ライフサイエンスコーパス: opening and closing of

1 w this instrument can be used to monitor the opening and closing of a DNA hairpin on millisecond time

2 us measurements of extension and FRET during opening and closing of a DNA hairpin under tension, and

3 that display events correspond to the rapid opening and closing of a fusion pore (or "kiss-and-run")

4 he argument that transport via LacY involves opening and closing of a large periplasmic cavity.

5 c structural fluctuations represented by the opening and closing of a non-canonical base-pair region.

6 park, those events that determine the sudden opening and closing of a small number of ryanodine recep

7 uggest an "all-or-nothing" mechanism for the opening and closing of AdK.

8 lk between the bound ligands to modulate the opening and closing of AnmK.

9 e ATP/ADP ratio, which can cause alternating opening and closing of ATP-sensitive K+ channels, leadin

10 elta'chipsi) clamp loader couples ATP to the opening and closing of beta in assembly of the ring onto

11 cell oxygenation can change rapidly with the opening and closing of blood vessels, leading to the act

12 ion is the prototype of nonslaved processes; opening and closing of channels are quintessential slave

13 to either side of the membrane by reciprocal opening and closing of cytoplasmic and periplasmic cavit

14 xposed to either side of the membrane due to opening and closing of cytoplasmic and periplasmic hydro

15 ch uses an alternating access mechanism with opening and closing of deep cavities on the periplasmic

16 adaptation modulator kinetics determine the opening and closing of each channel independently.

17 Because during transport the opening and closing of external and internal gates shoul

18 The results demonstrate the opening and closing of external gates in real time, with

19 ace-immobilized complexes to observe fingers-opening and closing of individual polymerase molecules i

20 ly exposed to either side of the membrane by opening and closing of inward- and outward-facing caviti

21 to either side of the membrane by sequential opening and closing of inward- and outward-facing hydrop

22 enzyme turnover by means of fluorescence and opening and closing of ion channel through the flux of i

23 dependent porin, FepA, ostensibly reveal the opening and closing of its channel during ligand uptake,

24 emical signaling in the brain involves rapid opening and closing of ligand gated ion channels (LGICs)

25 uch as the folding of globular proteins, the opening and closing of ligand-gated ion channels, and li

26 The opening and closing of loops on single DNA molecules can

27 The overall process is orchestrated by the opening and closing of molecular "gates" in the topoisom

28 Rapid opening and closing of pentameric ligand-gated ion chann

29 uch effect, and sugar binding induces normal opening and closing of periplasmic and cytoplasmic cavit

30 e self-activated pore membrane that achieves opening and closing of pores.

31 hese wavelets are pneumatic pulses caused by opening and closing of respiratory valves during air rec

32 tive fluorescent dyes to localize stochastic openings and closings of single Ca2+-permeable channels

33 um oscillations are caused by the stochastic opening and closing of small numbers of [Formula: see te

34 c intermediates in CcO are orchestrated with opening and closing of specific proton pathways, providi

35 Like most movements occurring in plants, the opening and closing of stomata are based on hydraulic fo

36 The rhythmic opening and closing of stomata confers a rhythm in sensi

37 cid (ABA) decreases water loss by regulating opening and closing of stomata.

38 The reversible opening and closing of the "gate" of the host is control

39 y be directly responsible for the reciprocal opening and closing of the actin and nucleotide-binding

40 Additionally, an investigation of the opening and closing of the actin nucleotide binding clef

41 he GTP-binding site provide snapshots of the opening and closing of the active site cleft through a s

42 both segments that flank the core; (ii) the opening and closing of the active site cleft, including

43 ion associated with domain rotation, and the opening and closing of the active-site cleft.

44 to communicate to Linker 2, resulting in the opening and closing of the alpha-helical domain and the

45 e object, the "transport" component, and the opening and closing of the aperture between the fingers

46 he binding site and the barrier to ions, and opening and closing of the barrier.

47 of the side chain of Arg38 appear to mediate opening and closing of the buried water channel.

48 ation system and the mechanics that regulate opening and closing of the capsid fivefold portals have

49 us photophysical studies that showed partial opening and closing of the capsule in the time range of

50 It is proposed that the opening and closing of the carrier may be coupled to the

51 Opening and closing of the catalytic chain domains expla

52 The first motion describes an opening and closing of the catalytic cleft located betwe

53 322, and Tyr236 act in concert to coordinate opening and closing of the cavities by binding water, wh

54 We propose that such temporary opening and closing of the cavities may occur in all bac

55 ic reticulum-facing loops with a role in the opening and closing of the cavity.

56 Opening and closing of the central ion-conducting pore i

57 on intact CFTR molecules, we directly follow opening and closing of the channel gates, and relate the

58 e conformational changes associated with the opening and closing of the channel pore.

59 pore and cytosolic domains that control the opening and closing of the channel.

60 ing conformation, which in turn leads to the opening and closing of the channel.

61 rt of the gating current associated with the opening and closing of the channel.

62 This coupling induces cooperative opening and closing of the channels.

63 The random opening and closing of the circuit represents, in fact,

64 ulator (NBD1 and NBD2) mediate ATP-dependent opening and closing of the Cl- channel pore.

65 E1 slows the movement of S4 segments, slows opening and closing of the conduction pore, or modifies

66 hat it works with the W-finger to coordinate opening and closing of the corridor through which the 3'

67 Opening and closing of the cystic fibrosis transmembrane

68 Opening and closing of the cystic fibrosis transmembrane

69 A molecular dynamics study of the opening and closing of the Ddl lid loop informs future s

70 cleavage and ligation; however, the dynamic opening and closing of the DNA gate has been less explor

71 The opening and closing of the DNA gate, a critical step for

72 The opening and closing of the DNA gate, a critical step for

73 l conformation change involving a reversible opening and closing of the entrance to the substrate-bin

74 is about 2-4 s(-1) and is attributed to the opening and closing of the enzyme loop over the bound me

75 o the binding pocket and plays a role in the opening and closing of the extracellular transporter gat

76 We show that the opening and closing of the gate are very fast, and diffu

77 tation of five aromatic rings leads to rapid opening and closing of the gate to the active site.

78 tions, complete analyses of the mechanism of opening and closing of the gate, the rate of collision o

79 energy transfer was used to investigate the opening and closing of the gp45 ring during holoenzyme a

80 onance energy transfer, we have investigated opening and closing of the gp45 ring during the holoenzy

81 inus, which is associated with regulation of opening and closing of the intracellular gate.

82 rucial for conformational transitions during opening and closing of the ion channel and represents a

83 on channel activity by measuring the dynamic opening and closing of the ion channel nanopores using s

84 The opening and closing of the ion conduction pathway in ion

85 sing in bacteria both rely on the controlled opening and closing of the ion-conducting pore in pentam

86 etween ligand and receptor (binding) and the opening and closing of the ligand-bound channel (gating)

87 for unligated samples, consistent with full opening and closing of the loop at a rate of order 10(4)

88 ing the residues of loop 6 is the correlated opening and closing of the loop.

89 ion of the nucleotide binding domains drives opening and closing of the MacB periplasmic domains via

90 in different functional states suggests that opening and closing of the main tunnel are dynamic featu

91 pport the structure-based model in which the opening and closing of the mechanosensor region regulate

92 veral decades of literature illustrating the opening and closing of the monovalent cation selective g

93 pyrrhocoricin binding prevents the frequent opening and closing of the multihelical lid over the pep

94 erved as a control to monitor Ca(2+)-induced opening and closing of the N-domain by Forster resonance

95 eling EPR spectroscopy was used to study the opening and closing of the nucleotide-binding interface

96 mational ensembles that explain the pH-gated opening and closing of the OmpG channel.

97 Opening and closing of the pore have been linked to ATP

98 molecular dynamics simulations, we study the opening and closing of the pore in Gloeobacter violaceus

99 he voltage sensor, little is known about how opening and closing of the pore is accomplished.

100 Opening and closing of the pore of voltage-gated ion cha

101 w affects the coupling of charge movement to opening and closing of the pore.

102 P hydrolysis cause a striking butterfly-like opening and closing of the RAD50 subunits, and each stru

103 NAP "switch region"--the hinge that mediates opening and closing of the RNAP active center cleft--to

104 oscillations of [Ca(2+)](SR) due to periodic opening and closing of the RyR2s.

105 central domain and is thought to control the opening and closing of the S6 helix bundle.

106 complex might be involved in regulating the opening and closing of the secretion pore and/or transdu

107 mplex that is required to either control the opening and closing of the secretion pore or to transduc

108 re we report that the N terminus impacts the opening and closing of the Top1 protein clamp.

109 We demonstrate here that the opening and closing of the transduction channels produce

110 nditure by the bird is required to drive the opening and closing of the trap.

111 rovides a structural flexibility that allows opening and closing of the two arms.

112 The opening and closing of the vertebrate CLC channels are a

113 Opening and closing of the vestibule might regulate acce

114 The associated openings and closings of the IP3-sensitive Ca2+ release

115 rizations were caused by repeated stochastic openings and closings of the transition pore.

116 The reciprocal opening and closing of these cavities is synchronized by

117 The random opening and closing of these channels introduces stochas

118 The opening and closing of these gates provide controlled ac

119 Opening and closing of these Kv channels (gating) occurs

120 membrane may be crucial for controlling the opening and closing of this beta-barrel, outer membrane

121 constant (kex) of 9000 s-1, consistent with opening and closing of this loop being partially rate-li

122 The timescale of the opening and closing of this loop has been measured, at t

123 passage mechanism that requires coordinated opening and closing of three protein interfaces, the N-,

124 as the adaptation motor, which regulates the opening and closing of transduction channels.

125 rmine changes that occur in the mechanism of opening and closing of transmembrane channels formed by

126 The transient opening and closing of tumor vasculature result in perio

127 The opening and closing of voltage-activated Na+, Ca2+ and K

128 The opening and closing of voltage-gated potassium (Kv) chan

129 Fast opening and closing of voltage-gated sodium channels are