hen explored the interaction of 3-NT and DNA oligonucleotides.

11 s9 or by knocking down UBE3A using antisense oligonucleotides.

12 utomated design of hybridization and priming oligonucleotides.

13 nly distributed or 8 specifically positioned oligonucleotides.

14 t SFM4-3 can also PCR amplify these modified oligonucleotides.

15 idated in zebrafish embryos using morpholino oligonucleotides.

16 te for solid-phase synthesis of modified RNA oligonucleotides.

17 noparticles with terminal phosphate-modified oligonucleotides.

18 on the cell surface, where it recognizes CpG oligonucleotide 2006.

19 a DNA duplex built from a self-complementary oligonucleotide (5-CTTATPPPZZZATAAG-3) in water over a p

20 An 11-nt long G-rich DNA oligonucleotide, 5'-d(GTGTGGGTGTG)-3', corresponding to

21 directly the binding and unbinding of short oligonucleotides (7-12 nt) to a complementary strand hel

22 eaning the complex and addition of initiator oligonucleotide, a series of toehold-mediated strand dis

23 elivered together with SMN2 splice-switching oligonucleotides additively increase SMN expression and

24 ase transition exhibited by over 25 distinct oligonucleotides adsorbed to single-walled carbon nanotu

25 al inhibition by sequence-specific antisense oligonucleotides allows the unprecedented telomere-speci

26 ide chemical probes with proximity-dependent oligonucleotide amplification and imaging to quantify en

27 odality approach combining an Xist antisense oligonucleotide and a small-molecule inhibitor of DNA me

28 hree participants who received the antisense oligonucleotide and three who received placebo reported

29 ssembled monolayers (SAMs) of thiol-modified oligonucleotides and alkanethiols on gold surfaces.

30 n in vivo inhibition of miR-182 by antisense oligonucleotides and improved post-injury kidney functio

31 es with a total of 2.14 x 10(6) bytes in DNA oligonucleotides and perfectly retrieved the information

32 ingtin-lowering strategies include antisense oligonucleotides and RNA interference targeting mRNA, an

33 The chemical synthesis of oligonucleotides and their enzyme-mediated assembly into

34 Detection of GalNAc-conjugated oligonucleotides and their metabolites was achieved by c

35 gation reduces protein interactions with the oligonucleotide, and helps to overcome their intrinsic b

36 re hybridized with the fluorescently labeled oligonucleotide, and the excess unhybridized probe was s

37 biotin, bispecific antibodies, complementary oligonucleotides, and bioorthogonal click chemistry.

38 enantioselective catalysis and glycosylated oligonucleotides, and conclusions and perspectives are p

39 repair/removal of the damage in the excised oligonucleotides, and thus it is applicable to essential

40 ester molecular dyes, functional enzymes and oligonucleotides, and undergo self-division when transfo

41 Importantly, transfected synthetic RNA oligonucleotides antagonistic to the miRNA candidate sig

42 Antisense oligonucleotides (AONs) were designed specifically to bl

43 gonucleotides is different from unconjugated oligonucleotides, appropriate analytical methods are req

44 fic immunoprecipitation, the adaptor-ligated oligonucleotides are converted to dsDNA with an appropri

45 The isolated oligonucleotides are ligated to adaptors, and after dama

46 Assemblies of these oligonucleotides are polymorphic, but may be controlled

47 key strategies for photoswitch inclusion in oligonucleotides are presented and illustrated with rece

48 as of myofiber regeneration, where antisense oligonucleotides are stored in macrophages and delivered

49 used to confer drug-like properties onto the oligonucleotide as a whole, with minor chemical changes

50 coated with Ova as a model allergen and CpG oligonucleotide as an adjuvant (MNs-CIT) into the skin s

51 tural DNA nanotechnology-the field that uses oligonucleotides as a molecular building block for the p

52 orescence CDs functionalized 5-amino-labeled oligonucleotides as capture probe and label free oligonu

53 onucleotides as capture probe and label free oligonucleotides as detection probe.

54 Systemically administered antisense oligonucleotide (ASO) inhibited miR-182 in the kidneys u

55 half million components persist in antisense oligonucleotide (ASO) therapeutics because it has been f

56 Antisense oligonucleotide (ASO) therapeutics show tremendous promi

57 We utilize an antisense oligonucleotide (ASO) to reduce apoE expression in the b

58 roof of principle that therapeutic antisense oligonucleotide (ASO) treatment can effectively target t

59 We used an antisense oligonucleotide (ASO)-based inducible mouse model of SMA

60 We have previously reported on an antisense oligonucleotide (ASO-29) that dramatically improves audi

61 y, we here report the synthesis of antisense-oligonucleotides (ASO) and thyroid hormone T3 conjugates

62 Targeted delivery of antisense oligonucleotides (ASO) to hepatocytes via the asialoglyc

63 The most promising oligonucleotide, ASO7, downregulated ATXN2 mRNA and prot

64 Antisense oligonucleotides (ASOs) and RNA-interference approaches

65 Antisense oligonucleotides (ASOs) are small sequences of DNA able

66 Antisense oligonucleotides (ASOs) are versatile tools that can reg

67 Here, we show that antisense oligonucleotides (ASOs) effectively suppress PMP22 mRNA

68 rgeted degradation of SMN-AS1 with antisense oligonucleotides (ASOs) increases SMN expression in pati

69 how that systemic delivery of Dnm2 antisense oligonucleotides (ASOs) into Mtm1KO mice efficiently red

70 Antisense oligonucleotides (ASOs) modified with phosphorothioate (

71 We evaluated antisense oligonucleotides (ASOs) targeting Angptl3 messenger RNA

72 hat translation can be enhanced by antisense oligonucleotides (ASOs) that target upstream open readin

73 of the JCI, successfully utilized antisense oligonucleotides (ASOs) to reduce PMP22 and ameliorated

74 Antisense oligonucleotides (ASOs) with phosphorothioate (PS) linka

75 ring (siRNAs), microRNAs (miRNAs), antisense oligonucleotides (ASOs), aptamers, synthetic mRNAs and C

76 at the ATXN2 gene by screening 152 antisense oligonucleotides (ASOs).

77 information storage in DNA using synthesized oligonucleotides assembled in vitro.

78 uce large amounts of any RNA or modified RNA oligonucleotide at a fraction of the cost of chemical sy

79 yces cerevisiae based on annealing synthetic oligonucleotides at the lagging strand of DNA replicatio

80 en achieved through modifications within the oligonucleotide backbone, sugar and heterocycles.

81 nitor cells lentivirally labeled with unique oligonucleotide barcodes flanked by sequencing primer ta

82 ique Molecular Identifiers (UMIs) are random oligonucleotide barcodes that are increasingly used in h

83 both datasets supporting our conclusion that oligonucleotide-based capture methods can be used to obt

84 hallenges in delivery to the brain, multiple oligonucleotide-based compounds are now being developed

85 st new central nervous system (CNS)-targeted oligonucleotide-based drug (nusinersen/Spinraza) was app

86 In this context, a structurally responsive oligonucleotide-based electrochemical impedimetric biose

87 sequences that are bound by protein-based or oligonucleotide-based fluorescent probes.

88 We developed an oligonucleotide-based inhibitor (CD5-2), which disrupted

89 In just the past 5 years, over 100 antisense oligonucleotide-based therapies have been tested in phas

90 of great benefit to boost the development of oligonucleotides-based antimicrobials of superior effica

91 In this work, hapten-oligonucleotide bioconjugate probes, with sequences comp

92 cking primers and peptide-nucleic acid (PNA) oligonucleotide blockers.

93 s increasing demand for RNA and modified RNA oligonucleotides, but in contrast to DNA oligonucleotide

94 a technique that uses hundreds of short DNA oligonucleotides, called staple strands, to fold a long

95 ulosis ribosomes we find that an interfering oligonucleotide can inhibit trans-translation, yet POA d

96 -induced dissociation (CID) data of modified oligonucleotides can be compared.

97 Guanine-rich oligonucleotides can form G-quadruplexes (G4), which are

98 over, pretreatment of the cells with a decoy oligonucleotide carrying wild-type p53-response element

99 We have developed a method for capturing oligonucleotides carrying bulky base adducts, including

100 One of these oligonucleotide chains has been specifically designed to

101 One outstanding challenge in oligonucleotide chemical development is the optimization

102 tant has globally increased amounts of Spo11-oligonucleotide complexes and altered Spo11-oligonucleot

103 Here, we use Spo11-oligonucleotide complexes, a byproduct of DSB formation,

104 This method utilizes oligonucleotide-conjugated polyclonal antibodies and qua

105 mode of TIA-1 RRM23 interaction with target oligonucleotides consistent with the role of TIA-1 in bi

106 ble-helical layers; we use a central weaving oligonucleotide containing a sequence of four six-base r

107 compatible modified DNA, we have synthesized oligonucleotides containing several structurally and ele

108 Oligonucleotides containing the G allele of this promote

109 Oligonucleotides containing these backbone modifications

110 Oligonucleotides containing two risk variants are bound

111 Engaging TLR9 with CpG oligonucleotide contributes to the development of IL17A(

112 Of the two major classes of CpG-containing oligonucleotides, CpG-A appears restricted to inducing t

113 The crystal structure of the complex of the oligonucleotide d[AAATTT]2 with compound 1 solved at 1.2

114 This leads to the design of two oligonucleotides d(TG4AC7) and d(TG(Br)GG(Br)GAC7) that

115 djuvanted by a robust formulation of the CpG oligonucleotide delivered in emulsion were superior to u

116 Deep sequencing of Spo11 oligonucleotides demonstrates that Tel1 shapes the genom

117 By borrowing knowledge from oligonucleotide design and nucleosome occupancy models,

118 This oligonucleotides detection probe was observed to detect

119 Its complexation to oligonucleotides determines a singular and very large de

120 rchitecture, and establish the importance of oligonucleotide distribution in the assembly behavior of

121 bservation, which revealed the importance of oligonucleotide distribution in this observed assembly b

122 microbial compounds, metabolic products, and oligonucleotides/DNA), rather than intact microorganisms

123 ither double-stranded DNA or single-stranded oligonucleotide donors by up to 5.6-fold.

124 are required for further optimization of the oligonucleotide drug development process for brain appli

125 Nusinersen is an antisense oligonucleotide drug that modifies pre-messenger RNA spl

126 One of the key advantages of oligonucleotide drugs is that their delivery and potency

127 be uniquely and efficiently modulated by the oligonucleotide drugs.

128 sphormadite easily incorporated into any DNA oligonucleotide during initial DNA synthesis.

129 Correlations are reported between oligonucleotide effective charges and current blockages,

130 ase chain reaction where one homology arm is oligonucleotide encoded.

131 Aptamers are short DNA or RNA oligonucleotides evolved from systematic evolution of li

132 t human clinical trial, with other antisense oligonucleotides expected to enter trials in the next 1-

133 ular photoswitches have been incorporated in oligonucleotides for 20 years, and the field has current

134 requires laborious PCR using many different oligonucleotides for each sequence analyzed.

135 s and their host genomes often share similar oligonucleotide frequency (ONF) patterns, which can be u

136 , we investigated the folding preferences of oligonucleotides from a chromosomal breakpoint hotspot i

137 rification of the DNA nanoswitches, removing oligonucleotides from the scaffold strand and causing lo

138 Oxidation sites on the oligonucleotide generated by two oxidants, catechol/Cu(2

139 Human testing of brain-targeted oligonucleotides has highlighted unusual pharmacokinetic

140 Although DNA oligonucleotides have been used extensively as the progr

141 Single-stranded DNA oligonucleotides have unique, and in some cases sequence

142 T-oligo, a guanine-rich oligonucleotide homologous to the 3'-telomeric overhang

143 nd Al) were successfully functionalized with oligonucleotides, illustrating the generality of this st

144 mRNA, siRNA and 2'O-methyl phosphorothioate oligonucleotide in vitro transfection abilities.

145 ist and h-rise than observed for a 'control' oligonucleotide in which nucleobase pairs are replaced b

146 a of structurally rigid, double-stranded DNA-oligonucleotides in aqueous buffer and in buffers with s

147 tabilizing these luminescent nanoprobes with oligonucleotides in biological systems.

148 e uptake and metabolism of GalNAc-conjugated oligonucleotides in incubations of primary rat hepatocyt

149 melt non-covalently attached double-stranded oligonucleotides in solution.

150 oducts of GalNAc conjugated and unconjugated oligonucleotides in target cells.

151 e H cleavage identified accessible sites for oligonucleotides in the revealed secondary structure of

152 elayed administration of periostin antisense oligonucleotides in wild-type animals with GN reversed a

153 robes (e.g., short fluorescently labeled DNA oligonucleotides) in combination with wide-field epifluo

154 by the feed ratio of nucleotide (monomer) to oligonucleotide (initiator), as typically observed for l

155 rate a specific output signal in response to oligonucleotide input patterns.

156 HSA did not hinder the activity of silencing oligonucleotides inside cells, and the degradation of DN

157 ation is an attractive approach to modifying oligonucleotides intended for therapeutic purposes.

158 chemical one-pot method for the assembly of oligonucleotides into a gene by click-DNA ligation.

159 tion of highly polar anionic single stranded oligonucleotides into cells and tissues.

160 ngs; enzymatic amplification and ligation of oligonucleotides into genes and genomes makes automation

161 The insertion of thiol-oligonucleotides into p-ATP monolayers previously oxidiz

162 very of phosphorothioated TRAF3IP2 antisense oligonucleotides into the LV in a clinically relevant ti

163 f these derivatives into the backbone of DNA oligonucleotides is described.

164 n and biotransformation of GalNAc-conjugated oligonucleotides is different from unconjugated oligonuc

165 the HIV-RNA for hybridization with a capture oligonucleotide, it is readily applicable to any HIV sys

166 ing a magnetic liquid support and ion-tagged oligonucleotide (ITO) probes.

167 d human cortical neurons following antisense oligonucleotide knockdown.

168 by sequencing (CITE-seq), a method in which oligonucleotide-labeled antibodies are used to integrate

169 y characterize the effect of GalNAc valency, oligonucleotide length, flexibility and chemical composi

170 -oligonucleotide complexes and altered Spo11-oligonucleotide lengths, consistent with conserved roles

171 dead tel1 mutation similarly increases Spo11-oligonucleotide levels but mutating known Tel1 phosphota

172 ngineering, Millstone allows users to design oligonucleotide libraries and create successive versions

173 dons K103N, Y181C, G190A, M184 V, or K65R by oligonucleotide ligation assay and Illumina sequencing.

174 Antisense oligonucleotides linked by phosphorothioates are an impo

175 etic measurements by LC-MS/MS sequencing for oligonucleotides longer than 20 base pairs (bp).

176 A-binding loops, such as the oligosaccharide-oligonucleotide loops, helix 2 insertion loops, and pres

177 Antisense oligonucleotides may be coupled to high-affinity ligands

178 ites based on insensitivity to DNA antisense oligonucleotide-mediated RNase H digestion.

179 ling studies of suicide and depression using oligonucleotide microarrays have often failed to disting

180 3.2), ASO 25mg/kg: 2.8 (0.7; 5.0), mismatch oligonucleotide (MM) 25mg/kg: 5.7 (5,0; 5.8), saline: 4.

181 out the need for prior sample preparation or oligonucleotide modification.

182 cal reaction impedance for Fe(CN)6(3-/4-) on oligonucleotide-modified electrodes showed remarkable (d

183 conjugates: (1) a single-stranded morpholino oligonucleotide (MORF1) attached to an anti-CD20 Fab' fr

184 MORF1); (2) multiple copies of complementary oligonucleotide MORF2 grafted to a linear polymer of N-(

185 tiles can be used as a platform to organize oligonucleotides, nanoparticles, and proteins into exten

186 oductivity, the chemical architecture of the oligonucleotide needs to be optimized with a combination

187 We probe the role of protein oligonucleotide number and conjugate size on this observ

188 nd familial mutations in the oligosaccharide-oligonucleotide (OB) folds of POT1 have been identified

189 A and that it also efficiently PCR amplifies oligonucleotides of mixed RNA and DNA composition.

190 rface native d-DNA with its enantiomer l-DNA-oligonucleotides of opposite chirality are incapable of

191 synthetic pathway with microchip-synthesized oligonucleotides (oligo).

192 gene-length fragments from shorter groups of oligonucleotides (oligos), is becoming an increasingly i

193 binds a conserved motif located between the oligonucleotide/oligosaccharide fold (OB-fold) and A sub

194 Oligonucleotide/oligosaccharide-binding (OB) domain-cont

195 sity for p261C and the phosphodiesterase and oligonucleotide/oligosaccharide-binding domains of p59.

196 otide, which hybridizes to its complementary oligonucleotide on the MPN.

197 rtant to determine the hypochromicity of the oligonucleotide or complex nucleic acid structure.

198 rimer extension or PCR synthesis of modified oligonucleotides or DNA.

199 nding protein Nanos2 by morpholino antisense oligonucleotides, or knockout of the Nanos2 gene by CRIS

200 circuits typically provide a single-stranded oligonucleotide output, limiting the ability to effect b

201 bited high selectivity for the complementary oligonucleotides over single-base-mismatch, two-base-mis

202 lidated our method using synthetic model DNA oligonucleotide-peptide heteroconjugates, which were sub

203 Significantly, higher-order structures (oligonucleotides, peptides and liposomes) are formed und

204 trophy (DMD), employing morpholino antisense oligonucleotides (PMO-AO) to exclude disruptive exons fr

205 LTA), thymidine homopolymer phosphorothioate oligonucleotide [Poly(dT)], and polyinosinic-polycytidyl

206 ion of T4 DNA ligase-catalyzed DNA templated oligonucleotide polymerization toward the evolution of a

207 and aptamer integrity was confirmed using an oligonucleotide precipitation assay.

208 e first time a "click" chemistry approach to oligonucleotide probe elongation as a novel approach to

209 An amino-modified single stranded DNA oligonucleotide probe synthesised based on complementary

210 using molecular beacons (MBs) - fluorogenic oligonucleotide probes - with minimal target engineering

211 The oligonucleotide probes consist on anabolic androgenic st

212 antibody binding to the corresponding hapten-oligonucleotide probes immobilized on the nanostructured

213 Oligonucleotide probes labeled with pyrene pairs that fo

214 ives rise to a heterogeneous distribution of oligonucleotide probes on the surface, negatively affect

215 Oligonucleotide probes targeting unmethylated sequences

216 Targeted genome capture (TGC) utilizes oligonucleotide probes to enrich specific nucleic acids

217 mer sensing element with covalently attached oligonucleotide probes.

218 dization with a set of fluorescently labeled oligonucleotide probes.

219 The technique utilizes oligonucleotide-probes that direct DSN activity to multi

220 erative transformations of a complex pool of oligonucleotides rapidly produced large combinatorial ge

221 by 4-color flow cytometry or allele-specific oligonucleotide real-time quantitative polymerase chain

222 Because oligonucleotide recombination is routinely performed in

223 ches' directly into the replication fork via oligonucleotide recombination, examine the directionalit

224 ent interferes with the hybridization of the oligonucleotide remain poorly understood.

225 Targeting tRNA(Arg)(UCU) with an antisense oligonucleotide replicated effects of Hili and also inhi

226 ragment ZF8-13 of PRDM9c, in complex with an oligonucleotide representing a known PRDM9c-specific hot

227 zed a 32 base pair (bp) double-stranded (ds) oligonucleotide representing exon 7 of the p53 gene.

228 ylgalactosamine-conjugated anti-microRNA-122 oligonucleotide, resulted in a significant viral load re

229 esent a variation of a previously described "Oligonucleotide Retrieval Assay" designed to measure DNA

230 Moreover, we developed an oligonucleotide retrieval immunoprecipitation (ORiP) ass

231 generated by array synthesis using parallel oligonucleotide retrieval.

232 allization of MAX with a 5caC modified E-box oligonucleotide revealed that MAX Arg36 recognizes 5caC

233 estigate the regulatory role of thousands of oligonucleotide sequences simultaneously.

234 non-complimentary, T-A and G-C base mismatch oligonucleotide sequences, respectively.

235 ) covalently linked to specifically designed oligonucleotide sequences.

236 is using single mismatched and complementary oligonucleotide sequences.

237 quence-specific responses of RNA variants to oligonucleotide signals.

238 etection probe was observed to detect target oligonucleotides specifically and sensitively in a linea

239 Analysis of dC homo-oligonucleotide strands ranging in length from 10 to 30

240 gh specific hybridization with complementary oligonucleotide strands.

241 In particular, the photoregulation of oligonucleotide structure and function is a rapidly deve

242 ntegrating large-scale computational design, oligonucleotide synthesis, yeast display screening and n

243 rmance of sensor was shown with the specific oligonucleotide target and attained the sensitivity of 0

244 ng conditions, the single stranded CCCVd RNA oligonucleotide target could be quantified in a wide ran

245 aneous injections of placebo or an antisense oligonucleotide targeting ANGPTL3 mRNA in a single dose

246 inical trials with drisapersen, an antisense oligonucleotide targeting exon 51: an open label study i

247 Oligonucleotides targeting mouse Angptl3 retarded the pr

248 The oligonucleotide targets were detected by measuring the c

249 rmodynamics of hybridization for full-length oligonucleotide-template alignments - thermoalignments -

250 Oligonucleotide-templated reactions are valuable tools f

251 , we report a novel platform for fluorogenic oligonucleotide-templated reactions between peptide nucl

252 motifs from Meg3 RNA, termed triplex-forming oligonucleotides (TFOs), in MIN6 cells suppressed c-Met

253 An intrathecally delivered antisense oligonucleotide that aims to lower huntingtin is now wel

254 te targeted N-acetylgalactosamine conjugated oligonucleotide that antagonises miR-122, in patients wi

255 Custirsen is a second-generation antisense oligonucleotide that inhibits clusterin production.

256 second generation highly specific antisense oligonucleotide that inhibits the production of clusteri

257 only approved SMA treatment is an antisense oligonucleotide that targets the intronic splicing silen

258 Aptamers consist of short oligonucleotides that bind specific targets.

259 rescent protein iLOV from ten functionalized oligonucleotides that contain 5'-azide and 3'-alkyne uni

260 unknown principles of the folding of G-rich oligonucleotides that could be applied to the prediction

261 Chemically modified oligonucleotides that disrupt the interaction between SM

262 t reversibly change direction in response to oligonucleotides that drive strand-displacement (17) rea

263 Consideration is given to the delivery of oligonucleotides that mimic or inhibit miRNA function us

264 The introduction of "poison" oligonucleotides that specifically disrupt critical nonc

265 After nearly 40 years of development, oligonucleotide therapeutics are nearing meaningful clin

266 as well as other classes of investigational oligonucleotide therapeutics to the liver.

267 Oligonucleotide therapeutics, such as antisense or Trans

268 Oligonucleotide therapies are currently experiencing a r

269 RNA oligonucleotides, but in contrast to DNA oligonucleotides, they are typically prohibitively expen

270 dily biofunctionalized with both protein and oligonucleotide through covalent immobilization.

271 smaller 3-deaza-adenosine analogs, into DNA oligonucleotides to assess RNA Pol II transcription elon

272 is an approach that uses single-stranded DNA oligonucleotides to capture specific genomic sequences i

273 ular hybrid minigene combined with antisense oligonucleotides to enable verification of functional RB

274 n as a mild, reagent-free strategy to attach oligonucleotides to gold surfaces.

275 We used Cavbeta antisense oligonucleotides to knock down Cavbeta and gabapentin, a

276 oxidized, and the covalent binding of amino-oligonucleotides to pure p-MBA monolayers give rise to i

277 MdMYB39L expression in pollen via antisense oligonucleotide transfection significantly reduced the e

278 nts of several different single-stranded DNA oligonucleotides trapped in an MspA nanopore.

279 l lines compared with wild-type or scrambled oligonucleotide-treated cells, respectively.

280 ckade of the inhibitory receptor CD96 or CpG-oligonucleotide treatment.

281 struct and release it upon recognition of an oligonucleotide trigger.

282 s was hybridized to three biomarker-specific oligonucleotides (TRs) via their 5'-end regions and to a

283 Further work on oligonucleotide uptake, development of formulations for

284 PEGylation of an oligonucleotide using a brush polymer can improve its bi

285 hod was developed to identify metabolites of oligonucleotides using capillary flow liquid chromatogra

286 an accurate determination of metabolites of oligonucleotides was achieved, independent of their sequ

287 -acetylgalactosamine conjugated anti-miR-122 oligonucleotide, was well tolerated and resulted in subs

288 ng of docking of oxidizing species on the ds-oligonucleotide were consistent with the experimental co

289 Oxidized oligonucleotides were cut by a restriction endonuclease

290 Antisense oligonucleotides were designed based on the secondary st

291 A quarter of a century has passed since oligonucleotides were first applied in living mammalian

292 When C9ORF72 was overexpressed or antisense oligonucleotides were targeted to the C9orf72 hexanucleo

293 primarily from the chemical structure of the oligonucleotide whereas their target is defined by the b

294 est is conjugated with a single-stranded DNA oligonucleotide, which hybridizes to its complementary o

295 lenges the identification of target-specific oligonucleotides, which limits genetics and genomics res

296 an be used as scaffolds to carry therapeutic oligonucleotides, while particles with strong interferon

297 MethylBreak (MB) is a 22-mer oligonucleotide with one hemimethylated and two unmethyl

298 Thus, as oligonucleotides with a particular chemical design show

299 d the simultaneous incorporation of up to 12 oligonucleotides with as many as 60 targeted mutations i

300 Formulation of miRNA-directed oligonucleotides with such skin-penetrating epidermal ag