ライフサイエンスコーパス: oppose

1 gulate gene expression, is controlled by the opposing action of histone acetyltransferases and histon

2 etabotropic receptor subtype, ACh exerts two opposing actions in cortical pyramidal neurons: transien

3 Overall, our results demonstrate how the opposing actions of a localized SUMO isopeptidase and a

4 f ribosomal DNA (rDNA) silencing through the opposing actions of a STUbL (Slx5:Slx8) and a SUMO isope

5 atases (GTPases), which are regulated by the opposing actions of guanine nucleotide exchange factors

6 sal cGMP level is strictly controlled by the opposing actions of phosphodiesterase (PDE6) and retinal

7 an) axonal degeneration is regulated via the opposing actions of pro-degenerative factors such as SAR

8 We propose that the opposing activities of ULK1-mediated phosphorylation and

9 As in eukaryotes, an opposing activity counteracts the modification by specif

10 st canopy may have complemented, rather than opposed, adaptations that facilitated precise manipulati

11 nd stability are impacted by a collection of opposing allosteric features that inhibit or promote pho

12 or T cells and regulatory T (T reg) cells in opposing and promoting solid organ carcinogenesis, respe

13 ry to probe the mechanical properties of the opposing antigen-presenting cell, giving rise to differe

14 the shell have been implicated in promoting opposing appetitive and aversive states, respectively.

15 Furthermore, we report unpredicted strong opposing associations with T.b. gambiense disease outcom

16 t longer times, trans-bilayer flip-flop that opposes asymmetric lateral segregation and causes a mism

17 des a mechanism whereby interphase cells can oppose autocatalytic cyclin E degradation and maintain c

18 hat nitrogen and phosphorous deficiency have opposing, auxin signalling-dependent effects on lateral

19 s to destabilization unless adenosine is the opposing basepair of 8-oxoGua; (ii) modification at the

20 ing properties for flexible specification of opposing behavioral learning states.

21 owth factor beta induced some cells to adopt opposing behaviors such as extremely high versus extreme

22 Together with opposing bilateral sclerites and a deep ventral visceral

23 functional in LUAD and show that astrocytes oppose brain metastasis by mediating the downregulation

24 active stress produced by motor activity is opposed by passive resistance to network deformation.

25 by the Parkinsonian neurotoxin rotenone and opposed by those induced by clioquinol, a compound with

26 nic acetylcholine receptor subtype 4 (M4) to oppose cAMP-dependent dopamine receptor subtype 1 (D1) s

27 duration by controlling the balance between opposing Cdc20 fates.

28 Genetic disruption of RCP or EphA2 opposes cell:cell repulsion and metastasis in an autocht

29 (Dvl), segregate into distinct complexes on opposing cell cortex to coordinate polarity among static

30 layed two combined properties that favorably opposed CF symptomatology: it reduced inflammation and i

31 Opposing changes in the expression of ZIP7 and ZnT7 were

32 RP-null defects, whereas PN silencing causes opposing changes.

33 thway and causes conformational changes that oppose channel activation.

34 transport will be limited to diffusion, and opposing chemical gradients that form as a result of con

35 We therefore show that members of two opposing clusters of risk TFs associated with ESR1-posit

36 occur in opposite directions, resulting from opposing controls of ENSO on precipitation between the N

37 ictions indicate that high pressure strongly opposes decomposition of isobutane, which may possibly c

38 The opposed defined-pathway model stems from experimental re

39 effect that creates backstresses (the forces opposing deformation) when precipitates are cut by dislo

40 dermine performance in another, but how such opposing demands play out in single cells and impact on

41 nerally mutually exclusive properties due to opposing dependencies on spin-orbit interactions.

42 ciation with fasting glucose in the expected opposing direction.

43 sized that ZIP7 and ZnT7 transport Zn(2+) in opposing directions across the S(E)R membrane in cardiom

44 gnitive function were non-significant and in opposing directions for DHCR7 and CYP2R1, with no overal

45 the gating is influenced by this surface in opposing directions for each auxiliary subunit.

46 nts contained either local motion signals in opposing directions or analogous static form cues depict

47 lygenic risk scores (PRSs) and CT, albeit in opposing directions.

48 hich affect the terminal seam cell number in opposing directions.

49 lating excitatory and inhibitory synapses in opposing directions.SIGNIFICANCE STATEMENT The correct b

50 thesis of the centrality of striatal ChIs in opposing dopamine regulation of BG output.

51 y mutations mapping to the same domain evoke opposing drug susceptibilities.

52 harmacological experiments revealed that the opposing effect on these neurons is mediated by the acti

53 These results highlight the opposed effects of rewards and punishments and provide f

54 SRSF1) to understand the foundation of these opposing effects in the nucleus.

55 g RNAi to zebrafish and reveal unanticipated opposing effects of a seed mismatch with implications fo

56 In conclusion, the opposing effects of environmental DNA damage and DNA rep

57 Underscoring the opposing effects of Tia1 deletion and low SMN level on B

58 This work revealed opposing effects of TLR9 and TLR3, TLR4, and TLR7 on the

59 ment can indeed be obtained by balancing the opposing effects of varying the ratio and by carefully a

60 We demonstrate that TREM2 deficiency has opposing effects on AD-related pathologies at early and

61 We hypothesize that UVR has opposing effects on BCC carcinogenesis-stimulatory via m

62 Furthermore, each factor has opposing effects on established neurogenic genes Neurog2

63 ation and trans-SNARE complex zippering have opposing effects on fragment formation and verify that t

64 ntial signal for axon guidance that mediates opposing effects on growth cone motility.

65 p35 is common to IL-35 and IL-12, which have opposing effects on inflammation.

66 triatonigral and striatopallidal neurons has opposing effects on LID.

67 Street canopy exerted opposing effects on loading, where elevated nutrient con

68 in which highly similar molecules may exert opposing effects on neurons.

69 The two forms have opposing effects on neurons: NGF induces proliferation,

70 current MRI) had highly significant (p<0.01) opposing effects on pain scores (std.

71 lations demonstrate that N addition can have opposing effects on separate soil C pools (particulate a

72 ion by the snail intermediate hosts, causing opposing effects on tadpole per capita exposure to trema

73 Hence, TSPY and TSPX exert opposing effects on the transactivation functions of AR

74 ct that targeted pathway modulators may have opposing effects on tolerance based on their impact on e

75 The two microRNAs had opposing effects on transcriptional heterogeneity within

76 Recombinant MIF exerted opposing effects on tubular cells in vitro and in vivo O

77 ic roles, yet the mechanisms underlying such opposing effects remain unclear.

78 is found that PEGylated DNA experiences two opposing effects: local excluded volume effect and chemi

79 These opposing emissions trends emphasize the importance of fu

80 The number of opposed excitatory presynaptic terminals was sharply red

81 The 3D printed specimens show, at two of its opposing faces along the same axis, different stiffness

82 s through the repeating building blocks, two opposing faces remain largely different in their mechani

83 Net changes in Pr, therefore, depend on two opposing factors: (1) Hebbian activity, which increases

84 turally similar, yet they have diametrically opposed fates.

85 support a role of immune selection under the opposing force of high outcrossing, a characteristic of

86 ing of ventral elements in the absence of an opposing force, possibly due to pretension.

87 ic nerve, suggesting that alterations of the opposing forces governing mitochondrial fusion and fissi

88 Such opposing forces led to no net evolutionary response over

89 ciples to ensure robust vesiculation against opposing forces like membrane tension.

90 ds to a 65kDa truncated protein isoform that opposes full-length eIF2Bepsilon to inhibit global trans

91 because engineering of this hotspot induces opposing functional outcomes by Stg and CNIH3.

92 e peptide-MHC and membrane cholesterol serve opposing functions as positive and negative allosteric r

93 These findings reveal unique and opposing functions for copper transporters of the host a

94 The molecular mechanisms underlying the opposing functions of glucocorticoid receptors (GRs) and

95 E4 interaction with the two kinases leads to opposing functions.

96 gous proteins may exert both overlapping and opposing functions.

97 , where it encounters complexes dedicated to opposing functions: recycling and degradation.

98 during the cell cycle, and that calcineurin opposes Fus3 to activate Rga2 and decrease Cdc42 signali

99 significant peer associations overall, those opposing "gain-of-function" research are more sensitive

100 Together, our data link opposing gradient dynamics in a growing tissue to precis

101 The unique ability to establish parallel or opposing gradients of gases and chemicals offers the pot

102 the prevalent patterns are expressed in two opposing gradients.

103 a LAZY-independent mechanism that creates an opposing gravity-induced auxin gradient.

104 and model demonstrate that an elastic force opposes growth of the utricular sensory epithelium durin

105 TCF7 retroviral transduction opposes GZMB expression and the formation of KLRG1(pos)

106 ation factor, Spt6 counteracts repression by opposing H3K27me3 deposition at critical genomic regulat

107 ha-H carbon donors and carbonyl acceptors on opposing helices (Calpha-H...O horizontal lineC hydrogen

108 Staggered coupling of the two opposing hexamers positions the DNA right in front of th

109 regions of multiple G box-containing genes, opposing in cis the promoting effect of the photomorphog

110 In cell culture, it opposed increased cancer cell invasiveness driven by upr

111 and inflammatory gene programs, which exert opposing influences on fibroblast to cardiac reprogrammi

112 1)H/(13)C methyl TROSY NMR measurements with opposing ligands.

113 reases GVL while decreasing GVHD through two opposing mechanisms: protection from fatal immunity by a

114 y aspects of metabolism, to separate in time opposing metabolic pathways and optimize metabolic effic

115 alized homeotic changes were associated with opposing miR172/Q gradients along the spike.

116 We show that these opposing modes depend on the stoichiometry of Lis1 bindi

117 o the surprising discovery that Lis1 has two opposing modes of regulating dynein, being capable of in

118 These areas naturally align in the opposing monolayers.

119 hing liquid or liquid-ordered domains in the opposing monolayers.

120 ic and stage-independent partners to produce opposing mRNA fates.

121 A) with different molecular weights produces opposing nociceptive effects.

122 ty signals through unique IPN circuitry that opposes novelty seeking to control NP.

123 en the kinematic errors associated with each oppose one another.

124 There are few data, but diametrically opposed opinions, about the impacts of forest logging on

125 at differentiation and self-renewal arise as opposing outcomes of sibling CD4(+) T cells.

126 TNF activates opposing pathways leading to caspase-8-mediated apoptosi

127 However, it is unclear how DA mediates opposing patterns of behavior by acting on different rec

128 Mechanistically, SAP opposed PD-1 function by acting as a molecular shield of

129 and water storage augmentation might lead to opposing perspectives on future water availability.

130 G-protein-coupled receptors (GPCRs) and have opposing physiological roles in insulin release and gluc

131 ected silencing [13, 14] and Drosophila PAF1 opposing PIWI/piRNA-directed silencing.

132 ata strongly support the hypothesis that the opposed placement of the 2 legs is essential for RRE fun

133 F (BAF) complex recruitment is sufficient to oppose Polycomb within minutes, leading to activation of

134 assay system through which we find that BAF opposes PRC by rapid, ATP-dependent eviction, leading to

135 We found that BKCa channel activity opposes pressure-induced constriction in human small res

136 ng diseases is caused by an imbalance of two opposing processes: persistent destruction of myelin and

137 me of a complex, switching between states of opposing prochirality in the process.

138 her our data suggest that CYK-4 GAP activity opposes Rac (and perhaps Cdc42) during cytokinesis.

139 mmon evolutionary history despite catalyzing opposing reactions.

140 ranscription factors NF-kappaB and IKAROS by opposing regulation of shared target genes.

141 Dmrt5 and Lhx2 also have opposing regulatory control on Pax6 and Neurog2, indicat

142 We found that NLRX1 exerted opposing regulatory effects on viral activation of the t

143 is a gene implicated in disease states with opposing responses in cell fate determination, yet its c

144 on humans and chimpanzees reported seemingly opposing results regarding cross-neutralizing antibodies

145 nterotoxin (ST), an exogenous GUCY2C ligand, opposed RIGS, a process requiring p53 activation mediate

146 rmone axis as a novel compensatory mechanism opposing RIGS, and they highlight the potential of oral

147 2C paracrine axis in compensatory mechanisms opposing RIGS.

148 a cross-suppressive role, alpha9beta1 has an opposing role in basement membrane assembly/maturation t

149 Our findings suggest that NRF2 and HSF1 have opposing roles during autophagy, and illustrate the exis

150 Previous work has shown opposing roles for D1 and D2 receptor MSN subtypes in de

151 erexpression of PcG member BMI-1, suggesting opposing roles for PEITC and PcG proteins in control of

152 Dpb11 mediates opposing roles in DNA end resection by coordinating both

153 2 play at times identical, distinct or even opposing roles in regulating various aspects of G protei

154 w Cas1 and the target-bound Csy complex play opposing roles in the regulation of Cas2/3 nuclease acti

155 nduced hypertension, although Sphk1 may have opposing roles in the regulation of vasoconstriction and

156 w that the two leukotriene B4 receptors have opposing roles in the sensitization of peripheral sensor

157 Thus different LINC complexes have opposing roles in the transcription-independent control

158 Moreover, the Wnt and Fgf pathways have opposing roles in transcriptional regulation of componen

159 Our results document the opposing roles of Celsr3 and Vangl2 in glutamatergic syn

160 ndings reveal unprecedented, pronounced, and opposing roles of rapid dopamine signaling across the ro

161 These opposing roles of the polysialyltransferases are based o

162 ing dopamine D1 or D2 receptors, which exert opposing roles on motivated behavior.

163 ce events have played important and possibly opposing roles throughout the history of this classic ex

164 The two opposed rotary molecular motors of the F0F1-ATP synthase

165 ts show that 5-HT transients have strong and opposing short and long-term effects on motor behavior t

166 tions with PI(4,5)P2 and heparan sulfates on opposing sides of the membrane.

167 egions but have intracellular sequences with opposing signaling functions.

168 state and Trithorax group (TrxG) proteins to oppose silencing.

169 Conversely, other proteins have opposing sites of phosphorylation that seemingly reflect

170 ion Canyon' in Israel, which consists of two opposing slopes with divergent microclimates.

171 ing their immediate targets, the readouts of opposing small RNA gradients enable specification of rob

172 x DNA can react with adenine residues on the opposing strand to generate a complex lesion consisting

173 gesting that Ulp2 promotes rDNA silencing by opposing STUbL-mediated degradation of silencing protein

174 monomer supplied a catalytic arginine to the opposing subunit, greatly accelerating the rate of GTP h

175 teraction nfGNPs-VLPs is not mediated by the opposing superficial electrostatic charges, suggesting t

176 free membrane proteins develops between the opposing surfaces and spherical parts of each cell's mem

177 ization of microvilli survey the majority of opposing surfaces within 1 minute.

178 symmetry between the number of soft modes on opposing surfaces.

179 This group showed an opposing sustained attentional disengagement.

180 nants that enable mature DCs to direct these opposing T cell outcomes.

181 trade-offs can be mitigated by assigning the opposing tasks to different signalling subnetworks.

182 hibitory component of glutamatergic PSPs and oppose temporal summation of inputs at intervals </= 20

183 Our results reveal opposing temporal gradients of Imp and Syp RNA-binding p

184 se in BAF (mSWI/SNF) complexes, are known to oppose the activity of Polycomb repressive complexes (PR

185 ed protein KIAA1199/CEMIP, which is known to oppose the degradation of activated EGFR kinase.

186 ators with anti-inflammatory properties that oppose the development of hypertension and CKD; 20-hydro

187 in are known to promote tissue stiffness and oppose the function of perlecan, which reduces tissue st

188 en coexisting species in an ecosystem, which oppose the hypothesis of neutral coexistence.

189 ized mechanical response from the VSMCs that opposed the pulling.

190 ized mechanical response from the VSMCs that opposed the pulling.

191 or the expression of physical withdrawal, it opposes the development of oxycodone tolerance, in both

192 is such as to generate a magnetic field that opposes the external field inside the ring (a 'diatropic

193 ppressed by the Rac isoform MIG-2; (2) RPM-1 opposes the function of microtubule stabilizers, includi

194 In this study, we show how KLF10 opposes the prometastatic effects of TGFbeta by limiting

195 Here, we show that IL-10 opposes the switch to the metabolic program induced by i

196 ion of hard-axis magnetic field favoring and opposing the Dzyloshinskii-Moriya interaction (DMI), res

197 ts directionally selective for inward motion opposing the excitation.

198 condition, players' interests were directly opposed: the partner tried to match the subject's choice

199 We assess opposing theoretical accounts for these effects through

200 o RAB25 expression, and treatment with RFP14 opposes this expression profile.

201 tylation (NuRD) chromatin remodeling complex opposes this transcriptional pioneering during B cell pr

202 hormone in glucose metabolism, with actions opposing those of insulin.

203 rt come from the same transmission chain, as opposed to 3% of cases separated by 1 to 5 kilometers.

204 Dryness and irritation symptoms, as opposed to a clinical diagnosis, were particularly stron

205 the comparison of structures in a crystal as opposed to a membrane environment.

206 bonding at the active TiO2-Pt interface, as opposed to a physico-chemical change within the RS film.

207 that participants implemented inverse RL as opposed to a simple imitation strategy, in which the act

208 d by cytopenias and autoimmune conditions as opposed to aggressive NK-cell LGL leukemia.

209 ses, and introducing mitotic catastrophe (as opposed to arbitrary delayed cell-death) as a means of m

210 f complex systems with many chromophores, as opposed to averages.

211 than competing single-photon transitions, as opposed to being as much as 8-10 orders of magnitude slo

212 ccumulation of alpha7 subunits in the ER, as opposed to being incorporated into functional alpha7 nAC

213 )4-n (-O-Al)n species is spatially biased as opposed to being random.

214 input from local and contralateral CCPCs as opposed to BLAPCs and BLA neurons (the prelimbic cortex-

215 ndergo cyclometalation by N-H metalation (as opposed to C-H metalation in meta-selective processes) a

216 engthens action-outcome encoding in rats (as opposed to chosen-outcome or stimulus-response encoding)

217 biochemical and clinical hyperandrogenism as opposed to clinical hyperandrogenism alone showed a meta

218 As opposed to closely related family members, the intermedi

219 based on hydrophobic and packing forces, as opposed to complementary hydrogen bonding, and while the

220 and pathological mechanisms of monogenic as opposed to complex retinopathies, using AMD as an exampl

221 in transmitting such epigenetic memories, as opposed to controlling or merely reflecting transcriptio

222 However, as opposed to conventional low molecular weight pesticides,

223 er that leads to severe vision impairment As opposed to corneal transplantation; corneal collagen cro

224 s designed for a single processing thread as opposed to currently predominant algorithms for large pa

225 es reflected endogenous arousal fluctuations opposed to differences in stimulus content.

226 valence value of cues in the environment, as opposed to either a more general emotional arousal value

227 Furthermore, opposed to existing deterministic (binary) approaches, t

228 attributed more harmful intent to unfair as opposed to fair dictators.

229 (EFP) site, a model of the human omentum, as opposed to free-floating in the intraperitoneal cavity (

230 mainly at the level of viral replication, as opposed to functioning as a mechanism that restricts vir

231 between the auditory and visual cortices, as opposed to fusion of AV percepts in a multisensory integ

232 these, the effects were fungus specific, as opposed to general alterations in phagocytosis.

233 ement was immediate for the implant group as opposed to gradual for the systemic group.

234 -anabolic effects of mTORC1 are functionally opposed to growth.

235 average were considered very low volume, as opposed to higher-volume surgeons.

236 of a conformational selection mechanism (as opposed to induced fit) in a supramolecular system.

237 ecific coordination between brain regions as opposed to information integration across the DMN.

238 Therefore, the presence, as opposed to its absence, of a slow rhythm, which in the p

239 In conclusion, Small aortic diameter (as opposed to large aortic diameter) is significantly assoc

240 nalysis for modulator-class neurons that, as opposed to laser-class neurons, are compatible with sili

241 ted rapidly in sensorimotor control loops as opposed to longer-term error correction mechanisms commo

242 paternal or postnatal nicotine exposure, as opposed to maternal or in utero nicotine exposure, this

243 n-load when using standard ESI conditions as opposed to nanoESI native-MS conditions.

244 o performed an NM procedure at least once-as opposed to never.

245 endothelial cells treated with targeting, as opposed to non-targeting siRNA.

246 per 100 infected explants were recovered as opposed to only 0.41% recovery when bar/phosphinothricin

247 highly and specifically expressed in BLBC as opposed to other breast cancer subtypes.

248 predict the development of schizophrenia as opposed to other psychoses.

249 ilarly, glucose was actively transported (as opposed to passive) and at higher rates under flow.

250 imensional pharmaceutical guest molecules as opposed to planar, rigid aromatics, was synthesized via

251 logical functions of PIP2 at postsynaptic as opposed to presynaptic sites.

252 inexpensive commercial starting materials as opposed to previous syntheses of these ligands, which ha

253 many marine ecosystems because consumers, as opposed to producers, often dominate organismal biomass.

254 Our work thus elucidates a pathogenic, as opposed to protective, role for IL-17A during Gram-posit

255 e lungs following subcutaneous injection, as opposed to pulmonary delivery.

256 strate that (aromatic) ketones/aldehydes, as opposed to quinones, play a far more prominent role in t

257 eceipt of ready-to-use supplementary food as opposed to ready-to-use therapeutic food during treatmen

258 tive responses to high-intensity training as opposed to recreational moderate physical exercise.

259 n are specific to the metastatic process, as opposed to representing natural primary tumor progressio

260 ggest land use and vegetation cover type, as opposed to rock properties, controls deep water drainage

261 cytotoxic potential against tumor cells, as opposed to salivary exosomes from mice with PDAC with no

262 ts indicate intrinsic transport enhancement, opposed to simply removing nonconductive carbons/residua

263 cycle and produce ethanol in mitochondria as opposed to slow growing cells.

264 Thus, as opposed to sole regulation by actin polymerases operatin

265 ed, which proves them to be true solitons as opposed to solitary waves for which such requirement is

266 mplexity measure, and hence for temporal, as opposed to spatial, signal diversity.

267 al model employing thermoneutral housing, as opposed to standard housing, resulted in lower stress-dr

268 echanisms in the generation of voluntary, as opposed to stimulus-driven actions, and highlights three

269 and (ii) total structure transformation, as opposed to surface reconstruction for Cd doping.

270 , as bears and foxes consumed more marine as opposed to terrestrial food, and as the availability of

271 alues within the value space of the agent as opposed to that of the observer, demonstrating that inve

272 biased to base their judgments on number as opposed to the alternatives.

273 c adenovirus infection induces pathology, as opposed to the chiefly immune-mediated pathology observe

274 uality and integrity of the extracted DNA as opposed to the conventional method.

275 skeleton, driven more by peripheral areas as opposed to the core WM where regions of interest were de

276 iology, very few consider the beneficial (as opposed to the detrimental) aspects of microbes.

277 oadening and primarily gradual unfolding, as opposed to the distinct transitions through gas-phase un

278 ifferences between cultures using the Mo- as opposed to the less efficient V-nitrogenase.

279 ss tangential to the interfacial surface, as opposed to the more universally reported maximum princip

280 cted control qubit in a more precise way, as opposed to the non-amplified case.

281 n the basal subtype of IDC breast cancer (as opposed to the other subtypes) and suggest HERV-K as a p

282 The formation of dinuclear Pd(I), as opposed to the Pd(0) complex, (tBu3P)2Pd was shown to de

283 cision and could cover the entire pocket, as opposed to the probe-based approach, which is limited to

284 ith three nonchelating pyrazole moieties, as opposed to the well-known "scorpionate" tris(pyrazol-1-y

285 table cardioverter-defibrillator therapy, as opposed to those with ICM.

286 kers featured heavily on the top-20 lists as opposed to traditional cardiovascular risk factors.

287 Our work shows that, as opposed to type I and II systems, the relaxed specificit

288 Cesarean delivery, as opposed to vaginal delivery, was associated with an incr

289 l plays a primary role in action planning as opposed to visual processing, that it exerts its stronge

290 Claudins interact within the same (cis) and opposing (trans) plasma membranes.

291 ur studies indicate that an imbalance of two opposing transcriptional programs drives B-ALL and sugge

292 Existence of localized clusters with opposing trend to that of broader geographic variation i

293 Overall, opposing trends in taxonomic similarity among different

294 ect on lupus pathology remains unclear, with opposing trials in murine models of the disease.

295 ble of driving and antagonizing behaviors of opposing valence.

296 ssing with ventral stream regions, while the opposing view suggests that both temporal channels contr

297 Conversely, chemogenetic inhibition opposed wakefulness and promoted NREM sleep, even in the

298 d by future climate in complex, and possibly opposing ways.

299 ng two distinct processes that are seemingly opposed yet synergistically combine to accelerate surfac

300 These two opposing yet coexisting phenomena implicate the potentia