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4 nscriptional control is generally thought to operate as a binary switch, a behavior that might explai
8 dients, we show that the doped mesophase can operate as a charge separation device relying only on th
9 Ano6 Cl(-) currents are probably required to operate as a Cl(-) bypass channel, thereby compensating
10 um SR-11 tricarboxylic acid (TCA) cycle must operate as a complete cycle for full virulence after ora
11 the human mirror system, and thereby make it operate as a countermirror system, by giving participant
16 t usually act as homohexamers, HrpR and HrpS operate as a highly co-dependent heterohexameric complex
21 er alterations in the brain's reward network operate as a mechanism across the spectrum of risk for d
22 A multicomponent [2]rotaxane designed to operate as a molecular shuttle driven by light energy ha
23 a more integrated framework, fire will never operate as a natural ecosystem process, and the impact o
25 c evidence that GRP and its neural circuitry operate as a negative feedback regulating fear and estab
26 fish mesoderm, no tail, spadetail, and tbx6, operate as a network of interacting genes to regulate re
27 apelin/apelin receptor signalling nexus may operate as a paracrine signal that sustains tumour cell
28 drial permeability transition pore (PTP) may operate as a physiological Ca2+ release mechanism and al
29 rythronolide B synthase has been proposed to operate as a racemase, aiding in the epimerization proce
30 cate a vertical cavity structure designed to operate as a saser oscillator device at a frequency of 3
31 prion protein (PrP(C)) has been suggested to operate as a scaffold/receptor protein in neurons, parti
32 patial variation in predator communities may operate as a selection mosaic that prevents complete fix
33 ion during early consolidation processes can operate as a switch between multiple memory systems is l
34 located in the medulla oblongata, which may operate as a switchboard for differential, behavior-appr
38 behavior allowed the integrated assembly to operate as a two-terminal, stand-alone, photoelectrochem
39 m built setup enabled the OWLS cuvette to be operated as a 1.5 ml mini-incubator, controlling both te
40 -low strain open framework structure, can be operated as a battery electrode in inexpensive aqueous e
47 land ecosystems over the last 10 Ma may have operated as a selection pressure for traits and behavior
49 electronic MD based on a single-electron box operated as a Szilard engine, where kBT ln 2 of heat is
50 iscovery that a 1,3-diazepinone riboside (4) operated as a tight-binding inhibitor of CDA independent
53 e absence of any external current, the model operated as a type I excitable medium that supported pro
55 it reflects an alternative form of NHEJ that operates as a backup (B-NHEJ) to the DNA-PK-dependent (D
56 rent near-IR-emitting lanthanide cations and operates as a barcode material with unique luminescence
57 ltaneously, the oxo group of phosphinic acid operates as a base abstracting the nucleophilic proton a
58 a reaction pathway where the phosphinic acid operates as a bifunctional catalyst in the intramolecula
61 xpands the current understanding that Dscam1 operates as a cell adhesion molecule that mediates homop
64 ity-based metabolomics, we report that CLYBL operates as a citramalyl-CoA lyase in mammalian cells.
65 etitive array of B cell peptide epitopes but operates as a classical immunological carrier to provide
67 our findings support the hypothesis that ETS operates as a cofactor with other insults such as interc
68 gies of mutant ESLs, suggesting that the ESL operates as a conserved rheostat between long inverted r
70 The ATP-gated P2X7 receptor channel (P2X7R) operates as a cytolytic and apoptotic receptor but also
71 lings, (1)O(2)-mediated cell death signaling operates as a default pathway that results in seedlings
73 Our study reveals a network in which HSFA6b operates as a downstream regulator of the ABA-mediated s
75 owed that the tricarboxylic acid (TCA) cycle operates as a full cycle during Salmonella enterica sero
76 and RING finger domain-containing protein 1) operates as a functional unit in cells, providing a defi
77 on), we conclude that the subesophageal zone operates as a general premotor center that regulates the
79 present a novel hybrid membrane system that operates as a heat engine capable of utilizing low-grade
80 A combinatorial fluorescent molecular sensor operates as a highly efficient molecular security system
81 results suggest that the CD28-B7 interaction operates as a key modulator of plasma cell function.
84 erefore provides novel evidence that the PRR operates as a limb-dependent stage that lies further alo
85 During growth on ethylamine, the EMC pathway operates as a linear pathway carrying the full assimilat
88 ngs suggest that reduced striatal activation operates as a mechanism across the risk spectrum for dep
91 pruning, and suggest that GluN3A expression operates as a molecular signal for controlling the exten
93 ction of IGS lncRNA by environmental signals operates as a molecular switch that regulates the struct
95 a copper-platinum (Cu-Pt) segmented rod that operates as a nanobattery in dilute aqueous Br(2) or I(2
96 t that the phosphorylation of RIG-I serine 8 operates as a negative switch of RIG-I activation by sup
97 ngs provide novel insight into how the brain operates as a network and suggest that the integration o
98 ous Disease Research Institute (IDRI), which operates as a not-for-profit biotech company, may start
100 resulting mechanically interlocked molecule operates as a perfect molecular switch, most readily des
101 primary receptor and a separate endoprotease operates as a portal for activation of SARS-CoV cell ent
103 is study investigated whether rs4307059 also operates as a quantitative trait locus underlying a broa
105 glycine-sensing RNAs from Bacillus subtilis operates as a rare genetic on switch for the gcvT operon
106 m spontaneous (or endogenous) brain activity operates as a regulated positive-feedback rehearsal mech
107 ne cluster in Paenibacillus sp. strain JDR-2 operates as a regulon, coregulated with the expression o
109 that localizes to synaptodendritic domains, operates as a requisite adaptor by specifically binding
111 ntain resistance to irradiation, but that it operates as a second-tier antioxidant adaptive response
112 We propose that meiotic crossover regulation operates as a self-limiting system in which meiotic chro
115 requency-dependent fluctuations in input and operates as a simple pulse counter over a wide range of
116 rs to the filament tip, suggesting that VASP operates as a single tetramer in solution or when cluste
117 ubiquitin E3 ligase, we find that TIF1gamma operates as a small ubiquitin-like modifier (SUMO) E3 li
118 tory of attempts to understand how the brain operates as a system began at the macrolevel in the fift
121 sion and helper virus influences), the p5IEE operates as a transcription/integration switch sequence
122 results delineate a mechanism by which STAT3 operates as a transcriptional repressor on Ube2n, thus m
123 well-established phagocytosis component that operates as a transducer of so-called "eat-me" signals d
125 is mutated in Peutz-Jeghers cancer syndrome operates as a tumor suppressor.We discuss evidence that
126 ndings suggest that cortical tissue normally operates as a type I excitable medium but it is locally
127 the marine diatom Thalassiosira weissflogii operates as a type of single-cell C(4) photosynthesis.
128 by cleaving and inactivating the AAT serpin, operates as a unique functional link that regulates a co
129 mechanism that receives input from a circuit operating as a Boolean OR gate and involves the activati
131 ) and NMe3 as intermediates, with the former operating as a catalyst and accelerating the redistribut
132 ctive alkene isomerization initiator, either operating as a catalyst itself, via a eta(3)-allyl mecha
134 ncer progression in mouse and human cells by operating as a competing endogenous RNA (ceRNA) for the
135 importance for precise thermal control when operating as a cooler, and for portable power when opera
136 of two parallel positive-feedback loops, one operating as a diffusion-based system, and the other inv
137 ing particular attention to the interstitium operating as a dynamic interface for water and solute di
138 fibres, with the centromeric spring tension operating as a feedback to slow or accelerate the clocks
139 ator in some lineages of Gammaproteobacteria operating as a functional replacement of the Cra regulat
144 ost likely candidate gene underlying ENDO-2, operating as a rate-determining factor of endoreduplicat
145 ecific sequence of the DNA tag is capable of operating as a secondary biocatalyst as well as bridging
146 of uncoupled or weakly interacting elements operating as a single whole; this is particularly the ca
147 plied that under reducing conditions GSH was operating as a thiol donor with minimal S-glutathionylat
152 refore, probably allowed bats to effectively operate as an array of sensors, increasing their searchi
153 ily conserved protein COP1 has been shown to operate as an E3 ubiquitin ligase complex, and a number
154 lar explantion for how hydrogen peroxide can operate as an endothelium-derived hyperpolarizing factor
157 lution of increased CO2 responsiveness or to operate as an important feedback in the global carbon cy
158 igger for innate immune cells, it appears to operate as an inhibitor of T lymphocyte immune adaptive
161 , otx, and krox inputs, as predicted, and it operates as an "AND" logic processor in that removal of
162 rganisms that suggest that sex determination operates as an antagonistic network with the emergent pr
163 egulated as part of the myogenic program and operates as an autocrine signal regulating skeletal myog
165 the discrete time birth-death process which operates as an efficient and accurate numerical solution
167 egulatory model in which the heme-PAS domain operates as an ensemble that couples to the kinase rathe
174 work that this behavior can only arise if V1 operates as an inhibition-stabilized network (ISN), in w
175 that one of the DHFR-TS isoforms (DHFR-TS3) operates as an inhibitor of its two homologs, thus regul
176 ; in relaxed muscles at low Ca(2+), troponin operates as an inhibitor, while in activated muscles at
177 7B trafficking, whereas lysosomal exocytosis operates as an integral process in copper excretion and
178 enhancer reporter assays revealed that Isl1 operates as an integrator factor, translating the densit
179 routes to the diiron active site, the enzyme operates as an NADH oxidase rather than a monooxygenase.
181 tagonize PS-dependent functions, possibly by operating as an active site-directed inhibitor of gamma-
184 yl H3K4 and monomethyl H3K4, with the latter operating as an epigenetic mark for repressed euchromati
186 ork of how neurotransmitter transporters can operate as anion-selective and ligand-gated ion channels
187 studied sample, gingivitis and periodontitis operate as antagonistic modulators of gingival perfusion
189 membrane currents showed that four receptors operated as ATP-gated channels (P2XA, P2XB, P2XD, and P2
191 rror-prone, alternative form of end joining, operating as backup (B-NHEJ) functions robustly througho
192 titutive production rates of Gal1p and Gal3p operate as bifurcation parameters because variations in
194 activated protein kinase (MAPK) cascades can operate as bistable switches residing in either of two d
195 y initially increased pCO2 levels would have operated as both a direct and indirect negative feedback
198 in an aprotic solvent 2-cyanothioacetamides operating as C-C-S building blocks produce 5-amino-4-cya
199 ing Golgi bodies and lysosomes, are known to operate as Ca(2+) storage sites in many cell types.
200 e a mutation in K-RAS or N-RAS, GTPases that operate as central hubs for multiple key signaling pathw
201 that DNA sequences can have a dual function, operating as coding exons in one tissue and enhancers of
202 Class II MHC-positive endothelial cells operate as competent superantigen-presenting cells for C
204 Two isoenzymes of malate dehydrogenase (MDH) operate as components of the malate-aspartate shuttle, i
206 reimbursement climate necessitates that ASPs operate as cost-cutting programs rather than focus on pa
207 ntify a program of NuRD-repressed genes that operate as critical regulators of presynaptic differenti
208 on of lysine 9 at histone H3 (H3K9me3), also operate as critical regulators of stem-cell functions (w
209 c templates for their own formation and also operate as cross-catalytic templates for each other.
210 desaturases, fish Fads2 have the ability to operate as Delta6 desaturases towards C24 PUFA enabling
214 e other enzymes or transporters necessary to operate as dopaminergic neurons and exert widespread GAB
216 inwardly rectifying K(+) (GIRK) channels can operate as dynamic integrators of alpha-adrenergic and c
219 ese results suggest that plate tectonics was operating as early as Paleoarchean times, approximately
220 lycerol lactones (DAG-lactones) are known to operate as effective agonists of protein kinase C (PKC),
221 pects of the emmetropization process may not operate as effectively under constant light as they do u
222 3) regulate cell fate in development and can operate as either oncogenes or tumor suppressors in canc
224 shown that the optical breadboard system is operating as expected based on modeling and can be used
226 al dendritic trees of hippocampal neurons to operate as facile computational subunits capable of supp
229 s that these single nucleotide substitutions operate as gain-of-function mutations that activate Shh
230 Because of their shape, these enzymes often operate as gates that separate distinct cellular compart
231 ed synaptic and intrinsic adaptive responses operating as global homeostatic mechanisms to maintain f
232 There are fewer examples of modifiers that operate as growth promoters, whereby modifier-crystal in
233 nitiation factors--the 4E-BP protein family--operate as guardians of a translational control checkpoi
234 d endocrine organ, secreting adipokines that operate as hormones to mediate the crosstalk with other
235 at the multiple firing fields of a grid cell operate as independent elements for encoding physical sp
236 hypothesis that spatial and olfactory memory operate as independent working memory resources in the r
238 -containing cells in the pituitary gland may operate as key calendar cells, transmitting seasonal tem
240 wafers are captured in a polymer matrix that operates as Li(+) gel-electrolyte and electrode separato
241 iological conditions BKCa channels primarily operate as ligand-activated channels gated by intracellu
248 pathogens that inhibit viral replication by operating as molecular barriers to steps of the viral li
250 RecA/Rad51), and helicases/translocases that operate as motor proteins and play central roles in geno
252 rting the notion that these interneurons can operate as multiplexors, containing numerous independent
253 t time, that individual nanoparticles can be operated as multistate switches in condensed media at ro
254 ermed the homeostat) engages mechanisms that operate as negative feedback elements to keep the biolog
256 ding apoptosis, necrosis and autophagy, thus operating as nodal points at the convergence of multiple
257 e the genesis of endothelial dysfunction and operate as part of the normal processes of developmental
259 chanistic target of rapamycin (mTOR) protein operates as part of two molecularly and functionally dis
261 ted that O-bonded palladium enolates did not operate as predominant intermediates in the insertion pr
265 the notion that 6TM AC membrane domains may operate as receptors which directly regulate AC activity
267 hes which presently harbor these populations operate as refugia during the current interglacial.
269 functionalized with Os-complex redox species operating as relay units to mediate electron transport b
270 des the biological function, but most ncRNAs operate as RNA-protein complexes, including ribosomes, s
272 pting chemotaxis proteins, and phosphatases, operate as signal mediators in two-component signal tran
275 provide clues on how this class of compounds operate as suicide substrate inhibitors leading to heme
276 Cs, NK cells, B cells, and T cells) that can operate as "super" immune cells, for example, through ge
280 e Armstrong-McGehee mechanism is unlikely to operate as the sole coexistence-promoting mechanism in c
283 ix-it" model as an independent rationale for operating as they deliberated about the value of surgery
284 ith conventional lithography may effectively operate as three-dimensional helical structures with bro
285 restricted feeding, and hormonal inputs may operate as time givers (zeitgebers) for the circadian cl
286 ay have dual receptor-transporter functions, operating as "transceptors" to sense extracellular (or i
287 e that the proposed sensing architecture can operate as transducer not only to confirm the adsorption
289 ng cascades, cGMP and cAMP respectively, and operate as transduction channels generating the stimulus
290 peration of linear ion guides allows them to operate as traps and mass filters by modulating the duty
292 e pgrl1 mutant, measured in photobioreactors operated as turbidostats, was similar to its wild-type p
293 tially distinct, lineage-specific mechanisms operate, as turnover in the macromeres depends on entry
294 UCNPs modified with porphyrin-dendrimers can operate as upconverting ratiometric pH nanosensors.
299 the frequency at which the chosen technique operates as well as the interactions with subcellular co
300 the dimeric class I tyrosyl-tRNA synthetase, operates as well in this homotetrameric class II tRNA sy
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