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1 ly common outcomes (although this remains an open question).
2 s, differs between the two phases remains an open question.
3 ase diagram of the iron pnictides remains an open question.
4 is to ensure karyotype stability remained an open question.
5  up to this challenge is, for some, still an open question.
6 of CO2 to formate and to methanol remains an open question.
7 terplay between these two factors remains an open question.
8 ctional changes during speciation remains an open question.
9 als to control emergency hematopoiesis is an open question.
10 pace weather but what causes them remains an open question.
11 y a human subject has remained a fundamental open question.
12 les of these topoisomerases have remained an open question.
13 on of transmembrane beta-barrels is still an open question.
14 ssues to cease migrating and heal remains an open question.
15  the remaining unexplained association as an open question.
16 n memory in nonpathological conditions is an open question.
17 gh southeast Asia, such as Denisovans--is an open question.
18 ion, but how cristae are formed, remained an open question.
19 contribution from stem cells has remained an open question.
20 nslate to natural QS systems has remained an open question.
21 f these competitive interactions is still an open question.
22  However, how the two are related remains an open question.
23 in photosynthetic organisms is still a major open question.
24 tcome of these two divergent processes is an open question.
25  classical band alignment picture remains an open question.
26 ures and regulate gene expression remains an open question.
27 ling to trigger signaling is a key but still open question.
28 es and iron-based superconductors remains an open question.
29 d inhibition of Smoothened (Smo) is still an open question.
30 integrity contributes to this epidemic is an open question.
31  these highly identical sequences remains an open question.
32 cytes in the uninjured liver has remained an open question.
33     How the cell builds a spindle remains an open question.
34  of parental care in crocodilians remains an open question.
35 chestrated at the molecular level remains an open question.
36 ated in the same diagnostic group remains an open question.
37 ins correct cell fates during regrowth is an open question.
38 istory of the chloroplast lineage remains an open question.
39 ation contained in morphogen gradients is an open question.
40 ick required for error-prone synthesis is an open question.
41 ence at individual synapses still remains an open question.
42 ace of environmental fluctuations remains an open question.
43    How periodic patterns are generated is an open question.
44 rganic carbon produced by diatoms remains an open question.
45 by the plasma membrane remains a fundamental open question.
46 hagic membrane formation remain an important open question.
47           What determines p* is currently an open question.
48 ntributes to chromatin compaction remains an open question.
49 on during development and disease remains an open question.
50 mones and their subsequent release remain an open question.
51 reflects adaptive differentiation remains an open question.
52  a gapped topological spin liquid remains an open question.
53 radimer C-C bond splitting, still remains an open question.
54 n of such tumor-promoting factors remains an open question.
55 on of the molecules composing DOM remains an open question.
56 ess tolerance vs stress avoidance is also an open question.
57 ed by overexpression of miR156, which was an open question.
58  in biological populations is a longstanding open question.
59 ed to integral membrane proteins remained an open question.
60 therefore what underlies activity remains an open question.
61 ing mesendodermal differentiation remains an open question.
62 e, leaving the activity of these proteins an open question.
63 d maintain size homeostasis is a fundamental open question.
64 duce temporally precise movements remains an open question.
65 k and the mechanisms underlying it remain an open question.
66 infant eczema or allergic disease remains an open question.
67 6 connects to Notch function has remained an open question.
68 observed social interactions has remained an open question.
69 heir power and frequency are regulated is an open question.
70  cerebrum organization are linked remains an open question.
71 ls intracellular dynamics largely remains an open question.
72 tum information protocols continues to be an open question.
73 the levels commonly consumed by humans is an open question.
74 to organs with specific 3D shapes remains an open question.
75 t firing in PFC-mediated behavior remains an open question.
76 se recognizes in their substrates remains an open question.
77 16 families also form CaCCs is an intriguing open question.
78 he need for hyper-complex numbers remains an open question.
79 wever, how IRF4 is activated in cancer is an open question.
80 tion between evolution and spread remains an open question.
81 transmembrane signaling processes remains an open question.
82 ules decoding chemotactic signals remains an open question.
83 sis of this conformational change remains an open question.
84 ion or sound from their predators remains an open question.
85 f rapid cell-to-cell signaling remains a key open question.
86 umor-prone environment to prevail remains an open question.
87 tails of their formation mechanism remain an open question.
88 nd responses to these transitions remains an open question.
89 ocally regulate the CME machinery remains an open question.
90 inases outside the plant lineage, remains an open question.
91 function and disease development is still an open question.
92 hese cues to navigate to healthy reefs is an open question.
93  full extent of this contribution remains an open question.
94 regulate the activity of these enzymes is an open question.
95 w risk attitudes vary with wealth remains an open question.
96 ct of aging on monocyte functions remains an open question.
97 ed and directed to the cell front remains an open question.
98  proliferative TA state remains an important open question.
99 in establishing superconductivity remains an open question.
100 ys are more important than others remains an open question.
101 triggers metabolon formation has remained an open question.
102 llite subsequently inserts into the NE is an open question.
103 ubcellular compartments, however, remains an open question.
104 tion accuracy can be achieved, are currently open questions.
105 e in healthy elderly humans remain important open questions.
106 w ATP hydrolysis drives DNA unwinding remain open questions.
107 d what could be their functional role remain open questions.
108  how ERAPs shape peptide repertoires, remain open questions.
109  binding strength to the substrate are still open questions.
110 that might be approached therapeutically are open questions.
111 e process of entry, thereby highlighting key open questions.
112  brain, poses many unresolved challenges and open questions.
113 ude and the fate of this pollution are still open questions.
114 stems and suggests answers to several of the open questions.
115 ivity extends to mammalian GMF have remained open questions.
116 timates and applying them to learning remain open questions.
117 nse approach, which will aid resolving these open questions.
118 ension transmission at tAJs, and discuss key open questions.
119 rgy funnel", the carotenoids still pose many open questions.
120 AG2 loss contributes to tumorigenesis remain open questions.
121 esulting from cotranslational folding remain open questions.
122  and how it relates to the transcriptome are open questions.
123 new directions in these fields and remaining open questions.
124 m-silicate-hydrates (C-S-H) still hosts many open questions.
125 ol of sulfur metabolism and discuss the main open questions.
126 d by growth limitation conditions remains an open question(1).
127 ht some of the recent advances and remaining open questions about how a mutation in a myofilament pro
128 lasses of theory explaining the limits leave open questions about key issues such as how multiple sim
129 al stimuli and simplified behaviors, leaving open questions about nervous system function in the cont
130 ons in optical lattices could help to answer open questions about the doped Hubbard Hamiltonian, and
131 te their apparent success, there remain many open questions about their intrinsic properties.
132 er personal questions with known answers and open questions all requiring a "yes" or "no" thought usi
133                      However, to answer this open question, an in-depth analysis of this metabolic br
134 skeletal binding sites are transmitted is an open question and an allosteric question.
135 attempt to address and delineate some of the open questions and areas of opportunity that discoveries
136 Dameshek's paradox and highlight some of the open questions and challenges in the field.
137 view examines what is known, and some of the open questions and controversies surrounding the transmi
138 emory, imagery, and planning, including some open questions and directions for further experiments.
139                   In this context we outline open questions and important areas of future research.
140 Here, we review these findings, highlighting open questions and important challenges to overcome in t
141        We conclude by discussing a number of open questions and propose systems of study that would b
142                         Finally, we indicate open questions and suggest possible directions for futur
143                           Here, we highlight open questions and theoretical predictions of the long-t
144  underlying cause of the failures remains an open question, and more effective CTPs are needed.
145 onships and crosstalk of systems, highlights open questions, and describes tools for studying monocyt
146  required for their initiation, but it is an open question as to what the sources of those inhomogene
147                               It is still an open question as to whether genome size (GS) variation i
148 formation.SIGNIFICANCE STATEMENT There is an open question as to whether human amygdala function trac
149      What maintains heterogeneity remains an open question because competition within a tumor leads t
150 cturing plant communities is nevertheless an open question because it is very difficult to isolate di
151 for nanoscale phase separation remains a key open question, because experiments have yet to probe the
152 deling of amorphous materials still has many open questions, because the PGM itself becomes questiona
153 ts criticality to human behaviour remains an open question, best addressed with interventional method
154                                      Further open questions concern how psychological essentialism co
155                        The model revealed an open question concerning the effect of ABA on red light-
156                                 An important open question concerns what happens in the turbulent wat
157 sorption of intense light largely remains an open question, despite the extensive variations in targe
158                                              Open questions exist regarding LTPs, which are thought t
159 mplications for clinical trials and identify open questions for future research.
160 ts of existing assays and data, and identify open questions for future studies.
161 on and discuss perspectives, challenges, and open questions for the diagnosis and management of patie
162 a, highlight conserved mechanisms, and raise open questions for the future.
163 on is introduced to help focus discussion on open questions for the origins of life in a planetary co
164 s and disadvantages in various settings, the open questions for which novel methods are needed, and e
165 ncentrations were much lower than today, yet open questions frustrate the translation of modern measu
166                                It remains an open question how biochemical reactions developed withou
167                                It remains an open question how neural responses in motor cortex relat
168                            However, it is an open question how tau can regulate microtubule dynamics
169                                It remains an open question how these events affected the genetic comp
170                                     It is an open question how these ground states governed by local
171                           However, there are open questions how plasma-generated RONS interact on a m
172                                     It is an open question, however, how strongly the SC-FC relations
173                                It remains an open question, however, how the large number of connecti
174                                     It is an open question, however, whether the hippocampus similarl
175                            However, it is an open question if and when these newly suitable habitats
176                                           An open question in bacterial molecular evolution is that o
177 ing the role of such enzymes is an important open question in biology.
178                                           An open question in cell biology is how the general intrace
179 systems before modern human activities is an open question in ecology and conservation.
180 ariability in ecosystem processes remains an open question in ecology.
181 od and guide cellular motility is a critical open question in eukaryotic chemotaxis.
182                                           An open question in evolutionary biology is the relationshi
183 ntation, sulfidation ratio, etc.) remains an open question in hydrotreating catalysis and biomass pro
184 g in its vicinity is therefore still a major open question in ice physics.
185  dynamics of the brain remains a fundamental open question in neuroscience.
186 on and organization remains an important and open question in non-equilibrium statistical mechanics.
187  of massive Wolf-Rayet stars (WRSs) is a key open question in stellar physics.
188                                  However, an open question in the field is how intracellular oscillat
189                                           An open question in the history of human migration is the i
190                       One of the fundamental open questions in condensed matter science is the origin
191          This is one of the most fundamental open questions in cosmology and particle physics.
192  paper are directly applicable to many other open questions in granular and soft matter systems, such
193      This commentary focuses on two related, open questions in Hulleman & Olivers' (H&O's) proposal:
194                                  A number of open questions in human evolutionary genetics would beco
195   This review focuses on recent advances and open questions in our understanding of the complex role
196  the state of the art, future directions and open questions in Raman spectroscopy of graphene.
197              In this article we review major open questions in single-cell physiology, provide a brie
198 ll also point out some of the most important open questions in the field and emerging evidence sugges
199                             We highlight the open questions in the field of cardiovascular calcificat
200 riate model species; testing them to resolve open questions in the field of LR patterning will reveal
201 have attempted to identify the most pressing open questions in the field.
202 ly, this review discusses the challenges and open questions in the rapidly expanding field of immunom
203 he core Hippo kinase cascade and discuss key open questions in the regulation and function of the Hip
204                                 There remain open questions in the signaling networks, the ultimate r
205 light the available information and indicate open questions in this field.
206                  In our review, we highlight open questions in this important area while examining po
207                                              Open questions, in addition to those shown in the Graphi
208                                  However, an open question is how a certain order of these repair ste
209                                          The open question is how much we can learn about human ills
210                                      A major open question is how the signals from different layers a
211                                           An open question is how the spatiotemporal distribution of
212                                           An open question is how these deficits impact the functiona
213                                        A key open question is how these elementary building blocks em
214                                           An open question is how to maximize the modularity of their
215                                One important open question is that of functional differences of our s
216                                A fundamental open question is then how many layers are indeed necessa
217                                 An important open question is to what extent epigenetic factors contr
218                                 An important open question is what characterizes the representational
219                                           An open question is whether and to what extent intermediate
220                                          One open question is whether cell types form discrete cluste
221                                           An open question is whether fear-related brain areas respon
222                                           An open question is whether orthographic processing is limi
223                                           An open question is whether proteins might function as tran
224                            A fundamental and open question is whether range adaptation is behaviorall
225                                           An open question is whether there are preexisting plexin di
226                                        A key open question is which specific HDAC is involved in the
227                              A long-standing open question is why the same causal porphyria mutations
228                                           An open question is: Does incorporating asymmetric branchin
229                        This work resolves an open question of how a key class of suspension-feeding o
230                               An outstanding open question of how neural coding supports Bayesian inf
231        Thus occlusion is linked with another open question of microvascular function: how are red blo
232 fractions of heritable variation, leaving an open question of whether accurate complex trait predicti
233           Here, we address the long-standing open question of whether every pure bipartite entangled
234    Our analysis of the key uncertainties and open questions of and beyond the inventory shows that, a
235                               There are many open questions on the role of environmental factors, suc
236               Recent trends in the field are opening questions on the diversity and sophistication of
237 s of tuning cytoskeletal mechanics remain an open question, one that we discuss herein.
238 with members of the trained teams asked more open questions (P = .022), expressed more emotional word
239                  In this context, we outline open questions, particularly regarding the shape of S1P
240                         Although a number of open questions persist, the available evidence is best c
241                                        A key open question pertains to the internal valuation systems
242 ow future research might solve the remaining open questions presently under discussion.
243 ide an outlook into clinical development and open questions regarding BTK inhibitor therapy.
244 despread use over four decades, there remain open questions regarding its fundamental limitations.
245 his review, we discuss current knowledge and open questions regarding the mechanisms involved in the
246                            There are several open questions regarding the origin, development, and di
247                     Throughout, we highlight open questions regarding the physical principles for DNA
248 use of both its technological importance and open questions regarding the physics of energy transfer
249                               There are many open questions regarding the processes that regulate hum
250  signals are non-stationary, there are still open questions regarding the stationarity of EEG during
251 ic simulations are well positioned to answer open questions regarding the thermodynamics and kinetics
252                               A crucial, yet open, question regards how babies deal with stimuli expe
253 ts and interpenetration are highlighted, and open questions related to state-of-the-art computational
254     Finally, we discuss major challenges and open questions related to the application of SERS for un
255   Despite extensive studies, there are still open questions relating to membrane phase behavior, part
256                                     However, open questions remain regarding the key mechanistic step
257 ed in mediating allergen tolerance, but many open questions remain to be answered.
258 domonas, and Stentor coeruleus Although many open questions remain, elucidating how cells repair them
259                                     Although open questions remain, further research should include p
260                                         Many open questions remain, however, about the spatial and te
261 doping and spin polarization, for which many open questions remain.
262                                        A key open question remains: How does blocking HDAC activity l
263 arbon nanotubes (CNTs) has been an important open question since the first reports of the strong modu
264                        Here, we analyze this open question systematically by using intracellular reco
265 stability against thermal fluctuations is an open question that must be answered before skyrmion-base
266                        This review indicates open questions that require further research and propose
267 mmunity and are highlighted here, along with open questions that require serious attention for full u
268 remodeling mechanisms and highlight exciting open questions that would continue to benefit from bioph
269                            We also highlight open questions, theoretical puzzles and problems shared
270                          By pointing to many open questions, these new studies highlight the limitati
271 red more than sixty years ago, it remains an open question to explain its ubiquity.
272 y in the Fe-based superconductors remains an open question to the scientific community.
273 cadC during cell state transitions, it is an open question to what extent such harmful AP-sites may a
274 ontexts and conclude with a consideration of open questions to be addressed in the future.
275 t reconciling confounding reports and define open questions to provide a conceptual framework for fut
276 bserved tonic signaling heterogeneity remain open questions today.
277 owever, their interface magnetism remains an open question up to this day.
278 of personal questions with known answers and open questions using linear support vector machine (SVM)
279                              To address this open question, we cultured primary human glioblastoma (G
280                                It remains an open question when and how the first cell fate decision
281 r despite long-running debate, it remains an open question whether a reliance on social learning can
282 s across the tree of life, but it remains an open question whether amphibian chemical defense phenoty
283                           It is therefore an open question whether and to what extent an ab initio-ba
284                                     It is an open question whether design methods tailored to build D
285 infant and adult brains, it is a crucial yet open question whether expectation-related feedback is an
286                 In particular, it remains an open question whether metacognitive judgments are based
287                       However, it remains an open question whether network-based strategies should be
288 anonical amino acids; however, it remains an open question whether organisms with additional amino ac
289                                It remains an open question whether Ric-8 has dual functions in cells
290 ifferent numbers of monomers, it is still an open question whether ring formation is crucial for memb
291                                     It is an open question whether such context-dependent memory effe
292 ntense interest in FOXP2, it has remained an open question whether the human protein's DNA-binding sp
293                                     It is an open question whether the same or different neural mecha
294                                     It is an open question whether turbulent mixing across density su
295 have been studied extensively, it remains an open question why microvessels need to be so narrow.
296 tracellular effector activity, it remains an open question why only few effectors are recognized dire
297  possible future directions to address still open questions will be suggested.
298 mechanical rhythm over a lifetime remains an open question with significant implications to human hea
299                           Answering the many open questions with regard to the role of DCs in immune
300                                           An open question within the Bienenstock-Cooper-Munro theory

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