ライフサイエンスコーパス: on (its|their) own

1 On its own, computational "inside-out" design can lead t

2 On its own, pol beta fails to copy TNRs during DNA synth

3 On its own, SA-4-1BBL outperformed MPL in this setting.

4 On its own, small t antigen controls cell survival and d

5 On its own, the Pol2 catalytic subunit of Pol epsilon is

6 On its own, this moderate, short-lived warming was unlik

7 On its own, this network can be bistable, but in a large

8 On their own, HDPDL1 exhibited no antitumor effect and C

9 On their own, the metrics proposed here explain a larger

10 IL-6 or IL-12 on its own did not induce PD-1.

11 hereas IL-21 is known to help B cells, IL-17 on its own drives B cells to undergo preferential isotyp

12 active RyR2 channels eager to release Ca(2+) on their own appear as essential components of this arrh

13 -regulating p21 expression, whereas Nutlin-3 on its own had no effect, consistent with its mechanism

14 Intra-AcbSh AC187 on its own disrupted PPI in a haloperidol-reversible man

15 By accreting on their own accumulated peat, these desert mangroves st

16 goal, which neither discipline could achieve on its own; (ii) finding common ground in shared methodo

17 Moreover, IFN-1s do not act on their own, and clearly there is much cross-talk betwe

18 To what extent MLL fusion proteins act on their own during tumor initiation, or if they collabo

19 ractions are more predictable when users act on their own rather than when attending group activities

20 onvert glucose-phosphates, as well as acting on their own definitive substrates.

21 iciently potent to be therapeutically active on their own.

22 SE-1 exhibited little or no agonist activity on its own.

23 esponse and had no overt anticancer activity on its own, it dramatically impaired the emergence of re

24 However, ExoU does not exhibit activity on its own but instead requires eukaryotic cell cofactor

25 tive prodrug or has pharmacological activity on its own remains unclear.

26 , called FOG-3(4E), had no rescuing activity on its own, but together with FOG-3(4A) rescue was compl

27 MEDI5117 also displayed robust activity on its own against trastuzumab-resistant HER2(+) tumor c

28 ibody mimetics that have no agonist activity on their own can be transformed into potent agonists thr

29 nds were found to have little redox activity on their own as measured by the DTT assay, but they enha

30 ch of them which of the CDRs may bind the Ag on its own as a peptide.

31 ls which fragments of the Ab may bind the Ag on their own.

32 ional benefit compared with cytotoxic agents on their own.

33 n individuals facing a social dilemma agreed on their own rules and used graduated sanctions, they we

34 use they appear incapable of recognizing Ags on their own and are perceived as nonreactive.

35 r researchers to easily use these algorithms on their own datasets.

36 olving CBFs are not sufficient to induce AML on its own and the full spectrum of mutations coexisting

37 thermal stimuli following hypnotic analgesia on their own hand, but also when they viewed pictures of

38 to conduct a voxel-based asymmetry analysis on their own, it may also be useful to experienced users

39 Dexamethasone or 8-Br-cAMP applied on their own produced cysts predominantly arising in pro

40 ibitory negative feedback regulation of ARF2 on its own transcription and thereby further promote GA

41 Although most of the filaments assemble on their own to form higher order structures, growing ev

42 CRMP-1 does not nucleate actin assembly on its own, nor does it directly activate the Arp2/3 com

43 xpressed construct, is a fully active ATPase on its own.

44 of a transcriptional feedback loop of auxin on its own transport through local regulation of flavono

45 The influence of postharvest UV-B on its own and in combination with fermentation (e.g. sa

46 nagement of sickle cell pain should be based on its own pathophysiologic mechanisms rather than borro

47 f each neuron in a 4 ms time interval, based on its own spiking history and the spatiotemporal kinema

48 n groups balance personal information (based on their own past experiences) with social information (

49 events should be prioritized in memory based on their own significance, as well as the significance o

50 ace that allows users to modify models based on their own experimental conditions.

51 erences from an initial starting point based on their own introspections.

52 es full advantage of limited resources based on their own performance features.

53 reductase could provide a selectable benefit on its own, and therefore, reduction of nitrate to dinit

54 is amino acid residues that, although benign on their own, could rescue the human mutations in vivo.

55 Each accession grew best on its own soil.

56 elevate apoCaM, we find that apoCaM binding on its own markedly upregulates opening, rivaling the st

57 r rat GTPCH and is required for GFRP binding on its own.

58 , as in vivo and in vitro anti-PD-1 blockade on its own only modestly improved T cell function.

59 what effect this topographic change has both on its own and in concert with the flux of freshwater fr

60 abidopsis Rubisco large subunits (AtL), both on their own (producing tob(AtL) plants) and with a cogn

61 d in hormone replacement therapy (HRT), both on their own and in combination with EE2.

62 e it is composed of two subunits, each built on its own ribosomal RNA (rRNA) scaffold.

63 ol for the discovery of these sequences, but on its own it cannot resolve their temporal and spatial

64 maintenance, whereas expression of cadherins on their own could only transiently support adhesion and

65 Caffeine on its own induced no phase shifts.

66 Nevertheless, because cAMP on its own does not activate these chimeric channels, cA

67 xing data from social contact surveys cannot on its own explain the observed pattern.

68 Each of these factors is capable, on its own, of inducing an EMT in the human mammary epit

69 ited capacity to translocate a peptide chain on its own.

70 is incapable of forming functional channels on its own.

71 nnel proteolysis do not form active channels on their own but, when properly paired, produce currents

72 s (HSPH1 and HSPH2) are bona fide chaperones on their own that collaborate with Hsp40 (DNAJA1 and DNA

73 Ciprofloxacin on its own did not induce DNA damage, but it did reduce

74 um can elaborate gaze reorientation commands on its own, rather than merely acting as a relay from up

75 who need to conduct whole-genome comparisons on their own computers.

76 Moreover, if each bar is a composite on its own, multiple resonant band gaps appear in the co

77 Each lobe was allowed to switch conformation on its own.

78 who cannot reduce their alcohol consumption on their own, despite substantial harm to themselves and

79 es both by making a significant contribution on their own and by synergistically enhancing the effect

80 of acetylcholine from inferotemporal cortex on its own has no effect on episodic memory.

81 ds identifying when network structure could, on its own, drive the resilience, sustainability, and ev

82 s that rarely cause midline craniosynostosis on their own make the development of the disorder a cert

83 in cis, which lack high affinity for the DCC on their own.

84 se results we conclude that APLP1 deficiency on its own does not lead to defects in synaptic plastici

85 ergy density as well as a high power density on their own.

86 mational changes in VWF, but also may depend on its own conformational activation.

87 , we show that MreB rotation does not depend on its own polymerization but rather requires the assemb

88 Since they encode no proteins, they depend on their own RNA and on host proteins for replication an

89 ure, none has proven accurate and dependable on its own under all scenarios where mutation analysis i

90 ffect in a manner that was largely dependent on its own modulatory function.

91 s, '2 up 1 down' or '2 down 1 up', depending on its own polarization.

92 m their preferred habitat by drift depending on their own traveling speed in relation to that of the

93 er ribonucleic acid (mRNA) anchoring depends on its own locally translated protein product.

94 O), neither of which develops overt diabetes on its own because of robust compensatory beta-cell hype

95 activity all fail to induce differentiation on their own or even to facilitate differentiation.

96 osteoblasts, had no effect on thymine dimers on its own but prevented the 1,25(OH)(2)D(3)-induced pro

97 id not influence grey matter volume directly on its own but in mutation carriers it modulated the slo

98 ch these forces; either by pressing directly on their own finger or by operating a robot that pressed

99 ed the force required when pressing directly on their own finger than when operating a robot.

100 ng enough to support stimulus discrimination on their own.

101 ariants may be insufficient to cause disease on their own but may modify phenotype in a genetically s

102 Anatomical variations are not diseases on their own and may be present as incidental findings i

103 nterestingly, despite not affecting division on its own, Arp2/3 inhibition potentiated the effect of

104 of peptidomimetic drugs, and potential drugs on their own.

105 ion, which does not influence actin dynamics on its own.

106 oly(I:C), and TSG-6 did not exert any effect on its own.

107 c receptors, although nicotine had no effect on its own.

108 antly fewer concerns about an adverse effect on their own practice (P < 0.01) and about nonradioactiv

109 ncerned about an economically adverse effect on their own practices if they referred patients for rad

110 eas the substances had no significant effect on their own.

111 CRF-induced deficits while having no effects on its own.

112 a mutation in BGLC1 had significant effects on its own, lack of BGLC3 had only minor effects.

113 In contrast, eIF4A on its own has little RNA substrate specificity.

114 step in protein structure predictions either on its own or complemented by NMR restraints.

115 very promising tool for this purpose, either on its own or in conjunction with other methods.

116 n cell therapy of autoimmune diseases either on their own or as graft complement in autologous stem c

117 n each generate a large pulse of barbed ends on their own, but have little synergy; high synergy occu

118 It can also act as an enzyme on its own in the presence of Eu(II)DTPA, displaying a s

119 r Anks1a is specifically localized to the ER on its own serine phosphorylation.

120 encouraging Whites to anchor their estimates on their own circumstances increased their tendency to o

121 monstrate that this simple gene fusion event on its own is sufficient to confer functional allostery

122 ients were encouraged to continue exercising on their own.

123 populations were initially unable to expand on their own, and were dependent on long-distance disper

124 enomena that neither perspective can explain on its own.

125 and prolonged plasma exposure, but exposure on its own did not explain the presence or absence of ei

126 g, agency, and ability to avoid SHS exposure on their own volition; they also have physiological or b

127 rm nanotubule-like structures when expressed on its own in the cytoplasm of Escherichia coli.

128 ironment have been identified, yet no factor on its own is known to stimulate overt myocardial hyperp

129 positive feedback of a transcription factor on its own synthesis - and assess its response to extrin

130 unlikely functions as a transcription factor on its own.

131 agic process, Tax exerts a positive feedback on its own stability.

132 their partner's, rather than simply focusing on their own contribution.

133 ing and ligand recognition, D1 does not fold on its own due to the loss of its interaction with the s

134 's discovery that purified proteins can fold on their own after removal from denaturant.

135 s are so poor that they cannot be formulated on their own, so new methods for increasing drug solubil

136 ciate and the helicase does not move forward on its own.

137 tam, the resultant dihydrothiazine fragments on its own or is assisted by an adjacent nucleophilic at

138 rmine whether IL-33 altered cardiac function on its own, we administered rIL-33 to undiseased mice an

139 oes not adequately predict 12-month function on its own, our findings do not support changing the def

140 teolytically cleaved form, does not function on its own.

141 specific transcription factors and functions on its own in vitro to activate promoter transcription.

142 omeric partner of CFD1 in metazoa, functions on its own in plants.

143 E-decorated proteoliposomes that cannot fuse on their own, we now demonstrate that full fusion activi

144 sed the question of whether loss of Siglec G on its own affects disease severity in animal models of

145 ioned gaping and produced conditioned gaping on its own (which was prevented by intracranially admini

146 erence (CPP) paradigm, we observed that GDNF on its own does not induce CPP, suggesting that the grow

147 s the gel; that is, no component forms a gel on its own.

148 ce of directional motion or force generation on its own.

149 etic effects (DGEs) of an individual's genes on its own phenotype and the indirect genetic effects (I

150 and keep pace with sea-level rise by growing on their own root remains.

151 pared, none yet are capable of activating H2 on their own.

152 ut does not methylate nucleosomal histone H3 on its own.

153 that sNASP makes a specific complex with H3 on its own in vitro, but not with H4, suggesting that it

154 The regulatory effect auxin has on its own transport is critical in numerous self-organi

155 rst demonstration that the amphipathic helix on its own is capable of this effect.

156 eriencing distress are unlikely to seek help on their own initiative.

157 e1, but can non-specifically modify histones on its own.

158 However, HOXA9 on its own is not sufficient to confer in vivo long-term

159 vation step, we found that full-length Hsp70 on its own could activate the Hsp104 hexamer by promotin

160 Crystal structures were determined for hXK, on its own and in complexes with Xu, ADP, and a fluorina

161 a phosphine being able to hydrodefluorinate on its own.

162 , were sufficient to induce mild hyperplasia on their own.

163 Here we show that although Skp2 inactivation on its own does not induce cellular senescence, aberrant

164 R antagonist, WAY-100635, which was inactive on its own.

165 ollect telephone metadata in bulk, including on their own citizens.

166 ly selecting and mating the best individuals on their own or relatives' performance.

167 ptor activation, WIN55,212-2 was ineffective on its own and antagonized the effects of CP55,940.

168 eral independent processes, each ineffectual on its own, can reinforce to ultimately develop the patt

169 on should be able to eradicate the infection on its own.

170 hypothesized that VPA does not cause injury on its own, but it predisposes patients to pancreatitis

171 Second, theta-modulated inhibitory input on its own generates membrane potential peaks that are i

172 , explaining why polyQ domains are insoluble on their own.

173 Although the lobes do not interact on their own, the sgRNA recruits them into a ternary com

174 ncy of a pre-mRNA therefore depends not just on its own concentration and affinity for limiting splic

175 However, CeA ChR2 laser on its own lacked any reinforcement value: laser by itse

176 d the opportunities for individuals to learn on their own outside of formal classroom settings have g

177 to induce aggressive AML, while both lesions on their own induce T-cell malignancies with long latenc

178 MD on its own potentiated VEPs contralateral to the NDE dur

179 whether the intrinsic biophysical mechanism on its own can change the surface temperature in a consi

180 e guest, are able to cross the cell membrane on their own.

181 2 fails to translocate across cell membranes on its own, addition of the palladium reagent induces an

182 itivity more accurately than each metabolite on its own or other published metabolic signatures.

183 x cannot erase H2B-Ub or histone methylation on its own.

184 taining ITAMs induced PKCtheta microclusters on their own, explaining previous observations that ITAM

185 higher prediction accuracy than either model on its own.

186 The block V motif on its own has been reported to be non-responsive to cal

187 Unexpectedly, use of MPL on its own was associated with unfavorable intratumoral

188 ID93-specific TH1 responses, whereas neither on their own are effective adjuvants for generation of I

189 1p, forms a GTP-hydrolysis-dependent network on its own, serving as both a fusion and curvature-stabi

190 rom one modality, which activates the neuron on its own, should suppress the response to a preferred

191 , but which cannot mediate neurotransmission on its own.

192 ty, suggesting that the tail of FPR2 was not on its own critical for inhibition.

193 essary component of HIV prevention, have not on their own been shown to be sufficient to stem the tid

194 uman and yeast Exo1 are processive nucleases on their own.

195 hat are distinct and discriminable may occur on their own, or in groups such as a stack of books.

196 types of spreading dynamics, each occurring on its own layer, by focusing on the two fundamental qua

197 of which is known to form a simple oligomer on its own (e.g., a dimer or trimer).

198 e not been observed to form stable oligomers on their own or with DNA, suggesting that important dete

199 ant to interact and thus induce TolC opening on its own.

200 graphlet degree signatures that can operate on its own or as a plug-in to the network analysis envir

201 effect than was treatment with either BA or on its own.

202 and sense of meaning by phone, in person, or on their own.

203 transmission and cannot sustain an outbreak on their own, they play an important role in establishin

204 Closed loop was started by participants on their own volition on 866 (89%) of 978 nights.

205 r by a heart failure nurse or by the patient on their own.

206 annot create diverse spatiotemporal patterns on its own; however, given temporally heterogeneous inpu

207 We show that these payloads on their own induced an immune response that prevented t

208 s but did not induce macrophage phagocytosis on their own.

209 fers only an extremely weak Cit(+) phenotype on its own.

210 r, creates a striking pigmentation phenotype on its own, but differences between them can be revealed

211 hed out to grasp a cylindrical target placed on its own and when it had two identical objects (flanke

212 ver, it is unclear why dynein-1 moves poorly on its own or how it is activated by dynactin.

213 sexual eukaryotes, sweep through populations on their own.

214 upport a time-dependent dilation of the pore on its own but rather reveal that the open pore of P2X r

215 identified, each of which has the potential on its own to drive the Earth system into a new state sh

216 f which can produce the paclitaxel precursor on their own.

217 ency that elicits no response when presented on its own as a signal.

218 judging visual or tactile stimuli presented on their own body surface, or pictures of hands and feet

219 ne analogs do not induce cytokine production on their own.

220 not access fibroblast chromatin productively on their own; instead, Ascl1 recruits Brn2 to Ascl1 site

221 Furthermore, activation of the EMT program on its own, as orchestrated by Zeb1, is sufficient to in

222 specialist nurse who followed the programme on their own.

223 Also, when Treg cells highly proliferated on their own, there was no additional Treg cell boost by

224 medicinal plants with antioxidant properties on their own, but that can be improved when mixed.

225 ity and ferroelectricity are rare properties on their own, combining them in one crystalline organic

226 ypically considered beneficial or protective on their own, to the basal media or feed stream may caus

227 the CVSC is not formed from pUL17 and pUL25 on their own but requires a contribution from pUL36.

228 beyond a level that individuals could reach on their own - is a topic of increasing interest.

229 igh recanalization rates, but recanalization on its own does not predict outcome.

230 r, they do not directly induce reinstatement on their own.

231 Bacteriophage T7 relies on its own RNA polymerase (RNAp) to transcribe its middl

232 nt, infectious diseases clinicians must rely on their own ingenuity to effectively treat infections w

233 fy pressure ulcer risk, and that nurses rely on their own knowledge and experience rather than resear

234 public policies, decision makers often rely on their own behavioral preferences.

235 osomal MTs or can be self-organized, relying on its own MTOC activity.

236 tions in their genomes and fail to replicate on their own.

237 integrate local command line tools residing on their own computers through a client-side Java applet

238 recommend allowing the condition to resolve on its own.

239 culosis CM, which has no allosteric response on its own, acquires allosteric behavior to facilitate i

240 dylethanolamines (LPEs), elicits no response on its own but synergizes with activating sulfonolipid r

241 or scattered seeds that one ant can retrieve on its own, so there is no need for spatial information

242 estingly, IFNs exert a negative retrocontrol on their own signaling by enhancing STAT1 SUMOylation.

243 nsonian rats: (1) it produced intense reward on its own and in parallel (2) decreased interest in oth

244 ogy, rotation resembles the Earth's rotation on its own axis, while revolving resembles the Earth's r

245 ally reversed the repression effect of SALL4 on its own as well as other Sal gene promoter activities

246 without the hinge region, cannot be secreted on its own and remains in the ER where it is bound to ER

247 stimulation that fails to activate secretion on its own.

248 a chemical message that E. coli cannot sense on its own to a molecule that activates a natural cellul

249 Compared with SF on its own, SF (at concentrations of 0.09-25%) in combin

250 The ability of SLAMF2 to signal on its own after it is engaged and the functional conseq

251 These approaches, although significant on their own, are not effective for elucidating the syne

252 elevant siRNA carriers is needed since siRNA on its own is an incompetent silencing agent.

253 act by forming phosphotyrosine-docking sites on their own endodomains that propagate signals through

254 nge, 1.02-1.03; P < .01), this was too small on its own to counterbalance the reduced fitness of affe

255 es and liposomes we now show that alpha-SNAP on its own interferes with the zippering of membrane-anc

256 GTP can exist in active and inactive states; on its own, GTP binding may not compel K-Ras4B activatio

257 control transmission if local ITN strategies on their own are insufficiently effective.

258 The D207H substitution on its own in the monomer did not result in fluorescence

259 Can plasma technology be successful on its own, or can synergies be achieved by combining it

260 esults establish that Igf2 LOI is sufficient on its own to increase rates of neoplastic development i

261 neither sorting nor plasticity is sufficient on its own to sharpen transition regions between differe

262 n and silencing, this site is not sufficient on its own to physically recruit miRISC.

263 s limited NOTCH1 activity and was sufficient on its own to transform primary human keratinocytes harb

264 immune protection, as neither was sufficient on their own.

265 No metazoan cell survives on its own, absent the signals and support of its milieu

266 These mutants cannot swarm on their own because they lack production of the biosurf

267 ish that SAS-6 can impose cartwheel symmetry on its own and indicate how this process might occur mec

268 Exogenous T on its own did not modulate aggressive behavior.

269 , they outperform Mfps or curli fibres taken on their own and exhibit better tolerance to auto-oxidat

270 h alignments is a complex computational task on its own; application of coevolutionary modeling has,

271 rs did not exhibit any sweetness when tasted on their own.

272 NTD and apoNGAL suggests that the N terminus on its own cannot account for the internalization of NGA

273 ch patient whether to manage genomic testing on their own, refer the patient for such testing, or ini

274 cellular module is inactivated when tethered on its own to the plasma membrane, and fluorescence cros

275 owth inhibitory activity in combination than on their own, supporting a combined delivery of PfCyRPA

276 in contrast to the (KLAKLAK)(2) peptide that on its own was not cell permeable.

277 These findings suggested that on its own high WNT activity may not be a reliable signi

278 inal conserved amphipathic helix (APH) that, on its own, interacts strongly with negatively charged m

279 -resolution shape and size information that, on its own, cannot lead to unique 3-D structures of biol

280 by mass action of copy number changes that, on their own, are benign.

281 We find that whereas B. thuringiensis on its own is not able to infect C. elegans, the additio

282 with cooperators than they would be able to on their own or by invading cooperators.

283 Mirror-touch synesthetes experience touch on their own body when observing touch to another person

284 ole in leaf blade outgrowth in M. truncatula on its own or in combination with STF.

285 hat a positive or negative result is unable, on its own, to confirm or exclude a suspected infection.

286 n which the individual subunits are unstable on their own.

287 We show that our method may be used on its own to make accurate identification of specific,

288 ays where each antibody preparation was used on its own.

289 ), but had also significant predictive value on its own (AUC=0.65, 95% CI 0.52-0.79).

290 n the population and that no gene or variant on its own has been shown to be fully deterministic of s

291 in vivo that is unable to support viability on its own.

292 Their focus was on their own unmet needs rather than their spouses' need

293 t mRNAs in the cell and act in distinct ways on their own and each other's transcripts to create a ne

294 itory and tactile stimuli that were too weak on their own to bias binocular rivalry were combined, th

295 an NPF that activates Arp2/3 complex weakly on its own, but with WASP/N-WASP, another class of NPFs,

296 lication-associated genome regions that were on their own "lethally recombinant." Surprisingly, mixed

297 Mutations in these two genes, whether on their own or combined with mutations in other exoglyc

298 other contains only unsaturated lipid, which on its own would be in the L(d) phase.

299 These insertions, which on their own shift the equilibrium distribution of ISP-H

300 rganelles, but none of these organelles work on their own.