ライフサイエンスコーパス: omental

1 e relationship between metastatic burden and omental adipocyte content.

2 Human omental adipocytes display a range of biochemical proper

3 We show here that primary human omental adipocytes promote homing, migration and invasio

4 d that endogenous oils from subcutaneous and omental adipocytes, and from healthy and unhealthy obese

5 hat LBSQ adipocytes, in contrast to UBSQ and omental adipocytes, store more FFA in women with greater

6 Thus, the omental adipose bed represents a highly insulin-resistan

7 This work highlights the critical role that omental adipose inflammatory pathways might play in the

8 Omental adipose is a site of prodigious metastasis in bo

9 Omental adipose stromal cells (O-ASC) are a multipotent

10 7.5 pmol mg-1 h-1 [82.1-209], p < 0.05) when omental adipose stromal cells were treated with cortisol

11 significantly higher in subcutaneous than in omental adipose tissue (p=0.004).

12 An omental adipose tissue biopsy and blood sample were coll

13 Interestingly, in omental adipose tissue explants, glucose significantly i

14 Furthermore, in omental adipose tissue explants, insulin and glucose sig

15 mediators (i.e., leukotriene B4 and PGs) in omental adipose tissue from Ob patients.

16 and adiponectin (ADIPOQ) mRNA expression in omental adipose tissue in adult, pedigreed baboons (Papi

17 port, for the first time, elevated serum and omental adipose tissue levels of vaspin in overweight PC

18 the abundance of resistin (RETN) mRNA in the omental adipose tissue of baboons (L0D score 3.8).

19 enes were significantly downregulated in the omental adipose tissue of obese individuals with extreme

20 ng circulating vaspin, from subcutaneous and omental adipose tissue of PCOS women and matched control

21 n mRNA (P < 0.05), and protein (P < 0.05) in omental adipose tissue of PCOS women.

22 -1 mRNA (P < 0.01) and protein (P < 0.05) in omental adipose tissue of women with PCOS (P < 0.01).

23 entin-1, including circulating omentin-1, in omental adipose tissue of women with PCOS and matched co

24 ion, likely because of the resistance of the omental adipose tissue to insulin suppression and the co

25 Human omental adipose tissue Treg cells also showed high ST2 e

26 Omental adipose tissue was obtained from 99 obese patien

27 Omental adipose tissue, a biologically active organ secr

28 t exposure of glucocorticoid specifically to omental adipose tissue, suggesting that central obesity

29 four metabolically relevant tissues: liver, omental adipose, subcutaneous adipose, and stomach.

30 ive tissues liver, subcutaneous adipose, and omental adipose.

31 are associated more strongly with increased omental adiposity than with subcutaneous adiposity.

32 ed a bolus of [1-(14)C]palmitate followed by omental and abdominal subcutaneous fat biopsies to measu

33 fatty acid (FA) storage enzymes/proteins in omental and abdominal subcutaneous fat.

34 Omental and paravesical tumors were each present in six

35 s, PD specimens had the highest abundance of omental and parietal arteriolar C1q, C3d, terminal compl

36 Findings were validated in omental and parietal arterioles from independent pediatr

37 tion of mesenteric edema and the presence of omental and retroperitoneal edema.

38 anges occurred in body weight, fat pad mass (omental and retroperitoneal), food intake, serum insulin

39 Strikingly, in both omental and s.c. WAT from BMI-matched obese humans, expr

40 r cells preferentially lodge and grow within omental and splenoportal fat, which contain milky spots,

41 soforms (1 and 2) of 11 beta-HSD in cultured omental and subcutaneous adipose stromal cells from 16 p

42 Paired omental and subcutaneous adipose tissue samples were obt

43 Paired samples of human omental and subcutaneous preadipocytes from 12 individua

44 Mesenteric, omental, and retroperitoneal edema occur commonly in pat

45 pots studied with a rank order of perirenal, omental, and subcutaneous.

46 Omental arteries and plasma were collected from healthy

47 ssayed the differences in DNA methylation in omental arteries from normal pregnant and preeclamptic w

48 ine and bradykinin) in small resistance-size omental arteries obtained during surgery from women with

49 se expression was significantly increased in omental arteries of preeclamptic women and in VSMCs co-c

50 Omental arteries were evaluated for gene and protein exp

51 ignificantly less methylated in preeclamptic omental arteries, whereas TIMP and COL genes either were

52 We microdissected omental arterioles from tissue layers not directly expos

53 UA endothelial (UAendo), UA VSM, omental artery endothelium (OA endo), and OA VSM protein

54 antigen-specific serum IgM, identifying the omental B cells as a source of IgM production in the SLP

55 Peritoneal or omental biopsies obtained from women diagnosed with stag

56 ovaries and fallopian tubes, peritoneal and omental biopsies, and collection of peritoneal washings

57 laparotomy and at least an oophorectomy and omental biopsy) in each group of the study.

58 In humans, omental but not subcutaneous IL-6 mRNA expression correl

59 Three marker lesions-primary ovarian mass, omental cake, and peritoneal deposit-were outlined by a

60 baseline ADCs among primary ovarian cancer, omental cake, and peritoneal deposits indicate that diff

61 tic indices were more than twofold higher in omental cells (serum-free medium: P < 0.05; TNF-alpha: P

62 nd CCAAT/enhancer-binding protein alpha than omental cells, as in primary preadipocytes, while hTERT

63 Omental cyst and omental torsion both are uncommon but i

64 On CECT abdomen the findings of omental cysts and torsion of greater omentum with free f

65 Two large omental cysts were found in the pelvic cavity along with

66 stantially greater in preadipocytes from the omental depot than in those from the subcutaneous depot,

67 11c-expressing B cells nearly eliminated the omental Ehrlichia-specific plasmablasts and reduced anti

68 cent to the abdominal wall without overlying omental fat and central displacement of colon and were f

69 Conversely, ECMs isolated from omental fat and lung did not redirect testicular cells t

70 at biopsies (abdominal and femoral) and then omental fat biopsy during tubal ligation surgery.

71 s, with separate models run for each medium (omental fat in the operative cohort, serum in both cohor

72 se findings provide evidence for the role of omental fat in the pathogenesis, and potentially, the pr

73 ed significantly (P < 0.001) more weight and omental fat mass compared with OLETF-EX and LETO-SED.

74 Expression of ST8SIA2 in omental fat of these individuals at baseline was signifi

75 Additionally, paired subcutaneous and omental fat samples were obtained during abdominal surge

76 Concentrations were higher in omental fat than in serum for all POPs.

77 t/activity of FA storage enzymes/proteins in omental fat was dramatically lower in those with more vi

78 The opposite pattern was seen in omental fat with the normal-fat meal and in all depots a

79 dominal wall mass, often involving subjacent omental fat, and may be the only site of recurrent disea

80 Adipose stromal cells from omental fat, but not subcutaneous fat, can generate acti

81 , and nine (75%) directly involved subjacent omental fat.

82 including elevated glucose levels and excess omental fat.

83 he time representing the delay in collecting omental fat.

84 led that STAT4 overexpression induced normal omental fibroblasts and adipose- and bone marrow-derived

85 one patient, and bilateral pectoralis and an omental flap in one patient who required additional cove

86 2000, the authors successfully harvested 135 omental flaps (64 pedicled, 71 free transfer) for recons

87 ridement followed by closure using muscle or omental flaps.

88 s, intermediate in mesenteric, and lowest in omental hTERT-expressing strains, as in primary preadipo

89 ngle abdominal subcutaneous, mesenteric, and omental human preadipocytes by stably expressing human t

90 is characterized by numerous peritoneal and omental implants composed of glial tissue.

91 celerating factor composite thymokidneys and omental implants of thymic tissue.

92 orpuscles under the renal capsule and in the omental implants, and with evidence of few host lymphocy

93 itated engraftment of nonvascularized thymic omental implants.

94 Omental infusion did not lower systemic free fatty acid

95 Omental insulin infusion was extracted at approximately

96 nd 17 miRNAs with differential expression in omental lesions compared to primary tumors.

97 iRNAs, miR-146a and miR-150, up-regulated in omental lesions, stimulate survival and increase drug to

98 s with significantly increased expression in omental lesions, with concomitant decreased expression o

99 Omental lipolysis was also pulsatile, with about 10 puls

100 that local infusion of insulin did suppress omental lipolysis, but only at extremely high insulin co

101 liver regenerative response in the residual omental liver lobes (weight, protein content, incorporat

102 sulting in liver necrosis; the remaining two omental lobes (8% liver mass) are left intact.

103 , we evaluated the tumor stroma of 108 human omental metastases and determined that fibronectin was c

104 ding protein 4 (FABP4, also known as aP2) in omental metastases as compared to primary ovarian tumors

105 Here, we aim to understand how omental metastases differ from primary tumors and how th

106 s of primary EOC tumors and their respective omental metastases from 9 patients using miRNA Taqman qP

107 home to and proliferate in the omentum, yet omental metastases typically represent the largest tumor

108 primary ovarian carcinoma tumors, secondary omental metastases, and ascites cells isolated from sero

109 o model the net accumulation of experimental omental metastases, we show that MKK4-expressing implant

110 ominant pathway responsible for hematogenous omental metastasis.

111 epletion of ErbB3 in ovarian cancer impaired omental metastasis.

112 tes play distinct and complementary roles in omental metastatic colonization.

113 the mouse genetic background does not alter omental milky spot number and size, nor does it affect o

114 anatomically associated with lymph nodes and omental milky spots have site-specific properties that e

115 Omental milky spots readily concentrate intra-abdominal

116 Inhibition of the omental neutrophil response exacerbates septic progressi

117 in abdominal subcutaneous (SC) compared with omental (Om) adipocytes.

118 No patient had omental or retroperitoneal edema alone.

119 ic edema occurred alone in 26 (38%) and with omental or retroperitoneal edema in 40 (58%) of the 69 p

120 Biocompatibility was demonstrated by either omental or subcutaneous xenotransplantation of liver sca

121 s lower than that for ovarian (P = .015) and omental (P = .006) sites.

122 In women, only omental palmitate storage rates were correlated (r = 0.5

123 Omental patch closure is appropriate therapy for patient

124 Omental patch closure was used in 49 patients and falcif

125 r cells to invade and proliferate into human omental pieces ex vivo and into the omentum of a mouse x

126 Omental plasmablasts elicited during Ehrlichia infection

127 Generation of the omental plasmablasts was route dependent, as they were d

128 Omental preadipocytes are therefore more susceptible to

129 Primary omental preadipocytes, in which telomeres were longest,

130 The three-tier CRS system applied to omental samples from the validation cohort showed high r

131 Adnexal and omental sections were independently scored by three path

132 ct appears to be mediated by the presence of omental stem cells and their secretory products.

133 However, the omental stromal cell-derived molecular determinants that

134 scle tumorlets diffusely stud peritoneal and omental surfaces in females, predominantly of reproducti

135 ated palmitate storage rates were greater in omental than abdominal subcutaneous fat in women (1.2 +/

136 han cortisol to cortisone) and was higher in omental than subcutaneous fat (cortisone to cortisol, me

137 Four of these baboons also received omental thymic tissue implants.

138 ndings of a cis-eQTL for RETN mRNA in baboon omental tissue and human lymphocytes lends support to th

139 Within the peritoneal cavity, omental tissue is a common site for metastatic disease a

140 ery uncommon however acute presentation with omental torsion and infarction is an unusual entity.

141 Omental cyst and omental torsion both are uncommon but important causes o

142 ysts in greater omentum leading to secondary omental torsion.

143 ur observations suggest that cancer cells in omental tumors express key miRNAs differently than prima

144 rived from neighbouring stromal cells in the omental tumour microenvironment, and that inhibiting the

145 The second major complication was an omental vessel bleed after a TV cholecystectomy.

146 In conclusion, increases in omental WAT mitochondrial content between 20 and 40 week

147 pared with cells isolated from mesenteric or omental white fat.

148 in the composite engineered bladders with an omental wrap (56%, 1.58-fold, and 2.79-fold, respectivel

149 tion and implanted either with or without an omental wrap.

150 ulture to precondition grafts and the use of omental wrapping to promote vascularization.