ライフサイエンスコーパス: open conformation

1 redoxin (Pdx), shows that P450cam adopts the open conformation.

2 th a specific subset of TRiC subunits in the open conformation.

3 nantly exists in a fully extended, headpiece open conformation.

4 hat the transporter lies in an inward-facing open conformation.

5 ws the trimer to adopt either a closed or an open conformation.

6 ermediate preceding transition to the inward-open conformation.

7 m a closed, autoinhibited conformation to an open conformation.

8 ilibrium between the fully closed and a more open conformation.

9 tein syntaxin-1 switches from a closed to an open conformation.

10 ck, which prevents its adoption of an active open conformation.

11 omain, allowing the helicase to adopt a more open conformation.

12 tructural change into a state resembling the open conformation.

13 terface with hydroxyls stabilize the channel open conformation.

14 of proliferating cell nuclear antigen in an open conformation.

15 und, the RyR pore adopts an extremely stable open conformation.

16 exhibiting a closed conformation, and one an open conformation.

17 a sodium- and chloride-bound outward-facing open conformation.

18 nd-binding alphaI domain in a high affinity, open conformation.

19 3-GK interaction, causing PSD-95 to adopt an open conformation.

20 NavMs prokaryotic sodium channel in a fully open conformation.

21 thought to render Syx1a in a constitutively open conformation.

22 a serine residue forces the channels into an open conformation.

23 sembled SNARE complex containing Syx1a in an open conformation.

24 of reduced Pdx to P450cam does not favor the open conformation.

25 m, the enzyme shifted from the closed to the open conformation.

26 t the distribution of LacY toward an outward-open conformation.

27 llar secretion apparatus from a closed to an open conformation.

28 with low nanomolar affinity and promotes the open conformation.

29 a slow interaction of the inhibitor with the open conformation.

30 rt of the translocation pathway in an inward-open conformation.

31 racellular vestibule of LeuT into an outward-open conformation.

32 allowed NA to transition from a closed to an open conformation.

33 p66 subunit and locking the thumb in a wide-open conformation.

34 and and phosphate ions, the D-loop adopts an open conformation.

35 of GK and of a GK-glucose complex in a wide open conformation.

36 closes the permeation pathway in the inward-open conformation.

37 nds directly to the transporter in an inward-open conformation.

38 rts GK from an apo conformation to an active open conformation.

39 closed VWA domain in a 15 A movement to the open conformation.

40 ons of glucose to be converted to the active open conformation.

41 the ion selectivity filter in the channel's open conformation.

42 ' the clamp loader-clamp complex in a stable open conformation.

43 THBs, which is lost when the pores assume an open conformation.

44 trate translocation by stabilizing an inward-open conformation.

45 The channel adopts an open conformation.

46 d conformation or a transamidation-competent open conformation.

47 al alteration in the direction of an outward-open conformation.

48 11 form an extracellular gate in the inward-open conformation.

49 ) gradually shifts the equilibrium toward an open conformation.

50 e active closed conformation or the inactive open conformation.

51 LIX transforms cytosolic ALIX from closed to open conformation.

52 l-beta) to rapidly transition to an inactive open conformation.

53 ts of ionic locks that stabilize the outward-open conformation.

54 f the enzyme, oscillating between closed and open conformations.

55 be crystallized in at least two clusters of open conformations.

56 olic (G-loop) gate captured in the closed or open conformations.

57 with the other 50% populating a continuum of open conformations.

58 here spontaneously adopt occluded and inward-open conformations.

59 ond time scale, switching between closed and open conformations.

60 and made only infrequent excursions to cleft-open conformations.

61 nd conformation, but not when MET is in the "open" conformation.

62 rectly interacts with Sec24C, requiring its "open" conformation.

63 d the AMP-bound ADPGK structures are in the "open" conformation.

64 es, the inner pore-lining helices are in an 'open' conformation.

65 basis by which HHARI recruits E2 Ub in an 'open' conformation.

66 inactive (bent-closed) and active (extended-open) conformations.

67 The open conformation (30%) is more susceptible to chymotryp

68 close enough to form a disulfide bond in an open conformation (6.9 A apart) because they are separat

69 d' conformation docked near the stalk to an 'open' conformation able to interact with membranes.

70 he bi-lobed structure of GluN2 ATD adopts an open conformation accompanied by rearrangement of the Gl

71 In addition, it identified an open conformation adopted late in splicing by a 3' splic

72 here a histidine-bearing loop will adopt an "open" conformation allowing hydrogen peroxide to bind to

73 ze the Kir1.1b selectivity filter gate in an open conformation, allowing rapid recovery of channel ac

74 tal structure of XylE in a new inward-facing open conformation, allowing us to visualize the rocker-s

75 olution structure of TpbA in the ligand-free open conformation, along with an analysis of the structu

76 ins results in a population shift toward the open conformation and a resulting increase of k(cat).

77 reveals that HHARI binds this E2 Ub in an open conformation and explains the specificity of this c

78 e forms of tTG that constitutively assume an open conformation and induce apoptosis.

79 The two unliganded lobes present a canonical open conformation and interact via their respective C- a

80 exchange at DSBs shifts the chromatin to an open conformation and is required for acetylation and ub

81 L1 mutations promote the open conformation and switch immune response from interf

82 beta subunit preferentially adopts the half-open conformation and that the transition to this confor

83 ion (residues 1 through 47) was found in the open conformation and was mostly ordered in both structu

84 lexible, fluctuating between closed and more open conformations and sometimes sampling the fully open

85 most closed conformation, E2 adopts the most open conformation, and E3 adopts an intermediate conform

86 lamp loaders bind and stabilize clamps in an open conformation, and in the second stage, clamp loader

87 rgy profile features a single minimum at the open conformation, and indicates that the closed state,

88 ith the Arp2/3 complex, induced the standard open conformation, and two new masses appeared at positi

89 TRAP VWA domains adopt closed and open conformations, and bind a Mg(2+) ion at a metal ion

90 ransition between the inside and the outside open conformation are modified.

91 Before irradiation, three open conformations are in equilibrium, whereas UV irradi

92 Structures obtained in closed and open conformations are reversibly interconvertible by ch

93 state that is different from the apo outward-open conformation as well as inward-facing conformations

94 s the change between outward-open and inward-open conformations as a unifying critical step in LeuT-t

95 todomain adopts extended-closed and extended-open conformations as well as a bent conformation.

96 ved the structure of full-length KcsA in the open conformation at 3.9 A.

97 despite the fact that FAK is in the active, open conformation at CAs, its kinase activity is dispens

98 Both subunits adopt an open conformation at rest, and only GBR1 closes on agoni

99 tart site and plays a role in maintaining an open conformation at that location.

100 conformation at the human NOS2 locus and an open conformation at the murine NOS2 locus.

101 The PIC, in an open conformation, attaches to the 5' end of the mRNA an

102 tant immobilized in an outward (periplasmic)-open conformation bind to the flexible WT protein and st

103 d recently, showing the protein in an inward-open conformation bound to two Na(+) and a taurocholic a

104 rom a functionally "closed" State 1 to more "open" conformations, but the molecular mechanisms underl

105 Ca(2+) binding stimulates its open conformation by altering the structure of transmemb

106 The structure is locked in an outward-facing open conformation by an inhibitor.

107 Antidepressants lock SERT in an outward-open conformation by lodging in the central binding site

108 troscopy, we demonstrate that EHD2 adopts an open conformation by tilting the helical domains upon me

109 The inward-open conformation, by contrast, involves large-scale con

110 The results show that an open conformation can be readily detected in cells and t

111 tal form reveals that the locally closed and open conformations coexist as discrete ones at acidic pH

112 ses camphor mobility yet retains a partially open conformation compatible with the required proton re

113 and of the mutant Y93A stabilized 80% in the open conformation directly document two envelopes that d

114 he transition of the active site to the half-open conformation, driven by the intrinsic elasticity of

115 the changes from an outwardly to an inwardly open conformation during the transport cycle use G93 as

116 phorylation and agents that stabilize inward-open conformations (e.g., 5-HT, ibogaine) increased phos

117 An open conformation emerges from an ensemble of closed con

118 ucture reveals two chains of saposin A in an open conformation encapsulating 40 internally bound dete

119 miscible interface setup being in the widely open conformation ensembles.

120 The more open conformation exhibits a second molecule of thiorida

121 ke contact with Nxf1, Nxf1 is driven into an open conformation, exposing its RNA-binding domain, allo

122 Calcium binding to either domain favors an "open" conformation, exposing a large hydrophobic surface

123 post-chemistry structure of hPolbeta in the open conformation, following incorporation of (-)3TC-MP,

124 linking pattern in U6 was consistent with an open conformation for the catalytic center of the splice

125 rmation of WT ADAMTS13 and suggested a more "open" conformation for GoF ADAMTS13.

126 r RG(9)K than for RA(9)K, suggesting a more "open" conformation for the former.

127 of the MalK dimer from the open to the semi-open conformation, from which it can proceed to hydrolyz

128 nt of transition to catalytically competent (open) conformation hypothesized from structural modeling

129 Th17 effector molecules failed to acquire an open conformation in CARMA1-KO T cells.

130 A flexible loop around Asp216 that adopts an open conformation in direct vicinity of the active site

131 To test for the presence of an open conformation in intact cells, reporter cysteines we

132 ors a higher-energy intermediate periplasmic-open conformation in situ, but collapses to a lower-ener

133 been shown to induce cell death, assumes an open conformation in solution as assessed by an enhanced

134 tering analyses revealed that AnmK adopts an open conformation in solution in the absence of ligand a

135 modeling results show that apo-IRP1 is in an open conformation in solution, and the ensemble optimiza

136 ity, indicating that the binding site has an open conformation in solution.

137 a complete closed conformation to a complete open conformation in the presence of ADP.

138 sence of calcium, are compacted but adopt an open conformation in the presence of calcium, enabling a

139 reason for the catalyst to adopt the gauche-open conformation in the transition state.

140 say we show that these mutations restore the open conformation in vivo.

141 n stabilizes a novel energetically favorable open conformation in which changes at the intersubunit i

142 on the Nipah-N structure we modeled a PIV5-N open conformation in which the CTD rotates away from the

143 the binding of NNRTIs forces RT into a wide-open conformation in which the separation between the th

144 mer, with each monomer adopting an extended, open conformation in which the two CH domains do not int

145 and that the free energy required to access open conformations in the glycine-bound LBD is largely r

146 forin-like) state that is distinct from the "open" conformations in C8.

147 The apo form adopts a distinct open conformation, in which the smaller subdomain of SIR

148 partially open Env trimer than to the fully open conformation induced by CD4.

149 voltage-dependent transitions from closed to open conformation induced MEK-ERK1/2-dependent Tyr-447 p

150 an intermediate state between the closed and open conformations involving direct transient interactio

151 studies and MD simulations indicate that an open conformation is also stabilized by peptide ligand b

152 " conformations, and the extent to which the open conformation is favored directly correlates with th

153 We demonstrate that the HD-PTP open conformation is functionally competent for binding

154 The open conformation is induced by ATP hydrolysis and corre

155 An open conformation is thus favored in solution with many

156 on of the gating ring, but the Ca(2+)-bound, open, conformation is not yet known.

157 gh the betaE-catalytic site is in the usual "open" conformation, it is occupied by the unique combina

158 The fully open conformation lies higher in free energy, indicating

159 osed" conformation to a potentially active, "open" conformation mediated by Mats, a conserved Mps1-bi

160 This "open" conformation not only rationalizes the inactivity

161 Rather, the fully open conformation observed in the F1 X-ray structure is

162 oscopic current amplitude by stabilizing the open conformation of 7.1/KCNE1 channels.

163 The crystal structure of the open conformation of a bacterial voltage-gated sodium ch

164 of the bilayer dictate the stability of the open conformation of a Kv pore module in the absence of

165 rmediate between the outward-open and inward-open conformation of ABC exporters.

166 onectin substrates suggest that the extended-open conformation of alpha5beta1 is adhesive and that th

167 Together, our findings show that the open conformation of AnmK facilitates binding of both th

168 eading to the transition from closed to semi-open conformation of apo Act.

169 The open conformation of apo EI allows phosphoryl transfer f

170 n promoted a standard (previously described) open conformation of Arp2/3 complex, with the N-terminal

171 nts to activate canonical Wnt signaling, the open conformation of Dvl more effectively activates Jun

172 he pyrrole rings in the substrate, iii) more open conformation of enzyme active site to accommodate t

173 ding to pro-TGF-beta1 does not stabilize the open conformation of its headpiece.

174 Promoting an outward-open conformation of LeuT by mutation abolished the K(+)

175 racterized by a Tyr(75)-iron-bound form with open conformation of loop L1.

176 state may reflect a physiologically relevant open conformation of MtrE.

177 Oseltamivir binds weakly with the open conformation of NA due to poor electrostatic intera

178 o7 by the t-SNARE Sec9, which results in the open conformation of Sro7, also acts to inhibit vesicle

179 pe that is accessible both in the closed and open conformation of TG2 and dependent on the relative p

180 omplex are crucial in yeast to stabilize the open conformation of the 40 S subunit and are required f

181 of Mn(2+) and pro-TGF-beta1 to stabilize the open conformation of the alphaVbeta8 headpiece.

182 his is the first observation that reports an open conformation of the C-terminal helix in a chemokine

183 s that GoSlo-SR-5-6 works by stabilizing the open conformation of the channel and the activated state

184 action, it is strong enough to stabilize the open conformation of the channel and thus slow deactivat

185 extracellular facing monolayer stabilize the open conformation of the channel.

186 iate between the closed conformation and the open conformation of the constitutively active mutant.

187 minent role for the loops in stabilizing the open conformation of the CorA channels.

188 ure of tyrosine-GlcNAcylated RhoA reveals an open conformation of the effector loop distinct from rec

189 dergoes a large angular reorientation in the open conformation of the enzyme.

190 RT) is characterized by a preference for the open conformation of the fingers/thumb subdomains, and a

191 An antagonist confines GBR1 to the open conformation of the inactive state, whereas an agon

192 the MIM interaction, in concert with a more open conformation of the Ist1 core, resulted in stimulat

193 te inhibitor imatinib leads to an unexpected open conformation of the multidomain SH3-SH2-kinase c-Ab

194 The structure unexpectedly revealed a novel open conformation of the PRODH active site, which is int

195 r is detrimental to, cell survival, with the open conformation of the protein being responsible for i

196 receptor, CD4, triggers the transition to an open conformation of the trimer, promoting interaction w

197 y controlled conditions in order to keep the open conformation of the tTG.

198 bly by a dynamic population shift toward the open conformation of U2AF65 to facilitate the recognitio

199 There is no trace of this open conformation of utrophin in the absence of actin, p

200 PK1 exhibits preferential binding toward the open conformation of vinculin, suggesting that the MAPK1

201 GMF induced two distinct open conformations of Arp2/3 complex, which correlated w

202 the Nbs stabilize several different outward-open conformations of LacY.

203 structural transition between the closed and open conformations of Sec61, the eukaryotic translocatio

204 as Na(+) and cocaine that stabilize outward-open conformations of SERT decreased phosphorylation and

205 involves a transition between the closed and open conformations of the 30S ribosomal subunit and requ

206 ndings and homology models of the closed and open conformations of the Kv7.3 PM, we propose a structu

207 ynamic exchange between partially closed and open conformations of the SAM-II riboswitch in the absen

208 The transition between the closed and open conformations of the Sec61 complex permits nascent

209 The exchange rate between the closed and open conformations of the wild-type fusion peptide is ~4

210 lly, we present evidence for a unique, "wide-open" conformation of Get3.

211 nt models concentrating on the "locked" and "open" conformations of the conserved carboxylate side ch

212 Tau adopts an open conformation on binding tubulin, in which the long-

213 static closed Get3*TA complex, Get3 samples open conformations on the submillisecond timescale upon

214 e refinement was used to generate closed and open conformations on which the alpha7 models were based

215 It is controversial, however, whether the open conformation only exists transiently in intact cell

216 ion of tissue transglutaminase enzyme in its open conformation (open-tTG) was developed and optimized

217 This domain of approximately 900 kb is in an open conformation over its length and is generally susce

218 sordered and the general acid loop adopts an open conformation, placing the catalytic aspartate, Asp1

219 e predicted glycosidic position, whereas the open conformation possibly represents an unreactive stat

220 strate that the NBP goes from a closed to an open conformation prior to the release of ADP, while the

221 A maximum open conformation probability approaching 1.0 and maximu

222 each transmitter molecule between closed and open conformations provides ~-5.1 kcal mol(-1) towards t

223 itch from a "closed" conformation to a more "open" conformation, reducing the DNA binding affinity by

224 er eliminates the barrier and stabilizes the open conformation relative to the closed.

225 ng a substrate-free structure that adopts an open conformation relative to the substrate-bound struct

226 her with a greater propensity to exist in an open conformation, resulting in increased OM permeabilit

227 vAb/1-226 captures the activation gate in an open conformation, revealing the open state of a BacNav

228 The structure is in a laterally open conformation showing that gating is independent of

229 rm of CaBP7 NTD is monomeric and exhibits an open conformation similar to that of CaM.

230 Active Cdk12/CycK is arranged in an open conformation similar to that of Cdk9/CycT but diffe

231 ral azoles revealed binding of ligands to an open conformation similar to that of the ligand-free sta

232 here trimeric Env displays a constitutively "open" conformation similar to that seen for HIV-1 BaL En

233 hibitory closed conformation to a permissive open conformation, speeding up actin polymerization.

234 ssociation of the filter gate with two novel open conformation stabilizers: an antidepressant and a p

235 the GBR2 ectodomain adopts a constitutively open conformation, suggesting a structural asymmetry in

236 g of preprotein to SecA induces an activated open conformation suitable for binding to SecYEG.

237 able for internal electron transfer, and an "open" conformation suitable for intermolecular electron

238 The trimers in an open conformation swap domains with each other.

239 te lipid, the wild-type Merlin adopts a more open conformation than in solution, but Merlin(S518D) re

240 nges for T308 phosphorylation, and causes an open conformation that allows for S473 phosphorylation b

241 in the crystal structure of hGGT1 adopts an open conformation that allows greater access to the acti

242 whereas addition of GAP converts DXPS to the open conformation that coincides with decarboxylation of

243 rganization requires the protein to adopt an open conformation that exposes the surfaces engaging in

244 ver, at a finite rate, TG2 transitions to an open conformation that exposes the transamidase catalyti

245 acking of the V3 loop, and (iii) activate an open conformation that exposes V3 to the effects of V3 A

246 hitecture to clamp a switch I tyrosine in an open conformation that facilitates access of the arginin

247 We find that the enzyme is present in an open conformation that precludes productive substrate bi

248 nzyme is very flexible, allowing it to adopt open conformations that can bind nucleotide and closed o

249 pre-existing equilibrium between closed and open conformations that facilitates ligand binding to th

250 closed dimeric structure, hIKK2 dimers adopt open conformations that permit higher order oligomerizat

251 tramolecular pi-stacking interaction and an "open" conformation that cannot form the interaction.

252 This motion propagates through further opening conformations that allow binding of an Ub-loaded

253 mutant can be trapped in a prolonged 'burst opening' conformation that is proposed to be equipped wi

254 Crystallized in an inward open conformation the structure identifies a hinge-like

255 ed that at low pH, the His-E7 gate is in its open conformation, the full relationship between the His

256 ystal structure of the monomeric AlnB in the open conformation to 1.25-A resolution showed that the p

257 omotes syntaxin-1 switch from a closed to an open conformation to accelerate soluble N-ethylmaleimide

258 lamp is closed in solution but must adopt an open conformation to be assembled onto DNA by a clamp lo

259 idase site locks the protein in the extended/open conformation to disorganize/inactivate the GTP bind

260 onverts this fully closed conformation to an open conformation to initiate productive substrate bindi

261 st a LacY mutant in an outward (periplasmic)-open conformation to stabilize this state of the WT prot

262 ion has GTP binding/GTPase activity, and the open conformation transamidase activity.

263 nt mutant that stabilizes the protein in the open conformation trapped by these miniproteins.

264 ed the expected shift from the closed to the open conformation upon protonation, but more importantly

265 the crystal structure of GLUT1 in an inward open conformation was reported.

266 Subsequently, an 'outward-open' conformation was determined in the presence of the

267 g an equally populated mixture of closed and open conformations, was necessary to fit all of the data

268 lamp dynamics contribute to formation of the open conformation, we identified conditions that destabi

269 full-length integrin adopts an extended and open conformation when bound to its physiological macrom

270 structures showed that RF1 and RF2 are in an open conformation when bound to the ribosome but are in

271 he GluN1 amino-terminal domain adopts a more open conformation when coassembled with GluN2A than with

272 ate that the well-studied P450cam adopts the open conformation when its redox partner, putidaredoxin

273 ound P450cam to shift from the closed to the open conformation when labeled on either the F or G heli

274 iation complex (PIC) is thought to assume an open conformation when scanning the mRNA leader, with AU

275 The TL remains in an inactive open conformation when the mismatched substrate is bound

276 mation observed in crystal structures and an open conformation where the PH domain moves away from th

277 t, the oxidized form of Rv2466c displays an "open" conformation, where tertiary structural changes in

278 the IP(5) 2-K apo-form structure displays an open conformation, whereas the nucleotide-bound form sho

279 st complementary base pair of the fork in an open conformation, whereas the second, third, and fourth

280 ond persists, and the channel remains in the open conformation, whereas when His-235 is deprotonated,

281 toplasmic syntaxin-1 with preference to its "open" conformation, whereas Munc13-1 binds to the first

282 ructures of substrate-free Tps2PD reveal an "open" conformation whereby the cap and core domains sepa

283 r role of Pdx is to shift P450cam toward the open conformation, which enables the establishment of a

284 ons successfully transitioned into the fully open conformation, which is known to be the dominant bin

285 on 288 causes the polymerase to adopt a more open conformation, which may be disrupting the nucleotid

286 n-glycosylated 99-loop seems to favor a wide open conformation, which mostly increases the apparent a

287 terestingly, the PapGIIp P5 pocket was in an open conformation, which, as molecular dynamics simulati

288 These trimers had an "open" conformation, which is distinct from the "closed"

289 ining M2 is splayed open, reminiscent of the open conformation, while the intracellular-half is const

290 The apo-form of the protein has an open conformation with a disordered P-loop but a structu

291 ggesting a competition between binding to an open conformation with an empty E7 channel and relaxatio

292 We find that sTf binds Ti(IV) in an open conformation with both carbonate and citrate as syn

293 As the structures of Mg(2+) channels in an open conformation with bound Mg(2+) have not yet been so

294 The transporter is locked in an outward-open conformation with nortriptyline wedged between tran

295 t-catalytic structures reveal hPolbeta in an open conformation with PPi bound in the active site, the

296 be of the C-subunit, which is in a partially open conformation with the C-tail disordered.

297 hereas the CYP2B37 structure demonstrated an open conformation with three 4-CPI molecules, one within

298 ier spends most of its time in the closed or open conformation, with relatively few statistics collec

299 ex structure, the catalytic domain adopts an open conformation, with the K36M/I peptide snuggly posit

300 , one of them accessible only in the active, open conformation, would be sufficient to explain calmod