ライフサイエンスコーパス: oncogenic protein

1 eal other novel activities of this important oncogenic protein.

2 d, thus, AMF/PGI represents a novel class of oncogenic protein.

3 y to the BCR or the ABL parts of the BCR-ABL oncogenic protein.

4 kinase (P13-K) was recently identified as an oncogenic protein.

5 polyadenylation (pPA) of RNA can produce an oncogenic protein.

6 l-1, a Bcl-2 family protein, functions as an oncogenic protein.

7 t least one case leading to expression of an oncogenic protein.

8 necessitating new approaches to inhibit this oncogenic protein.

9 specifically regulate the function of these oncogenic proteins.

10 Ls), CD44 homing receptor, and p53 and Bcl-2 oncogenic proteins.

11 ith sequence similarity to developmental and oncogenic proteins.

12 68 controls the alternative splicing of many oncogenic proteins.

13 und in several receptor tyrosine kinases and oncogenic proteins.

14 A translation and the expression of specific oncogenic proteins.

15 nd activation of its clients, including many oncogenic proteins.

16 to serum of EV containing some similar human oncogenic proteins.

17 gle variable domains binding to RAS and LMO2 oncogenic proteins.

18 al stability, thus enhanced binding to the 2 oncogenic proteins.

19 , stabilization/degradation, and function of oncogenic proteins.

20 anslation of mRNAs, including those encoding oncogenic proteins.

21 lity to induce the breakdown of a variety of oncogenic proteins.

22 bit a characteristic profile of depletion of oncogenic proteins and concomitant elevation of Hsp72.

23 tringent regulation by tumor suppressors and oncogenic proteins and enhanced RNA pol III transcriptio

24 90 inhibitors simultaneously target multiple oncogenic proteins and provide an advantage for cancer t

25 cluding 5 S rRNAs and tRNAs, is regulated by oncogenic proteins and tumor suppressors.

26 Many oncogenic proteins are more dependent on Hsp90 in mainta

27 dies to develop the detection of immunity to oncogenic proteins as tumor markers, as well as the deve

28 ole in the folding and maturation of several oncogenic proteins, associates with Tcl1 protein and sta

29 ole in the folding and maturation of several oncogenic proteins, associates with WT1 protein and stab

30 The oncogenic protein Bcl-2 functions as a potent inhibitor

31 poptosis and mediates the degradation of the oncogenic protein BCL6.

32 presents a novel activating mechanism of the oncogenic protein beta-catenin that could contribute to

33 dicate that LRP6 may function as a potential oncogenic protein by modulating Wnt/beta-catenin signali

34 ate production of unwanted proteins, such as oncogenic proteins, by blocking the function of their mR

35 The 120-kDa proto-oncogenic protein c-Cbl is a multidomain adaptor protein

36 SS) that translocates a pro-inflammatory and oncogenic protein, CagA, into epithelial cells.

37 ess protein kinase Cepsilon (PKCepsilon), an oncogenic protein capable of promoting autocrine cell-si

38 cancer evolution by specifically regulating oncogenic proteins closely related to malignant transfor

39 s induced by many receptor and intracellular oncogenic proteins commonly activated in cancer, renderi

40 cells in vitro revealed higher abundance of oncogenic proteins compared to EV released by normal hum

41 iophysical characterization of, gankyrin, an oncogenic protein composed of seven ARs and six T/SxxH t

42 Moreover, it is apparent that oncogenic proteins comprise complex signaling networks t

43 tegies to therapeutically target homodimeric oncogenic proteins considered undruggable.

44 CKIs), and CDH1, and upregulation of the pro-oncogenic proteins cyclin E, cyclin-dependent kinase 2 (

45 BM-MSC-derived exosomes had higher levels of oncogenic proteins, cytokines, and adhesion molecules co

46 cancer cells (i.e., increased expression of oncogenic proteins, decreased expression of tumor suppre

47 Among the oncogenic proteins dephosphorylated by PP2A, the MYC onc

48 Oncogenic proteins derived from tumor-associated HPV ind

49 t future studies targeting the "undruggable" oncogenic protein dimers.

50 urvival and sustained expression of multiple oncogenic proteins downstream of CypB may thus contribut

51 in tumor cells are mutated or overexpressed oncogenic proteins driving cancer cell growth, leading t

52 on anoscopy, we measured responses to HPV-16 oncogenic proteins E6 and E7, using the CD25/CD134 assay

53 4EGI-1 inhibits cellular expression of oncogenic proteins encoded by weak mRNAs, exhibits activ

54 lastoma pathogenesis downstream of the major oncogenic protein epidermal growth factor receptor varia

55 es have suggested that overexpression of the oncogenic protein epithelial membrane protein-2 (EMP2) c

56 The LIM-domain protein LMO2 is a T-cell oncogenic protein first recognized by gene activation th

57 ith a Fli-1 expression vector shows that the oncogenic protein Fli-1 can transactivate the GPIX promo

58 Galectin-3 is a multifunctional oncogenic protein found in the nucleus and cytoplasm and

59 proteins, and inhibition of DUBs that rescue oncogenic proteins from proteasomal degradation is of em

60 ancer cell death is inevitable after loss of oncogenic protein function.

61 The newly discovered oncogenic protein gankyrin, which contains six ankyrin r

62 velopment of targeted therapies against such oncogenic proteins has imparted clinical benefit.

63 HER-2/neu, an overexpressed oncogenic protein, has been proposed as a human cancer v

64 Human immune responses to oncogenic proteins have been reported and are continuing

65 Immune system based treatments targeting oncogenic proteins have shown therapeutic efficacy in an

66 growth-inhibitory humanized Ab targeting the oncogenic protein HER-2/neu.

67 consistent with their ability to degrade the oncogenic protein, Her2.

68 r HRAS genes are mutated to encode an active oncogenic protein in a quarter of human cancers.

69 hese findings suggest that Rad may act as an oncogenic protein in breast tissues and demonstrate a po

70 JCV DNA sequence and expression of the viral oncogenic protein in human brain tumors.

71 ost differentially expressed and established oncogenic protein in PC, MUC4 regulation in terms of mic

72 membrane protein 1 (LMP-1) is the principal oncogenic protein in the EBV transformation process.

73 anslocation in pro-B lymphocytes, encodes an oncogenic protein in which the E2A trans-activation doma

74 of astrocytoma have been designed to express oncogenic proteins in astrocytes, but have had limited s

75 of key mutational events in one of the most oncogenic proteins in cancer.

76 s and dysregulation of tumor suppressors and oncogenic proteins in cancer.

77 ion and conformational maturation of various oncogenic proteins in cancer.

78 is associated with assembly of numerous pro-oncogenic proteins in the plasma membrane and may play a

79 on, TFIIIB is bound and activated by several oncogenic proteins, including c-Myc.

80 beta-Catenin is an oncogenic protein involved in regulation of cell-cell ad

81 Expression of these known oncogenic proteins is enhanced on BCR activation and is

82 The subcellular localization of many oncogenic proteins is thought to be important for their

83 ted motility receptor (HMMR), a cell surface oncogenic protein, is widely up-regulated in human cance

84 r the correct folding and maturation of many oncogenic proteins, it has become a significant target f

85 The oncogenic protein kinase Aurora A is a critical regulato

86 r CDC37 in concert with HSP90 in maintaining oncogenic protein kinase clients and endorse the therape

87 BRAF(V600E) is the most frequent oncogenic protein kinase mutation known.

88 stimulate in vitro the activity of the proto-oncogenic protein kinase PKB/Akt, as has phosphatidylino

89 BRAF is an oncogenic protein kinase that drives cell growth and pro

90 gnaling network operating downstream of this oncogenic protein kinase to actively advance the surviva

91 itical activator of multiple prosurvival and oncogenic protein kinases and has garnered considerable

92 Several oncogenic protein kinases including c-raf-1 and pp60(v-s

93 nophilins can assemble steroid receptors and oncogenic protein kinases, such as v-Src and v-Raf, into

94 of clients, particularly activated or mutant oncogenic protein kinases.

95 Translational regulation by oncogenic proteins may be a rapid and efficient mechanis

96 Apoptosis of oncogenic protein Mcl1-expressing cells is mainly regula

97 s been associated with the overexpression of oncogenic proteins (MUC1), multiple emerging reports hav

98 ll autonomous effects on the upregulation of oncogenic proteins, NFATc1 activation has non-cell auton

99 nhibitors (GSIs) block the activation of the oncogenic protein Notch homolog-1 (NOTCH1) in T cell acu

100 d steroid receptor coactivator 3 (SRC-3), an oncogenic protein overexpressed in multiple human cancer

101 eye-antennal discs, cooperation between the oncogenic protein Ras(V12) and loss-of-function mutation

102 onstrated induction of DR5 expression by the oncogenic proteins Ras and B-Raf and revealed the underl

103 ruly tumor-specific antigen that is also the oncogenic protein required for neoplasia.

104 entral events that leads to dysregulation of oncogenic protein Six1 in human cancers.

105 The oncogenic protein Ski associates with Smad proteins and

106 Here we show that both oncogenic proteins specifically downregulate the express

107 with, and is tyrosine-phosphorylated by, the oncogenic protein Src during mitosis.

108 trated an interaction between MUC1 and other oncogenic proteins such as beta-catenin, erbB receptors

109 y a variety of signaling proteins, including oncogenic proteins such as Ras and Rho GTPases.

110 We further demonstrate that oncogenic proteins such as STAT3 or BCL-X(L) are effecti

111 HPV-encoded oncogenic proteins, such as E7, are promising tumor-spec

112 ing the N- and C-terminal regions of the JCV oncogenic protein, T antigen, in 11 of 23 samples and th

113 The oncogenic protein Tax, encoded by human T-cell leukemia

114 ces and function as complexes with the viral oncogenic protein Tax.

115 HTLV-I encodes an oncogenic protein, Tax, which affects a variety of cellu

116 Ski is an oncogenic protein that acts as a TGF-beta repressor and

117 Bcl-2 is an oncogenic protein that acts by inhibiting programmed cel

118 binding protein 2 (IGFBP2) is a pleiotropic oncogenic protein that has both extracellular and intrac

119 d activator of transcription 3 (STAT3) is an oncogenic protein that is constitutively activated in nu

120 Previous roles for IRS1, an oncogenic protein that is essential for IGF-mediated pro

121 Survivin is an oncogenic protein that is highly expressed in breast can

122 nuclear chaperone nucleophosmin, a proposed oncogenic protein that is overexpressed in many differen

123 Thus, our results revealed NELFE as an oncogenic protein that may contribute to transcriptome i

124 r results demonstrate that HHV-8 vFLIP is an oncogenic protein that mimics the signaling activities o

125 s expressed in human cancer and generates an oncogenic protein that promotes tumorigenesis in gliobla

126 gnant phenotype depends on oncogenic and non-oncogenic proteins that are essential to mediate oncogen

127 Bcl2 and c-Myc are two major oncogenic proteins that can functionally promote DNA dam

128 Bcl2 and c-Myc are two major oncogenic proteins that cooperatively promote tumor deve

129 al of exogenously applied miRNAs to suppress oncogenic proteins, the ERBB oncogene family was chosen

130 ristoylation of Src family kinases and other oncogenic proteins, thereby regulating their function.

131 lysis inhibitors to target the expression of oncogenic proteins through HuR degradation might foster

132 urther understand how c-Myc switches from an oncogenic protein to an apoptotic protein, we examined t

133 The ability of oncogenic proteins to regulate the rate of translation o

134 In this study, we identified the oncogenic protein, TWIST1 (Twist), which is overexpresse

135 terstitial stroma through the release of the oncogenic protein tyrosine kinase (KIT)-containing exoso

136 in the transformation of epithelial cells by oncogenic protein tyrosine kinases.

137 stimuli, as well as in cells transformed by oncogenic protein tyrosine kinases.

138 Bcr-Abl is the oncogenic protein-tyrosine kinase responsible for chroni

139 The signaling functions of the oncogenic protein-tyrosine kinase v-Ros were studied by

140 nificant role in cancer biology because many oncogenic proteins undergo prenylation.

141 The oncogenic protein Vav harbours a complex array of struct

142 Due to its negative regulation of many oncogenic proteins, we hypothesized that GSK3beta may fu

143 (EBV) latent membrane protein 1 (LMP1) is an oncogenic protein which has previously been shown to eng