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1 ger loop (TL), allowing visualization of its open state.
2 opts a potentially desensitized or partially open state.
3 bind when the trimer transiently samples an open state.
4 ates a non-fouling, liquid-lined pore in the open state.
5 reas the McjD-based model could represent an open state.
6 YE, which was determined to be in a "primed" open state.
7 49-A agonist-bound structure at pH 6.0 in an open state.
8 are found to prefigure the transition to the open state.
9 eines in TMs 1 and 12 stabilized the channel open state.
10 utward-open state to the Na(+)-bound, inward-open state.
11 that fourfold pore symmetry persists in the open state.
12 e indicative of changing from a closed to an open state.
13 nsition state decreases the stability of the open state.
14 ck, whereas the fast mode blocks RyR2 in the open state.
15 y be exchanged if the channel resides in the open state.
16 pore gate closure, trapping channels in the open state.
17 whereas incorrect dNTPs are delivered to the open state.
18 rgy barrier between them is located near the open state.
19 n the closed state, but not in the ATP-bound open state.
20 onal changes and approaching or reaching the open state.
21 a conductor with a prolonged lifetime in the open state.
22 125 and Arg104 biases the hemichannel to the open state.
23 ethiosulfonate, but only when applied in the open state.
24 er, but instead we found that Pdx favors the open state.
25 :G, which samples conformations close to the open state.
26 ich appears to help stabilize a well-defined open state.
27 ely 12 orders-of-magnitude lower than in the open state.
28 time at subconductance levels than the fully open state.
29 d by mechanisms with only one fully liganded open state.
30 annel C terminus and variably stabilizes its open state.
31 increases the energetic favorability of the open state.
32 leating promoter opening and stabilizing the open state.
33 utation (E1371Q) that stabilizes the channel open state.
34 , and subsequently turns back to the outward-open state.
35 SLO3 gating ring structure may represent an open state.
36 l model of an ion channel-CaM complex in the open state.
37 to induce a conformational change toward the open state.
38 loop stabilization of the G-loop gate in the open state.
39 and mdx muscle that fail to reach the fully open state.
40 s sufficient to stabilize this complex in an open state.
41 (L267N/L270N) stabilized channels in a fully open state.
42 competes with PIP2 to stabilize the channel open state.
43 ensor that are associated with the channel's open state.
44 und P450cam to change from the closed to the open state.
45 nels by prolonging the residence time in the open state.
46 to the change in conformation from closed to open state.
47 f the N terminus and transition to an inward-open state.
48 xpected to have closed clefts in the channel-open state.
49 n with the conformation similar to the fully open state.
50 hen it enters the central pore cavity in the open state.
51 Binding to the GPCR stabilizes the open state.
52 ive to the Gate domains may access an inward-open state.
53 cyclic guanosine monophosphate (cGMP)-bound open state.
54 ation, the HBC gate can be stabilized in the open state.
55 t states: an inward-open state and a lateral-open state.
56 ndent dynamic equilibrium between closed and open states.
57 g solvent exposure of Y671 in the closed and open states.
58 the other TM segments both in the closed and open states.
59 tions that lead to a significant fraction of open states.
60 d that IDE exists as a mixture of closed and open states.
61 ody fragments in the outward-open and inward-open states.
62 related to the resting-closed and activated-open states.
63 cupies a minimum of two kinetically distinct open states.
64 n outward-open, outward-occluded, and inward-open states.
65 ich suggested the presence of a continuum of open states.
66 ribute to gating and selectivity in discrete open states.
67 in the late-activation and fully-activated (open) state.
68 tense (closed) state toward a more relaxed (open) state.
69 conformational transition toward the inward-open state, a role that is likely to be shared across th
71 bsence of ligand and that it remains in this open state after binding AMPPCP, as we had observed for
72 e wherein KCNQ1 is able to transition to the open state after zero to four voltage-sensor movements.
73 at, unlike the well-characterized closed and open states, allows ready access to the metal cluster in
75 (AM(C)), MYO1C(16) populated the actomyosin open state (AM(O)) and AM(C) equally, and MYO1C(35) favo
76 (AMD(C)) 5-fold more than the actomyosin.ADP open state (AMD(O)) and to a greater degree than MYO1C(C
77 tude, consistent with a stabilization of the open state and 2) a loss-of-function effect by positive-
79 ely uniform distribution of cellulose in the open state and a more fibrillar pattern in the closed st
81 final voltage-independent transition to the open state and closely replicate the experimental data.
82 mechanisms for the transition from closed to open state and describe the role Tm plays in blocking my
84 revents the transition of the receptor to an open state and increases its dwell time in an intrinsica
86 g ranolazine does not selectively affect the open state and may also interact with inactivated states
87 orms were crystallized, one in an apparently open state and one in an occluded state, indicating that
89 ix is located inside the pore of VDAC in the open state and remains associated with beta-strand 11 of
90 ortion of S(4) decrease the stability of the open state and the active voltage-sensing domain configu
91 , whereas the fast gate operates between the open state and the closed state and exhibits a residual
92 torted active site in the closed relative to open state and the high energy barrier in the conformati
93 he smaller effect of cAMP on stabilizing its open state and the opening of unliganded HCN1, which occ
94 e of WT-CFTR by stabilizing a posthydrolytic open state and thereby fosters decoupling between the ga
95 PRE complex equilibrium toward the classical/open state and toward states that favor EF-G dissociatio
96 uT, including a substrate-free state, inward-open state, and competitive and non-competitive inhibito
97 article only blocks sodium channels from the open state, and mutagenesis studies demonstrate that thi
98 e IVM binding between subunits stabilizes an open state, and that the relaxed nonIVM conformations mi
99 hey undergo a transition from a closed to an open state, and therefore influence protein function in
100 a previously uncharacterized 'outward-facing open' state, and highlight the relevance of global struc
101 we show that homocellular GJs in a passively open state are crucial for electrical uniformity within
105 l microstates, stabilizing a substrate-bound open state at the expense of a substrate-bound closed st
107 in the x-ray atomic structures of closed and open state bacterial pLGICs, we propyose that the model
108 cing conformation corresponds to the channel open state, based on homology with other ABC proteins.
113 po resting/closed state, in an activated/pre-open state bound with partial agonists and a positive al
114 tep for catalysis occurs during the enzyme's open state, but with a nearly 2-fold longer duration for
115 in constructs locked in either the closed or open state by chemical cross-linking or deletion mutagen
116 tations mainly impaired stabilization of the open state by propofol, i.e., reduced gating efficacy.
117 the sialic acid-binding site in the cytosol-open state by two phenylalanine to tyrosine mutations ab
118 m that allows CFTR shuffling among different open states by undergoing multiple rounds of ATP hydroly
119 ts, both mutations markedly destabilized the open state, causing a dramatic decrease in channel volta
120 tes and increased the energy barriers toward open states, causing NMDA receptors to dwell longer in p
121 rug access to a side pocket generated in the open-state channel configuration and lined by S6 and S4-
123 ding sites must be saturated to stabilize an open state conducive to peptide recognition, yet the pEF
125 se c-di-GMP-binding motifs also stabilize an open state conformation in apo MrkH via contacts from th
126 s suggest that the permeation pathway in the open state constricts below the gate, restricting the pa
127 rts the idea that this substrate-independent open state correlates with an intermediate outward facin
129 ount that the variable equilibria of the two open states depend on light intensity, voltage, and the
130 e activation of ELK channels involves a slow open-state dependent rearrangement of the direct interac
131 Binding of ranolazine to either preopen or open states did not affect the excitability of the simul
132 prehydrated gate in functionally closed and open states differ by only 1.2 kcal/mol, compared to an
133 H3 tail may stabilize the nucleosome in the open state during the initial stages of the nucleosome r
134 stepwise sojourns through multiple discrete open states, each with unique channel gating and conduct
135 a closed state (engaged with duplex DNA), an open state (engaged with a transcription bubble), and an
136 at causes some channels to transition to the open state even in the absence of voltage-sensor movemen
140 the transmembrane regions, however with the open state facing inwardly and the closed state facing o
141 his prompts the ATP binding site to adopt an open state, favoring ATP release and reducing the veloci
142 tion from a closed-state initial model to an open-state final model using just one class-averaged pro
146 esized that the Pdx-induced shift toward the open state frees the essential Asp251 from salt bridges
148 d but homology models of the CFTR closed and open states have been produced based on the crystal stru
149 a spontaneous closing transition to the half-open state in response to the gamma rotation in the synt
150 NS2B is remote from NS3pro and exists in an open state in the absence of an inhibitor; however, in t
152 the active site O-helix transitions from an open state in the absence of nucleotide substrates to a
154 Among our key findings is the existence of open states in all SNase mutants containing "buried" res
155 ts have less stable closed states than their open states, in marked contrast to the wild-type enzyme,
156 E, A1632T failed to slow current decay (i.e. open-state inactivation) and did not increase resurgent
157 lpha(1)R132A also conferred a new long-lived open state, indicating that this arginine influences the
159 ansition to this conformation from the fully open state is accompanied by well-defined changes in the
160 The rate of conformational relaxation of the open state is approximately 18,000 s(-1) in alpha subuni
162 unlesioned pol-beta anti(G:C) system, whose open state is energetically higher than the closed state
165 (+)-selective, voltage-gated) channel in the open state is known (Protein Data Bank ID code 2R9R).
167 activates TRPV2_Quad but the ligand-induced open state is relatively unstable, whereas binding of ca
169 lf-saturated configuration suggests that the open state is unstable and reverts toward a closed state
171 tion, elevated retinal affinity, an extended open-state lifetime, and photocurrent amplitudes greatly
172 ercolates" 10 times slower than Na(+) in the open state, likely due to a conformational and orientati
175 of ATP is rate-limiting, (ii) the binding of open-state MalE to the transporter induces ATP cleavage
176 looser substrate-protein interactions in the open state may not be compatible with the observed regio
177 uctural differences between their closed and open states may help in designing improved drugs that bi
178 In combination with docking to closed and open state models of TRPA1, photoaffinity labeling sugge
179 C paralog transitions from the closed to the open state more readily than the ssTnC paralog, an unfav
182 ure, ChR2 transitions from a high-conducting open state (O1) to a low-conducting open state (O2) with
183 Under steady-state light conditions, the two open states, O1 and O2, mediate the photocurrents with d
186 ed insights into the structure of a possibly open state of a eukaryotic Cys-loop receptor, the basis
189 We propose that Pds5 stabilizes a transient, open state of cohesin to promote its release from chromo
190 nds bind in the central cavity of the inward-open state of hGLUT1, and all binding sites overlap the
191 and impairs working memory by increasing the open state of hyperpolarization-activated cyclic nucleot
192 reduces the ability of PIP2 to stabilize the open state of KATP channels, similar to mutations in the
193 ound MBP promotes the transition to the semi-open state of MalK when the transporter is in the membra
195 /S45A) at biotin-binding sites stabilize the open state of SA L3,4 loop, thereby further reducing bio
196 1 can contribute to the stabilization of the open state of syntaxin-1 during its transition from "clo
197 ch the active receptor conformation sets the open state of the channel for 11-cis-retinal and all-tra
202 the 'cytoplasmic cap', which stabilizes the open state of the ion channel pore and creates lateral,
208 reveal an opposing relationship between the open states of GJ channels versus hemichannels during ac
210 We constructed models of both the closed and open states of Hv1 channels that are consistent with the
212 the vibrational changes associated with the open states of the channel (P(2)(390) and P(3)(520)) and
213 les in the transition between the closed and open states of the channel and are not directly involved
215 facilitated by the formation of short-lived "open" states of the pores upon linker dissociation.
218 an alternative flap orientation of a curled open state or an asymmetric configuration when interacti
220 Thus, increased temperature stabilized the open state over the closed state of Kv11.1a/1b channels
221 ockade of a Shaker Kv channel that undergoes open-state P/C-type inactivation exhibits fast onset and
222 isruption of the networks that stabilize the open-state parahelix configuration, allowing the parahel
223 initiating ATP prolongs the lifetime of the open state, plausibly explaining the 'ATP sensing mechan
228 8C/S1118C are closer together in the channel open state, R334C/G1127C are close together and can form
232 nd to the V23T-MscL sub-conductive and fully open states recorded in native bacterial membranes or li
233 d unitary conductance (gamma(j)) of the main open state, reduced open dwell time at +/-40 mV, and abs
237 s in the intermediate-open and the activated-open states, resulting in changes of open pore propertie
238 ional switch between the outward- and inward-open states results from rigid body motions of the hash
239 ons with a structure of Band 3 in an outward-open state reveal that the Core domains of Bor1 have rot
240 csA channel determined at low K(+) or in the open state revealed a constricted conformation of the se
242 MBPP bound are restricted from accessing the open states sampled by the substrate-free simulations.
243 pyran (a ring-close) and merocyanine (a ring-open) states, simple exposure of the hydrogels to white
244 HF2 accelerates the rate of closed-state and open-state sodium channel inactivation, which synergizes
245 t leucine substitution, results in increased open state stability and hence significantly reduced ATP
246 istent with this notion, when PIP2-dependent open state stability was substantially increased by addi
247 However, as a consequence of the increased open state stability, both Kir6.1(V65M) and Kir6.2(V64M)
250 nd the molecular basis of Ca(2+) binding and open-state stabilization, we performed 100 ns molecular
251 free from crystal packing and remain in an 'open state', stabilized by a consistent H-bonding networ
252 mics simulations to predict an AMPA receptor open state structure and rationalize the results of muta
254 fts measured, it can be interpreted that the open-state structures are transient at physiological pH,
256 SC is flexible and exists in both closed and open states, suggesting that the mammalian SC D2 domain
257 e 5,000-fold higher affinity of the extended-open state than the bent-closed and extended-closed stat
258 ons confirm designation of NaVAb/1-226 as an open state that allows permeation of hydrated Na(+), and
259 We propose a model for the structure of the open state that has stabilizing intersubunit interaction
260 e channel stochastically switches between an open state that permits ion conductance and a closed sta
262 nct structural states, a closed state and an open state, that are adopted by the C-terminal arm of Cc
263 ot pass through the side channel, but in the open state, the leading strand surprisingly interacts wi
265 at the pathways for opening, and perhaps the open states themselves, are very different in the AFM an
267 In contrast, TL switches from an inactive open state to a closed active state to facilitate nucleo
268 on conferred reduced conductance with a long open state to DMI1 and improved its efficiency in mediat
270 otion that alternates between the closed and open states to shuttle electrons from the CTD via the NT
272 to identify residues that contribute to the open-state transitions and the discrete ion selectivity
275 at these sites could be latched into a full open state using the bifunctional cross-linker 1,2-ethan
276 and Asn-258), the transition between the two open states (Val-86), open channel stability, and the hy
280 he physical consistency of the CG long-lived open state was verified by mapping a CG structure repres
282 sted that F56Bpa interacts with KCNQ1 in the open state, whereas F57Bpa interacts predominantly in re
283 ity by increasing intrinsic stability of the open state, whereas the cluster of Y981S/G985E/M1056I su
284 de bond (E235C/K393C) sets the channel in an open state, whereas the other (E235C/Y389C) switches the
286 med ChR2-XXL (extra high expression and long open state), which displays increased expression, improv
287 t the double mutant is trapped in the inward-open state, which binds the drug, but cannot couple to t
288 and its analogue-dependent transition to the open state, which is one step that was proposed to compl
290 es in a graded manner occupancy of the fully open state, while reducing occupancy of subconductance l
291 s and formation of new hydrogen bonds in the open state, while the mutant pore residue reshaped the p
293 /cofactor pair is spatially separated in the open state with inhibited enzyme function, whereas in th
294 of F233 mutated to alanine indicate that the open state with the fourth arginine in S4 above the hydr
295 to force the fructosyl moiety to bind in an open state with the O3' ideally positioned to explain th
296 e protein N gate is present in an 'arms-wide-open' state with the undimerized N-terminal ParE ATPase
297 and the linker, that becomes flexible in the open state, with 627 and NLS dislocating into a highly d
298 of the total energy, toward stabilizing the open state, with a smaller contribution from VSD I ( app
300 that the RNA binding pore adopts closed and open states, with the latter able to accommodate RNA.
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