ライフサイエンスコーパス: opening

1 rmation by alamethicin or Ca(2+)-induced PTP opening.

2 upon acid-promoted cyclopropyl carbinol ring opening.

3 taining, neuronal activity-induced chromatin opening.

4 n almt4 mutants impaired growth and stomatal opening.

5 RPV1 translates diverse stimuli into channel opening.

6 on the probability and consequences of mPTP opening.

7 ached by electrophilic cyclopropanation-ring opening.

8 he membrane deformation changes upon channel opening.

9 uses nanoscale information to mimic seedpod opening.

10 role for ERA1 in blue light-induced stomatal opening.

11 formational equilibria in favor of headpiece opening.

12 kely prime the channel for voltage-dependent opening.

13 th tunable diameter, height, and size of cup opening.

14 intracellular vestibule, precluding channel opening.

15 ission to layer 4 as well as the ear and eye opening.

16 he fracture surfaces, and therefore fracture opening.

17 slowing correlated with the kinetics of pore opening.

18 overexpression of PGX3 accelerates stomatal opening.

19 tochondrial outer membrane and inhibited its opening.

20 s increase of stomatal complex length during opening.

21 d coating with surfactant closed the surface openings.

22 otrusions that expand tiny basement membrane openings.

23 yellowish keratin (42 [31.3%]), comedo-like openings (41 [30.5%]), and milia-like cysts (30 [22.4%])

24 ase control and treatment-related mortality, opening a doorway to understanding the powerful impact o

25 tric fields to stimulate deep brain regions, opening a frontier in the biophysics and technology of b

26 ient separation is the formation of Jupiter, opening a gap in the disk and preventing the exchange of

27 smoprotective emergency valve in bacteria by opening a large, water-filled pore in response to change

28 In addition to opening a new avenue for material characterization, the

29 species co-occurs with other cuckoo species, opening a new avenue for standardized citizen science on

30 e used to identify drug-target interactions, opening a new research direction in target identificatio

31 used for construction has been articulated, opening a path to a rich diversity of geometrically defi

32 input, addressing a fundamental question and opening a path to future therapies.

33 ery of MEMS functionality in fibres, thereby opening a path towards flexible, high-aspect ratio, and

34 hanced brain-to-plasma ratio relative to 14, opening a possible clinical path for the treatment of HA

35 NCs, leading to more complex patternings and opening a whole new set of possible applications.

36 a class of hybrid supramolecular composites, opening a window into fiber technology through low-energ

37 urthermore, the selective imidazolidine ring opening accompanied by CH2 extrusion yielded tetra-subst

38 ARTEMIS showing DNA-PKcs-independent hairpin opening activity.

39 The reversible ring-opening addition and fragmentation reaction of p-cresol-

40 l)benzene give access to functionalized ring-opening alkyne metathesis polymerization (ROAMP) initiat

41 tion results in increased retro-Bergman ring opening, allowing C(1)-C(5) cyclization to become a comp

42 occur in other van der Waals materials, thus opening an unexplored avenue toward efficient heat manag

43 e or complex, and shows the site of internal opening and associated complications; all in easy to und

44 rance, while another domain acts like a lid, opening and closing access to the hydrophobic tunnel, wh

45 By directly measuring KcsA's activation gate opening and closing in conditions that promote or halt C

46 processes under circadian control; stomatal opening and closing occurs under constant conditions, ev

47 hese wavelets are pneumatic pulses caused by opening and closing of respiratory valves during air rec

48 cleavage and ligation; however, the dynamic opening and closing of the DNA gate has been less explor

49 ion of the nucleotide binding domains drives opening and closing of the MacB periplasmic domains via

50 Fast opening and closing of voltage-gated sodium channels are

51 although these exhibit opposite coupling to opening and closing transitions.

52 ormational rearrangements during ion channel opening and closing.

53 TP-dependent mechanism that controls channel opening and closing.

54 in the opposite leaflet, resolution of pore opening and content release was lost.

55 flop isoform accelerates the rate of channel opening and desensitization for GluA1/2R channels more p

56 n-sulfur cluster cofactors in reductive ring opening and hydroxy-group elimination.

57 the permeation pathway changes upon channel opening and identify conformational changes throughout t

58 anhydride underwent selective anhydride ring opening and intersected an established precursor in the

59 ately 3 kcal/mol energy barrier to TM domain opening and the approximately 2 kcal/mol energy differen

60 Besides, bandgap closing followed by bandgap opening and the visible PL appearing at the point of the

61 uctural changes in mtRNAP to enable promoter opening and trapping of the DNA non-template strand.

62 a surface film, but vessel perforation plate openings and intervessel pits were filled with air.

63 esults suggest both vicariance (the Atlantic opening) and dispersal.

64 The mechanism of ion-pairing, ring-opening, and catalyst deactivation have been studied in

65 ic coupling between Na(+) release and inward-opening, and identifies diverse, yet well-defined roles

66 o microglial activation, blood-brain barrier opening, and later, myelin damage.

67 as photosynthesis, photoprotection, stomatal opening, and photoperiodic development, as well as molec

68 activation following T-type calcium channel opening, and resulted in the truncation of a regulatory

69 lginate staple-line reinforcement of fissure openings as compared with stapling alone, with or withou

70 erved to have both well-defined "square top" openings as well as fast current fluctuations, similar t

71 w examples able to undergo nucleophilic ring opening at a quaternary carbon with complete inversion o

72 pleted within 2 ms and occur without channel opening at low proton concentration, indicating that the

73 Visualization of the actin meshwork openings at the immunologic synapse revealed that the co

74 16-cell barrel-shaped structure surrounds an opening between epidermal cells that facilitates the exc

75 al coherence tomography (OCT) Bruch membrane opening (BMO) algorithm and stereoscopic optic disc phot

76 lantic heat transport across the Barents Sea Opening (BSO).

77 higher open probability due to more frequent opening bursts.

78 more deformable due to the softer interlayer opening but stiffens with decreased spacing and/or incre

79 I-driven respiration was reduced after mPTP opening but sustained in the presence of complex II-link

80 the NMDAR that is required for NMDAR channel opening, but which cannot mediate neurotransmission on i

81 ult of reconfiguration of the pore gate upon opening by a mechanism that is influenced by the S4-S5 l

82 It has been suggested that clamp opening by the clamp loader takes advantage of spontaneo

83 Asymmetric pigmented follicular openings by dermoscopy correlated with follicular locali

84 herein is an exceptional chemoselective ring-opening/C(sp(3) )-C(sp(3) ) bond formation in the copper

85 clamp loader takes advantage of spontaneous opening-closing fluctuations at the clamp's interface, b

86 lysis of MD trajectories and redox-dependent opening-closing structure variations are highlighted on

87 tensity is restricted by the relatively slow opening/closing of stomata, activation/deactivation of C

88 ng cell nuclear antigen (PCNA) clamp binding/opening/closure/release, ptDNA binding/release, and ATP

89 The ring-opening copolymerization of maleic anhydride and propyle

90 ed because the beta2 extension and headpiece opening could occur independently of the alphaI activati

91 In addition, imidazolidine ring opening coupled with SO2 extrusion provided syntheticall

92 ectivity (de, ee up to >99%) via domino ring opening cyclization (DROC) of activated aziridines with

93 A Bi(OTf)3-catalyzed ring-opening cyclization of (hetero)aryl cyclopropyl carbinol

94 Through these openings, cytoplasmic membrane material protrudes into t

95 mPTP opening decreases the mitochondrial membrane potential l

96 thylation in the absence of cyclopropyl ring opening, disfavoring mechanisms that involve unpaired el

97 Trabecular-iris angle (TIA), angle opening distance 500 mum from the scleral spur (AOD500),

98 It is required for opening DNA hairpins generated during antigen receptor g

99 ause they are initiated by L-type Ca channel openings during the action potential.

100 We find that the opening dynamics are dictated by the mechanical stress r

101 stabilised by CpG-rich ubiquitous chromatin opening elements (UCOEs).

102 e previously shown that PtDd are involved in opening epithelial junctions, thus facilitating lateral

103 ing the probability of L-Type Ca(2+) channel opening events.

104 We validate these predictions with stomatal opening experiments in selected Arabidopsis cell wall mu

105 We found that the channel opening extends from the pre-TM2 region through the oute

106 forded cyclopentene derivatives through ring opening followed by cyclization (vinylcyclopropane-cyclo

107 ere the aldol condensation, cyclopropyl ring opening followed by cyclization took place in a single-p

108 diene derivatives stereoselectively via ring opening followed by proton elimination.

109 the strongest ON responses shortly after eye-opening, followed by an increase in the strength of OFF

110 on logging operations do not create suitable openings for the regeneration of these species, whereas

111 e soft X-ray range with a laboratory source, opening, for example, the possibility of in-line or even

112 1,6-Anhydro ring opening gave suitable substrates for efficient synthesis

113 The resulting cyclopropanone ring openings gave unsaturated aldehydes.

114 complete reaction coordinate for ion channel opening have never been observed.

115 that G100V/C103V retards initial fusion-pore opening, hinders its expansion and leads to premature cl

116 ctions followed by fully regioselective ring opening/Hofmann rearrangement/nitrogen protection, in a

117 can pass directly through the endothelium by opening holes in endothelial cells, known as transcellul

118 , switching off and on the nucleophilic ring-opening in a controlled manner.

119 t changes and of circadian-mediated stomatal opening in constant light.

120 iPLA2gamma or lipoxygenases attenuated mPTP opening in failing hearts.

121 ibutes to coupling ligand binding to channel opening in human alpha7 nAChR.

122 ault at c. 0.5 mm yr(-1) tensile dislocation opening in the eastern Sevier Desert.

123 ding site of complex II (site IIf); (b) pore opening in the inner membrane resulting in rapid efflux

124 predicted to form in proximity to a band gap opening in the underlying band structure.

125 titative particle exclusion assays that show openings in the pericellular matrix microstructure rangi

126 In contrast, OXPHOS inhibition or PTP opening increased synthasome disassembly in WT, but not

127 Simultaneously, in 2012, daily record openings increased for involuntary commitment by 96.8% (

128 demonstrate that the mechanisms of pore gate-opening-induced and relaxation-induced voltage-sensor st

129 dducts were produced firstly by epoxide-ring opening initiated by the attack of one phenolic hydroxyl

130 opropyl carbinyl cations, which undergo ring opening, intramolecular trapping by the neighboring este

131 In other words, channel opening is a highly concerted, switch-like process.

132 Here, we show that the mechanism of F pocket opening is dictated by the charge of the first charged a

133 Following extension, headpiece opening is energetically favored.

134 rimer of gated beta-barrel channels in which opening is regulated by a helical plug connected to an e

135 P active site cleft suggests that RNAP clamp opening is required for Nun to establish its interaction

136 ted early puberty, observed as early vaginal opening, larger litters, and early reproductive senescen

137 hic activated forms with very different pore openings, markedly different gas-adsorption capacities a

138 r an iterative one-pot cross metathesis-ring-opening metathesis polymerization (CM-ROMP) strategy tha

139 The rate of living ring-opening metathesis polymerization (ROMP) of N-hexyl-exo-

140 ored architectures via grafting-through ring-opening metathesis polymerization (ROMP).

141 bution of grafts in polymers via living ring-opening metathesis polymerization (ROMP).

142 reat potential for novel surface patterning, opening new avenues for molecular level information stor

143 gut microbiota for brain-gut axis disorders, opening new avenues in the field of nutritional neuropsy

144 ncluding feedback-controlled drug delivery), opening new dimensions in personalized medicine.

145 r cancer have been released in recent years, opening new horizons in the treatment of patients with c

146 can be engineered to alter PAM recognition, opening new opportunities to develop CRISPR-based tools

147 kaloids enhance pollinator flower constancy, opening new perspectives in co-evolutionary process betw

148 nchronized in time for high tumor targeting, opening new possibilities to further improve the targeti

149 n via altering its charge distribution, thus opening new possible roles for betaS in Parkinson's and

150 n potassium channel and A1 receptor-mediated opening of a G-protein-coupled inwardly rectifying potas

151 Therefore, opening of a non-selective cation channel causes cell de

152 ermeable to osmolytes, proposedly due to the opening of a non-selective protein channel of unknown mo

153 Ring opening of a P-B-containing cyclobutene isostere provide

154 ctive desymmetrization catalysts in the ring opening of a variety of cyclic anhydrides.

155 doles via Lewis acid-catalyzed SN2-type ring opening of activated aziridines with indoles having subs

156 oincident with oxidative stress, precipitate opening of an inner mitochondrial membrane, high-conduct

157 The reactions involve a regiospecific ring opening of aziridines with benzimidazoles to give benzoi

158 ctive and challenging gold(I)-catalyzed ring-opening of cyclic 1,3-dioxolanes and dioxanes by trimeth

159 butadiene with ethylene, electrocyclic ring-opening of cyclobutene, electrocyclic ring-closing of Z-

160 se is dynamically regulated by the transient opening of different types of voltage-gated calcium chan

161 ient low-cost method for regioselective ring-opening of donor-acceptor cyclopropanes with the Zn-AcOH

162 As an example, it is applied to the opening of epoxides by titanocene in THF, a catalytic sy

163 Although derived specifically from the opening of epoxides, the prediction capabilities of the

164 has implications for the question of whether opening of FNIII domains contributes to the stretching o

165 junctional tensions of VECs to result in the opening of gaps before the initiation of leukocyte trans

166 structural changes occur in the ATP-induced opening of Hsp70 to allow substrate exchange.

167 stores via activation of phospholipase C and opening of inositol trisphosphate (InsP3) receptors.

168 rily through poration sites for fast ICWs or opening of mechanosensitive ion channels for slow ICWs,

169 lso demonstrated that metformin inhibits the opening of mPTP and induces mitochondrial biogenesis.

170 depletion of the endoplasmic reticulum with opening of plasma membrane calcium channels.

171 dily synthesized through a nucleophilic ring opening of spiro[cyclopropane-1,3'-oxindoles] with the a

172 d to their isolation and divergence; (1) the opening of the Atlantic Ocean, (2) the breakup of Gondwa

173 chable following the reversible ring closure/opening of the central dithienylethene via irradiation w

174 e eag domain and CNBHD, which stabilizes the opening of the channel.

175 Activation of the P2X7 receptor leads to opening of the characteristic dye-permeable membrane por

176 cific genes correlated with ploidy-dependent opening of the chromatin as well as, in a subset of test

177 etween imbibition of the mature dry seed and opening of the cotyledons, the final stage of seedling e

178 cular blood flow after ischaemia, despite re-opening of the culprit artery.

179 Opening of the cytoplasmic channel to cations in GtCCR2

180 to sound at very young ages, even before the opening of the ears.

181 MIDA boronate (24) comprise two steps: ring opening of the epoxide to a carbocation intermediate fol

182 ation can be explained by Lewis acid induced opening of the epoxy bridge with transfer of one alkyl g

183 t of the chromophores became more polar with opening of the external gates as the protein transitione

184 attern at the site of modification, a slight opening of the hm(5)rC-G pair compared to the unmodified

185 30 seconds of reperfusion immediately after opening of the infarct-related artery and before stent i

186 binding rotates cytoplasmic domains to favor opening of the inner helical gate.

187 Comparison of MD trajectories show that opening of the intracellular gate causes a structural ch

188 um ylide to metal-free azirinium ylide, ring-opening of the latter to give a 1,5-diazahexa-1,3,5-trie

189 plasmic domains that subsequently drives the opening of the luminal gate, and thereclosing of luminal

190 stically, HETEs activated the Ca(2+)-induced opening of the mPTP in failing human myocardium, and the

191 in-protein interactions that begins with the opening of the N-terminal domain of cTnC, followed by cT

192 in the disassembly of adherens junctions and opening of the paracellular pathways.

193 The opening of the proton channel involves association of th

194 three cycloadditions and electrocyclic ring opening of the strained Dewar anthracene.

195 Here we show that opening of the Strait involved at least two major episod

196 to the polymer, as well as in the subsequent opening of the sulfamate ring once it has been installed

197 used by the CH2-localized mutation is due to opening of the two CH domains.

198 The opening of TRPML1 is associated with distinct dilations

199 Thermal ring openings of the cyclobutenes give (Z,Z)-1,3-diene produc

200 of principle, we predict and measure the gap opening on the magnesium-based surface band up to a crit

201 ed folds, and behind them up to four conical openings on either side of the body as well as possible

202 logous dCas9 or Cpf1 effector proteins, thus opening options for multidimensional control of function

203 However, "swing effect" or "gate opening" phenomena resulting in an enlargement of the wi

204 n can be regulated and switched between ring-opening polymerization (ROP) of BBL and CHO/CO2 copolyme

205 Radical ring-opening polymerization (rROP) combines the advantages of

206 (rROP) combines the advantages of both ring-opening polymerization and radical polymerization, that

207 ethylene carbonate, was synthesized by ring-opening polymerization of ethylene carbonate.

208 ced commercially by the metal-catalyzed ring-opening polymerization of lactide.

209 ously fast and selective for the living ring-opening polymerization of several common monomers, inclu

210 synthetic cascades of ROAMP followed by ring-opening polymerization of strained epsilon-caprolactone.

211 Our six-membered cyclic phosphoester ring-opening polymerization strategy is demonstrated, herein,

212 rained 3',5'-cyclic monomer can promote ring-opening polymerization to afford the resulting poly(3',5

213 hieved via a regio- and stereoselective ring opening polymerization to generate multiple glycosidic b

214 polyoxazoline chain is grafted through ring opening polymerization, possess homogeneous spherical na

215 initiation sites by the living anionic ring opening polymerization.

216 s to calculate both the size of the vascular opening (pore) with solute permeability values.

217 atistics of spatial molecular configurations-opening possibilities for a robust dimension and model r

218 re, the effect persists at room temperature, opening possibilities for practical valleytronic devices

219 e switching is involved in IPF pathogenesis, opening potential therapeutic avenues to treat patients.

220 mistry, a novel C-N bond activation and ring-opening process is described for these increasingly impo

221 s triggering allergens released by S aureus, opening prospects for diagnosis and causal therapy of as

222 ng a Michael addition-6pi-electrocyclic ring opening-proton transfer and 6pi electrocyclization, in w

223 mide is unprotected, the characteristic ring-opening reaction is completely silenced, which explains

224 deeper understanding of the reversible ring-opening reaction mechanism of 1,3-benzoxazine with thiol

225 cules stochastically generated from the ring-opening reaction of a spiropyran, we provide mechanistic

226 The ring-opening reaction of trans-2-aroyl-3-styrylcyclopropane-1

227 bond breaking or bond formation, namely ring-opening reactions and cis-trans isomerizations, respecti

228 elevance of the protonation step in the ring-opening reactions of 1,3-benzoxazines with thiols in abs

229 which explains that the majority of the ring-opening reactions reported in the literature invoke N-al

230 s responsible for modulating myocardial mPTP opening remain unclear.

231 short-lived channel closures during channel openings represent subtle changes in the structure of CF

232 on conductance and may prevent the gate from opening, representing an alternative view for how these

233 excitable tissues, with their activation and opening resulting in the initial phase of the action pot

234 e of the methylene aziridine promotes a ring-opening/ring-closing cascade that efficiently transfers

235 ing metathesis/base-induced eliminative ring opening sequence was used.

236 ication of nanoparticle-based drug delivery, opening several exciting avenues for selective and prolo

237 Measuring the opening shape of the epidermal actin cortex after laser

238 indicating that the agonist promotes channel opening similar to that of volume-dependent activation.

239 coupling between gates, preventing them from opening simultaneously.

240 Here, the mechanism of the initial clamp opening stage is investigated.

241 ave followed using an original in-situ crack opening technique.

242 Stomata are microscopic openings that allow for the exchange of gases between pl

243 ome evolution was the development of lateral openings that subsequently were co-opted as pharyngeal g

244 ins are targetable by dietary interventions, opening the avenue to a precision intervention for patie

245 ne residue carrying out nucleophilic attack, opening the cyanuric acid ring, and the mobile lysine gu

246 DNA enantiomers via an achiral intermediary, opening the door for "heterochiral" DNA nanotechnology h

247 y is possible in other chalcogenide spinels, opening the door for the realization of other magnesium

248 mage the temporal retinal nerve fiber layer, opening the door next for testing of the high dose.

249 observation of Bi-B double and triple bonds, opening the door to design main-group metal-boron comple

250 ul for studying fundamental spin behaviours, opening the door to exploring new applications such as u

251 odel that generates mature human astrocytes, opening the door to future studies of their function.

252 actual diploid genome sequence in a sample, opening the door to new approaches in genomic biology an

253 ancing a number of existing applications and opening the door to new developments.

254 gahertz response of metallic nanostructures, opening the door to new optomechanical device strategies

255 ds for solar cells and photodetectors, while opening the door to new possibilities in ionizing-radiat

256 timulates a depolarizing chloride current by opening the olfactory Ca(2+)-activated chloride channel

257 , the VSD-pore coupling has less efficacy in opening the pore, producing inactivation.

258 ins similar antigenicity to wild-type virus, opening the possibility for its use as a live-attenuated

259 ghly conserved in vertebrate CSL homologues, opening the possibility of a general and novel mechanism

260 rmoelectrically cooled temperatures, thereby opening the possibility of polarisation-based quantum do

261 human biomonitoring at the community scale, opening the possibility to assess population-wide exposu

262 led by more general phenotype-based screens, opening the possibility to identify a wide range of smal

263 nct residues, like multiple keys (receptors) opening the same lock (G protein) using non-identical cu

264 stic detail is possible through backmapping, opening the way for improved quantum mechanical calculat

265 Understanding these processes is opening the way to better treatment based on disrupting

266 influences the rate of the uncaging process, opening the way to exploiting these new coumarin scaffol

267 veral orthogonal split intein pairs, thereby opening the way to the creation of multiplexed sensor sy

268 showed that an agent that promotes chromatin opening, the histone deacetylase inhibitor (HDACi) AR-42

269 as been shown to promote CNG and HCN channel opening, the precise mechanism underlying gating remains

270 inolines involves, besides the triazole ring opening, the unusual migration of the cyano group.

271 understand better the regulation of channel openings, the dysfunction of CFTR in CF and the action o

272 t VECs facilitate paracellular diapedesis by opening their cell-cell junctions in response to the pre

273 Modulation of flap opening through protease-Gag interactions fine-tunes the

274 MscL opening times were found to increase with the addition o

275 pursuit of prey during the period from mouth opening to closing, and although they need thrust force

276 ven shape changes required for stomatal pore opening to occur [1-4].

277 evolved into an electrophilic acyl azolium, opening to the aldehyde-to-ester conversion.

278 e primary products underwent a triazole ring opening under the basic arylation conditions, providing

279 ccompanied by a reduction in activation-gate opening, underscoring the important role of the surround

280 peak twisting and untwisting at mitral valve opening (%untwMVO) using speckle-tracking echocardiograp

281 the near-zero magnetocrystalline anisotropy, opening up a large spin-wave excitation gap.

282 In addition to opening up in meso crystallization to a broader range of

283 in supporting or limiting virus replication, opening up new avenues for antiviral research.IMPORTANCE

284 dynamics of atomically thin materials, thus opening up new avenues for realizing active metasurfaces

285 nd stability in Japanese encephalitis virus, opening up new avenues for therapeutic interventions aga

286 increase of Ca(2+) affinity in site II, thus opening up new insights into the HCM phenotype.

287 ble gas atoms using surface science methods, opening up new opportunities for fundamental research.

288 Single-crystal measurements reveal opening up of the hysteresis loop for {CrTb6 } and {CrHo

289 smon-polaritons were predicted and observed, opening up opportunities for optoelectronics, bio-sensin

290 ct of the illusion of owning a child's body, opening up possibilities for health applications.

291 of photonic operators akin to that of FPGA, opening up possibilities where photonic elements can be

292 complex biosynthesis of multicellular fungi, opening up the possibility of using yeast to accelerate

293 By opening up this discussion, we hope to stimulate future

294 ed to be linked with partial degradation and opening-up of cell wall networks.

295 stmitotic mouse cones, between birth and eye opening, using serial block-face electron microscopy (EM

296 of kiri-kirgami, and their actuation of pore opening via both mechanical stretching and temperature,

297 The channels synchronize their openings via Ca-induced Ca release, generating high-ampl

298 circadian-mediated anticipation in stomatal opening, we have generated SGC (specifically guard cell)

299 nctional consequences of Ca(2+)-induced mPTP opening were assessed by Ca(2+) retention capacity, usin

300 terventional procedure consisting of fissure opening with linear cutting staplers buttressed with pai