ライフサイエンスコーパス: onset

1 ementia (10 before and 14 after parkinsonism onset).

2 nsient ischaemic attack (TIA) within 48 h of onset.

3 s with strong family history or early age at onset.

4 ent stages of language planning until speech onset.

5 d spikes with longer latencies from stimulus onset.

6 oci and 14 novel loci associated with age at onset.

7 dentifiable modular network prior to hearing onset.

8 were enrolled within 12 hours from symptoms onset.

9 lready at 17.8 years before expected symptom onset.

10 disease-modifying time window after symptom onset.

11 pite treatment within 12 hours after symptom onset.

12 n scan obtained less than 12 months from CIS onset.

13 y of EBV to cause lymphomas but delays tumor onset.

14 s in the timing of initial response to sound onset.

15 ochore component recruited prior to anaphase onset.

16 esponded to 255 days (228-287) after disease onset.

17 accurately predict the delay to therapeutic onset.

18 t expansion by means of a decrease in age at onset across successive generations.

19 cation and study of inherited forms of early-onset AD and genetic risk factors that provide insights

20 els of AD and in patients with sporadic late-onset AD suggest that impaired mitophagy contributes to

21 Among individuals with impairing late-onset ADHD symptoms, the most common reason for diagnost

22 New onset AF was associated with increased risk of all outco

23 e 0.83) showed good predictive value for new-onset AF.

24 erum albumin concentration, and CKD stage at onset affected ESRD risk.

25 disease that is particularly severe when its onset affects children aged 6 years or younger.

26 ical tolerance with aging suppresses disease onset after late young adulthood in mice.

27 Eruptions are associated with revolt onset against elite rule, and the cessation of Ptolemaic

28 he LT and Wnt pathways during early- or late-onset allergic airway inflammation and to address regula

29 The older age of onset among female cases in general, and among female bu

30 pression of contrast sensitivity at saccadic onset and an enhancement after saccadic offset.

31 ected at acute respiratory distress syndrome onset and at 24 hours in 352 children between 2011 and 2

32 PKBP1 as a genetic cause of juvenile or late-onset and cilia-independent NPH.

33 dermatitis were identified depending on the onset and course of the disease.

34 with the acute phase response and its age of onset and female preponderance appear to have evolved fr

35 acute retinal pigment epitheliitis (ARPE) at onset and in the course of recovery by serial spectral-d

36 ncy in hematopoietic cells accelerated tumor onset and increased levels of tumor-infiltrating immune

37 sk locus, showed association with delayed AD onset and lower expression of SPI1 in monocytes and macr

38 rs after extracorporeal membrane oxygenation onset and mortality (2010-2015).

39 ntified as gut microbiota signatures of NAFL onset and NAFL-NASH progression, respectively.

40 DSC studies revealed increased values of onset and peak temperatures and enthalpy of melting of t

41 g and misfolding is critically linked to the onset and progression of a broad range of human diseases

42 ncer cells may offer novel insights into the onset and progression of cancer and may provide specific

43 argely unknown how gut dysbiosis affects the onset and progression of CNS autoimmunity.

44 ese folding patterns are miswired during the onset and progression of mammalian disease states.

45 atopic dermatitis depending on the timing of onset and progression of the disease in childhood is lac

46 t the molecular mechanisms which provoke the onset and progression of the syndrome are largely unknow

47 derable inter-patient variability in disease onset and progression, which can confound the results of

48 unger and had a shorter delay between stroke onset and randomisation but they had similar pre-treatme

49 mals display a significantly earlier disease onset and reduced overall survival, compared to controls

50 We also find that the onset and termination of the calling activity of users f

51 inside the same time-zone, we show that the onset and termination of the calling activity synchroniz

52 s subtypes, indicating differences in age at onset and thereby implying differences in the underlying

53 rotective effect of physical activity on the onset and/or progression of AMD.

54 inct tau pathologies have different temporal onsets and functional consequences on neural activity an

55 einforcement schedules based on detection of onsets and offsets of alpha waves, and employ these stat

56 an obtained less than 3 months from clinical onset, and a follow-up brain scan obtained less than 12

57 etime psychiatric disorders, disorder age at onset, and disorder severity in a nationally representat

58 oliosis, gastrostomy feeding, age of seizure onset, and late age of diagnosis were independently asso

59 y of three unique drugs, with reported rapid onset antidepressant properties, is coupled with a rapid

60 Preclinical identification of fast-onset antidepressants requires animal models that can ac

61 We found a high burden of community-onset antimicrobial-resistant infection among patients w

62 rations), although the differences in age at onset are not entirely accounted for by repeat length.

63 When the stimulated ictal onset area was hyperperfused, 82% of studies demonstrate

64 ined by days between vaccination and symptom onset as the predictor.

65 nical information for 1354 patients (disease onset at >3 months and <20 years of age): 612 had docume

66 ure of the unique hues 230 ms after stimulus onset at a post-perceptual stage of visual processing.

67 ent [n = 67; 6.5%]), the late phenotype with onset at age 2 years or older (n = 50; 4.8%), and the ne

68 ecentral gyri immediately following question onset; at the same time, high-gamma activity was attenua

69 New-onset atrial fibrillation was subclinical or went undocu

70 To determine the association of new-onset atrial fibrillation with outcomes, including ICU l

71 mber and function, leading to a fatal, early-onset autoimmune disorder.

72 nically isolated syndrome (CIS) with disease onset before 18 years of age and duration of less than 4

73 atitis in childhood: 2 early phenotypes with onset before age 2 years (early transient [n = 96; 9.2%]

74 reported incidents of pertussis with symptom onset between 1 January 2010 and 31 December 2015.

75 1058 visits, 67 (6.3%) of which preceded new-onset BPSD within the next 5 years.

76 enous levels of mutant CHMP2B developed late-onset brain volume loss associated with frank neuronal l

77 and that iNKT cells critically delay disease onset but become functionally impaired upon disease prog

78 , and that TrpA1 specifically impacts siesta onset, but not night sleep onset, in response to elevate

79 mic acid decarboxylase 65 (GAD)] delayed T1D onset, but published data are conflicting regarding dose

80 n adult- and earlier-onset MDD, with earlier-onset cases having a greater genetic overlap with schizo

81 le cases in general, and among female bulbar-onset cases in particular, was the most striking finding

82 ted in 26 patients (52%), progression or new-onset cataract was noted in 22 patients (44%), neovascul

83 for sleep-onset latency and wake after sleep onset, collected prospectively for 10 days at each asses

84 he renal manifestation of JBTS is a juvenile-onset cystic kidney disease, known as nephronophthisis,

85 demiologic links among patients, and illness onset dates inconsistent with a point-source exposure.

86 ice of both sexes (Atoh1(lacZ/+)) have adult-onset deafness.

87 ptors is followed shortly afterward by early-onset degeneration.

88 tral nervous system (CNS), causing the adult-onset degenerative disease amyotrophic lateral sclerosis

89 Three signals explained late-onset degradation: miR-430 seeds, AU-rich sequences, and

90 th anti-inflammatory effects and risk of new-onset depression and anxiety among adult patients admitt

91 A 72-year-old woman developed new-onset depression, sustained an unexplained fall, and sta

92 ncy, sleep efficiency, and awake after sleep onset, derived from sleep diaries; polysomnography; and

93 ions and comorbidities in contemporary youth-onset diabetes are unknown.

94 1alpha (HNF-1A) are associated with maturity-onset diabetes of the young form 3 (MODY 3) and type 2 d

95 as has been shown in patients with maturity onset diabetes of the young.

96 e therapy-induced tolerance in mice with new-onset diabetes on the presence and functionality of CD4(

97 analyzed data from 109,385 patients with new-onset diabetes.

98 SLE progression (but not onset) does not require the participation of synaptic tr

99 ent-mixing model and extract the likely PETM onset duration.

100 ontrol global aspects of the behavior (e.g., onset, duration); and within these two ends, specific ne

101 mptoms of botulism in a prison A inmate with onset during 30 September-9 October 2011.

102 Both models recreate the progressive adult-onset dysfunction and degeneration of a neuronal network

103 with increased risk of DCGF; however, later-onset dysfunction requiring IBx had far greater impact (

104 with spastic quadriplegia, and an infantile onset encephalopathy, suggesting multiple cell types may

105 stonia evaluated within 5 years from symptom onset, enrolled in the Natural History Project of the Dy

106 nalysis in adults with unexplained childhood-onset epilepsy and intellectual disability.

107 n-based cohort of individuals with childhood-onset epilepsy in southwestern Finland, together with 46

108 ess common than in other causes of childhood onset epilepsy.

109 Gestational age, age at illness onset, exposure to environmental tobacco smoke, bacteria

110 Men with classic or later-onset FD caused by GLA missense mutations developed prom

111 Severe early-onset fetal growth restriction can lead to a range of ad

112 y the motor manifestations of isolated adult-onset focal dystonias.

113 hereas intermediate "Hybrid" events, have HF onsets followed by LF ringing.

114 , 4,001 controls), the most severe and early onset form of periodontitis.

115 A subset of patients with early onset formed hallucinations (n=21) had reduced higher vi

116 intravenous tPA within 4.5 hours of symptom onset from 888 surveyed hospitals between June 2014 and

117 o 0.19+/-0.12 mm/year in eyes developing new-onset GA (5/21).

118 omputes the probabilities of CP-visible, new-onset GA and central GA after 1 to 5 years.

119 roups that reflect differences in the age of onset, gender predominance and response to therapy.

120 34 weeks) and late-onset PE (LO-PE; symptom onset > 34 weeks) cohorts.

121 ted with less years before estimated symptom onset, higher global Abeta brain burden, and with lower

122 the first known ingestion with typical rapid onset IgE-mediated symptoms.

123 to the corona observed 29 s after the event onset in 171 A by the Atmospheric Imaging Assembly/Solar

124 spiking and the precise encoding of stimulus onset in afferent neurons.SIGNIFICANCE STATEMENT Numerou

125 ovided approximately 90 ms prior to movement onset in each group.

126 th genetic anticipation (ie, earlier disease onset in successive generations), although the differenc

127 myoclonic epilepsy with photosensitivity and onset in young Rhodesian Ridgeback dogs (6 wk to 18 mo)

128 ly impacts siesta onset, but not night sleep onset, in response to elevated temperatures.

129 rrent mainstay of prevention, reducing early-onset infant disease in high-income contexts.

130 oral changes in gene expression from disease onset involving phagosome formation as well as natural k

131 NTATION: A 50 year male presented with acute onset jaundice, significant weight loss and elevated liv

132 online sleep diary-derived values for sleep-onset latency and wake after sleep onset, collected pros

133 mnia; sleep quality; total sleep time, sleep onset latency, sleep efficiency, and awake after sleep o

134 stration of CTDP-32476 alone produced a slow-onset, long-lasting increase in extracellular nucleus ac

135 sociated with early-onset PE (EO-PE; symptom onset < 34 weeks) and late-onset PE (LO-PE; symptom onse

136 signed patients (1:1:1 stratified by symptom onset </=4 days or 5-6 days) to receive 300 mg or 600 mg

137 nd 1.1% (p = 1.30e(-05)) for MDD with age at onset <18 years.

138 thesized that BPD cases with an early age of onset (</=21 years old) would be particularly likely to

139 C9orf72 expansion was being driven by spinal onset males (HR 1.56 (95% CI 1.25 to 1.96).

140 ion, EMG- and ultrasound-detected activation onsets may not correspond.

141 thways that lead to first-episode adolescent-onset MDD (incident cases) in those at high familial ris

142 of different pathways to incident adolescent-onset MDD composed of contributions from familial/geneti

143 ty to MDD differs between adult- and earlier-onset MDD, with earlier-onset cases having a greater gen

144 After pediatric onset MS (POMS) diagnosis, age at onset younger than 15

145 mutation in the PTRH2 gene causes infantile-onset multisystem disease with progressive muscle weakne

146 ype 1 (DM1) is the most common form of adult-onset muscular dystrophy, which is characterised by prog

147 In music, we found a boundary-onset music-CPS for both groups during pauses between mu

148 206510), which has been identified for early onset myocardial infarction (MI), modified the associati

149 -control cohorts for the evaluation of early-onset myocardial infarction, participants with CHIP had

150 PD-ligands, both TS1 TEM and TN induced late-onset myocarditis.

151 At acute respiratory distress syndrome onset, neither mechanical variables nor PaO2/FIO2 were a

152 should be reclassified as an early-childhood-onset neurodevelopmental condition in DSM-5.

153 was composed of younger patients with early-onset nonsevere asthma and reversible airflow obstructio

154 uction appears a necessary condition for the onset of a convection collapse.

155 supplementation in APOE4 carriers before the onset of AD dementia can be a promising approach to decr

156 ntation may reduce the risk for or delay the onset of AD symptoms in APOE4 carriers.

157 re the main causal agent associated with the onset of AD.

158 ical functions and pathways before and after onset of AF.

159 of Ca(2+) -based arrhythmogenicity after the onset of AF.

160 Increased R gnavus was observed before the onset of allergic manifestations, and was associated wit

161 olar simplification is first observed at the onset of alveologenesis at postnatal day 3.

162 Prior to the onset of AN, premorbid body mass index (BMI) spans the e

163 mitant cleavage of caspase-3, indicating the onset of apoptosis of LX-2 cells, as was confirmed by th

164 x during its translocation to the MOM in the onset of apoptosis.

165 nal study in which adult patients with adult-onset of asthma (defined as starting at age >/=18 years)

166 Paratyphi A in stool typically preceded onset of bacteremia.

167 nd mammalian biostratigraphy that refine the onset of basin fill to approximately 25.5 Myr and reveal

168 uild a risk calculator to predict the 5-year onset of BPSD in youth at familial risk for BPSD.

169 s cleavage is temporally correlated with the onset of brain inflammation.

170 and their nuclei as critical drivers for the onset of cancer.

171 Knockdown of RIMA causes delayed onset of cell differentiation, phenocopying the effects

172 on, severely impaired EGFR signaling and the onset of cellular senescence.

173 detectable levels after birth and after the onset of circadian synchrony.

174 Surprisingly, the onset of clathrin waves, but not individual endocytic ev

175 w for identification of the disease prior to onset of clinical signs.

176 mediated shortening of these overlaps at the onset of cytokinesis proved to be required to spatially

177 les in the SNpc of LRRK(-/-) mice before the onset of DA neuron loss.

178 sted that the clock influences the timing of onset of degradation.

179 the interval from onset of motor symptoms to onset of dementia, and overall survival in groups with v

180 perinatal period is a time of high risk for onset of depressive disorders and is associated with sub

181 ere of suppressive phenotype and delayed the onset of diabetes in NOD mice.

182 NN27 (10 mg/kg i.p.) was administered at the onset of diabetes, every other day for 4 weeks (paradigm

183 ice with a Y1 receptor antagonist delays the onset of diabetes.

184 ingle nucleotide polymorphisms influence the onset of disease, prognosis, or response to treatment.

185 and declines rapidly at the time of clinical onset of disease.

186 ts in the mitochondrial axonal transport and onset of disease.

187 -response and repair pathways and the age at onset of disease.

188 ntify microbial patterns associated with the onset of eczema.

189 r omalizumab demand precise knowledge of the onset of effects, the objective of this study was to det

190 truncating MLH1 mutations had later ages of onset of endometrial cancer than those with nontruncatin

191 e drug combination significantly delayed the onset of epilepsy, blocked disease progression between 2

192 Median age at onset of eye disease was 60 months and duration of eye d

193 ed Spectroscopy (NIRS) method to monitor the onset of fat phase transition (freezing/melting) in huma

194 tients were followed up for 2 years from the onset of first-episode psychosis.

195 l. explain how breastfeeding can prevent the onset of food allergies in offspring by instructing T re

196 12-10 k years ago, around or just before the onset of food production.

197 of Xenopus TRPM6 (XTRPM6) is elevated at the onset of gastrulation and is concentrated in the lateral

198 clear the pluripotency protein Ventx2 at the onset of gastrulation.

199 er ophthalmicus diagnosed 3 weeks before the onset of GCA symptoms.

200 specific embryonic expression, preceding the onset of gonadal sex differentiation.

201 pose the high E eff value corresponds to the onset of high energy dynamic instabilities in this drive

202 ormula: see text], which we interpret as the onset of homogeneous etch pit nucleation.

203 n exon-1 of Huntingtin protein (Htt) and age onset of Huntington's disease (HD); however, the underly

204 mice, a single dose of IRAB-B induces rapid onset of hyperglycemia within 6 h, and severe hyperglyce

205 gestion develops in two phases: (1) from the onset of isolated orofacial movements in utero to the po

206 g neuroblasts with hydroxyurea (HU) prior to onset of larval proliferation (generates secondary neuro

207 terval between surgical excision of OSSN and onset of LSCD was 8 weeks (median, 6 weeks; range, 6-12

208 We assessed the interval from onset of motor symptoms to onset of dementia, and overal

209 congruent events can trigger an accelerated onset of neural encoding mechanisms supporting the integ

210 l administration of Cu(II)(atsm) delayed the onset of neurological symptoms, improved locomotive capa

211 PPT1-deficient (Ppt1(-/-) ) mice before the onset of neuropathology in the brain.

212 The end point was the risk difference in the onset of new allergen sensitizations between patients tr

213 fying treatment, including prevention of the onset of new allergen sensitizations.

214 CRT reduced the rate of onset of new ventricular arrhythmias detected by ICDs in

215 eport of myocardial ischemia before or after onset of ocular condition was 52% in AF, 22% in OIS, 22%

216 ary outcome measures included the time until onset of pain and the time until patients required rescu

217 rtem muscle, early protein oxidation and the onset of pale, soft and exudative (PSE) condition in chi

218 lesions significantly reduced, but also the onset of pancreatic cancer is delayed.

219 serotonergic innervation preceding the motor onset of Parkinson's disease.

220 e followed up until January 1, 2015, for the onset of parkinsonism through serial in-person examinati

221 the temporal association between surgery and onset of PCSON.

222 ecursor stage and the resulting delay in the onset of PDAC-associated pain.

223 dentified by characteristic symptoms (abrupt onset of photopsias, followed by large scotomata at or c

224 ligands dampen platelet activation, and the onset of piconewton integrin tension coincides with calc

225 ition since 550 Ma and potentially since the onset of plate tectonics.

226 the steady-state level, was associated with onset of PMDD symptoms.

227 inical features include extracolonic tumors, onset of polyps in adolescence, and rapid progression of

228 ave an efficiently-wired connectome at first onset of psychosis show a better subsequent response to

229 leading to progressive dysregulation and the onset of psychosis.

230 At the onset of puberty, ovarian hormones increase inhibitory t

231 sfunction and in the kidney, it predicts the onset of renal failure.

232 Instead, FEF inactivation delayed the onset of saccade-related accumulation, emphasizing the i

233 ers of AAOs, and during idiophase (after the onset of secondary metabolism).

234 ring tumor progression corresponded with the onset of seizures and tumor invasion.

235 The onset of seizures occurred before 18 years of age in 75.

236 Median time to onset of select AEs ranged from 5 weeks for skin to 15 w

237 nce imaging scan within 6 months after first onset of symptoms.

238 AD), and its expression levels influence the onset of the AD-like phenotype in mouse models.

239 vel was four times higher 7 hours before the onset of the attack.

240 time within the first 180 seconds after the onset of the cardiac arrest.

241 rapidly ( approximately 200-800 ms from the onset of the event boundary) and was specific to context

242 This limit is set by the onset of the rapid coarsening of the precipitates and co

243 nomalies peaked in the dry period before the onset of the summer monsoon, suggesting that local land-

244 e, leads to embryonic lethality prior to the onset of their expression within the embryo proper.

245 trafiltration performed at fixed rates after onset of therapy-induced increased serum creatinine was

246 The progressive and early onset of these defects suggest a primary myopathy in HD.

247 strongly influenced the magnitude and age at onset of these effects.

248 tones and transcription factors regulate the onset of transcription in the embryo.

249 r several physiological processes and in the onset of various diseases.

250 rivation experiments have suggested that the onset of visual experience determines when interneurons

251 tative pluripotency factors expressed at the onset of ZGA.

252 gonists with distinct clinical durations and onsets of action (indacaterol, two indacaterol analogues

253 to a 250 nm blue-shift of the dye absorption onset on TiO2.

254 Time until disease onset or last examination, time from disease onset until

255 mortality; secondary end points included new-onset organ failure.

256 that is significantly correlated with age at onset (p=2 x 10(-89)).

257 Patients from a large family with early-onset pain symptoms were evaluated by clinical examinati

258 erative day 1 undilated examination, delayed-onset painless vision loss, mild anterior chamber and vi

259 adenylation signatures associated with early-onset PE (EO-PE; symptom onset < 34 weeks) and late-onse

260 E (EO-PE; symptom onset < 34 weeks) and late-onset PE (LO-PE; symptom onset > 34 weeks) cohorts.

261 n-propanol are the major C2-C3 products with onset potential at -0.53 V (vs. reversible hydrogen elec

262 h oxygen reduction reaction activity with an onset potential of 0.92 V, and a half-wave potential of

263 a Pt UME, allowing for the determination of onset potentials, while the substrate current, which is

264 s from previously published studies in adult-onset primary CNS tumors and replicated these in survivo

265 We observed that dC+dT delayed disease onset, prolonged life span of Tk2-deficient mice and res

266 th glomerular disease characterised by early onset proteinuria and ultrastructural thickening and spl

267 suggest a correlation between age at disease onset, response to sodium channel blockers and the funct

268 molecular cause of autosomal recessive early onset retinal degeneration in a consanguineous pedigree.

269 Stargardt disease is a juvenile onset retinal degeneration, associated with elevated lev

270 Mutations in the SRD5A3 gene may cause early-onset retinal dystrophy, a previously underdescribed fea

271 We also identify age-onset rhythmicity in several putative primary piRNA tran

272 middle frontal gyrus of patients with recent-onset schizophrenia, who were previously shown to displa

273 Patients presented with early-onset sensorineural deafness and distal renal tubular ac

274 age >/=18 years) as compared with childhood-onset severe asthma (<18 years) were selected from the U

275 We report seven individuals with an early-onset spastic-ataxia phenotype.

276 y was found to shift farther from a movement onset state during beta oscillations that were neurofeed

277 luble AXL had poor 1-year outcomes after ICH onset, suggesting that therapeutically augmenting effero

278 that MEK inhibition adversely affects early onset T-cell effector function.

279 ted much earlier (<100 ms following stimulus onset) than previously estimated.

280 nimals that had been earplugged from hearing onset throughout auditory critical periods displayed imp

281 tive drift and magnitude of illusion through onset time to illusion only for the black RH.

282 for how circadian phases, such as wake-sleep onset times, can become unstable in humans, and we prese

283 riches at attachment sites prior to anaphase onset to dampen chromosome motion.

284 Scale [NIHSS] = 16, median time from symptom onset to endovascular therapy = 5.2 hours).

285 Childhood-onset type 1 diabetes.

286 onset or last examination, time from disease onset until death or last examination, or age at death w

287 cidence of TIA /stroke within 3 months after onset was 6% (95% CI: 2%, 17%) for OIS, 3% (95% CI: 0.4%

288 Melanoma onset was accelerated in kit(lf); Tg(mitfa:BRAF(V600E));

289 Plasticity onset was restored by a homeoprotein Otx2, which binds t

290 trant syndromic feature with early postnatal onset, we would gain new insights into the mechanisms by

291 sit occurred more than 12 years from disease onset were excluded.

292 tervention (<3 versus >3 months from symptom onset) were associated with CA3 atrophy.

293 NRF2)-dependent gene expression precedes PPK onset, which can be prevented by topical sulforaphane-me

294 revealed regional differences in activation onset, which decreased with higher contraction speed (Sp

295 ated to the latency of the response to sound onset, which is found in left auditory cortex.

296 ing over 5 mA cm(-2) before the dark current onset, which originated from the large surface area and

297 nclusion criteria were (1) pediatric seizure onset with ongoing seizure activity in adulthood, (2) in

298 promoting microglial action prior to disease onset would inform potential preventative intervention t

299 pediatric onset MS (POMS) diagnosis, age at onset younger than 15 years and DMD exposure decreased t

300 ibution of spikes in relation to the seizure onset zone as well as anatomical regions of the brain.