ライフサイエンスコーパス: oncogene product

1 E1A has been shown to bind to the active Ras oncogene product.

2 vaccines for tumors expressing the HER2/neu oncogene product.

3 that express abnormally high levels of mdm2 oncogene product.

4 re inhibited by mdm2 (murine double minute2) oncogene product.

5 One such substrate is the Cbl proto-oncogene product.

6 ed by Mos express only low levels of the mos oncogene product.

7 ated transcription factors and a human proto-oncogene product.

8 full transforming potential of the resulting oncogene product.

9 express cyclin D1, and all BCs exhibit VPAC1 oncogene products.

10 ortantly, it occurs in response to activated oncogene products.

11 e of its interaction with the c-Myc and BCL6 oncogene products.

12 iRNAs), and suppression of miR-targeted anti-oncogene products.

13 n may be directly regulated by cytokines and oncogene products.

14 al general transcription factors and to some oncogene products.

15 orming activity than the closely related Ras oncogene products.

16 tion and increases levels of the c-myc proto-oncogene product, a DNA-binding protein and established

17 These tumors did not express the VPAC1 oncogene product and had benign histology.

18 The constitutive activation of the Stat3 oncogene product and mutation of the p53 tumor suppresso

19 highly related to the mammalian c-cbl proto-oncogene product and to the C. elegans Sli-1 protein, a

20 Cancer-associated mutations in oncogene products and tumor suppressors contributing to

21 plicated in the regulation of cell growth by oncogene products and tyrosine kinase growth factor rece

22 ts tyrosine kinase receptor, the c-met proto-oncogene product, and is required for normal development

23 The cellular homologs of the v-Crk oncogene product are composed exclusively of Src homolog

24 llular signaling events initiated from these oncogene products are emphasized.

25 cer cell lines expressing low levels of mdm2 oncogene product as efficiently as wt p53.

26 the yeast homolog of the mammalian MOZ proto-oncogene product, as its catalytic subunit.

27 y, YccA is a functional homolog of the proto-oncogene product Bax Inhibitor-1, which may share a simi

28 The proto-oncogene product Bcl-2 regulates cell survival in both t

29 Imatinib therapy, which targets the oncogene product BCR-ABL, has transformed chronic myeloi

30 hat p120(cbl) (Cbl), the 120-kDa c-cbl proto-oncogene product, becomes tyrosine-phosphorylated during

31 al role in regulating cellular levels of the oncogene product beta-catenin.

32 the Abl-related kinase Arg and the Cbl proto-oncogene product bound preferentially to the first two S

33 The human proto-oncogene product c-Cbl and a similar protein in Caenorha

34 We report here that the proto-oncogene product c-Cbl is tyrosine-phosphorylated in a S

35 aenorhabditis elegans homologue of the proto-oncogene product c-Cbl, is a negative regulator of LET-2

36 The proto-oncogene product c-Myc has a direct role in both metazoa

37 (TFIIIB) is bound and regulated by the proto-oncogene product c-Myc, the mitogen-activated protein ki

38 Key regulators of this balance include the oncogene product c-Myc, which promotes either entry into

39 The c-rel proto-oncogene product, c-Rel, belongs to the Rel/NF-kappaB tr

40 ore recent studies have shown that the proto-oncogene product Cbl co-precipitates with p85 following

41 The proto-oncogene product Cbl has emerged as a negative regulator

42 The proto-oncogene product Cbl has emerged as a potential negative

43 g the protein tyrosine kinase Syk, the proto-oncogene product Cbl, and phospholipase C (PLC)-gamma2 i

44 eam event of transforming activities of many oncogene products commonly found in human cancers.

45 The cellular homologs of the v-Crk oncogene product consist primarily of Src homology regio

46 The v-Crk oncogene product consists of two protein interaction mod

47 Galpha12 gep oncogene product couples to G-protein-coupled receptors,

48 lance of opposing factors--oncogene and anti-oncogene products, cyclins, growth factors, and so on; a

49 v-Src is a transforming viral oncogene product encoded by Rous sarcoma virus (RSV).

50 The rat neu oncogene product encodes a 185 kDa receptor tyrosine kin

51 nds to the extracellular domain of the human oncogene product ErbB2.

52 he yeast two-hybrid system with Vav, a proto-oncogene product exclusively expressed in hematopoietic

53 sely related or identical to the c-fes proto-oncogene product (FES) and association of this protein w

54 The oncogene product from the avian reticuloendotheliosis vi

55 th properties similar to the mammalian proto-oncogene product GFI-1.

56 The Cbl proto-oncogene product has emerged as a novel negative regulat

57 aling proteins suggest a role for this proto-oncogene product in mitogenic signaling through growth f

58 ) and accumulation of c-Fos (the c-fos proto-oncogene product) in Swiss 3T3 cells overexpressing wild

59 we show that, like Mos, both v-ras and v-raf oncogene products induce apoptosis in p53+/+ MEFs.

60 -3-3 proteins and several oncogene and proto-oncogene products involved in signal transduction pathwa

61 The Cbl proto-oncogene product is a complex adapter protein that funct

62 The human lbc oncogene product is a guanine nucleotide exchange factor

63 The dbl proto-oncogene product is a prototype of a growing family of g

64 The MDM2 oncogene product is a regulator of the p53 tumor suppres

65 An interaction with the Ras proto-oncogene product is a requirement for Raf-1 activation i

66 The Crk proto-oncogene product is an SH2 and SH3 domain-containing ada

67 thers have demonstrated that the c-cbl proto-oncogene product is one of the earliest targets of tyros

68 The BCR/ABL oncogene product is one of the genes associated with and

69 The dbl oncogene product is the defining member of a family of o

70 The Cbl proto-oncogene product is tyrosine phosphorylated in response

71 ein 2 (Grb2) that is bound to p185(HER2) (an oncogene product), is also associated with the CD44v3-Va

72 Da were identified as Cbl and Vav, two proto-oncogene products known to become prominently phosphoryl

73 We propose that combined control of proto-oncogene product levels and proteins involved in DNA rep

74 Critical to the inhibitory action of the oncogene product, MDM2, on the tumour suppressor, p53, i

75 Inhibitors of the oncogene product MDMX therefore might help reactivate p5

76 cribe an unexpected function for the myeloid oncogene product Mef2c in lymphoid development.

77 The function of the Xenopus c-mos proto-oncogene product (Mos(xe)) has been investigated during

78 Several oncogene products, most notably bcl-2, c-raf-1, protein

79 resence of human papilloma virus (HPV) E6/E7 oncogene products not only prevented ICN1 from inducing

80 acid E5 transmembrane protein is the primary oncogene product of bovine papillomavirus.

81 ciate with the tyrosine-phosphorylated proto-oncogene product of Cbl.

82 poptosis, we investigated the effect of this oncogene product on signaling by tumor necrosis factor (

83 The dbl oncogene product (onco-Dbl) is the prototype member of a

84 The proto-oncogene product, p21(ras), has been implicated in the c

85 In hematopoietic cell lines, the BCR-ABL oncogene product, p210(BCR-ABL), interacts with a variet

86 The vav proto-oncogene product, p95vav or Vav, is primarily expressed

87 Here we report that the proto-oncogene product PML induces expression of LMP-2, LMP-7,

88 Cysteine farnesylation of the ras oncogene product Ras is required for its transforming ac

89 The Ras oncogene products regulate the expression of genes in tr

90 ar export pathway may be used to regulate an oncogene product's activity and modulate cellular growth

91 Cell transformation by viral oncogene products such as adenovirus E1A and SV40 large

92 sformation and the problem is accentuated by oncogene products, such as c-Myc, that stimulate the out

93 onstitute the N-terminal segment of a fusion oncogene product, SYT-SSX, routinely detected in synovia

94 Neu (c-erbB2) is a proto-oncogene product that encodes an epidermal growth factor

95 resentative prototype of a growing family of oncogene products that contain the Dbl homology/pleckstr

96 on murine leukemia virus encodes the related oncogene product, v-Abl, and also causes pre-B-cell leuk

97 Cbl is known to associate with the proto-oncogene product Vav, a hematopoietic-restricted Rac gua

98 r (HGF/SF) and its receptor, the c-met proto-oncogene product, was examined by in situ hybridization

99 We have shown previously that the dbl oncogene product, which represents a prototype for a fam