ライフサイエンスコーパス: operationally

1 say and colleagues describe in Drosophila an operationally analogous phenomenon to paramutation that

2 However, if time is defined operationally, as a pointer position of a physical clock

3 s: the naive strategy, based on treating all operationally available area and the optimized strategy,

4 cation-based approach to defining cell types operationally by input/output (I/O) relationships links

5 e dialkylation reactions are conducted under operationally convenient conditions without recourse to

6 Operationally convenient experimental procedures, mild r

7 This operationally convenient process can be thought of not o

8 We report an operationally convenient room temperature hydroboration

9 ns occur under mild reaction conditions, are operationally convenient to execute, and are effective f

10 The protocol is modular and operationally convenient.

11 l loss of TLRs in gp96-deficient macrophages operationally created a conditional and cell-specific TL

12 of chlorophyll a fluorescence can be used to operationally define plant death arising from drought, a

13 Segmental duplications (SDs) are operationally defined as >1 kb stretches of duplicated D

14 o capture appropriately sized microplastics (operationally defined as 0.3-5.0 mm).

15 imethyl-1,3-butadiene, with an outlier being operationally defined as a substance showing a more than

16 ntly higher than saline-contingent rates was operationally defined as acquisition of cocaine reinforc

17 Participants were operationally defined as clinically immune tolerant (IT)

18 the Contemporary Theory of Metaphor and were operationally defined as familiar and readily interpreta

19 20.2% of 18,062 patients and persistent MDA, operationally defined as having MDA during >or=2 consecu

20 nd in the particle-associated (PA) fraction, operationally defined as prokaryotes captured on 2.7 mic

21 generally accepted that awareness should be operationally defined as reportable knowledge, and that

22 This functional subset of cancer cells is operationally defined as the "cancer stem cell" (CSC) su

23 hases of reactivation from latency, which we operationally defined as the escape from latency.

24 Fear and anxiety were operationally defined as the increase in startle reactiv

25 Marrow HSPCs, operationally defined as the Lin-c-Kit+ and Lin-Sca-1+c-

26 rvival time into clinically distinct periods operationally defined by cutpoints on rating scales.

27 r plate, a ventral midline structure that is operationally defined by the expression of the molecule

28 SV40 chromosomes undergoing transcription operationally defined by the presence of RNA polymerase

29 Here we show that LRL territory, operationally defined by Wnt1 expression, is parceled in

30 ll subsets might be predictive of a state of operationally defined clinical immune tolerance during p

31 chanisms that are associated with a model of operationally defined clinical tolerance.

32 The distribution of operationally defined field dissolvable Fe(II) and Fe(II

33 s quality control, systematic differences in operationally defined forms of Hg were measured by the s

34 and a putative nucleotide sequence for each operationally defined gene cluster.

35 Our operationally defined gene clusters aim to address a maj

36 A number of operationally defined methods exist for pretreating plan

37 rmore, a weathering-dependent increase of an operationally defined oxygenated fraction relative to th

38 ic regression examining group differences in operationally defined response (controlling for baseline

39 An operationally defined second-order rate constant (based

40 t the majority of Pb was associated with the operationally defined sorbed and non-EDTA-exchangeable f

41 An analytical procedure for operationally defined speciation of Cd, Cu, Pb and Zn in

42 nts with PEs were subdivided into those with operationally defined suspected PEs, definite PEs, and p

43 Obligate endosymbiosis is operationally defined when loss or removal of the endosy

44 al sequelae (OR 7.64, 95% CI 5.29-11.31) and operationally defines severe Buruli ulcer.

45 ed the original patient tumors in vivo, thus operationally defining CCICs.

46 significance demonstrates opportunities for operationally defining cultural services in terms of soc

47 nt theory, important issues to consider when operationally defining reliability for a particular stud

48 imary, tendril, and distal branches could be operationally differentiated by the relative size of the

49 hough classical and operant conditioning are operationally distinct, it is unclear whether these two

50 vities, exercise protocols, or equipment and operationally driven schedule changes.

51 enzoic acid (IBX) was found to be efficient, operationally easy, and superior to other common oxidant

52 We also report an operationally facile two-step, one-pot procedure for the

53 Pakistan, and Sri Lanka suggests that it is operationally feasible to implement fIPV vaccination on

54 are utilized when molecular methods are not operationally feasible.

55 Recombinant human proMMP-9, operationally free of TIMP-1, also induced angiogenesis

56 late Cenozoic time slices, that most clades (operationally here, genera) tend to originate in the tro

57 Recent functional neuroimaging studies that operationally identify varying levels of awareness, memo

58 erprint examination process; procedures used operationally include additional safeguards designed to

59 Operationally, indeterminacy shows up as nonunique solut

60 MOPRs have been divided operationally into mu(1) and mu(2) receptor subtypes on

61 a set of source emissions aerosols are first operationally isolated by thermally clearing the aerosol

62 Such routes are operationally jeopardized by the steric hindrance of the

63 These two opposite behavioral outcomes are operationally linked by the number of cue presentations

64 in we describe a novel survival pathway that operationally links alternative pre-mRNA splicing of the

65 A wide substrate scope, operationally mild conditions, the use of single substra

66 Operationally, modifications function either by disrupti

67 al and dietary modules of SHEDS-MM have been operationally modified to reduce the user burden, input

68 Our new reaction conditions are operationally more practical and broaden the accessibili

69 ve conditions can be readily mimicked in the operationally much simpler and smaller conventionally he

70 ue is establishing the epidemiologically and operationally optimal screening radius around each passi

71 RM is often operationally quantified as the sum of particle bound Hg

72 ct sensory qualities of food materials under operationally realistic conditions.

73 species including an adsorbed U(IV) species, operationally referred to as monomeric U(IV).

74 od delivery route, these organisms are often operationally referred to as next-generation probiotics,

75 ppropriate electrode nanoarchitectures under operationally relevant conditions, for example, via redo

76 ducts deposited and later extracted from two operationally relevant surfaces: stainless steel and vin

77 A dual domain model, which operationally separates reactive transport properties in

78 Establishing whether resistance is operationally significant is technically challenging.

79 The rapid selection and spread of operationally significant pyrethroid resistance in Afric

80 mechanisms in Bioko malaria vectors are not operationally significant, and on this basis, a differen

81 the Bayesian bootstrap, a resampling method operationally similar to the standard bootstrap.

82 This C-H trifluoromethylation protocol is operationally simple (avoids gaseous CF(3)I), scalable,

83 This method is operationally simple (i.e., one-pot), scalable, and fast

84 Thus, this operationally simple aerobic reaction demonstrates that

85 ion of propargylic ethers was explored using operationally simple air- and moisture-insensitive condi

86 Therefore, the discovery of a mild, operationally simple alternate carboxylation that occurs

87 gorously exclude water, thus representing an operationally simple alternative to traditional cross-co

88 The reaction procedure is operationally simple and amenable to large-scale prepara

89 The reaction is operationally simple and amenable to multigram-scale syn

90 The reaction is operationally simple and broad in scope while providing

91 nd Fmoc deprotections, is rapid (about 5 d), operationally simple and can be used to generate over 1

92 now be synthesized on a large scale via two operationally simple and discrete solid-state processes.

93 The transformation is operationally simple and efficient and has the unusual f

94 We report an operationally simple and environmentally friendly protoc

95 The method is operationally simple and extractive isolation provides a

96 An operationally simple and general method for copper-catal

97 The transformation is operationally simple and generally efficient for effecti

98 An operationally simple and high yielding protocol for the

99 This operationally simple and highly regioselective process o

100 center at the pseudobenzylic position in an operationally simple and inexpensive procedure.

101 The reaction is operationally simple and insensitive to air and moisture

102 The method is operationally simple and involves low-cost starting mate

103 An operationally simple and metal-free cross-coupling of qu

104 An operationally simple and mild one-pot protocol for the s

105 This operationally simple and scalable method offers Markovni

106 An operationally simple and scalable synthesis of enantiome

107 eating extremely hindered dipeptides that is operationally simple and uses mild conditions and commer

108 Our new method provides an operationally simple and versatile route for a selective

109 reaction conditions are mild, tolerant, and operationally simple and will be easily implemented.

110 This reaction is operationally simple and, unprecedentedly, affords high

111 An operationally simple approach for the regioselective tan

112 This mild and operationally simple approach takes advantage of the ele

113 In this letter we report an operationally simple approach that makes use of readily

114 An efficient and operationally simple approach to complex cis-hexahydroin

115 A highly convergent and operationally simple approach to mycotoxin-related 4-ami

116 ent' (FIDR) assay is introduced herein as an operationally simple approach toward determination of th

117 rein is a highly sensitive, inexpensive, and operationally simple assay for the rapid assessment of P

118 An operationally simple cascade protocol has been developed

119 The reaction operates under preparative, operationally simple conditions (1 equiv of olefin, 1 at

120 syl hemiacetals, and are coupled under mild, operationally simple conditions (amine base, organoboron

121 mides (primary, secondary) and lactams under operationally simple conditions without the aid of metal

122 An operationally simple copper-BINAP-catalyzed, highly enan

123 this is the first time to report a novel and operationally simple coupling reaction of vinylarenes an

124 An operationally simple domino approach for the silver-cata

125 saccharide derivatives can be accessed in an operationally simple fashion without purification of int

126 mperature, 50 degrees C or less), direct and operationally simple formation of medicinally relevant C

127 de chains through the use of rapid, mild and operationally simple free-radical chemistry performed on

128 ation of these electrophilic reagents, their operationally simple handling, broad substrate scope, an

129 An operationally simple ipso fluorination of phenols with a

130 A mild and operationally simple iron-catalyzed protocol for the sel

131 The operationally simple isomerization protocol has been app

132 We present an operationally simple iterative coupling strategy for the

133 We present an operationally simple lactone-to-lactam transformation ut

134 This operationally simple method allows direct access to cycl

135 this transformation provides a practical and operationally simple method for effecting allylic amidat

136 This process represents an expedient, operationally simple method for the construction of new

137 We report herein an operationally simple method for the direct conversion of

138 The versatility of this operationally simple method has been demonstrated throug

139 This mild, user-friendly, and operationally simple method is characterized by an exqui

140 This operationally simple method is compatible with the most

141 air and moisture, providing a practical and operationally simple method of synthesizing enantioenric

142 oad range of different densities provides an operationally simple method that may find application to

143 A mild and operationally simple method to synthesize diphenylhexatr

144 The general and operationally simple methodology provides an alternative

145 This operationally simple methodology was expanded to reactio

146 The operationally simple methods described in this communica

147 This one-pot, operationally simple microwave-assisted synthetic protoc

148 The reaction is operationally simple offering a broad scope and function

149 clopropylnitriles led to the discovery of an operationally simple one-pot method for Knoevenagel cond

150 An operationally simple one-pot procedure generates product

151 Two operationally simple one-pot protocols have been develop

152 rall C-H to C-N transformation is a mild and operationally simple one-pot sequential multistep proces

153 The operationally simple oxidative process, performed in the

154 gical interest were synthesized by using the operationally simple Pd(II)-catalyzed arylation reaction

155 Herein, we report an easily accessible and operationally simple photoinitiated reaction that can ac

156 Herein we describe an operationally simple probabilistic structure-activity re

157 Herein described is an operationally simple procedure for generating benzyl ind

158 An operationally simple procedure gives instant access to v

159 mmercially available materials, this new and operationally simple procedure provides a rapid entry to

160 The operationally simple procedure using very low quantities

161 ethod features a wide substrate scope and an operationally simple procedure, affording the spiroindol

162 Using readily available reactants in an operationally simple procedure, the protocol smoothly yi

163 actions to completion in a few hours through operationally simple procedures.

164 This fast, operationally simple process offers straightforward acce

165 This operationally simple process produces CO2 as the only by

166 Therefore, the discovery of a mild and operationally simple protocol allowing such challenging

167 This mild and operationally simple protocol allows rapid access to ena

168 a library of tetrazoles through a novel and operationally simple protocol effecting the direct conve

169 reagents, which make it a user-friendly and operationally simple protocol en route to carboxylic aci

170 lic reagents and thus is a user-friendly and operationally simple protocol for assembling phenylaceti

171 catalysts, thus becoming a user-friendly and operationally simple protocol for C(sp(2))-H hydroxylati

172 We disclose an efficient and operationally simple protocol for the preparation of fus

173 An operationally simple protocol for the selective deoxyflu

174 An operationally simple protocol for the synthesis of gamma

175 This operationally simple protocol is able to form Csp(3)-Csp

176 This operationally simple protocol proceeds through a substit

177 This direct and operationally simple protocol provides a fundamentally n

178 This mild, operationally simple protocol that can be conducted in o

179 This mild, operationally simple protocol transforms a wide variety

180 This mild, operationally simple protocol transforms a wide variety

181 The procedure features the use of operationally simple protocol utilizing the commercially

182 The procedure features the use of an operationally simple protocol utilizing the commercially

183 ing in a scalable, rapid, high-yielding, and operationally simple protocol, this procedure is applied

184 This operationally simple reaction can be carried out in argo

185 glycals has been accomplished under mild and operationally simple reaction conditions through the use

186 saturated, spirocyclic N-heterocycles under operationally simple reaction conditions.

187 tion products in high efficiency under mild, operationally simple reaction conditions.

188 The operationally simple reaction protocol is applicable to

189 probe that permits a direct, real-time, and operationally simple readout of AKR1C2 enzyme activity i

190 The methodology is operationally simple requiring no high pressure equipmen

191 development of an optimized protocol with an operationally simple setup (ligated copper(II) precataly

192 An operationally simple silver-catalyzed tandem strategy fo

193 F films on single-layer graphene (SLG) under operationally simple solvothermal conditions.

194 The synthesis consists of six operationally simple steps and can be utilized to make m

195 to diverse areas of chemical space in three operationally simple steps from commercially available r

196 on from DHP triflates provides a unified and operationally simple strategy for preparing chiral homop

197 Here we report a mild, operationally simple strategy for the direct trifluorome

198 An operationally simple synthesis of N-BOC-2-hydroxymethylm

199 Taking advantage of an operationally simple technique to perform transmission p

200 The method is operationally simple to implement with a wide variety of

201 ns typically proceed at 22 degrees C and are operationally simple to perform.

202 an be accomplished through application of an operationally simple treatment of an imidazolium salt wi

203 trifluoroacetic anhydride for a scalable and operationally simple trifluoromethylation reaction using

204 This [3 + 2]-annulation is operationally simple under metal-free reaction condition

205 This process is found to be mild and operationally simple with broad substrate scope.

206 This process is found to be mild and operationally simple with broad substrate scope.

207 The method is very general and operationally simple, affording a series of iminocyclito

208 The method is operationally simple, affords good yields of adducts, an

209 The reaction conditions are mild and operationally simple, and a variety of aryl functional g

210 partners, proceeds under mild conditions, is operationally simple, and exhibits high functional group

211 All hydrometalation reactions are reliable, operationally simple, and practical and afford an assort

212 This direct, mild, operationally simple, and safe chlorinating method is co

213 We report a rapid, one-pot, operationally simple, and scalable preparation of valuab

214 A mild, operationally simple, and single-step transition-metal-f

215 The protocol is operationally simple, and the chiral reagent is readily

216 high atom economy, is remarkably modular and operationally simple, and tolerates a variety of functio

217 We report an operationally simple, atom-economical, carboxylate-direc

218 The reaction is operationally simple, can be carried out on the benchtop

219 This mild, operationally simple, chemoselective, and scalable diflu

220 Here we describe the operationally simple, direct, regioselective and enantio

221 Overall this transformation is operationally simple, does not require an external oxida

222 The strategy is operationally simple, exhibits a remarkably wide substra

223 ylsilylene transfer was developed as a mild, operationally simple, functional-group-tolerant method f

224 We here present an operationally simple, high yielding and scalable method

225 ines could also be accessed using this fast, operationally simple, high yielding, chemoselective and

226 held single-cell pipet (hSCP) that is rapid, operationally simple, highly efficient, and inexpensive

227 An operationally simple, inexpensive, and rapid route for t

228 While the reaction is operationally simple, it provides a powerful method for

229 to achieve such a transformation under mild, operationally simple, metal-free conditions is outlined.

230 An operationally simple, metal-free, one-pot synthetic proc

231 An operationally simple, mild, redox-neutral method for the

232 We report here an operationally simple, palladium-catalyzed cyclization re

233 This metal-free reaction is operationally simple, proceeds at mild temperature, and

234 peptide sequence determination is reliable, operationally simple, rapid, and inexpensive and should

235 This operationally simple, redox-neutral fluorination method

236 The reaction is operationally simple, requires only a slight excess of a

237 The new domino reaction is operationally simple, robust, substrate specific, select

238 The development of a system for the operationally simple, scalable conversion of polyhydroxy

239 This operationally simple, scalable transformation proceeds e

240 The reaction is operationally simple, scalable, and displays broad scope

241 The transformation is operationally simple, scalable, and environmentally frie

242 The methodology is operationally simple, scalable, and fast at or below amb

243 ition, it utilizes bench-stable reagents, is operationally simple, shows high functional-group tolera

244 This method provides operationally simple, sustainable, and efficient access

245 readily available starting materials and is operationally simple, thus representing a practical meth

246 We report an operationally simple, tin-free reductive dehalogenation

247 The method is practical, operationally simple, tolerates a wide scope of function

248 The method is fast, operationally simple, totally regio- and stereoselective

249 and versatile catalysts that function under operationally simple, user-friendly conditions.

250 ature procedures, this synthetic approach is operationally simple, uses simple substrates, and offers

251 This procedure is operationally simple, versatile, inexpensive, and quick

252 y, involves mild reaction conditions, and is operationally simple.

253 ox/Ni dual-catalyzed procedure very mild and operationally simple.

254 t method leading to the chloro nucleoside is operationally simpler compared to previously reported gl

255 ee, or two, contiguous (3)J(H,H) profiles is operationally simpler than one based on (13)C and (1)H c

256 ixture of water and tetrahydrofuran) and are operationally simpler to perform than the NHC-Cu-catalyz

257 osensors that offer robust, inexpensive, and operationally simplified alternatives to conventional an

258 Here, we introduce a new, mechanically and operationally simplistic magnetic manipulation system fo

259 he use of metals, and features the use of an operationally stable and robust potassium organotrifluor

260 The development of operationally straightforward and cost-effective routes

261 In an operationally straightforward and efficient method, amid

262 The reaction protocol is operationally straightforward and found to be applicable

263 Notably, the reaction is operationally straightforward and has no special require

264 This amidation reaction is operationally straightforward and provides primary, seco

265 The operationally straightforward palladium-catalyzed proces

266 Herein, we describe an operationally straightforward radiosynthesis of a chiral

267 H-KITPHOS monophosphine is prepared via an operationally straightforward three-step procedure and i

268 Enantiopure Me(2)-CATPHOS is obtained in an operationally straightforward three-step procedure and i

269 Operationally, the acoustic filter concentrates micropar

270 Operationally, the PIP can be used for monitoring and st

271 ; stable (n = 25) on maintenance tacrolimus; operationally tolerant (n = 7).

272 roups of stable liver transplant recipients: operationally tolerant (TOL), prospective immunosuppress

273 Before initiation of drug withdrawal, operationally tolerant and non-tolerant recipients diffe

274 ranscriptional profile has been recorded for operationally tolerant kidney graft patients, the role t

275 effector T cells in blood from patients with operationally tolerant kidney grafts.

276 Long-term outcomes of operationally tolerant liver transplant patients are at

277 signatures have recently been identified in operationally tolerant long-term kidney transplant patie

278 X, serum HLA-G levels did not differ between operationally tolerant patients and patients on regular

279 e, as compared with non-tolerant recipients, operationally tolerant patients exhibited higher serum l

280 Taken together, our data demonstrate that operationally tolerant patients mobilize an array of pot

281 B cells from operationally tolerant patients overexpressed miR-142-3p

282 rgeted cell sorting of peripheral blood from operationally tolerant patients showed a significant shi

283 RNA in peripheral blood mononuclear cells of operationally tolerant patients with those of stable pat

284 The primary end point was the proportion of operationally tolerant patients, defined as patients who

285 study, we analyzed the role of B cells from operationally tolerant patients, healthy volunteers, and

286 ecules previously identified in the blood of operationally tolerant patients.

287 us to more thoroughly characterize Tregs in operationally tolerant patients.

288 Operationally tolerant pediatric liver transplant recipi

289 g by rare event, flow cytometric analysis in operationally tolerant pediatric liver transplant recipi

290 tal living donor liver grafts, identified as operationally tolerant through complete IS withdrawal (W

291 tal living donor liver grafts, identified as operationally tolerant through complete IS withdrawal, w

292 amines with cyanoaromatics by using mild and operationally trivial conditions.

293 as allowed for the development of a mild and operationally trivial protocol for the direct formation

294 reaction is now highly enantioselective and operationally trivial.

295 Operationally unsaturated (i.e., 16/18-electron) (PNPR)R

296 then to (PNP(R))Re(H)(4), the last being an operationally unsaturated species which can bind PMe(3)

297 s a unique opportunity to produce global GPP operationally using the Southampton CARbon Flux (SCARF)

298 Moreover, the method is operationally very simple because the organotrifluorobor

299 This protocol involves operationally very simple, facile and cost-effective rea

300 Operationally, we use an inducible promoter to express t