ライフサイエンスコーパス: oligopeptidase

1 idase IV, dipeptidyl peptidase 9, and prolyl oligopeptidase.

2 they are predicted to be cleaved by a prolyl oligopeptidase.

3 than the analogous Y473F mutation of prolyl oligopeptidase.

4 , act separately from SPP as a novel stromal oligopeptidase.

5 ability of peptidase IImes to act also as an oligopeptidase.

6 acts and synthetic peptides, an enzyme named oligopeptidase 1 (OLP1) was found that catalyzes the cle

7 es dipeptidyl peptidase 3 (DPP-3) and thimet oligopeptidase 1 (TOP-1), both of which are present in n

8 Escherichia coli encodes the metalloprotease oligopeptidase A (OpdA).

9 We found that among oligopeptidases, a residue of the catalytic apparatus is

10 The group B streptococcal enzyme also showed oligopeptidase activity and degraded a variety of small

11 ial covalent reversible inhibitors of prolyl oligopeptidase activity.

12 Additionally, with prolyl oligopeptidase and aminopeptidase B we identified two ne

13 opeptidase class of serine proteases, prolyl oligopeptidase and oligopeptidase B, showed that resonan

14 including DPP-4, DPP-7, DPP-8, DPP-9, prolyl oligopeptidase, and acylpeptide hydrolase.

15 e cytosol, endopeptidases, especially thimet oligopeptidase, and aminopeptidases degrade many proteas

16 Oligopeptidase B (OPB) is a serine peptidase with dibasi

17 the activity of a T. cruzi serine peptidase, oligopeptidase B (OPB).

18 ity followed by mass spectrometry identified oligopeptidase B (OPB; Clan SC, family S9A) as the respo

19 Oligopeptidase B (OpdB) is a serine peptidase broadly di

20 or OPB and provide the first structure of an oligopeptidase B at high resolution.

21 85-residue peptide with high homology to the oligopeptidase B family in prokaryotes and eukaryotes.

22 work implicated the T.cruzi serine hydrolase oligopeptidase B in the generation of Ca2+-signaling act

23 n defect is associated with the inability of oligopeptidase B null mutant trypomastigotes to mobilize

24 Our data suggest that the T. cruzi oligopeptidase B participates in processing events in th

25 Exogenous recombinant oligopeptidase B reconstitutes the oligopeptidase B-depe

26 id t-butoxycarbonyl-(D)Val-Leu-(L)boroArg to oligopeptidase B resulted in potent, slow binding inhibi

27 e we show that deletion of the gene encoding oligopeptidase B results in a marked defect in host cell

28 The T. cruzi oligopeptidase B was expressed as a fully active product

29 serine proteases, prolyl oligopeptidase and oligopeptidase B, showed that resonances corresponding t

30 he H652A and H652Q active center variants of oligopeptidase B, there are two resonances observed in t

31 evealed a novel enzyme, denominated T. cruzi oligopeptidase B, which is homologous to members of the

32 combinant oligopeptidase B reconstitutes the oligopeptidase B-dependent Ca2+ signaling activity in nu

33 yl endopeptidase and the bacterial peptidase oligopeptidase B.

34 de chain to form the oxyanion hole is prolyl oligopeptidase, but the Y44F mutation of cocE has a more

35 ies between the active centers of the prolyl oligopeptidase class of serine proteases and the pancrea

36 on NMR spectra for two members of the prolyl oligopeptidase class of serine proteases, prolyl oligope

37 e-substituted dirhodium catalyst to a prolyl oligopeptidase containing a genetically encoded L-4-azid

38 Thimet oligopeptidase (EC 3.4.24.15) and neurolysin (EC 3.4.24.

39 ls overexpressing mouse neurolysin or thimet oligopeptidase (EC 3.4.24.15), a closely related metallo

40 peptidase IV (DP-IV), a member of the prolyl oligopeptidase family of peptidases, is involved in the

41 which is homologous to members of the prolyl oligopeptidase family of serine hydrolases, known to par

42 triad residues characteristic of the prolyl oligopeptidase family of serine proteinases (Ser-Asp-His

43 d sequence showed 66.4% identity to the PepF oligopeptidase from Lactococcus lactis, a member of the

44 structure of a hexameric serine protease, an oligopeptidase from Pyrococcus horikoshii (PhAAP), revea

45 This mutant lacks the Dictyostelium prolyl oligopeptidase gene (dpoA).

46 Oligopeptidases impose a size limitation on their substr

47 II-(1-7) or bradykinin(1-5), and the prolyl oligopeptidase inhibitor Fmoc-Ala-Pyr-CN (IC(50) = 50 nm

48 -KO mice were treated with S-17092, a prolyl-oligopeptidase inhibitor that inhibits the formation of

49 s, we have reported covalent bicyclic prolyl oligopeptidase inhibitors that were highly selective for

50 Thimet oligopeptidase mutated so that neurolysin residues are a

51 The oligopeptidase neurolysin (EC 3.4.24.16; Nln) was first

52 tems in Arabidopsis thaliana, the organellar oligopeptidase, OOP (At5g65620).

53 P3 is induced in wild-type cells by a prolyl oligopeptidase (POase) inhibitor.

54 Prolyl oligopeptidase (POP) is a large 80 kDa protease, which c

55 Prolyl oligopeptidase (POP) is widely distributed in mammals, w

56 processing enzyme is a member of the prolyl oligopeptidase (POP) subfamily of proteases (EC 3.4.21.2

57 es, each containing a gene encoding a prolyl oligopeptidase (POP).

58 tides, similar to the closely related prolyl oligopeptidase (POP).

59 Prolyl oligopeptidase (PREP) accelerates the aggregation of alp

60 Prolyl oligopeptidase (PREP) can accelerate the aSyn aggregatio

61 exert toxic effects on neurons, while prolyl oligopeptidase (PREP) has been shown to interact with aS

62 shares exopeptidase specificity, and prolyl oligopeptidase (PREP), with which it shares endopeptidas

63 idases (DPPs) DPPIV, DPP9, DPPII, and prolyl oligopeptidase (PREP).

64 The intracellular enzyme prolyl oligopeptidase probably degrades tasidotin to P5.

65 expression of leucine aminopeptidase, thymet oligopeptidase, puromycin-sensitive aminopeptidase, and

66 His-495/Asn-496, and Arg-498/Thr-499; thimet oligopeptidase residues listed first) in their substrate

67 Inhibitors of prolyl oligopeptidase reverse the effects of all three drugs on

68 n neurolysin switch hydrolysis to the thimet oligopeptidase site.

69 Therefore, cytosolic oligopeptidases such as TPPII normalize rates of intrace

70 that proteases, such as the trypanopains and oligopeptidases that are released by trypanosomes, could

71 er one of the two sites is mutated in thimet oligopeptidase, then the enzyme cleaves almost equally a

72 rolylprolinal (BCPP), an inhibitor of prolyl oligopeptidase, there was a 30-fold increase in the IC(5

73 bitor of the cytosolic endopeptidase, thimet oligopeptidase (TOP) (EC ), whose physiological function

74 Thimet oligopeptidase (TOP) is a zinc metallopeptidase that met

75 One such endopeptidase, thimet oligopeptidase (TOP), which was recently shown to degrad

76 igest matched the protein sequence of thimet oligopeptidase (TOP).

77 degraded by the metalloendopeptidase, thimet oligopeptidase (TOP).

78 We demonstrate that thimet oligopeptidases (TOPs) constitute a class of SA-binding

79 We show that a large oligopeptidase, tripeptidylpeptidase II (TPPII), can com

80 ent aggregation, and we found that different oligopeptidases use different strategies to achieve such

81 e ITC-ERM approach to another enzyme (prolyl oligopeptidase), we unexpectedly discovered non-Michaeli

82 y deletion of the gene that codes for prolyl oligopeptidase, which also regulates inositol metabolism

83 quences of a T. denticola surface-associated oligopeptidase with BANA-hydrolyzing activity, we identi