ライフサイエンスコーパス: open probability

1 RGS7(-/-)/RGS11(-/-) rod BCs have a very low open probability.

2 nse time course and increases single-channel open probability.

3 hannel environment, which change the channel open probability.

4 ed Na(+) self-inhibition and reduced channel open probability.

5 AC substantially reduces ENaC single channel open probability.

6 ipid composition strongly increased the KcsA open probability.

7 i, voltage and cAMP, exclusively control the open probability.

8 activated ENaC by increasing single-channel open probability.

9 s mediated by an allosteric reduction of the open probability.

10 ked ENaC palmitoylation also reduced channel open probability.

11 y via its own receptor affecting the channel open probability.

12 it, likely reflecting an increase in channel open probability.

13 ed an ohmic behavior and a voltage-dependent open probability.

14 te dimerization and thereby increase channel open probability.

15 s open as well as an increase in the maximum open probability.

16 lyoxal increased and then decreased the RyR2 open probability.

17 nced calcium influx due to increased channel open probability.

18 and ryanodine receptor type 2 (RyR2) channel open probability.

19 KII and results in a decrease in the channel open probability.

20 drophilic pore of large conductance and high open probability.

21 ed TRPV3 single-channel conductance, but not open probability.

22 eceptors, and estimate the subunit-dependent open probability.

23 cts on single-channel conductance as well as open probability.

24 nsferase increased InsP(3)R-3 single channel open probability.

25 e in the plasma membrane, and single-channel open probability.

26 from proteolytic cleavage and stimulation of open probability.

27 nnels from NOS1(/) hearts had decreased RyR2 open probability.

28 ryl reduction had limited effects on channel open probability.

29 results from a voltage-dependent increase in open probability.

30 tivity of these channels by increasing their open probability.

31 Ca diffusion, SERCA uptake activity, and RyR open probability.

32 s and rates inversely correlate with channel-open probability.

33 of sIPSCs and potentiation of single-channel open probability.

34 e significant changes in ATP sensitivity and open probability.

35 rotein kinase A results in increased channel open probability.

36 s with different single-channel kinetics and open probability.

37 70N, respectively), while increasing channel open probability.

38 than the GluN2A subunit, which has a higher open probability.

39 nce of ?160 pS and high, voltage-independent open probability.

40 ations and thus generated a broader range of open probabilities.

41 g NMDA receptors also have a two-fold higher open probability (0.037) than exon 5-lacking receptors (

42 Ca(2)(+) channels in IHCs showed a low mean open probability (0.21 at -20 mV), but this increased si

43 ficient mdx muscle: (1) increased MS channel open probability, (2) a shift of MS channel gating to la

44 emble alpha1 receptors in their high maximum open probability (99.1% cf. 98% for alpha1), but differ

45 ensitivity to inhibitory ATP and increase in open probability, a direct molecular explanation for red

46 e Ca(V)1.3 Ca(2+) channels showed a very low open probability (about 0.15 at 20 mV: near the peak of

47 at a decreased TRPV5 pore size and a reduced open probability accompany the plasmin-mediated reductio

48 pendence in the opposite direction, reducing open probability; acidification also reduced the number

49 Open probability also is influenced by the ATD.

50 -RyR) have increased calcium sensitivity and open probability, amplifying calcium transient at a cost

51 entiation was attributable to an increase in open probability, an interpretation confirmed for a subs

52 to three conductance levels with comparable open probabilities and displays modal behavior similar t

53 ver, these mutant channels have higher basal open probabilities and limited responses to the agonist

54 in induces a dose-dependent increase in both open probabilities and mean open times on KcsA in artifi

55 truncated form of TREK1 with a much reduced open probability and a proposed increased permeability t

56 he hKv7.4a channel by decreasing the channel open probability and altering activation kinetics.

57 bited CFTR activity by primarily reducing an open probability and an opening rate, and inhibition was

58 ce had abolished vasopressin-stimulated ENaC open probability and apical membrane channel number.

59 C activity acutely by reducing the channel's open probability and chronically by decreasing the numbe

60 With a low intrinsic open probability and high propensity toward the inductio

61 tage-dependent changes in the single-channel open probability and is not species- or subunit-dependen

62 The channel has a low open probability and is tightly regulated, to avoid deco

63 D receptors are characterized by low channel open probability and prolonged deactivation time course

64 It also decreased TRPV1 current density and open probability and reduced the proportion of pancreati

65 ls causes adaptation, rapidly reducing their open probability and resetting their operating range.

66 CPVT-CaMs caused greater RyR2 single-channel open probability and showed enhanced binding affinity to

67 d reduced Ca(2+) sensitivity, single-channel open probability and tamoxifen sensitivity.

68 dogenous AA-dependent inhibition, increasing open probability and the fraction of functional channels

69 We showed that [Mg(2+)]i affects both open probability and the number of functional channels,

70 ity was twofold smaller because of a smaller open probability and unitary conductance.

71 d that activation by POPG increases both the open probability and unitary conductance.

72 2)O(2) significantly increased TRPC6 channel open probability and whole-cell currents.

73 TP block, dramatically increased the channel open probability, and affected the interaction of Kir6.2

74 endently with respect to voltage-activation, open probability, and facilitation.

75 l domains of GluN2A subunits reduces channel open probability, and low-affinity voltage-dependent bin

76 ein expression, fewer active channels, lower open probability, and reduced effective activity.

77 t an H620Q mutant, shown to increase channel open probability, and the dual corrector/potentiator CFF

78 s revealed that FMRP loss reduced BK channel open probability, and this defect was compensated in dKO

79 y hyperpolarization and saturating cAMP, the open probability approaches unity.

80 ility approaching 1.0 and maximum functional open probability approaching 0.7 imply that, within the

81 ignificant "window current" at that voltage (open probability, approximately 1%), Ca(V)3.1 channels r

82 ignificant "window current" at that voltage (open probability, approximately 1%), which makes them a

83 nce, whereas external protons affect channel open probability as well as single-channel conductance o

84 in the range of 15 to 250 pS, with a larger open probability at 0 mV as compared with Cx43, which su

85 , stabilized by NS309, increases the channel open probability at a given Ca(2+) concentration.

86 ted by calmodulin (CaM), which decreases its open probability at diastolic and systolic Ca(2+) concen

87 0C channels exhibited a significantly higher open probability at diastolic Ca(2+) concentrations, ass

88 hips (I-V) and substantial modulation of the open probability at negative holding potentials.

89 itutively open mutant BK channels, with high open probability at negative voltages, as well as a loss

90 1 pS (n = 17; symmetrical 150 mm K(+) ) with open probability being both voltage- and Ca(2+) -depende

91 he channel, nor is there a difference in the open probability between high and low [K(+)] as determin

92 ock-insensitive channels had lower intrinsic open probabilities but retained high sensitivity to zinc

93 C-terminal domains form channels with higher open probability but still exhibiting dynamic behavior.

94 creases both alpha and alphabeta4 BK channel open probability, but only alpha BK develops acute toler

95 how that PAS (0.1 mM) reduces single-channel open probability by 50% solely by increasing approximate

96 glycine potency by 2-fold, increases channel open probability by 6-fold, and reduces receptor sensiti

97 found that 4 mM NPA caused a 62% decrease in open probability by decreasing mean open time 2.5-fold a

98 increase in ryanodine receptor type 2 (RyR2) open probability by direct oxidation of the RyR2 protein

99 on, an allosteric down-regulation of channel open probability by extracellular Na(+).

100 enprodil decreased NMDA receptor equilibrium open probability by raising an energetic barrier to acti

101 tching and subsequent ROS production on RyR2 open probability, Ca2+ sparks, and the myoplasmic calciu

102 y enhanced Na(+) self-inhibition and reduced open probability compared with wild type ENaCs.

103 2-MARCKS complex, which is necessary for the open probability conformation of the channel and preserv

104 rameters, a reflection of ryanodine receptor open probability, consistent with the effect of IP3 sign

105 receptors activate in long episodes of high open probability, consisting of groups of openings in qu

106 ies including modest desensitization and low open probability could be described by gating schemes si

107 to produce frequent firings, decreasing RyR open probability counter-intuitively promotes long-lasti

108 By comparison, RyR open probability declined more slowly, suggesting releas

109 channels are constitutively active and their open probability depends on the lipidic composition of t

110 navailable to the available mode with a high open probability dominated by the fully open state, with

111 ctivation, reflecting an increase in channel open probability due to a loss of the inhibitory effect

112 .1 in giant liposomes, resulting in a higher open probability due to more frequent opening bursts.

113 In the context of channels that have a low open probability due to retention of an inhibitory tract

114 In the context of channels that have a low open probability due to retention of an inhibitory tract

115 showed that the mutant channels have higher open probability, due to a modification of gating, and n

116 Na(+) self-inhibition and with an increased open probability, ENaCs still undergo transitions betwee

117 ing the existence of an optimal range of RyR open probability favoring long-lasting sparks.

118 based on the subunit and match the reported open probabilities for the receptor.

119 this reduction we solve for the equilibrium open probability for calcium release in the model.

120 nsors, the different dose-response curves of open probability for one stimulus have the same slope at

121 Kalpha macroscopic conductance or fractional open probability (FP(o)) as a function of voltage.

122 The gating characteristics, open probability, frequency, and current decrease, provi

123 of caveolin-1 significantly reduced channel open probability (from 0.05 +/- 0.01 to 0.005 +/- 0.001;

124 In this setting, decreasing RyR open probability further suppresses long-lasting sparks

125 arresting surface Ca(V)1.2 channels in a low open probability gating mode, rather than by interfering

126 and also by biasing the receptor toward low open probability gating modes.

127 recombinant receptors suggests that the high-open-probability gating mode of AMPA receptors containin

128 low open probability GluN2C- than the higher open probability GluN2A-subunit-containing receptors.

129 , being more effective in the inherently low open probability GluN2C- than the higher open probabilit

130 F mutation was highly active (single-channel open probability >0.3) in the absence of ATP and protein

131 e open conductance levels but with different open probabilities in each level.

132 or BAPTA caused smaller increases in resting open probability in Bth mutant OHCs than in wild-type co

133 ituted into lipid bilayers revealed enhanced open probability in cAF samples, providing a molecular b

134 spontaneous Ca(2+) release events, and RyR2 open probability in cAF, whereas protein kinase A inhibi

135 centrations of bupivacaine decreased channel open probability in GluN2 subunit- and pH-independent ma

136 enuated stimulatory effect on BK(Ca) channel open probability in inside-out membrane patches.

137 inated variation in ATP:ADP and KATP channel open probability in intact cells.

138 se events are associated with increased RyR2 open probability in lipid bilayer preparations.

139 ternate kinetic behavior, consisting of high open probability in lower conductance states.

140 annel analysis showed that PKA decreased the open probability in wild-type but not S334A mutant chann

141 sly showed that PIP(2) increases the channel open probability, in this work we find that activation b

142 (2+)] = 25 muM, tauac = 0.082 ms, the IP(3)R open probability increased by approximately 20% and mean

143 e activity in as little as 0.01% PIP(2), and open probability increases to approximately 0.4 at 1% PI

144 When activated, [Ca2+]i-sensitive RyR2 open probability increases, and the Ca2+ spark rate chan

145 +) binding site, both modulating the resting open probability independent of adaptation.

146 C456S) mutant channels have a higher channel open probability, induce more calcium influx, and enhanc

147 mics simulations show that the difference in open probability is caused by one long closed state in K

148 arks can occur when ryanodine receptor (RyR) open probability is either increased or decreased.

149 essed by extracellular [Au(CN)2](-) when the open probability is markedly reduced by introducing a se

150 98% for alpha1), but differ in that maximum open probability is reached when all five binding sites

151 he GluN2B subunit, which has a lower channel open probability, is on average more closed than the Glu

152 muM Ca(2+), Ln(3+) potently inhibited RyR's open probability (Kd Eu(3+) = 167 +/- 5 nM and Kd Sm(3+)

153 +) currents as a consequence of their higher open probabilities, leading to increased firing rates in

154 Ethanol also increased BK channel open probability measured in single-channel recordings f

155 cate that the channel switches between a low open probability mode and a high open probability mode i

156 ative and positive potentials, with the high open probability mode becoming more prominent at positiv

157 tween a low open probability mode and a high open probability mode in which the behavior of the chann

158 ilized long openings characteristic of "high-open-probability" mode).

159 rotein, gamma-2, gating in the low- and high-open probability modes, respectively.

160 (-20 mmHg) caused a 19-fold increase in the open probability (NPo) of human TREK-1 channels.

161 BKCa channel normalized open probability (NPo) versus membrane potential (Vm) cu

162 Furthermore, the peak open probabilities of alpha1(D43C)beta2gamma2 and alpha1

163 Moreover, at negative potentials open probabilities of EAAT5 anion channels were much lar

164 d may provide a mechanism for modulating the open probabilities of the individual tetramers.

165 n of cysteamine that elicits an intracluster open probability of >0.9.

166 steroid alfaxalone had an estimated maximal open probability of 0.6 in oocytes and 0.01 in HEK cells

167 wild type) and reached a maximum one-channel open probability of about 45% at 100 mm glycine (compare

168 ate ENaC-mediated currents by increasing the open probability of active channels without recruiting a

169 s were activated to similar extents (maximum open probability of approximately 0.8 at 0 mV) by 0.1-30

170 The open probability of BK channels is regulated by the intr

171 t activated alpha2M (alpha2M*) increased the open probability of BKCain an oscillatory pattern in hMS

172 Finally, we found that the open probability of Ca(2+) channels, but not their openi

173 f theophylline was due to an increase in the open probability of calcium-activated potassium channels

174 pharmacologic strategies for modulating the open probability of channels obeying equilibrium versus

175 owed that PKC activation lowered the overall open probability of ClC-1 in the voltage range relevant

176 ltage-dependent mechanisms that regulate the open probability of connexin channels.

177 bability on VG; 2), the voltage at which the open probability of each gate equals 0.5; 3), the gating

178 +) self-inhibition, a down-regulation of the open probability of ENaC by extracellular Na(+).

179 d A6 collecting duct cells revealed that the open probability of ENaC was sensitive to the sgk1 inhib

180 uates fast P-type inactivation and increases open probability of hERG1 channels.

181 timuli which act to increase or decrease the open probability of individual K2P channels.

182 2+) signals and augmented the single channel open probability of InsP(3)R2.

183 used to continuously monitor the number and open probability of InsP3R channels in the same excised

184 tagamma subunits (2-250 ng /mL) enhanced the open probability of Kv7.4 channels without changing unit

185 id (10 mum), a channel opener, increased the open probability of methionine-inhibited unitary current

186 tein phosphatase 2a inhibition increased the open probability of mitoK(ATP) channels through GSK3beta

187 ound to increase both the mean open time and open probability of NMDA receptors.

188 DCS increased the mean open time and open probability of NR1/NR2C receptors compared with gly

189 ollowed by quiescence, leading to an overall open probability of only approximately 0.15 after 4 s un

190 keletal SR vesicles; (3) CLIC2 decreased the open probability of RyR1 channel, through increasing the

191 2814 phosphorylation in CREM mice normalized open probability of RyR2 channels and SR Ca(2+) release,

192 Ser2814 (S2814D(+/+) mice) exhibit a higher open probability of RyR2, higher sarcoplasmic reticulum

193 timulation of cardiac myocytes increases the open probability of sarcolemmal voltage-sensitive Ca2+ c

194 east in part, by upregulating the levels and open probability of Shaker (Sh) potassium channels to su

195 ) spark frequency in atrial myocytes and the open probability of single RyR2 channels from JPH2 knock

196 important role in determining the intrinsic open probability of SK channels in the absence of Ca(2+)

197 itivity, activation rate, and single-channel open probability of SLO-2.

198 s, and we found that acidic pH increases the open probability of SspA.

199 Trypsin, which increases open probability of the channel by proteolytic cleavage,

200 ng to shorter mean close-time and hence high open probability of the channel in comparison to IP3R in

201 d that the GORK S722E mutation increases the open probability of the channel in the absence, but not

202 Thus, the open probability of the channel must be close to unity.

203 -alpha that is crucial for activation of the open probability of the channel, but not membrane expres

204 Oxidation of RyR2s was found to increase the open probability of the channel, whereas CaMKII can be a

205 and are themselves sufficient to affect the open probability of the channel.

206 s to the amino-terminal domain determine the open probability of the channel.

207 face thiol disulfide formation increases the open probability of the heme pocket and allows nitrite b

208 lation; and 3) phosphorylation increases the open probability of the heme pocket, which increases lig

209 alcium concentration, which sets the resting open probability of the mechanosensitive channels.

210 esent in the immature cochlea, the increased open probability of the mechanotransducer channels cause

211 Depolarization did not increase the resting open probability of the MET current of Tmc1(Bth/Bth) OHC

212 Similarly, ATP increased the single channel open probability of the mutated InsP3R1 to the same exte

213 ations within the GluN2D pre-M1 region alter open probability of the NMDA receptor.

214 ved shut conformations, thereby reducing the open probability of the receptor with no change in the m

215 to a total absence of one and increased the open probability of the remaining two thermoresponsive C

216 dition, protonation conditions determine the open probability of TMEM16A without changing its calcium

217 nel-closing rate constant and thus a channel-opening probability of 0.85 vs 0.96 for rGluK2.

218 optical fluctuation analysis to estimate the opening probability of individual voltage-gated calcium

219 capsaicin (CAP) responses, thus reducing the opening probability of the channel by stabilizing its cl

220 orter and thereby possibly in regulating the opening probability of the inner gate.

221 e mean channel conductance, but not the peak open probability, of recombinant GluA2-containing AMPARs

222 racterizing 1), the steepness of each gate's open probability on VG; 2), the voltage at which the ope

223 ned by comparing steady-state single-channel open probability or macroscopic peak responses elicited

224 pioglitazone did not significantly alter the open probability or number of ENaC channels per patch in

225 deactivation, an increase in single channel open probability, or a reduction in C-type inactivation.

226 SCCaFTs displayed widely variable open probabilities (P(o)) and stepwise transitions among

227 ation, H(2)O(2) significantly increased ENaC open probability (P(o)) and single-channel current ampli

228 The [AMT], voltage, and open probability (P(o)) dependencies of burst frequency

229 ombinant cells VX-770 increased CFTR channel open probability (P(o)) in both the F508del processing m

230 Another mutation, K1250A, known to increase open probability (P(o)) of DeltaF508 CFTR channels, exac

231 ed [(3)H]ryanodine binding and increased the open probability (P(o)) of single RyR2 channels reconsti

232 sitive distal nephron (ASDN) and inhibit the open probability (P(o)) of the epithelial sodium channel

233 Raising cAMP markedly enhanced the open probability (P(o)) of the InsP(3)R-1 and induced bu

234 enhance receptor function by increasing the open probability (P(o)) of the ion channel.

235 The open probability (P(o)) of the RyR is found by simulatio

236 of R163C channels exhibit >/=2-fold greater open probability (P(o)) than WT, with prolonged mean ope

237 ent endocytosis, (2) a diminution of channel open probability (P(o)) that occurs without impacting on

238 revealed InsP(3)-independent gating and high open probability (P(o)) under optimal cytoplasmic Ca(2+)

239 constituted RyR1 and RyR2 channels, reducing open probability (P(o)), shortening mean open time, and

240 a dramatic decrease in the receptor-channel open probability (P(o)).

241 ecreases ENaC activity via affecting channel open probability (P(o)).

242 a(2+)]i, suggesting Ca(2+) regulation of MCU open probability (P(O)); (iii) in the heart, two feature

243 The resting open probability (P(open)) of MET channels determines th

244 Ensemble averages of the open probability (p(open)) of single K(ATP) channels ove

245 s agonist potency, deactivation time course, open probability (P(OPEN)), and mean open/shut duration.

246 ction effects, with the gain of constitutive open probability paralleling disease severity.

247 t activation, Ca(2+)-dependent inactivation, open probability), permeation (ion selectivity, affinity

248 en and close times, and the resulting IP(3)R open probability PO.

249 ctance (g) and a approximately 13-fold lower open probability (Po ), were found with the R117H mutati

250 FTR, but found a approximately 13-fold lower open probability (Po ).

251 60Y mutation increases the intrinsic channel open probability (Po(0)), thereby indirectly producing a

252 ulin on the channel, thus increasing channel open probability (PO) and Ca(2+)-dependent inactivation.

253 ngle channel conductance, maximal achievable open probability (Po) and the [Ca2+] required for activa

254 m indicate an approximately fourfold greater open probability (PO) for CaV2.1.

255 roduct of the number of channels (N) and the open probability (Po) of a channel).

256 K201 (>/=5 microM) increased the open probability (Po) of very active ("high-activity") R

257 The luminal Ca(2+) dependence of open probability (Po) over the physiologically relevant

258 hyl)-2'-deoxy-ATP (P-dATP), can increase the open probability (Po) to approximately 0.7, implying tha

259 bin1, and displayed increased single channel open probability (Po).

260 due less hydrophobic (L596A/G/W/Q/K) reduces open probability [Po; loss-of-function (LOF)], likely du

261 e presence of PIP2, although with only a low open-probability profile.

262 ticulum (SR) Ca load is high, increasing RyR open probability promotes long-lasting sparks by potenti

263 vated by tens of mm Hg pipette suctions with open probability rising with suction even in the presenc

264 d InsP3Rs open independently, but with lower open probability, shorter open time, and less InsP3 sens

265 Rat, but not human, T-tubule LTCCs had open probability similar to crest LTCCs, but exhibited a

266 Maneuvers that lock ENaC in a high open-probability state ("DEG" mutation, proteolytic clea

267 nel closing by holding the channel in a high open-probability state, was found to slow both tauQ(Off)

268 pendent decrease in mutant channel intrinsic open probability, suggesting the mutations may reduce AT

269 e structure affects both zinc inhibition and open probability, supporting the general model in which

270 Because of differences in open probability, synaptic triheteromeric receptors outn

271 ure of the dynamic changes in single-channel open probability that account for changes in macroscopic

272 and made careful measurements of the maximum open probability the channel can attain at different tem

273 ating agent SNAP reversed the depressed RyR2 open probability, the reduced CaSpF, and caused a leftwa

274 We subsequently assayed for increased open probability time and membrane expression, both of w

275 TIP peptide increased open probability time in H441 cells overexpressing wild

276 With sparse Ca(2+) channels and low opening probability, triggering of fusion for each vesic

277 proteins formed conductive pores with a low open probability, two well defined conductance states, a

278 Slo2 potassium channels have a very low open probability under normal physiological conditions,

279 ctivator of TRPM8 channels, because absolute open probability values measured with fully activated vo

280 Kbeta4 subunit alleviated reduced BK channel open probability via increasing BK channel open frequenc

281 gate in each apposed hemichannel (aHC); aHC open probability was a Boltzmann function of the fractio

282 The increase in overall steady-state open probability was accompanied by a reduction in activ

283 Second, open probability was augmented because the frequency and

284 -native crest of the sarcolemma, where their open probability was dramatically increased (0.034+/-0.0

285 s of split open collecting ducts, where ENaC open probability was increased by 40% in the ECD group.

286 High open probability was linked to enhance calcium-calmoduli

287 ductance calcium-activated K(+) (BK) channel open probability was reduced by loss of fragile X mental

288 rrelation between intracellular pH and Panx1 open probability was shown in oocytes.

289 Low, high, and intermediate open probabilities were observed in oocytes expressing a

290 yH-101-sensitive CFTR conductances, and CFTR open probabilities were reduced by 80% in GFP-positive c

291 odine receptor expression and single-channel open probability were increased.

292 Single channel conductance and open probability were reduced for R43C and V168M, respec

293 Unitary conductance and maximum open probability were unaffected by stretch, but peak cu

294 ted in RyR2 channels that had relatively low open probability, whereas the fast block was unaffected

295 id sequence identity, they exhibit different open probabilities with ca. 90% in KcvNTS and 40% in Kcv

296 ge-dependent gating, which increases channel open probability with depolarization.

297 ce that the location of Ca channels with low open probability within nanometers of the release sites

298 4C mutation dramatically reduced the maximum open probability without altering channel conductance.

299 e cell currents by decreasing single channel open probability without loss of surface receptors.

300 that protons regulate TMEM16A by tuning its open probability without modifying the single channel cu