ライフサイエンスコーパス: omega-hydroxylase

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1 on of a terminal hydroxyl to the substrates (omega-hydroxylase).

2 have been functionally defined as fatty acid omega-hydroxylases.

3 xygenase-1 and smooth muscle cytochrome P450 omega-hydroxylase activities, and by astrocytic and smoo

4 ed as either arachidonic acid or lauric acid omega-hydroxylase activity (1.4-2.0-fold increases) and

5 se results demonstrate the existence of P450 omega-hydroxylase activity and 20-HETE formation in the

6 f the fact that 1-ABT causes the loss of the omega-hydroxylase activity both in microsomal preparatio

7 Sesamin potently inhibited tocopherol-omega-hydroxylase activity exhibited by CYP4F2 and rat o

8 fic reductions in liver microsomal vitamin E-omega-hydroxylase activity ranging from 93% (gamma-TOH)

9 liver P450 enzymes revealed that tocopherol-omega-hydroxylase activity was associated only with CYP4

10 In contrast, cortical omega-hydroxylase activity was reduced by treatment with

11 Thus, inhibition of NOS increased omega-hydroxylase activity, CYP4A expression, and renal

12 otein levels and arachidonic and lauric acid omega-hydroxylase activity.

13 ghts into a cytochrome P450 with predominant omega-hydroxylase activity.

14 The gene encoding the alkane omega-hydroxylase (AlkB; EC 1.14.15.3) from Pseudomonas

15 a) the presence of an endogenous lauric acid omega-hydroxylase and arachidonic acid epoxygenase in th

16 regulates the expression of Cyp4a fatty acid omega-hydroxylases and Cyp2c arachidonic acid epoxygenas

17 of arachidonic acid (AA), the expression of omega-hydroxylase, and the efflux of 20-hydroxyeicosatet

18 tween blood pressure, sex hormones, and P450 omega-hydroxylases, and suggest the human CYP 4A homolog

19 The CYP4A fatty acid omega-hydroxylases are involved in important physiologic

20 rized as the most efficient arachidonic acid omega-hydroxylase catalyzing the formation of 20-hydroxy

21 prior to this screen (among them, fatty acid omega-hydroxylase CYP704B1, putative glycosyl transferas

22 in knockouts for CYP77A6 and the fatty acid omega-hydroxylase CYP86A4 provided genetic evidence that

23 The omega-hydroxylase cytochrome P450-4F2 (CYP4F2) is the on

24 P-epoxygenase but not cyclooxygenase- or CYP-omega-hydroxylase-dependent pathways completely abolishe

25 50 enzyme CYP86A22 is the key fatty acyl-CoA omega-hydroxylase essential for the production of omega-

26 Tocopherol-omega-hydroxylase exhibited similar binding affinities b

27 Expression of the fatty acid omega-hydroxylase gene Cyp4a14, a commonly used indicato

28 YP4A11, the principal known human fatty acid omega-hydroxylase, has been expressed as a polyhistidine

29 4F14 is the major but not the only vitamin E-omega-hydroxylase in mice.

30 ene CYP86A22, which encodes a fatty acyl-CoA omega-hydroxylase involved in estolide biosynthesis in t

31 P450 family 4 fatty acid omega-hydroxylases preferentially oxygenate primary C-H

32 oth enzymes were also C-8 to C-10 fatty acid omega-hydroxylases preferentially, with total rates of h

33 amino acid identity with CYP4C7, a terpenoid omega-hydroxylase previously cloned from this tissue.

34 HETE and greatly increased the expression of omega-hydroxylase protein, but this treatment had only a

35 -metabolizing proteins, including Cyp4g1, an omega-hydroxylase regulating triacylglycerol composition

36 d that sxe1 likely functions as a fatty acid omega-hydroxylase, suggesting that male courtship and ma

37 s are important fatty acid and prostaglandin omega-hydroxylases that are highly inducible by fibric a

38 red metabotropic glutamate receptors and CYP omega-hydroxylase, the enzyme regulating 20-hydroxyeicos

39 hrome P450 (P450) enzyme of the 4A family of omega-hydroxylases was localized in renal microvessels,

40 in contrast, were blocked by an inhibitor of omega-hydroxylase, which synthesizes 20-hydroxyeicosatet

41 onclusively demonstrated that this P450 is a omega-hydroxylase with a substrate preference for both s

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