ライフサイエンスコーパス: oncogenic effect

1 utionary depths is an important predictor of oncogenic effect.

2 a deficiency alone does not exhibit a strong oncogenic effect.

3 with CDC73 in HEK293 cells abrogated its pro-oncogenic effect.

4 of Jak2 tyrosine phosphorylation in Bcr-Abl oncogenic effects.

5 Substance P and its truncated receptor exert oncogenic effects.

6 on of gene expression, and likely additional oncogenic effects.

7 apoptosis, partially recapitulating SRSF1's oncogenic effects.

8 s while v-Src activates STAT3 to promote its oncogenic effects.

9 UTR structure can significantly increase its oncogenic effect and worsen the clinical course of MCL p

10 that GPC3 overexpression and its associated oncogenic effects are linked to the down-regulation of m

11 Studies in cell lines suggest that its oncogenic effects are mediated through the induction of

12 21(Cip1) induction, suggesting that Bcl11a's oncogenic effects are mediated, in part, through suppres

13 ts indicate that SYT-SSX2 exerts part of its oncogenic effect by altering cytoskeletal architecture i

14 uced in the skin by UVR protects against its oncogenic effects by inhibiting Hedgehog signaling, wher

15 The corepressor Evi-1 exerts its oncogenic effects by repressing TGF-beta/Smad3-mediated

16 Mechanistically, ATDC exerted its oncogenic effects by suppressing miR-29 and subsequent u

17 Despite its oncogenic effect, cells with TSC deficiency were more se

18 an induce local inflammation and distant pro-oncogenic effects compared with hepatic radiofrequency a

19 of Akt is cholesterol sensitive and that the oncogenic effects conferred by myristoylation arise, in

20 with NFATc1 activation, indicating that NFAT oncogenic effects depend on cell types and tissue contex

21 mor suppressor effect of SULF1, SULF2 has an oncogenic effect in HCC mediated in part through up-regu

22 raise the possibility that ErbB2 exerts its oncogenic effect in part by impairing TGFalpha-dependent

23 is tumor suppressor might have a paradoxical oncogenic effect in some hematopoietic cells.

24 fects of increased Bcr expression on Bcr-Abl oncogenic effects in a more physiological system, we tes

25 le gammaretroviruses have well-characterized oncogenic effects in animals, they have not been shown t

26 PGE(2) has been shown to exert pro-oncogenic effects in colorectal neoplasia through produc

27 genes dysregulated by loss of SIRT6 possess oncogenic effects in hepatocarcinogenesis.

28 polycomb repressive complex 2 (PRC2) exerts oncogenic effects in many tumour types.

29 hanism through which B-Raf(V600E) exerts its oncogenic effects in melanoma.

30 ntrast, rap-2 was found to cause significant oncogenic effects in OVCA cells, while SKIIP promotes on

31 ely, our results argue that MYC mediates its oncogenic effects in part by altering mevalonate metabol

32 ggest that the AR and miR-21 axis exerts its oncogenic effects in prostate tumors by downregulating T

33 B-cell CLL/lymphoma 6 (BCL6) exerts oncogenic effects in several human hematopoietic maligna

34 (eIF-4E), a downstream effector of mTOR, has oncogenic effects in vivo and cooperates with c-Myc in B

35 t how activated Notch1 signaling exerts this oncogenic effect is not completely understood.

36 less, the downstream signaling mediating its oncogenic effects is not well defined.

37 olves genetic and epigenetic alterations and oncogenic effects mediated by viral proteins in the acti

38 ivity to near normal levels and reversed the oncogenic effects (morphology changes and foci formation

39 Our studies reveal a novel cooperative oncogenic effect of AEG-1 and c-Myc that might explain t

40 proliferation, and that efforts to block the oncogenic effect of aerobic glycolysis must target react

41 We propose that a portion of the oncogenic effect of AIB1 could be through control of EGF

42 ciated with tumor progression, suggesting an oncogenic effect of amplified REL in B-lymphoid cells th

43 Here, we address the oncogenic effect of Bcl3 in vivo and describe how this S

44 ced transformation, and MITF potentiates the oncogenic effect of BRAF(V600E) in these progenitor cell

45 To study the oncogenic effect of chronically elevated insulin on hepa

46 This suggests that the oncogenic effect of distinct Ras mutants has a different

47 CA mutation was found to have alleviated the oncogenic effect of either the TP53 mutation or MYC ampl

48 We propose that the oncogenic effect of ETS fusion oncoproteins is in part m

49 These data demonstrate that part of the oncogenic effect of EWS/FLI1 is to transcriptionally der

50 These observations suggest a model for the oncogenic effect of high-risk HPV16 E7.

51 pressor activity of IRF-1 expression and the oncogenic effect of IRF-2 in human and murine tumor mode

52 hich suggests that pancreatitis enhances the oncogenic effect of KRAS through induction of IER3 expre

53 GTPase reaction rate that characterizes the oncogenic effect of many of the p21 mutants found in hum

54 The elusive oncogenic effect of mutating Gln61 is also explored.

55 ion in our simulations, we conclude that the oncogenic effect of mutation of Gln61 is indirect and is

56 Furthermore, the oncogenic effect of Notch1 on primary melanoma cells was

57 the development of new drugs to silence the oncogenic effect of SET/TAF-Ibeta's histone chaperone ac

58 Last, we demonstrated that the oncogenic effect of SLPI may be due to protection of gro

59 We have previously shown that the oncogenic effect of SULF2 in HCC may be mediated in part

60 This potentially oncogenic effect of tetraploidy is countered by a p53-de

61 is likely to significantly contribute to the oncogenic effect of the inactivation of BRCA1 or BRCA2.

62 on occurrences in cancer that potentiate the oncogenic effect of upstream lesions on the PI3K pathway

63 ch functions downstream of AKT, mediates the oncogenic effects of activated PI3K/AKT in ALK+ ALCL.

64 ses the oncogenic AKT, and mTOR mediates the oncogenic effects of AKT.

65 The oncogenic effects of Akt2 and Akt3 described here are in

66 function of the WWW element may explain the oncogenic effects of an alternative splicing variant of

67 These oncogenic effects of APEX1 were mediated by the upregula

68 indings that Bcr(64-413) interferes with the oncogenic effects of Bcr-Abl and therefore has the poten

69 r's inhibitory effects but also enhanced the oncogenic effects of Bcr-Abl in a solid tumor model and

70 at BCR gene expression strongly inhibits the oncogenic effects of Bcr-Abl in NOD/scid mice, yielding

71 wn that c-Myc expression is required for the oncogenic effects of Bcr-Abl, and that over-expression o

72 d that expression of Bcr interferes with the oncogenic effects of Bcr-Abl.

73 estigated the role of the Bcr protein in the oncogenic effects of Bcr-Abl.

74 hosphoserine form of Bcr, which inhibits the oncogenic effects of BCR-ABL.

75 generated and may be targeted to reduce the oncogenic effects of beta-catenin in intestinal cells.

76 hus, CDK4 provides a direct link between the oncogenic effects of c-MYC and cell-cycle regulation.

77 In cancer, these anti-oncogenic effects of CDK5 can provide selective pressure

78 fferentiated cells are more sensitive to the oncogenic effects of certain signaling abnormalities tha

79 and tobacco smoke exposure and the relative oncogenic effects of chemically stable versus unstable D

80 ion-transplantation approach to evaluate the oncogenic effects of E2a-Hlf on murine B-cell progenitor

81 the tumor microenvironment in promoting the oncogenic effects of EBV.

82 The oncogenic effects of Gab2 in HepG2 cells were promoted b

83 , these results strongly argue that the anti-oncogenic effects of LO on ras-mediated transformation a

84 fic factors determine the sensitivity to the oncogenic effects of loss or overexpression of Runx fact

85 rmal HAI-1 expression completely negated the oncogenic effects of matriptase.

86 sting that TOR activity is essential for the oncogenic effects of mutant Rheb.

87 ream signaling node for the pleiotropic, pro-oncogenic effects of Nanog.

88 Given the oncogenic effects of Notch2, we analyzed its gene dosage

89 The oncogenic effects of nutrients were reversed by SIRT3, w

90 exogenous BMI1 overexpression mitigates anti-oncogenic effects of PLK1 inhibition and overcomes senes

91 direct pharmacological target that overcomes oncogenic effects of PML/RARalpha by triggering its degr

92 nctions may be partially responsible for the oncogenic effects of PPM1D when it is amplified and over

93 ecific signaling circuitry sensitizes to the oncogenic effects of RB1 mutations.

94 ependent signaling pathway that mediates the oncogenic effects of secondary BAs in gastrointestinal c

95 vidence for a novel mechanism underlying the oncogenic effects of secondary bile acids.

96 ts that will guide further research into the oncogenic effects of SF3B1 mutation.

97 Thus, STAT3 is a critical mediator of the oncogenic effects of somatic EGFR mutations and targetin

98 We found that ARPs were required for many oncogenic effects of Src including Mmp1 expression and i

99 v-Jun from JNK signaling that underlies the oncogenic effects of the delta-domain deletion; however,

100 Overall, these results define the oncogenic effects of the GARP-TGFbeta axis in the tumor

101 nd as a result this SH2 binding inhibits the oncogenic effects of the oncoprotein.

102 The primary mediator of the oncogenic effects of the Wnt signaling pathway is beta-c

103 ure a critical level of gene product for the oncogenic effects of these fusions.

104 ls in the cell and likely contributes to the oncogenic effects of these pathways in human cancer.

105 To understand the developmental and oncogenic effects of two closely positioned point mutati

106 ever, we found that GRIM-19 inhibits the pro-oncogenic effects of v-Src independently of STAT3.

107 These oncogenic effects of YAP were associated with activation

108 The tumor suppressor p53 mediates its anti-oncogenic effect on cells by functioning as a sequence-s

109 ing functional p53, RUNX1 has apparently pro-oncogenic effects on cell growth that include cytoskelet

110 ular mechanisms by which menin decreases the oncogenic effects on cell morphology and other phenotype

111 Coexpression of CD40 and CD40L confers oncogenic effects on immortalized human epithelial cells

112 regulates MDM2 protein levels and exerts its oncogenic effects on p53 in tumor cells.

113 Here, we report that GARP exerts oncogenic effects, promoting immune tolerance by enrichi

114 ults suggest that COX-2/PGE(2) may exert pro-oncogenic effects through synergistic induction of recep

115 able targets in glioblastoma, relating their oncogenic effects to activation of the Wnt/beta-catenin

116 ese results demonstrate that WAP-Int3 has no oncogenic effect upon PI-MECs and that the expansion of

117 y component in this pathway may have similar oncogenic effects, we studied the relationship between a

118 anscription factor STAT3 and ablates its pro-oncogenic effects while v-Src activates STAT3 to promote

119 pression of cytokine expression and the anti-oncogenic effect with inhibition of angiogenesis.