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1 ger loop (TL), allowing visualization of its open state.
2 opts a potentially desensitized or partially open state.
3  bind when the trimer transiently samples an open state.
4 ates a non-fouling, liquid-lined pore in the open state.
5 reas the McjD-based model could represent an open state.
6 YE, which was determined to be in a "primed" open state.
7 49-A agonist-bound structure at pH 6.0 in an open state.
8 are found to prefigure the transition to the open state.
9 eines in TMs 1 and 12 stabilized the channel open state.
10 utward-open state to the Na(+)-bound, inward-open state.
11  that fourfold pore symmetry persists in the open state.
12 e indicative of changing from a closed to an open state.
13 nsition state decreases the stability of the open state.
14 ck, whereas the fast mode blocks RyR2 in the open state.
15 y be exchanged if the channel resides in the open state.
16  pore gate closure, trapping channels in the open state.
17 whereas incorrect dNTPs are delivered to the open state.
18 rgy barrier between them is located near the open state.
19 n the closed state, but not in the ATP-bound open state.
20 onal changes and approaching or reaching the open state.
21 a conductor with a prolonged lifetime in the open state.
22 125 and Arg104 biases the hemichannel to the open state.
23 ethiosulfonate, but only when applied in the open state.
24 er, but instead we found that Pdx favors the open state.
25 :G, which samples conformations close to the open state.
26 ich appears to help stabilize a well-defined open state.
27 ely 12 orders-of-magnitude lower than in the open state.
28 time at subconductance levels than the fully open state.
29 d by mechanisms with only one fully liganded open state.
30 annel C terminus and variably stabilizes its open state.
31  increases the energetic favorability of the open state.
32 leating promoter opening and stabilizing the open state.
33 utation (E1371Q) that stabilizes the channel open state.
34 , and subsequently turns back to the outward-open state.
35  SLO3 gating ring structure may represent an open state.
36 l model of an ion channel-CaM complex in the open state.
37 to induce a conformational change toward the open state.
38 loop stabilization of the G-loop gate in the open state.
39  and mdx muscle that fail to reach the fully open state.
40 s sufficient to stabilize this complex in an open state.
41 (L267N/L270N) stabilized channels in a fully open state.
42  competes with PIP2 to stabilize the channel open state.
43 ensor that are associated with the channel's open state.
44 und P450cam to change from the closed to the open state.
45 nels by prolonging the residence time in the open state.
46 to the change in conformation from closed to open state.
47 f the N terminus and transition to an inward-open state.
48 xpected to have closed clefts in the channel-open state.
49 n with the conformation similar to the fully open state.
50 hen it enters the central pore cavity in the open state.
51           Binding to the GPCR stabilizes the open state.
52 ive to the Gate domains may access an inward-open state.
53  cyclic guanosine monophosphate (cGMP)-bound open state.
54 ation, the HBC gate can be stabilized in the open state.
55 t states: an inward-open state and a lateral-open state.
56 ndent dynamic equilibrium between closed and open states.
57 g solvent exposure of Y671 in the closed and open states.
58 the other TM segments both in the closed and open states.
59 tions that lead to a significant fraction of open states.
60 d that IDE exists as a mixture of closed and open states.
61 ody fragments in the outward-open and inward-open states.
62  related to the resting-closed and activated-open states.
63 cupies a minimum of two kinetically distinct open states.
64 n outward-open, outward-occluded, and inward-open states.
65 ich suggested the presence of a continuum of open states.
66 ribute to gating and selectivity in discrete open states.
67  in the late-activation and fully-activated (open) state.
68  tense (closed) state toward a more relaxed (open) state.
69  conformational transition toward the inward-open state, a role that is likely to be shared across th
70 terminal half, UNC-112 is converted into the open state, able to bind to PAT-3.
71 bsence of ligand and that it remains in this open state after binding AMPPCP, as we had observed for
72 e wherein KCNQ1 is able to transition to the open state after zero to four voltage-sensor movements.
73 at, unlike the well-characterized closed and open states, allows ready access to the metal cluster in
74 ausing NMDA receptors to dwell longer in pre-open states along the activation pathway.
75  (AM(C)), MYO1C(16) populated the actomyosin open state (AM(O)) and AM(C) equally, and MYO1C(35) favo
76 (AMD(C)) 5-fold more than the actomyosin.ADP open state (AMD(O)) and to a greater degree than MYO1C(C
77 tude, consistent with a stabilization of the open state and 2) a loss-of-function effect by positive-
78 AM complex in two distinct states: an inward-open state and a lateral-open state.
79 ely uniform distribution of cellulose in the open state and a more fibrillar pattern in the closed st
80  drastic structural change between an active open state and an inactive closed conformation.
81  final voltage-independent transition to the open state and closely replicate the experimental data.
82 mechanisms for the transition from closed to open state and describe the role Tm plays in blocking my
83                           In the MitTx-bound open state and in the previously determined low-pH desen
84 revents the transition of the receptor to an open state and increases its dwell time in an intrinsica
85 that these domain interactions stabilize the open state and limit the rate of charge return.
86 g ranolazine does not selectively affect the open state and may also interact with inactivated states
87 orms were crystallized, one in an apparently open state and one in an occluded state, indicating that
88 ermectin and related molecules stabilize the open state and potentiate neurotransmitter binding.
89 ix is located inside the pore of VDAC in the open state and remains associated with beta-strand 11 of
90 ortion of S(4) decrease the stability of the open state and the active voltage-sensing domain configu
91 , whereas the fast gate operates between the open state and the closed state and exhibits a residual
92 torted active site in the closed relative to open state and the high energy barrier in the conformati
93 he smaller effect of cAMP on stabilizing its open state and the opening of unliganded HCN1, which occ
94 e of WT-CFTR by stabilizing a posthydrolytic open state and thereby fosters decoupling between the ga
95 PRE complex equilibrium toward the classical/open state and toward states that favor EF-G dissociatio
96 uT, including a substrate-free state, inward-open state, and competitive and non-competitive inhibito
97 article only blocks sodium channels from the open state, and mutagenesis studies demonstrate that thi
98 e IVM binding between subunits stabilizes an open state, and that the relaxed nonIVM conformations mi
99 hey undergo a transition from a closed to an open state, and therefore influence protein function in
100 a previously uncharacterized 'outward-facing open' state, and highlight the relevance of global struc
101 we show that homocellular GJs in a passively open state are crucial for electrical uniformity within
102 e dimensional changes between the closed and open state are unaffected by the mutations.
103                  Energetically, the lesioned open states are similar in energy to those of the corres
104                                        These open states are stably maintained in highly condensed mi
105 l microstates, stabilizing a substrate-bound open state at the expense of a substrate-bound closed st
106 aVAb mutants that capture tightly closed and open states at a resolution of 2.8-3.2 A.
107 in the x-ray atomic structures of closed and open state bacterial pLGICs, we propyose that the model
108 cing conformation corresponds to the channel open state, based on homology with other ABC proteins.
109      One of these conformational states, the open state, binds to the GPCR; the second conformation,
110  of the channel but seems to be caused by an open state block of RyR1.
111      Thus, our data support a model in which open state block of this channel occurs not via binding
112                      X-ray structures of the open state bound to a nonhydrolyzable ATP analog (AMPPCP
113 po resting/closed state, in an activated/pre-open state bound with partial agonists and a positive al
114 tep for catalysis occurs during the enzyme's open state, but with a nearly 2-fold longer duration for
115 in constructs locked in either the closed or open state by chemical cross-linking or deletion mutagen
116 tations mainly impaired stabilization of the open state by propofol, i.e., reduced gating efficacy.
117  the sialic acid-binding site in the cytosol-open state by two phenylalanine to tyrosine mutations ab
118 m that allows CFTR shuffling among different open states by undergoing multiple rounds of ATP hydroly
119 ts, both mutations markedly destabilized the open state, causing a dramatic decrease in channel volta
120 tes and increased the energy barriers toward open states, causing NMDA receptors to dwell longer in p
121 rug access to a side pocket generated in the open-state channel configuration and lined by S6 and S4-
122                                       In the open-state channel model, F351 lines a pocket that also
123 ding sites must be saturated to stabilize an open state conducive to peptide recognition, yet the pEF
124 dergoes spontaneous deviations away from the open-state configuration.
125 se c-di-GMP-binding motifs also stabilize an open state conformation in apo MrkH via contacts from th
126 s suggest that the permeation pathway in the open state constricts below the gate, restricting the pa
127 rts the idea that this substrate-independent open state correlates with an intermediate outward facin
128                                          An "open"-state crystal structure of lysine 5,6-aminomutase
129 ount that the variable equilibria of the two open states depend on light intensity, voltage, and the
130 e activation of ELK channels involves a slow open-state dependent rearrangement of the direct interac
131   Binding of ranolazine to either preopen or open states did not affect the excitability of the simul
132  prehydrated gate in functionally closed and open states differ by only 1.2 kcal/mol, compared to an
133  H3 tail may stabilize the nucleosome in the open state during the initial stages of the nucleosome r
134  stepwise sojourns through multiple discrete open states, each with unique channel gating and conduct
135 a closed state (engaged with duplex DNA), an open state (engaged with a transcription bubble), and an
136 at causes some channels to transition to the open state even in the absence of voltage-sensor movemen
137 e nexus transforms Orai1 into a persistently open state exactly mimicking the action of STIM1.
138                                      The pre-open state exhibits a conformation that is intermediate
139                                       In the open state, ezrin can bind a number of ligands, but in t
140  the transmembrane regions, however with the open state facing inwardly and the closed state facing o
141 his prompts the ATP binding site to adopt an open state, favoring ATP release and reducing the veloci
142 tion from a closed-state initial model to an open-state final model using just one class-averaged pro
143 closed state" steric barrier compared to an "open state" for the re-face.
144 tructural differences between the closed and open states form the basis for drug design.
145  OsSWEET2b in an apparent inward (cytosolic) open state forming homomeric trimers.
146 esized that the Pdx-induced shift toward the open state frees the essential Asp251 from salt bridges
147 ed, causing the conformation to change to an open state from which NO can easily escape.
148 d but homology models of the CFTR closed and open states have been produced based on the crystal stru
149 a spontaneous closing transition to the half-open state in response to the gamma rotation in the synt
150  NS2B is remote from NS3pro and exists in an open state in the absence of an inhibitor; however, in t
151 ions increase the contribution of the active open state in the absence of Ca(2+) (M(-)).
152  the active site O-helix transitions from an open state in the absence of nucleotide substrates to a
153       The transitions from the closed to the open state in the two VSDs are known to occur cooperativ
154   Among our key findings is the existence of open states in all SNase mutants containing "buried" res
155 ts have less stable closed states than their open states, in marked contrast to the wild-type enzyme,
156 E, A1632T failed to slow current decay (i.e. open-state inactivation) and did not increase resurgent
157 lpha(1)R132A also conferred a new long-lived open state, indicating that this arginine influences the
158                                It is both an open state inhibitor and a resting state inhibitor.
159 ansition to this conformation from the fully open state is accompanied by well-defined changes in the
160 The rate of conformational relaxation of the open state is approximately 18,000 s(-1) in alpha subuni
161                   Its negative charge in the open state is decisive for proton selectivity.
162  unlesioned pol-beta anti(G:C) system, whose open state is energetically higher than the closed state
163                                  However, an open state is enhanced in full-length membrane reconstit
164                Metal ion coordination in the open state is identical to that seen in the open high-af
165 (+)-selective, voltage-gated) channel in the open state is known (Protein Data Bank ID code 2R9R).
166                                     While an open state is known from the Kv1.2/2.1 X-ray structure,
167  activates TRPV2_Quad but the ligand-induced open state is relatively unstable, whereas binding of ca
168                                          The open state is short-lived and has weak or nonexistent in
169 lf-saturated configuration suggests that the open state is unstable and reverts toward a closed state
170 tructural transitions between the closed and open states is asymmetrical.
171 tion, elevated retinal affinity, an extended open-state lifetime, and photocurrent amplitudes greatly
172 ercolates" 10 times slower than Na(+) in the open state, likely due to a conformational and orientati
173               CAD binding supports a role in open state maintenance and reveals a second phase of CAD
174                             We conclude that open-state MalE stabilizes MalFGK2 in the outward-facing
175 of ATP is rate-limiting, (ii) the binding of open-state MalE to the transporter induces ATP cleavage
176 looser substrate-protein interactions in the open state may not be compatible with the observed regio
177 uctural differences between their closed and open states may help in designing improved drugs that bi
178    In combination with docking to closed and open state models of TRPA1, photoaffinity labeling sugge
179 C paralog transitions from the closed to the open state more readily than the ssTnC paralog, an unfav
180 ional switch between inward-open and outward-open states necessary for drug efflux.
181 model activator binds to the closed (C3) and open states (O).
182 ure, ChR2 transitions from a high-conducting open state (O1) to a low-conducting open state (O2) with
183 Under steady-state light conditions, the two open states, O1 and O2, mediate the photocurrents with d
184 nducting open state (O1) to a low-conducting open state (O2) with differing ion selectivity.
185  gate in an open conformation, revealing the open state of a BacNav with intact voltage sensors.
186 ed insights into the structure of a possibly open state of a eukaryotic Cys-loop receptor, the basis
187 ium-selective ion channels, and captures the open state of an ASIC.
188  coral snake, to define the structure of the open state of ASIC1a.
189 We propose that Pds5 stabilizes a transient, open state of cohesin to promote its release from chromo
190 nds bind in the central cavity of the inward-open state of hGLUT1, and all binding sites overlap the
191 and impairs working memory by increasing the open state of hyperpolarization-activated cyclic nucleot
192 reduces the ability of PIP2 to stabilize the open state of KATP channels, similar to mutations in the
193 ound MBP promotes the transition to the semi-open state of MalK when the transporter is in the membra
194 nnels, and the generation of Ip requires the open state of Orai1, not STIM1 itself.
195 /S45A) at biotin-binding sites stabilize the open state of SA L3,4 loop, thereby further reducing bio
196 1 can contribute to the stabilization of the open state of syntaxin-1 during its transition from "clo
197 ch the active receptor conformation sets the open state of the channel for 11-cis-retinal and all-tra
198  with the plasma membrane and stabilizes the open state of the channel.
199 n four K(+) channel subunits, inducing a pre-open state of the channel.
200 e nearest lipid charges as compared with the open state of the channel.
201 nalogues could trigger the transition to the open state of the enzyme.
202  the 'cytoplasmic cap', which stabilizes the open state of the ion channel pore and creates lateral,
203 hat the cognate nucleotides are bound to the open state of the polymerase.
204  reduction in the time spent in a long-lived open state of the receptor.
205                  They preferably bind to the open state of the sodium channel by interacting with two
206  a parallel coiled coil state, mimicking the open state of the stator.
207 work also applies to the previously reported open state of the wild-type apo-SA.
208  reveal an opposing relationship between the open states of GJ channels versus hemichannels during ac
209 osamide targets the intermediate preopen and open states of hNav1.5 Na(+) channels.
210 We constructed models of both the closed and open states of Hv1 channels that are consistent with the
211 ever, the molecular nature of the closed and open states of syntaxin is not well defined.
212  the vibrational changes associated with the open states of the channel (P(2)(390) and P(3)(520)) and
213 les in the transition between the closed and open states of the channel and are not directly involved
214 open, outward-partially occluded, and inward-open states of the transport cycle.
215 facilitated by the formation of short-lived "open" states of the pores upon linker dissociation.
216                    The newly identified wide-open state offers further opportunities for small-molecu
217 ed state (in the free hormone) and an active open state (on receptor binding).
218  an alternative flap orientation of a curled open state or an asymmetric configuration when interacti
219 allowing substrate entry or product release (open state), or catalysis (closed state).
220   Thus, increased temperature stabilized the open state over the closed state of Kv11.1a/1b channels
221 ockade of a Shaker Kv channel that undergoes open-state P/C-type inactivation exhibits fast onset and
222 isruption of the networks that stabilize the open-state parahelix configuration, allowing the parahel
223  initiating ATP prolongs the lifetime of the open state, plausibly explaining the 'ATP sensing mechan
224 ling a strong temperature dependence of both open-state population and exchange rate.
225 type fusion peptide is ~40 kHz, with a total open-state population of ~20%.
226       The resulting structural model for the open state provides an explanation for the Ca(2+) permea
227                                       In the open state, R3 appears to interact with an aspartate (D1
228 8C/S1118C are closer together in the channel open state, R334C/G1127C are close together and can form
229 to derivatives in which the lifetimes of the open state range from 19 ms to 5 s.
230           Here, by measuring the closed- and open-state reactivity of MTSET to substituted cysteines
231 l guest molecule, while the other, the fully open state, recognizes a cationic guest molecule.
232 nd to the V23T-MscL sub-conductive and fully open states recorded in native bacterial membranes or li
233 d unitary conductance (gamma(j)) of the main open state, reduced open dwell time at +/-40 mV, and abs
234  mediate anesthetic binding and stabilize an open state regulated by pore residue Leu-122.
235            The transition from the closed to open states requires the sites identified here, even whe
236 ion gate equilibria toward the activated and open state, respectively.
237 s in the intermediate-open and the activated-open states, resulting in changes of open pore propertie
238 ional switch between the outward- and inward-open states results from rigid body motions of the hash
239 ons with a structure of Band 3 in an outward-open state reveal that the Core domains of Bor1 have rot
240 csA channel determined at low K(+) or in the open state revealed a constricted conformation of the se
241                 The general features of the 'open state' SA among different SA variants may facilitat
242 MBPP bound are restricted from accessing the open states sampled by the substrate-free simulations.
243 pyran (a ring-close) and merocyanine (a ring-open) states, simple exposure of the hydrogels to white
244 HF2 accelerates the rate of closed-state and open-state sodium channel inactivation, which synergizes
245 t leucine substitution, results in increased open state stability and hence significantly reduced ATP
246 istent with this notion, when PIP2-dependent open state stability was substantially increased by addi
247   However, as a consequence of the increased open state stability, both Kir6.1(V65M) and Kir6.2(V64M)
248 e revealed the major impact of PIP(2) on the open state stabilization.
249        Consequently, it was proposed that an open-state stabilization of the PD imposes a mechanical
250 nd the molecular basis of Ca(2+) binding and open-state stabilization, we performed 100 ns molecular
251  free from crystal packing and remain in an 'open state', stabilized by a consistent H-bonding networ
252 mics simulations to predict an AMPA receptor open state structure and rationalize the results of muta
253                                          The open state structure harbours an intracellular motif we
254 fts measured, it can be interpreted that the open-state structures are transient at physiological pH,
255                                  The 'early' open states substantially contribute to IK,L activation
256 SC is flexible and exists in both closed and open states, suggesting that the mammalian SC D2 domain
257 e 5,000-fold higher affinity of the extended-open state than the bent-closed and extended-closed stat
258 ons confirm designation of NaVAb/1-226 as an open state that allows permeation of hydrated Na(+), and
259  We propose a model for the structure of the open state that has stabilizing intersubunit interaction
260 e channel stochastically switches between an open state that permits ion conductance and a closed sta
261 ormation of a labeled UvrD monomer to a more open state that shows no helicase activity.
262 nct structural states, a closed state and an open state, that are adopted by the C-terminal arm of Cc
263 ot pass through the side channel, but in the open state, the leading strand surprisingly interacts wi
264                           In the ligand-free open state, the loop is exposed to solvent, where it can
265 at the pathways for opening, and perhaps the open states themselves, are very different in the AFM an
266 mol energy difference between the closed and open states, thus oversensitizing the receptor.
267    In contrast, TL switches from an inactive open state to a closed active state to facilitate nucleo
268 on conferred reduced conductance with a long open state to DMI1 and improved its efficiency in mediat
269 he antiporter from the proton-bound, outward-open state to the Na(+)-bound, inward-open state.
270 otion that alternates between the closed and open states to shuttle electrons from the CTD via the NT
271 g closed states while facilitating closed-to-open state transitions.
272  to identify residues that contribute to the open-state transitions and the discrete ion selectivity
273 e and undergo a conformational change to the open state upon binding.
274 ite dynamic and exchanges between closed and open states upon interaction with FHA.
275  at these sites could be latched into a full open state using the bifunctional cross-linker 1,2-ethan
276 and Asn-258), the transition between the two open states (Val-86), open channel stability, and the hy
277        This state is easily reached from the open state via low free energy barriers.
278                                  The outward-open state was obtained by electron crystallography with
279                                   The inward-open state was obtained by x-ray crystallography in the
280 he physical consistency of the CG long-lived open state was verified by mapping a CG structure repres
281 amics of the spike motion between closed and open states when CD4 is bound.
282 sted that F56Bpa interacts with KCNQ1 in the open state, whereas F57Bpa interacts predominantly in re
283 ity by increasing intrinsic stability of the open state, whereas the cluster of Y981S/G985E/M1056I su
284 de bond (E235C/K393C) sets the channel in an open state, whereas the other (E235C/Y389C) switches the
285 namics model of the channel structure in the open state which confirms our direct observations.
286 med ChR2-XXL (extra high expression and long open state), which displays increased expression, improv
287 t the double mutant is trapped in the inward-open state, which binds the drug, but cannot couple to t
288 and its analogue-dependent transition to the open state, which is one step that was proposed to compl
289                                        These open states, which are distinct from the swinging door s
290 es in a graded manner occupancy of the fully open state, while reducing occupancy of subconductance l
291 s and formation of new hydrogen bonds in the open state, while the mutant pore residue reshaped the p
292  the enzyme preferentially adopts a globally open state with accessible binding sites.
293 /cofactor pair is spatially separated in the open state with inhibited enzyme function, whereas in th
294 of F233 mutated to alanine indicate that the open state with the fourth arginine in S4 above the hydr
295  to force the fructosyl moiety to bind in an open state with the O3' ideally positioned to explain th
296 e protein N gate is present in an 'arms-wide-open' state with the undimerized N-terminal ParE ATPase
297 and the linker, that becomes flexible in the open state, with 627 and NLS dislocating into a highly d
298  of the total energy, toward stabilizing the open state, with a smaller contribution from VSD I ( app
299                              Occasionally an open state, with diffusive water permeability very close
300  that the RNA binding pore adopts closed and open states, with the latter able to accommodate RNA.

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