ライフサイエンスコーパス: operon

1 to -135 bp of the transcription start of the operon.

2 antitoxin gene, usually encoded in a single operon.

3 eat located upstream of the biotin synthesis operon.

4 with isoniazid and ethambutol is the iniBAC operon.

5 y altering the natural regulation of the His operon.

6 rolled by the accessory gene regulator (agr) operon.

7 d C71), FisR activates the expression of the operon.

8 in constitutive expression of the hom-thrCB operon.

9 to orthologs of the mmpS5-mmpL5 drug efflux operon.

10 operon, and Lrp positively regulates the tos operon.

11 in constitutive expression of the hom-thrCB operon.

12 asmic transducer that is encoded on the same operon.

13 be monocistronic or part of a polycistronic operon.

14 redicted on the basis of the Ms. sp. LW4 Mbn operon.

15 in the untranslated leader of the trpEDCFBA operon.

16 of yxaJ, the yybNM operon and the sunA-bdbB operon.

17 xpressed the five enzymes from the P. putida operon.

18 tative autolysin located adjacent to the Isd operon.

19 ansfer RNA gene (trnI.2) located in the rRNA operon.

20 ffects PQS production by repressing the qapR operon.

21 proteins are typically found together in an operon.

22 production through control of the pigA-pigN operon.

23 d that regulates translation of a third T4SS operon.

24 nonical promoter of the Escherichia coli fis operon.

25 binds to the regulatory region of the almEFG operon.

26 scent protein under the control of the c-fms operon.

27 ae pv. oryzicola (Xoc) contains a homologous operon.

28 members of the capsular polysaccharide (cps) operon.

29 on abolishes TCR genome-wide and in the lacZ operon.

30 sp protein encoded in the Y. bercovieri Anbu operon.

31 some typically as a divergent but contiguous operon.

32 n of the pan-Aspergillus ITS1/5.8S ribosomal operon.

33 ced by the homologous genes of the other mce operons.

34 um tuberculosis have over 90 toxin-antitoxin operons.

35 ry regions upstream of the liaFSR and liaXYZ operons.

36 kbp, fragments large enough to contain whole operons.

37 including those in operons or in subsets of operons.

38 of unknown function that are linked in these operons.

39 responding coding genes being colocalized in operons.

40 s of a set of transcriptionally co-regulated operons.

41 hes a role for 3'-UTRs as evolved eukaryotic operons.

42 n of large building blocks such as genes and operons.

43 ese factors indirectly via the pqs and phnAB operons.

44 transcriptional termination of waaQ and rfb operons.

45 pression level ratios within multi-cistronic operons.

46 veral non-LEE-encoded effectors and fimbrial operons.

47 ize of the cells reflected the number of rrn operons.

48 ding a transcriptional activator for the cys operons.

49 by constructing isogenic variants with 5-10 operons.

50 within two different antibiotic biosynthesis operons.

51 egulates the E. coli K-12 and Salmonella nrf operons.

52 nce of four putative plasmids harbouring rib operons.

53 of gene function in the context of bacterial operons.

54 ains were engineered to express specific gtr operons.

55 teria with densely packed genes organized in operons.

56 the human CF operon CS18 and the porcine CF operon 987P (F6).

57 viously identified ctrABCD (ABC transporter) operon, a lipA (kpsC)-like gene, a lipB (kpsS)-like gene

58 to the same level as deletion of the empABC operon, a phenotype that was restored by reconstituting

59 by the activity of glycosyltransferase (gtr) operons acquired by horizontal gene transfer.

60 n the leader region of the Salmonella mgtCBR operon actually enables transcription of its associated

61 emophore-dependent PhuR is encoded within an operon along with proteins required for heme translocati

62 The groEL protein is part of the groESL operon and enables a large range of proteins to fold cor

63 llus subtilis protein regulator of the gabTD operon and its own gene (GabR) is a transcriptional acti

64 HcpR1 binds upstream of the hcpR1 operon and its synthesis is regulated coordinately with

65 a the bioH gene is within a biotin synthesis operon and its transcription is coregulated with the oth

66 ene is not located within a biotin synthetic operon and its transcription is not coregulated with the

67 deletion of the endogenous riboflavin (rib) operon and presence of four putative plasmids harbouring

68 , specifically interacted with the relBE2sca operon and repressed its transcription.

69 e recombination events, involving the cps IV operon and resulting in the expansion of serotype IV to

70 to repress transcription of yxaJ, the yybNM operon and the sunA-bdbB operon.

71 cription factor that regulates the hom-thrCB operon and the thrD aspartokinase gene.

72 bb0405 is a member of an operon and ubiquitously expressed throughout the rodent-

73 rgenic region separating the capsule ctr-css operons and adjacent deletion of cssA/B/C and a part of

74 n between the number of cytochrome c oxidase operons and heterotrophic or diazotrophic capabilities.

75 conserved germline expression, enrichment in operons and more slowly evolving coding sequences than o

76 are provided: differentially-abundant genes, operons and pathways).

77 bilize the 3' fragments of the LEE4 and LEE5 operons and promote translation of the non-LEE-encoded e

78 2 contains two additional cellulose synthase operons and several previously undescribed genes associa

79 or fluorescent proteins adjacent to the rRNA operons and then examining their positions pairwise in l

80 o predict expression level ratios in natural operons and to design synthetic operons with desired exp

81 Microarray analysis highlighted the cadC/BA operon, and additional experiments confirmed that it was

82 H-NS is a negative regulator of the tos operon, and Lrp positively regulates the tos operon.

83 of Fur correlates with derepression of each operon, and the graded response observed here results, a

84 from substrates and is encoded in a two-gene operon, and the other protein, CidA, binds CidB.

85 yrimidine biosynthesis operon, the betA-betB operon, and the pathogenicity island, SaPI5, while virul

86 uringiensis These species have 11 to 14 rRNA operons, and sequence variability occurs among the multi

87 do-revertants having a derepressed hom-thrCB operon appear in the presence of threonine.

88 functions of the remaining genes in the Xoc operon are elucidated and the distribution of the operon

89 Bacterial operons are considerably more complex than what were tho

90 The seven rRNA operons are nearly identical and separated from each oth

91 of the D. desulfuricans hcpR1, hcpR2 and hcp operons are reported.

92 We identified the per operon as the key component of the hysteretic switch.

93 the previously described cellulose synthase operon, ATCC 53582 contains two additional cellulose syn

94 novel co-regulation score between a pair of operons based on accurate operon identification and cis

95 nalyses cannot be implemented due to lack of operon-based functional organization.

96 activation of the phenylalanine biosynthetic operon becomes less responsive to phenylalanine limitati

97 A two-gene operon bgsBA required for production of this ML beta-glu

98 le genomic plasticity in that in some biotin operons bioH is replaced by other alpha/ss hydrolases of

99 tive regulators of toxin (AtxA1) and capsule operon (both) transcription in G9241 and that a Deltaatx

100 ize a protein that is conserved across these operons but has not been previously studied.

101 e combined positive regulation of the feoABC operon by ArcA and FNR partially antagonized Fur-mediate

102 ch topoisomerase is transcribed from its own operon by the major chlamydial RNA polymerase.

103 The deletion of genes from the wca operon caused a persistent-infection E. coli strain to b

104 This operon codes for three cell wall-anchored proteins - Prg

105 egulator (Agr) and downregulation of the ica operon coding for the biofilm exopolysaccharide polysacc

106 Two proteins encoded by the comF operon, ComFA and ComFC, are involved in transformation

107 nvoke long-range conservation or the selfish operon concept(7).

108 Bacterial mRNAs are organized into operons consisting of discrete open reading frames (ORFs

109 ting of operator DNA sequences in a two-gene operon containing overlapping promoters.

110 he prediction of diverse Mbn structures from operon content and precursor peptide sequence.

111 enhances transcription of a select group of operons controlling bacterial surface features such as l

112 y regulates the staphyloxanthin-biosynthetic operon crtOPQMN, promoting survival of S. aureus in the

113 egulator of the staphyloxanthin-biosynthetic operon, crtOPQMN, but is epistatic to alternative sigma

114 seven genes, csmA-G, related to the human CF operon CS18 and the porcine CF operon 987P (F6).

115 f S. pneumoniae TIGR4 in polyamine transport operon (DeltapotABCD) with the wild type in a mouse mode

116 This result suggests that different mce operons do not provide redundant capabilities and that M

117 anscriptional activator for xylose catabolic operons, either CRP or XylR, and these mutations are dem

118 The mce operons encode up to 10 different proteins of unknown fu

119 We hypothesized that the operon-encoded BioH might differ in its expression level

120 rmatics analysis places the freestanding and operon-encoded BioH proteins into distinct clades.

121 Differential translation of operon-encoded genes facilitates precise cell cycle-timi

122 aradigm "freestanding" E. coli BioH with the operon-encoded P. aeruginosa BioH.

123 In bacteria, the kdp operon encodes a four-subunit potassium pump that mainta

124 The Escherichia coli K-12 nrf operon encodes a periplasmic nitrite reductase, the expr

125 The second gene of the hcp-hcr operon encodes an NADH-dependent reductase, Hcr.

126 the C. canimorsus genome comprises a single operon encoding a lipid A 1-phosphatase (LpxE) and a lip

127 by fourfold the expression of an eight-gene operon encoding an actinobacteria-type H2-uptake [NiFe]-

128 d by loss of function mutations in the feoAB operon encoding ferrous (Fe(2+)) iron uptake proteins.

129 g the T7 bacteriophages engineered with lacZ operon encoding for beta-galactosidase (beta-gal).

130 mS), which contains the promoter for the fim operon encoding T1P.

131 found within the oxygen-regulated pufQBALMX operon encoding the reaction centre-light-harvesting pho

132 vieA is part of an operon encoding the VieSAB signal transduction pathway t

133 presented uPSS and iPSS in the polycistronic operons encoding ribosomal proteins, and the majority up

134 ranscription of lapA and the lapBC, and lapE operons, encoding a LapA-specific secretion system.

135 f pufQ and the photosystem genes in the same operon ensures that switching of tetrapyrrole metabolism

136 eats) and the nearby Cas (CRISPR-associated) operon establish an RNA-based adaptive immunity system i

137 Here, we reinvestigate lac operon expression in single cells using a combined exper

138 g CssA, in the 5'-untranslated region of the operon for capsule biosynthesis.

139 d of the transcription activation of the cus operon for defending against metals.

140 t of an unannotated gene in the biosynthetic operon for NOS, as an acyl carrier protein that delivers

141 in multiple full and partial (i.e. 'orphan') operons for cbb3-type oxidases and oxidase subunits.

142 s mutant indicated reduced expression of the operons for production of the exopolysaccharide and TasA

143 ts (CRISPRs) and the cas (CRISPR-associated) operon form an RNA-based adaptive immune system against

144 ci that come into close proximity, with rRNA operons forming a structure reminiscent of the eukaryoti

145 The almEFG operon found in El Tor V. cholerae confers >100-fold res

146 Deletion of genes in the wca operon from a persistent-infection strain resulted in a

147 led that lpiA/acvB were co-transcribed as an operon from an RpoN promoter.

148 odel of Ag(+) resistance, encoded by the sil operon from pMG101, involves export of Ag(+) via an ATPa

149 required for expression of genes in the sbn operon from sbnD onward.

150 e variation of the Salmonella enterica opvAB operon generates a bacterial lineage with standard lipop

151 Expression of the feoAB operon genes was elevated under iron limitation, but mut

152 ription is coregulated with the other biotin operon genes.

153 sensitive hemagglutinin (MSHA) type IV pilus operon), had reduced infectivity of A. cytherea.

154 The plastid psbB operon harbours 5 genes, psbB, psbT, psbH, petB and petD

155 r MrpJ, which is encoded by the mrp fimbrial operon, has been shown to repress both swimming and swar

156 rved that strains lacking almE or the almEFG operon have enhanced biofilm formation.

157 eats (CRISPR)-associated] bacterial immunity operons have divergent activities.

158 A number of arsenic resistance (ars) operons have two genes of unknown function that are link

159 between a pair of operons based on accurate operon identification and cis regulatory motif analyses,

160 of 2,068 Mtb genes from the predicted first operons identified the most upregulated IVE-TB genes dur

161 We found that a deletion in the p27-p55 operon impairs the replication of M. bovis in bovine mac

162 Deletion of toxR and the MSHA operon in a second strain of V. coralliilyticus, OCN008,

163 egulates the expression of the hca catabolic operon in Acinetobacter and related bacterial strains, a

164 the tos operon, which could control the tos operon in association with H-NS and Lrp.

165 Moreover, we identified a four-gene operon in B. cereus ATCC 14579 that encodes proteins wit

166 re we describe the expression of a synthetic operon in Escherichia coli that produces carboxysome she

167 The lar operon in Lactobacillus plantarum encodes five Lar prote

168 known to methanotrophs as well as the pxmABC operon in M. denitrificans sp. nov. strain FJG1(T) in re

169 ata provide insight into the role of the cop operon in pneumococcal pathogenesis.

170 cated directly downstream of a type IV pilus operon in strongly cellulolytic members of the genus, wh

171 n are elucidated and the distribution of the operon in X. oryzae is investigated in over 100 isolates

172 e encoded by different numbers of homologous operons in Actinobacteria.

173 mining has enabled the identification of Mbn operons in bacterial genomes and the prediction of diver

174 actors determining the optimal number of rrn operons in E. coli by constructing isogenic variants wit

175 lative positions of the ribosomal RNA (rRNA) operons in space.

176 roduces a mixture of amplicons from all rRNA operons in the genome, and the sequence data generally y

177 lator, CidR, activates the expression of two operons including cidABC and alsSD that display pro- and

178 ver bacterial contigs that comprise multiple operons, including 22 contigs of >1 Mbp.

179 ession of the formate hydrogenlyase 1 (fhl1) operon increased with added H2 .

180 A paralogous operon involves a putative nuclease (CinB) rather than a

181 er genes, including chemotaxis and flagellar operons, iron-regulated genes, and genes of unknown func

182 The tos operon is AT rich, resides on pathogenicity island aspV,

183 The alpha-carboxysome operon is embedded in a cluster of additional, conserved

184 ansposon mutagenesis, we identified that the operon is highly induced by mutations in genes encoding

185 in the regulatory region of the E. coli GUS operon is identified, and structure-guided GusR mutants

186 The ars1 operon is located nearby the aio operon that is essentia

187 The zauPzapA operon is present in diverse Gram-negative bacteria, ind

188 The Escherichia coli lac operon is regulated by a positive feedback loop whose po

189 The Xoc operon leads to production of the bioactive GA4 , an add

190 ures: (i) an integrated alignment tool, (ii) operon-level analysis, and (iii) the ability to process

191 the added features of integrated alignment, operon-level analysis, and the ability to process large

192 However, our discovery of highly localized operon-like co-regulated regions of chromatin modificati

193 an adjacent putative restriction enzyme (RE) operon likely form a restriction modification (RM) syste

194 It is encoded within the four-gene lktCABD operon: lktA encodes the structural protoxin, and lktC e

195 In transgenic Drosophila, the cidA-cidB operon mimics CI when sperm introduce it into eggs, and

196 on factors do not behave as per the textbook operon model.

197 ntribute to the selection of the optimal rrn operon number.

198 tudies have found that variation of the MgPa operon occurs by recombination of repetitive chromosomal

199 The multiple antibiotic resistance (mar) operon of Escherichia coli is a paradigm for chromosomal

200 ually deleting each of the genes of the mce4 operon of M. smegmatis, which mediates the transport of

201 A regulator gene is adjacent to the operon of the sulfide-oxidizing genes, encoding a sigma(

202 The ethanolamine utilization (eut) operon of this bacterium encodes all functions needed fo

203 methods, due to mutations within the capsule operon; of the isolates identified by genotypic methods,

204 tanding the impact of the copy number of rrn operons on the fitness of the cell is an important step

205 Either deletion of the entire mce4 operon or single point mutations that eliminate the tran

206 ltiple clusters of genes, including those in operons or in subsets of operons.

207 There were exceptions, and these involved operons or large genes with multiple Trp codons: downstr

208 t TE temporal patterns, independent of their operon organization.

209 Non-rRNA operon pairs did not colocalize, and the magnitude of th

210 ToxR requires its operon partner ToxS, a periplasmic integral membrane pro

211 arily responsible for recognition of the trp operon pause signals.

212 tory pause elements, such as the ops and his operon pauses.

213 enous leucine also inhibits Lrp-mediated tos operon positive regulation.

214 ontrols the expression of over 100 genes and operons, principally by repressing during growth genes w

215 Whereas bacterial operons promote the interaction of two subunits, 3'-UTRs

216 in vitro techniques, we mapped both the tos operon promoter and TosR binding sites.

217 re, we investigate the expression of the nrf operon promoter from various pathogenic enteric bacteria

218 a new strain containing a tunable arabinose operon promoter PBAD to quantitatively control the expre

219 We created a library of Escherichia coli lsr operon promoters using error-prone PCR (ePCR) and select

220 protein expression patterns of Esx and mce1 operon proteins in JAL and BND strains, respectively.

221 on levels in synthetic and natural bacterial operons, providing a deeper understanding of an importan

222 during expression of the second AhlR-driven operon (Psyr_1620-1616, paoABCDE), only in a pdhQ mutant

223 ate precursor GA9 mediated by the homologous operons recently characterized from rhizobia.

224 Mutation of the corresponding operon reduced the cytotoxicity of CM from both UAMS-1 a

225 nsition from zinc sufficiency to deficiency, operons regulated by Zur are derepressed in three distin

226 a better understanding of the hca catabolic operon regulation mechanism by the transcription factor

227 s, is also hypothesized to contribute to tos operon regulation.

228 Peroxide operon regulator (PerR) is a broadly conserved hydrogen

229 The current study describes Terminator Operon Reporter (TOR), a new gene assembly technology ba

230 series of novel fluorescent protein and lux operon reporter systems to differentially label pathogen

231 -symmetric, homotetrameric copper-sensitive operon repressor (CsoR) as a function of Cu(I) ligation

232 Colocalization of the rRNA operons required the rrn P1 promoter region but not the

233 Analysis of the genome context of the adm operon revealed a gene encoding a predicted LysR-type re

234 ning expression of the rhamnolipid synthesis operon rhlAB.

235 re, we show that the number of ribosomal RNA operons (rrn) in bacterial genomes predicts two importan

236 Here, we identify the ninth gene of the sbn operon, sbnI, as encoding a ParB/Spo0J-like protein that

237 Antarctic phylotype exclusively contains an operon structure consisting of a dicitrate transporter f

238 e one observed in a mutant lacking all 6 mce operons suggesting a pleiotropic role for this system.

239 ve genes, ssl2245 and sll1130, constitute an operon that also has characteristics of a toxin-antitoxi

240 In addition, we identify an operon that confers TDA resistance to the producing mari

241 is autoregulated and is typically part of an operon that contains other ars genes involved in arsenic

242 The XNAC operon that contains the genes for the assembly of pzX i

243 ication and characterization of a seven-gene operon that enables LA catabolism in Pseudomonas putida

244 manLMN, was expressed as a mannose-inducible operon that exhibited the most influence on PTS sugar me

245 eral transfer of a complete biotin synthesis operon that has the potential to transform Wolbachia-hos

246 The ars1 operon is located nearby the aio operon that is essential for AsIII oxidation.

247 The frmRA(B) operon that is present in many bacteria represents one s

248 existence of NusA-binding sites in different operons that are also the targets of Rho-dependent termi

249 Here we investigate the role of two gtr operons that we identified in the S Typhi genome.

250 e urease operon, the pyrimidine biosynthesis operon, the betA-betB operon, and the pathogenicity isla

251 , highly upregulated loci include the urease operon, the pyrimidine biosynthesis operon, the betA-bet

252 For the Rho terminated metNIQ operon, the tails for all three mRNAs were predominately

253 ons of different genes associated with these operons, the collective role of the CidR regulon in stap

254 ictates the extent of transcription into the operon, thereby ensuring tight control of cellular NusA

255 Encoded in operons, these components are likely representative of t

256 A and PknB are expressed as part of the same operon, they appear to be regulating cellular processes

257 he biofilm matrix exopolysaccharide and TasA operons through the regulator slrR.

258 AIPs) and the accessory gene regulator (agr) operon to coordinate expression of virulence factors req

259 we characterized the contribution of the cop operon to copper homeostasis and virulence in Streptococ

260 ellar biosynthesis operon transcript.fla/che operon transcript abundance has been shown to be inhibit

261 f the 32-gene fla/che flagellar biosynthesis operon transcript.fla/che operon transcript abundance ha

262 eus BirA is an effective regulator of biotin operon transcription and that the prior data can be attr

263 The relBE2sca operon transcription was induced under osmotic stress, a

264 iptional Ci regulator mutant ndhR (for ndhF3 operon transcriptional regulator).

265 es, reactions, metabolic pathways, predicted operons, transport systems, and pathway-hole fillers.

266 gut-associated Proteobacteria maintain a GUS operon under the transcriptional control of a glucuronid

267 red the expression of this glucosylating gtr operon uniform in the population.

268 attempt systematic recoding in an essential operon using eight synonymous recoding schemes.

269 and UvrD in TCR genome-wide and in the lacZ operon using the XR-seq method, which directly measures

270 We annotated internal promoter usage in operons using SL1 and SL2 data.

271 In the first class the hom-thrCB operon was derepressed unmasking the threonine dehydrata

272 Moreover, this GA biosynthetic operon was found to be widespread in Xoc (> 90%), but ab

273 lyticus in which a putative ZPS biosynthetic operon was genetically disrupted.

274 hich is located proximally to the archaellum operon was identified.

275 transcribed spacer (ITS) region of the rRNA operon was validated for application to equine clinical

276 enomic regions around alpha-type carboxysome operons, we characterize a protein that is conserved acr

277 terature and comparing them to a database of operons; we detect two novel clusters, which were confir

278 ation origin in which highly transcribed rrn operons were forced to be replicated opposite to normal.

279 anscriptase PCR showed that fruRBA formed an operon which was repressed by FruR in the absence of fru

280 ains 6 homologous mce (mammalian cell entry) operons which have been proposed to encode ABC-like impo

281 entified TosR as a dual regulator of the tos operon, which could control the tos operon in associatio

282 mination process relies on the mlp-actA-plcB operon, which encodes ActA, a bacterial nucleation-promo

283 The opp operon, which encodes an oligopeptide permease that is e

284 In addition, TosR binds to the pap operon, which encodes another important UPEC adhesin, P

285 Differences in the wca operon, which encodes colanic acid, were identified by D

286 spR on transcriptional control of the espACD operon, which is required for ESX-1-dependent ESAT-6 sec

287 to the MG191 and MG192 genes carried on this operon, which may lead to antigenic variation and immune

288 d ainR genes were predicted to constitute an operon, which we corroborated using RT-PCR.

289 tified two genes lngR and lngS in the Longus operon, whose predicted products share homology with tra

290 We found that ZapA is encoded in an operon with a small coiled-coil protein we named ZauP.

291 been demonstrated to contain a biosynthetic operon with cyclases capable of producing the universal

292 proteins of unknown function and forming an operon with ORF207 (gp19).

293 of PA4330 and PA4331, located in a predicted operon with sadC, have a major impact on alginate produc

294 NA-seq) indicated that htrA is encoded in an operon with two subsequent genes, HP1020 and HP1021.

295 A three-gene operon with unknown function that is strongly up-regulat

296 wed consistent expression of six hydrogenase operons with and without added H2 .

297 offering the ability to rationally engineer operons with desired behaviors.

298 s in natural operons and to design synthetic operons with desired expression level ratios.

299 120 synthetic bi-cistronic and tri-cistronic operons with rationally designed intergenic regions and

300 E is comprised of four genes in two adjacent operons, with the regulatory two-component MaeKR require