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1 o relax away from the pore axis to create an open channel.
2 ared to conventional microfluidic SERS in an open channel.
3 each binding step in both the closed and the open channel.
4 cleavage site) resulted in a constitutively open channel.
5 are exposed in the permeation pathway of the open channel.
6 due to a decreased rate of flux through the open channel.
7 1a- 3) both activate the AChR and block the open channel.
8 and R237 residues produced a constitutively open channel.
9 ith KCNE3 (Mirp2) producing a constitutively open channel.
10 as a deformed beta-like conformation in the open channel.
11 channels is related to a fast flicker of the open channel.
12 a monomeric eight-stranded barrel lacking an open channel.
13 the conformational transition from closed to open channel.
14 ecting the countercharge centers favored the open channel.
15 ered channel gating and current flow through open channels.
16 the full-length beta4 protein did not block open channels.
17 oes not result from memantine escape through open channels.
18 ng the low flow resistance commensurate with open channels.
19 nly about 5% of the OprF population produced open channels.
20 teine was greater in closed channels than in open channels.
21 in response to Ca(2+) microdomains near the open channels.
22 in-of-function effect leading to permanently open channels.
23 clude the orientation, length, and number of open channels.
25 s 24 Si atoms per unit cell (oC24), contains open channels along the crystallographic a-axis that are
27 al rates of cation translocation through the open channel and this is achieved at the expense of the
28 s(-1) and 22 s(-1), respectively, for Nav1.4 open channels and 7.1 microM(-1) s(-1) and 14 s(-1), res
29 for the current-voltage relationships of an "open" channel and they also show several subconducting t
30 conductance-voltage relation, decreases mean open-channel and burst duration by about sixfold, and re
32 NP(o) x i(Ca) (where NP(o) is the number of open channels), and NP(o) and i(Ca) both depend on V(m).
33 ions to channel opening, the behavior of the open channel, and recovery from the desensitized state c
34 the GluN2A M3 helices from the lumen of the open channel, and reveals why the Lurcher mutation in Gl
35 the observation that phencyclidine (PCP), an open channel antagonist of the NMDA subtype of glutamate
37 domain composition in a manner that favours open channel area expansion, as well as allowing diffusi
38 ntified cytosolic Ca(2+)-binding site in the open channel as the Ca(2+) ions pass through the pore.
39 Fe(2)(+) of approximately 20 ions/s for each open channel at -60 mV and pH 7.2, with 1 muM extracellu
41 t increase resulted from DC6C binding to the open-channel based on its prevention by proadifen, a non
42 n alpha-helix, and we propose a model of the open channel, based on MthK, in which Phe-1579 and Val-1
43 As confirmed by docking calculations, the open channel binds amantadine at the more favorable inte
45 preparation to test the recent proposal that open channel block of the acetylcholine receptor by acet
46 ctivation, but Mg caused a greater degree of open channel block than Ca, making it unlikely that Kir1
47 the channel at negative membrane potentials (open channel block) by the nucleotide and not by a phosp
53 nt models via a dual allosteric mechanism of open-channel block and NO/redox modulation of the recept
54 show that diminazene blocks ASIC1a by a slow open-channel block and suggest that diminazene is an int
55 g cells of the cerebellum, are subject to an open-channel block and unblock by an endogenous protein.
57 tage-dependent blocking kinetics indicate an open-channel block mechanism, which can be well describe
58 nt currents arise after relief of ultra-fast open-channel block mediated by an endogenous blocking pa
59 g that, like in NaV1.6-expressing cells, the open-channel block of NaV1.1 and NaV1.2 subunits is regu
60 ting that these residues are required for an open-channel block that approximates physiological resur
61 olarization, which results from relief of an open-channel block that terminates current flow at posit
62 were prolonged and the voltage dependence of open-channel block was reduced relative to control cells
63 aV1.6 is not unique in its susceptibility to open-channel block, because under appropriate conditions
64 re fast inactivation, slow inactivation, and open-channel block, we recorded voltage-clamped, tetrodo
65 tion of the few highly conserved residues to open-channel block, we synthesized several mutant peptid
66 late the susceptibility of alpha subunits to open-channel block, we voltage clamped wild-type and med
67 y 3alphaCOOH5betaP is consistent with simple open-channel block, with voltage dependence reflecting i
74 g the rate of block of NMDA receptors by the open channel blocker MK-801, we confirmed that the initi
76 sis approaches, we identified citrate as an "open channel blocker" of AtALMT9 and used this tool to e
77 out a prepulse was completely blocked by the open channel blocker, (+)-5-methyl-10,11-dihydro-5H-dibe
78 using MK-801, an N-methyl-D-aspartate (NMDA) open channel blocker, implicates glutamate receptors in
80 by MK801 (dizocilpine hydrogen maleate), an open channel blocker, this potentiation was attributable
81 potential and/or Memantine, an NMDA receptor open channel blocker, would reduce noise-induced loss of
84 Moving the positive charge also restored open-channel blocker interactions that are lost in K95Q.
85 Argiope lobata, is a potent but nonselective open-channel blocker of ionotropic glutamate (iGlu) rece
86 We conclude that PhTX-343 mainly acts as an open-channel blocker of nAChRs with strong subtype selec
90 interpreted as deoxycholic acid acting as an open-channel blocker, which may relate to deoxycholic ac
93 these data suggest that amiloride and other open channel blockers bind to sites revealed during the
94 he activation gate in the VSD is unknown and open channel blockers for VSDs have not yet been identif
96 ribe a class of small molecules which act as open channel blockers on the Hv1 VSD and find that a hig
97 channels are dilating, and as a consequence open channel blockers such as amiloride are allowed deep
98 are clinically useful NMDA receptor (NMDAR) open channel blockers that inhibit NMDARs with similar p
99 petitive NMDA antagonists, more specifically open channel blockers, which may be alternatives to high
102 several D1 ligands act as voltage-dependent, open-channel blockers for NMDA receptors, regardless of
104 ine toxins from spiders and wasps are potent open-channel blockers of ionotropic glutamate (iGlu) rec
105 CMS include cholinergic agonists, long-lived open-channel blockers of the acetylcholine receptor ion
106 ibition; this effect was largely occluded by open-channel blockers, suggesting that lidocaine binding
108 The results also demonstrate that a known open-channel blocking peptide not only permits a rapid r
110 current express an intracellular endogenous open-channel blocking protein, whose rapid binding upon
112 rsion of KCNQ1 by hKCNE3 to a constitutively open channel, but prevented its inhibition of Kv4.2 and
113 transmembrane domain allowed blockade of the open channel by the MTS reagents MTSEA, MTSET, and MTSES
114 americ p7 complex, which forms a transiently-open channel capable of conducting ions in simulation.
116 oated with chitosan for DNA extraction in an open channel configuration without the need for an addit
117 roosmotic pumping principles, has a multiple open-channel configuration consisting of hundreds of par
119 rocess of AMPA receptors is to stabilize the open channel conformation, presumably by its pivotal str
123 tive inhibitor that selectively inhibits the open-channel conformation of AMPA receptors with nanomol
124 -channel conformation and the fully liganded open-channel conformation of different members of the ni
125 Here we report the crystal structure of an open-channel conformation of NavMs, the bacterial channe
127 y site with equal or higher affinity for the open-channel conformation than for the closed-channel co
128 ion of the TM23 linker, and destabilized the open-channel conformation that can lead to inhibition of
129 ning transmembrane alpha-helices (M2) in the open-channel conformation, in terms of the excess free e
133 assembles and isomerizes between closed- and open-channel conformations we measured changes in the di
134 ion rate constants from both the closed- and open-channel conformations, have been estimated experime
139 ur model by mutations around the closed- and open-channel constriction sites (Gln-4933 and Ile-4937).
143 he C<-->O isomerization process; and 3), the open-channel current amplitude (i(0)), which reports whe
145 ic receptors in which activation to form the open channel depends on the binding of possibly multiple
146 al single-channel current amplitude and mean open-channel duration but that homoquinolinate slows act
147 c) in which the helix is undistorted, and in open channels (e.g. MthK) in which the M2 helix is kinke
148 Both operations are programmed by carving open channels either longitudinally or perpendicularly t
149 istance to protein adsorption was studied by open-channel electrophoresis for bovine serum albumin la
151 rs bind with equal or higher affinity to the open-channel form and alleviate picrotoxin inhibition.
152 ity for the closed-channel form than for the open-channel form and thereby inhibits the receptor by d
153 finity to the picrotoxin-binding site on the open-channel form of the receptor and the closed-channel
154 s mechanism describes the time course of the open-channel form of the receptor as a function of gluta
155 dissociation constant of picrotoxin for the open-channel form of the receptor was approximately 5 ti
157 ne (ACh) receptor converts transiently to an open-channel form when activated by ACh released into th
158 ity for the closed-channel form than for the open-channel form, thus shifting the equilibrium toward
162 ing in the external end of the pore, whereas open channels have a narrowing midway, the length of TM2
164 re nonlinear in a way similar to macroscopic open-channel I/Vs, so divalent gamma was underestimated
167 red AQP5 proteins retain the ability to form open channels in the cell membrane and conduct water.
168 e change produced by current flowing through open channels in the HC membrane should occur with no de
170 anemone toxin anthopleurin B, which impairs open-channel inactivation, exclusively enhanced inward g
174 attenuated if applied in the presence of an open-channel inhibitor and showed voltage-dependent reco
175 ng by rapidly binding to allosteric sites on open channels, initiating a rate-limiting conformation c
176 Single-channel conductance of the fully open channel is approximately 85 pS, and it is permeable
178 f the lipids, whereas the conductance of the open channel is much less sensitive to this parameter.
179 ws for rapid diffusion of oxygen through the open channels, leading to efficient and reversible quenc
180 th a unique single channel conductance, mean open channel lifetime, and sensitivity to the allosteric
182 eurotransmitter-gated ion channels where the open-channel lifetime increases with the number of bindi
183 ptors with only one intact binding site, the open-channel lifetime is indistinguishable from receptor
184 its identical binding sites, we measured the open-channel lifetime of individual receptors in which f
185 t need to be occupied to achieve the maximal open-channel lifetime, thus revealing a unique interdepe
186 obile phase diminishes analyte dispersion in open-channel liquid chromatographic columns due to minim
188 in cation transport number and by pronounced open-channel low-frequency current noise with a peak at
189 on neglects the fact that Ca(2+) released by open channels may influence subsequent gating through th
190 V to +50 mV to rapidly increase and decrease open channel-mediated sarcoplasmic reticulum lumenal to
191 is proof of principle study, we developed an open-channel membrane device that allows long-term conti
194 are difficult to achieve using conventional open-channel microsystems made from glass or polymers.
195 Computational docking in the Kv1.2-based open channel model yielded a complex in which a pyrethro
196 er goal of the present study, an approximate open channel model, consistent with many experimental fi
199 e of ion-pulling simulations produces a RyR1 open-channel model, which can provide insights into the
200 nces between the liganded closed-channel and open-channel models could be detected at the level of th
202 m was tested using curare to demonstrate the open channel nature of the block and by identifying meth
204 evoked glutamate release, measured with the open-channel NMDA (N-methyl-D-aspartate) receptor antago
205 acts in a sequence-independent manner as an open-channel NMDAR antagonist at or near the Mg(2+) site
208 mIPSCs is accompanied by an increase in the open channel number and requires activity-dependent tran
212 nabling the end user to generate patterns of open-channels on demand by carving the porous material o
213 flux directly by binding in and blocking the open channel or indirectly by stabilizing closed states
214 maximization algorithm, taking the number of open channels (or molecules in the on-state) at each tim
218 ysis of the pH dependences of the gating and open channel parameters yielded similar pKa values close
221 rized in a mortar and pestle showed that the open channel persistence length was reduced from 50 to 6
222 stic for certain applications is the average open channel persistence length, i.e., the ensemble aver
226 likely candidate for the binding site of an open-channel pore blocker such as N-(2-naphthalenyl)-[(3
229 application of 1 mum Ins(1,4,5)P3 increased open channel probability (NP(o)) by approximately 3-fold
230 al [Ca] from 20 microM to 5 mM increased the open channel probability (Po) of native RyRs in SR vesic
231 crease was caused by an increase of both the open channel probability and the number of functional ch
235 gle-channel recordings showed an increase in open-channel probability due to a three- to fivefold inc
236 of these opposing actions determines the low open-channel probability, P(O), which controls the excit
238 ity for the closed-channel form than for the open-channel receptor form and inhibit the receptor; cla
240 al-organic framework (MOF) with two types of open channels, representing a MOF featuring a (4,8)-conn
242 istribution of current amplitudes within the open channel showed MS channels fluctuate between subcon
243 work illustrates the ability to increase MOF open channel sizes by using the mixed linker approach an
244 ially, quinidine intracellularly blocked the open channel so rapidly it overlapped with activation.
245 sition between the two open states (Val-86), open channel stability, and the hydrogen-bonding network
246 te in the dark and after illumination in the open channel state and (ii) time-resolved fluorescence q
247 We show that Rgc2 maintains Fps1 in the open channel state in the absence of osmotic stress by b
248 tate clearly shows that the formation of the open channel state is associated with a large conformati
249 as part of a cation selective filter in the open channel state of CaChR1 as well as other low-effici
250 is an authentic Ypk1 substrate and that the open channel state of Fps1 requires phosphorylation by Y
251 dium- and glutamate-independent constitutive open channel state that rarely transitions to complete t
253 of the nAChR transmitter binding site in the open channel state with that of the ACh binding protein,
254 stabilizes the receptor in an agonist-bound open channel state, and the glycine/ivermectin complex a
255 sing rate, a measure of the stability of the open channel state, controls an apparent tendency of the
257 ore potent inhibitor in that it inhibits the open-channel state approximately 5-fold stronger than BD
258 from the inserted intermediate state to the open-channel state in the insertion/translocation pathwa
259 the binding free energy of a ligand with the open-channel state is higher than that with the closed-c
260 y calculated for the ligand binding with the open-channel state is significantly lower than that for
261 y functional states (particularly the active open-channel state) were only resolved at moderate resol
262 d that both compounds preferably inhibit the open-channel state, although BDZ-2 is a more potent inhi
266 interacts with D993 in TM9 to stabilize the open-channel state; D993 is absolutely conserved between
267 human brain NMDA receptors in the activated "open channel" state would be useful for research on such
271 ed ligand binding domain crystallizes in the open channel structure, the longer LRET distances would
272 ally considered an immutable property of the open channel structure, whereas gating involves transiti
273 del presented here differs from the liganded open-channel structure of GLIC in the pre-M1 linker, the
274 l from Caenorhabditis elegans (GluCl), whose open-channel structure was determined complexed with the
275 sistent with the RyR1 and cardiac RyR (RyR2) open-channel structures reported while this paper was in
276 contrast, alcohols inhibited constitutively open channels, such as IRK1 or GIRK2 engineered to stron
277 rs access the closed channel slower than the open channel, suggesting that the intracellular entryway
278 ups onto beta2E155C closed the spontaneously open channels, suggesting that beta2Glu155 is a control
279 tween the first transmembrane helices of two open channels, suggesting that the observed Arg-189 conf
280 ng by nearly 8-fold but is unable to inhibit open channels, suggesting that this toxin inhibits chann
281 These results, mapped onto a model of the open channel surrounded by five alpha-helical M2s, imply
282 We conclude that hAQP1 is a constitutively open channel that closes mediated by membrane-tension in
283 al blocker could bind to three states of the open channel that differed in the locations and number o
285 roaching 0.7 imply that, within the class of open channels, there is a subclass that is not permeable
286 ed PSA, called colominic acid, prolonged the open channel time of AMPA-R-mediated currents by several
288 from all inactivated states was slower, and open-channel unblock was less voltage-dependent than in
289 ses of memantine, a low to moderate affinity open channel uncompetitive N-Methyl-d-aspartate receptor
290 interact with a blocking protein that binds open channels upon depolarization and unbinds upon repol
293 hat TBA can enter the cavity only through an open channel whereas Dauda can bind to the closed channe
294 eines from the cytoplasmic side is faster in open channels, whereas access to these same sites from t
295 channel closure and produces constitutively open channels, whereas the R243W mutation disrupts chann
298 rtz quadruple-barreled pipet and filling the open channels with electrolyte solution, and quasi-refer
299 xin that is able to convert the pump into an open channel, with consequent loss of cellular K(+) and
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