ライフサイエンスコーパス: opening of

1 A domain opening of 13-14 degrees was seen compared to the struct

2 which is initiated via isobenzofuranone ring opening of 2 in a Michael-type reaction.

3 s of 2-alkyl indoles via regioselective ring-opening of 2-(2-haloaryl)-3-alkyl-N-tosylaziridines with

4 rt the tandem base-promoted elimination/ring-opening of 2-benzyl-1,3-dithianes with subsequent cross

5 intramolecular cyclization/carbohydrate-ring opening of 2-haloenones with 1,3-dicarbonyl compounds or

6 poly(dimethylsiloxane), PDMS, gasket with an opening of 3.2 cm x 1.5 cm on the chip, and a glass slid

7 Contrary to the G2 case, however, the ring-opening of 3MCOE by MAP catalysts prefers a proximal (3-

8 eration of 2-amidoallyl cations through ring-opening of 4-benzylidene-2-oxazolines with Sc(OTf)3.

9 has a moderate Tc of 20 K with a smaller gap opening of 4.2 meV.

10 Oxidative cyclopropane ring-opening of 5-substituted 3-azabicyclo[3.1.0]hex-2-enes w

11 LiNH2BH3-promoted reductive opening of 8-substituted phenylglycinol-derived oxazolop

12 of the two lobes around a central pivot and opening of a "lid" region that facilitates substrate rec

13 ) topological insulators (TIs), and thus the opening of a 'Dirac-mass gap' in the linearly dispersed

14 on 4 of heptose followed by a regioselective opening of a 6,7-O-(1,1,3,3-tetraisopropyl-1,3-disiloxan

15 used to induce the disrotatory outward ring opening of a cis-dialkyl substituted syn-chloro-gem-chlo

16 hin the Munc18-1 domain 3a helix 12 leads to opening of a closed Munc18-1:syntaxin complex, followed

17 pi*-band Fermi surface, we then observe the opening of a Delta approximately 0.9-meV temperature-dep

18 n potassium channel and A1 receptor-mediated opening of a G-protein-coupled inwardly rectifying potas

19 ease in carrier mobility, accompanied by the opening of a gap in the optical conductivity.

20 t the entrance of the cytoplasmic funnel and opening of a hydrophobic gate at the end of the funnel.

21 id inhibitory modulation of swimming via the opening of a K(+) channel.

22 hought to be controlled by the Chi-dependent opening of a molecular latch, which enables part of the

23 famous Donora Zinc Works yet record both the opening of a nearby coal-fired power plant and amendment

24 Therefore, opening of a non-selective cation channel causes cell de

25 ermeable to osmolytes, proposedly due to the opening of a non-selective protein channel of unknown mo

26 The opening of a nonspecific channel, known as the permeabil

27 ansition in human mitochondria refers to the opening of a nonspecific channel, known as the permeabil

28 Ring opening of a P-B-containing cyclobutene isostere provide

29 tation of a new triage system at KGH and the opening of a second ETU within the district.

30 Our results indicate the opening of a superconducting gap in the pi* band and rev

31 adical generated from Ti (III) mediated ring opening of a terminal epoxy ring tethered to a butenolid

32 of presynaptically released glutamate to the opening of a transmembrane cation channel.

33 ctive desymmetrization catalysts in the ring opening of a variety of cyclic anhydrides.

34 izable appendages has been developed by ring-opening of activated aziridines with 2-hydroxyphenyl acr

35 doles via Lewis acid-catalyzed SN2-type ring opening of activated aziridines with indoles having subs

36 cellular membrane requires the simultaneous opening of activation and inactivation gates of the K(+)

37 oducts formed with 100% selectivity for ring opening of all reactants catalyzed by the Rh NP.

38 d = 2.4 nm) is unable to enter the vestibule opening of alphaHL on the cis side, leading to unzipping

39 Asn-85 has a proposed role in regulating the opening of an active site channel.

40 lasticity; pubertal hormones may trigger the opening of an adolescent critical period for experience-

41 osphine oxide diastereomers accessed by ring-opening of an amino alcohol-derived cyclic sulfamidate.

42 transcription factor IIH involved the rapid opening of an extended transcription bubble, averaging 8

43 oincident with oxidative stress, precipitate opening of an inner mitochondrial membrane, high-conduct

44 annel, conduction is believed to result from opening of an intracellular constriction that prevents i

45 he presence of microH+, the limiting step is opening of apo LacY on the other side of the membrane; (

46 th the bilayer at acidic pH, followed by the opening of APOL1-induced cation-selective channels upon

47 Results BBB openings of approximately 1 cm(3) in volume were visuali

48 mplemented a method to control optically the opening of ASIC1a in brain slices and also in awake anim

49 ives have also been synthesized via the ring-opening of aziridines with 2-bromobenzyl alcohols and -m

50 The reactions involve a regiospecific ring opening of aziridines with benzimidazoles to give benzoi

51 , we hypothesized that taurine-driven E-ring opening of bacteriochlorophyll derivatives and net-charg

52 ting the symmetry forbidden disrotatory ring opening of benzocyclobutene (BCB).

53 Opening of BLINK1 channels hyperpolarizes the cell to th

54 ular, a single application of CIM0216 causes opening of both the central calcium-conducting pore and

55 is process is spatially organized, such that opening of Ca(2+) -channels allows rapid translation of

56 temporal Ca cycling incorporating stochastic openings of Ca channels and ryanodine receptors to inves

57 that ERK1/2-MAPK cascade is regulated by the opening of CALHM1 Ca(2+) channel in TBCs to modulate oro

58 Patch clamp recordings revealed facilitated opening of Cav1.2 channels containing these mutations, w

59 an fetal lung development via cAMP-dependent opening of CFTR.

60 oiling tendrils, spasmoneme springs, and the opening of chiral seedpods.

61 The copper-catalyzed ring opening of chiral-pool-derived 1,1'-diBoc-2,2'-biaziridi

62 egulatory events, often leading to the local opening of chromatin.

63 cient method for complete regioselective 5-O-opening of conformationally restricted 3,5-O-di-tert-but

64 tion process, and it is now established that opening of CRAC channels is governed through direct inte

65 ctive and challenging gold(I)-catalyzed ring-opening of cyclic 1,3-dioxolanes and dioxanes by trimeth

66 l cyclase III activation, cAMP increase, and opening of cyclic nucleotide-gated channels.

67 y a cAMP-signaling cascade that leads to the opening of cyclic-nucleotide-gated (CNG), nonselective c

68 butadiene with ethylene, electrocyclic ring-opening of cyclobutene, electrocyclic ring-closing of Z-

69 The ring-opening of cyclopropane-1,1-dicarboxylates with vicinal

70 and-directed beta-C-H arylation and the ring opening of cyclopropanecarboxamides is proposed based on

71 3) C-H activation/arylation followed by ring opening of cyclopropanecarboxamides, which were assemble

72 strated through the catalytic oxidative ring-opening of cyclopropanes for the synthesis of 1,3-fluoro

73 ted in mesoporous silica, catalyzed the ring opening of cyclopropylbenzene at room temperature under

74 se is dynamically regulated by the transient opening of different types of voltage-gated calcium chan

75 from the outer Solar System, possibly by the opening of disk gaps from the early formation of gas gia

76 een DNA and platinum-based drugs hinders the opening of DNA, and therefore, DNA duplication and trans

77 ient low-cost method for regioselective ring-opening of donor-acceptor cyclopropanes with the Zn-AcOH

78 t re-winding activity that is coupled to the opening of dsDNA.

79 indoles has been developed via SN2-type ring opening of enantiopure N-activated aziridines with 2-bro

80 a phospholipase C gamma (PLCgamma)-mediated opening of EnR IP3R calcium channels, enabling passage o

81 Ad3 binding to DSG2 triggers the transient opening of epithelial junctions.

82 In addition, ring-opening of epoxide by an intermediate comprising multipl

83 As an example, it is applied to the opening of epoxides by titanocene in THF, a catalytic sy

84 Although derived specifically from the opening of epoxides, the prediction capabilities of the

85 has implications for the question of whether opening of FNIII domains contributes to the stretching o

86 junctional tensions of VECs to result in the opening of gaps before the initiation of leukocyte trans

87 est and the nonscissile mechanochemical ring opening of gem-dichlorocyclopropane mechanophores and (i

88 imulation or stress weakens PFC function via opening of HCN channels at network synapses.

89 -dependence of Ih activation that causes the opening of HCN channels at rest, thereby increasing VSN

90 ctivation significantly reduced FFSS-induced opening of hemichannels and disrupted the interaction be

91 Consistently, the opening of hemichannels by FFSS was blocked by PGE2 and

92 esults in hemichannel closure, as continuous opening of hemichannels is detrimental to cell viability

93 structural changes occur in the ATP-induced opening of Hsp70 to allow substrate exchange.

94 were synthesized by stereocontrolled epoxide opening of hydroxyl protected forms of the cyclohexane e

95 from the general mechanism of oxidative ring openings of imidazoles, likely affecting the bioactivity

96 following incubation with alpha-Btx, monitor opening of individual receptor channels with defined sub

97 which affords lactams following nucleophilic opening of initially formed iminium ether more efficient

98 stores via activation of phospholipase C and opening of inositol trisphosphate (InsP3) receptors.

99 ulation cascade (SDAC) strategy involving an opening of isatoic anhydride and annulation to benzimida

100 ble mechanism by which OprM is activated via opening of its periplasmic aperture through a concerted

101 thern Ocean that was enabled by the tectonic opening of key oceanic gateways during the break-up of G

102 The opening of Kv3.4 channels effectively reduces growth con

103 we observe robust exocytosis elicited by the opening of L-type Ca(2+) channels located on the lobular

104 iator/chain end to effect the selective ring-opening of lactones and carbonates.

105 tion of chromatin accessibility revealed the opening of large numbers of distal regulatory elements a

106 structures in endothelial cells promote the opening of large-scale apertures, thereby breaching the

107 nspiration and closely followed the stomatal opening of leaves receiving direct light, which represen

108 also observed in the Z form during the ring opening of leflunomide.

109 us emerges as a key messenger to trigger the opening of light-dependent channels in melanopsin-expres

110 The flow-induced opening of lipid membranes can be exploited to deliver d

111 shown that ATP promotes closure of MalK2 and opening of MalFG toward the periplasm.

112 se cells into electrical signals through the opening of mechanically gated ion channels at the tips o

113 rily through poration sites for fast ICWs or opening of mechanosensitive ion channels for slow ICWs,

114 ransfer catalysis: the enantioselective ring-opening of meso-aziridinium and episulfonium cations pro

115 Conversely, opening of mitochondrial high-conductance and long-lasti

116 ochondrial respiration and in preventing the opening of mitochondrial permeability transition pore in

117 ction with cyclophilin D, and sensitized the opening of mitochondrial permeability transition pore.

118 lso demonstrated that metformin inhibits the opening of mPTP and induces mitochondrial biogenesis.

119 icular action potential requires synchronous opening of multiple CaV1.2 channels.

120 -cTnC and cTnI stabilizes the Ca(2+)-induced opening of N-cTnC and is presumed to also destabilize cT

121 bound to RNA, both K18E and K20E induced the opening of new pockets in the template channel where the

122 Aberrant opening of nonjunctional connexin hemichannels at the pl

123 The stereospecific ring-opening of O-heterocycles to provide acyclic alcohols an

124 he nucleosome are orchestrated such that the opening of one end helps to stabilize the other end, pro

125 The opening of osteocytic Cx43 hemichannels by mechanical st

126 e that HIV infection results in the extended opening of Panx1 channels (5-60 min), allowing for the s

127 Our results indicate that opening of Panx1 channels in response to chemokines is r

128 ploited, for the first time, to trigger ring-opening of photochromic diarylbenzo-/naphthopyrans into

129 dence that CIP oxidation proceeds through an opening of piperazine ring via N-dealkylation.

130 depletion of the endoplasmic reticulum with opening of plasma membrane calcium channels.

131 e of ATP and activation of P2X7Rs to trigger opening of Px1 HCs, which release further ATP.

132 The opening of single TRPV1 channels produced sparklets, rep

133 vely-charged Glu did not induce constitutive opening of Slo2.1 or Slo2.2, suggesting that ion permeat

134 n of sodium channels, resulting in prolonged opening of sodium channels.

135 ion of fluorescing aromatics resulted in the opening of some aromatic rings.

136 increased micropore volume results from the opening of some of the small (sodalite) cages, otherwise

137 dily synthesized through a nucleophilic ring opening of spiro[cyclopropane-1,3'-oxindoles] with the a

138 in intracellular Ca(2+) that accompanies the opening of store-operated Orai1/CRAC channels.

139 catalysis (regioselective methanolysis ring-opening of styrene oxide), oxidative cyclization catalys

140 Adk is rate-limited by slow opening of substrate binding domains and the urea-depend

141 f this process involves a base-mediated ring opening of the 3-aroylbenzofurans and subsequent Michael

142 noside, obtained by regioselective reductive opening of the acetal ring in the parent 4(I),6(I)-O-ben

143 eds via a Lewis acid catalyzed SN2-type ring-opening of the activated aziridine followed by a concomi

144 ments of the voltage sensor that precede the opening of the activation gate.

145 sor conformational changes to the subsequent opening of the activation gate.

146 translocation is not strongly coupled to the opening of the active site following catalysis.

147 eric conformational change that leads to the opening of the active site.

148 A deaminase activity, likely by facilitating opening of the active site.

149 Opening of the anion permeation path in this iChS is con

150 d to their isolation and divergence; (1) the opening of the Atlantic Ocean, (2) the breakup of Gondwa

151 substep, our simulations show no significant opening of the ATP-bound beta subunit; instead, we obser

152 the influence of N-substituents on the ring opening of the aziridinium intermediate indicated differ

153 Pericyte pathology causes opening of the BBB and microvascular dysfunction.

154 anges in PlyB are a approximately 70 degrees opening of the bent and distorted central beta-sheet of

155 Debromoacetylation followed by reductive opening of the benzylidene acetal afforded the disacchar

156 Partial opening of the beta-propeller structure due to thermal r

157 Known early events include opening of the blood-brain barrier (BBB) and astrocytosi

158 s studies suggest that this process involves opening of the blood-brain barrier in capillaries at the

159 Construction of the five Cu(I) sites at the opening of the bundle lags behind the main core, and the

160 mbrane (PM) junctions where STIM1 stimulated opening of the Ca(2+)channel, Orai1.

161 age-gated calcium channel directly activates opening of the calcium release channel (RyR1) in the sar

162 ascade was activated by Ca(2+) signaling via opening of the calcium-homeostasis modulator-1 (CALHM1)

163 displayed significance in terms of the outer opening of the cavity and protein flexibility.

164 C exporters that only requires the transient opening of the cavity for release of the peptide.

165 The latter is related to the opening of the cavity of the macrocycle at lower tempera

166 TcSKR1 contained a larger outer opening of the cavity than that in TcSKR2, which allows

167 th the RuvbL1 barrel-like structure near the opening of the central channel.

168 chable following the reversible ring closure/opening of the central dithienylethene via irradiation w

169 cannot reach the amplitude required for the opening of the channel because they are impeded by inter

170 tion of KCNE1 with KCNQ1 dramatically delays opening of the channel but the mechanisms by which this

171 rast to cation-conducting channelrhodopsins, opening of the channel occurs prior to deprotonation of

172 changing membrane properties, leading to an opening of the channel.

173 ical displacement of the cytoskeleton to the opening of the channel.

174 e eag domain and CNBHD, which stabilizes the opening of the channel.

175 Activation of the P2X7 receptor leads to opening of the characteristic dye-permeable membrane por

176 , linear tetrapyrroles that are derived from opening of the chlorin macrocycle by the Rieske-type oxy

177 cific genes correlated with ploidy-dependent opening of the chromatin as well as, in a subset of test

178 ther MutSalpha or MutSbeta and a more likely opening of the clamp domains when noncognate substrates

179 tion may help capture substrate, whereas the opening of the cleft upon transient dephosphorylation al

180 driven by Arf1 in live cells and found that opening of the complex is prerequisite for oligomerizati

181 formational change, which we attribute to an opening of the conformation resulting in monomeric prote

182 situ ring-expansion (via intramolecular ring-opening of the corresponding aziridinium intermediates w

183 Following the opening of the corridor, multiple dispersals of human gr

184 etween imbibition of the mature dry seed and opening of the cotyledons, the final stage of seedling e

185 n of GAD67 expression rescued the precocious opening of the critical period, suggesting its major rol

186 cular blood flow after ischaemia, despite re-opening of the culprit artery.

187 bridges of model peptides, resulting in the opening of the cyclic structures, (ii) to separate the g

188 tution on the alkene moiety, subsequent ring-opening of the cyclopropane affords either cyclopentane

189 of cGMP-dependent protein kinase (PKG), and opening of the cystic fibrosis transmembrane conductance

190 Opening of the cytoplasmic channel to cations in GtCCR2

191 Previously, we showed the ATP-induced opening of the cytoplasmic gate I in TM5 helices, later

192 Both situations lead to a partial opening of the D4Z4 chromatin structure and transcriptio

193 topological surface states and controllable opening of the Dirac gap are of fundamental and practica

194 ing Death Receptor 5, involves a scissorlike opening of the disulfide-linked transmembrane (TM) dimer

195 les at the core promoter is required for the opening of the duplex DNA and identification of the star

196 rated formation of the middle ear cavity and opening of the ear canal.

197 to sound at very young ages, even before the opening of the ears.

198 that signals via the G-protein Go to control opening of the effector ion channel, TRPM1.

199 The first step of the ring opening of the epoxide is the rate-determining step of t

200 MIDA boronate (24) comprise two steps: ring opening of the epoxide to a carbocation intermediate fol

201 ropenes formed in situ via base-induced ring opening of the epoxide-leads to the syn-selective produc

202 Nucleophilic ring-opening of the epoxides with water, alcohols, and HF pro

203 ation can be explained by Lewis acid induced opening of the epoxy bridge with transfer of one alkyl g

204 mational shifts in the barrel domain lead to opening of the exit pore and rearrangement at the latera

205 t of the chromophores became more polar with opening of the external gates as the protein transitione

206 We found that NNRTI binding to RT induces opening of the fingers and thumb subdomains, which incre

207 External opening of the fistula was overlying an old surgical sca

208 , it interacts with the RNAP and induces the opening of the flexible RNAP clamp domain, concomitant w

209 tions to the hemifusion intermediate and the opening of the fusion pore.

210 terminal zipping of the SNARE complex to the opening of the fusion pore.

211 tic hydroxylation of prephenalenone and ring opening of the gamma-pyrone ring simultaneously.

212 This inflammatory caspase triggers the opening of the GSDMD pore in the plasma membrane, result

213 s wider than all other HAs due to a tilt and opening of the HA1 subunits of the head domain.

214 tely twice that of Abeta18-35, suggesting an opening of the hairpin bend.

215 and C-terminal insertion domain, inducing an opening of the head domain that provides access to the a

216 he context of the steric factors that permit opening of the heme crevice, suggests that higher organi

217 attern at the site of modification, a slight opening of the hm(5)rC-G pair compared to the unmodified

218 bits an increase of Ueff/kB to 42.0 K and an opening of the hysteresis loop observable at 1.8 K.

219 margin of the southern Gondwana prior to the opening of the Indian Ocean.

220 30 seconds of reperfusion immediately after opening of the infarct-related artery and before stent i

221 binding rotates cytoplasmic domains to favor opening of the inner helical gate.

222 haped ligand binding domains (LBDs) triggers opening of the integral ion channel, but how the four LB

223 to helicase domain 2, followed by transient opening of the interface between the Arch and 4FeS domai

224 n with the receptor causes fiber tilting and opening of the internal tail channel by untwisting the n

225 Comparison of MD trajectories show that opening of the intracellular gate causes a structural ch

226 Activation of HTR7 promoted opening of the ion channel TRPA1, which in turn triggere

227 into the binding of agonists, the subsequent opening of the ion channel, and the mechanism of channel

228 Initially, a stereoselective ring-opening of the key intermediate N-acetylneuraminic acid

229 GTP hydrolysis by IF2 induces opening of the L1 stalk and the transition to the nonrot

230 um ylide to metal-free azirinium ylide, ring-opening of the latter to give a 1,5-diazahexa-1,3,5-trie

231 l groups of the natural substrate, cause the opening of the LID and SB domains, and capture the essen

232 maximal rates of catalysis, and promotes the opening of the lid to achieve optimal product release.

233 ingle addition and the rate-determining ring opening of the low-strain olefin.

234 med by S6 and the TRP domain, which cause an opening of the lower TRPV1 channel gate.

235 plasmic domains that subsequently drives the opening of the luminal gate, and thereclosing of luminal

236 Opening of the mitochondrial permeability transition por

237 uces lipid second messengers that facilitate opening of the mitochondrial permeability transition por

238 the loss of ATP production, in part through opening of the mitochondrial permeability transition por

239 sociated with myocardial infarction involves opening of the mitochondrial permeability transition por

240 rther suggests that OmpU may be inducing the opening of the mitochondrial permeability transition por

241 leading to mitochondrial Ca(2+) overload and opening of the mitochondrial permeability transition por

242 /apoptosis, associated with the pathological opening of the mitochondrial permeability transition por

243 compounds in this series, able to attenuate opening of the mPTP and limit reperfusion injury in a ra

244 stically, HETEs activated the Ca(2+)-induced opening of the mPTP in failing human myocardium, and the

245 in-protein interactions that begins with the opening of the N-terminal domain of cTnC, followed by cT

246 the Kras target owing to reorganization and opening of the nanobeacons, thus increasing the distance

247 d lateral actin-actin contacts and restricts opening of the nucleotide-binding cleft in actin subunit

248 Our results also show that the opening of the OCP during photoactivation is caused by t

249 for colorimetric sensing of fluoride by ring-opening of the otherwise photochromic benzo-/naphthopyra

250 Opening of the oxazole ring and deoximation reaction giv

251 in the disassembly of adherens junctions and opening of the paracellular pathways.

252 ns-epithelial electric resistance (TEER) and opening of the paracellular route to 4kDa fluorescent de

253 behavior as a result of the reversible ring opening of the pendant 1,2-dithiolanes.

254 in three pairs of periplasmic probes due to opening of the periplasmic cavity.

255 escence intensity still increased 120s after opening of the pore, this resulted in cell death.

256 the interchain displacements, leading to the opening of the pore.

257 ntrol over temperature-sensor activation and opening of the pore.

258 fusion proceeds via a hemifusion step before opening of the productive fusion pore.

259 The opening of the proton channel involves association of th

260 , implying that the kinetic event leading to opening of the proton conductance are different than tho

261 diones are labile compounds since through an opening of the pyranone ring upon heating they easily ta

262 uction of acetate groups, and reductive ring opening of the resulting hemiacetal as the key steps.

263 n forms in the RNA exit channel and promotes opening of the RNAP clamp domain, which in turn stabiliz

264 ant with DNA melting, is coordinated with an opening of the RNAP clamp that is stimulated by TFE.

265 We show that ATP binding by SecA causes opening of the SecY-channel at long range, while substra

266 lation enables further modification and ring opening of the single-ring aromatics vanillate and 3-O-m

267 n, as the entropic term does not help in the opening of the sites.

268 y the stress hormone ABA, which triggers the opening of the SnR kinase OST1-activated anion channel S

269 istry, exhibits pH-gated photochromism, with opening of the spiro moiety by irradiation with UV light

270 three cycloadditions and electrocyclic ring opening of the strained Dewar anthracene.

271 Here we show that opening of the Strait involved at least two major episod

272 nal analysis of data collected following the opening of the study to accrual from October 10, 2006, t

273 to the polymer, as well as in the subsequent opening of the sulfamate ring once it has been installed

274 he break-up of Gondwana (for example, by the opening of the Tasmanian Gateway, which connects the Ind

275 of template secondary structure and gradual opening of the template DNA, through a series of visuall

276 In the absence of sulfur as a trap, the opening of the triazole ring occurs with the formation o

277 cid leads to an unprecedented oxidative ring opening of the triptycene scaffold, resulting in a new c

278 used by the CH2-localized mutation is due to opening of the two CH domains.

279 -energy landscapes were calculated along the opening of the two flexible lid domains for apo and holo

280 ranching enzymes and are located at opposite openings of the 8-stranded parallel beta-barrel of the a

281 processes and failed to close laser-induced openings of the BBB.

282 them small enough to extravasate through the openings of the bone's sinusoidal capillaries and thus l

283 Thermal ring openings of the cyclobutenes give (Z,Z)-1,3-diene produc

284 tem dating to Agassiz [16] that identify two openings of the digestive system opposite of the mouth-c

285 Ca(2+) efflux from mitochondria during brief openings of the mitochondrial permeability transition po

286 ined by mislocalized, oversized, or multiple openings of the penile urethra.

287 centrations of testosterone resulted in full openings of the purified TRPM8 channel in planar lipid b

288 In all cases, S(N)2-type ring opening of these epoxides upon treatment with aqueous H2

289 ,3-dihydro-2H-benzimidazol-2-ones via a ring opening of thiazolo[3,2-a]benzimidazolium or benzimidazo

290 trate-binding rate is limited by the rate of opening of this cavity.

291 The initial opening of this ocean cavity followed a period of strong

292 th the proposed model in which the transient opening of this region allows a switch between binding m

293 endoplasmic reticulum through the concerted opening of tightly clustered inositol trisphosphate rece

294 lation by external forces leads to the rapid opening of transduction channels followed by an electric

295 potential physiological consequences of the opening of TRPM3.

296 The opening of TRPML1 is associated with distinct dilations

297 Excessive opening of undocked Cx26 hemichannels in the plasma memb

298 At inhibitory synapses, stochastic openings of VACCs trigger the majority of spontaneous re

299 involves cell depolarization and subsequent opening of voltage-dependent Ca2+ channels to elicit ins

300 Depolarization leads to the opening of voltage-gated Na(+) channels (Nav) and subseq