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1 sponsiveness, SLC1A5/38A2 knockdown elicited opposing effects.
2 ociated genes were observed, many times with opposing effects.
3 yclase to cAMP to protein kinase A--but with opposing effects.
4 larified how the same receptor mediates such opposing effects.
5 ing, with Ala and Asp substitutions inducing opposing effects.
6 having profibrotic effects and others having opposing effects.
7 whereas inhibition by Dkk1 (Dickkopf-1) had opposing effects.
8 d that an early-career setback has powerful, opposing effects.
9 ine is a signaling nucleoside with potential opposing effects; adenosine can either protect against a
10 define a novel regulatory mechanism of GDFs' opposing effects and their relevance in RGC differentiat
16 noninvasive electrical stimulation, we show opposing effects at beta and gamma frequencies and inter
17 invade the parenchyma during pathology; the opposing effects (beneficial or detrimental) of these ce
18 DRG neuron activation by chloroform and the opposing effects chloroform has on different TRP channel
21 TOMM40, TCF7L2, and CETP variants, many with opposing effects (eg, the same rs7901695/TCF7L2 allele i
22 iators of arthritis, suggesting reciprocally opposing effects either via NF-kappaB or at the genomic
23 tion was determined by a balance between two opposing effects: enhanced presynaptic vesicular release
26 A, consistent with the recent recognition of opposing effects for these phytohormones on the microbia
27 determined by nuclear stiffness, as well as opposing effects from actin and intermediate filaments.
28 phin release, which inactivates the DAP, the opposing effects generating successive periods of bursti
29 has attracted considerable attention for its opposing effect in carcinogenesis as tumor suppressor (e
30 ty acid (VLCFA) derangement has dramatically opposing effects in astrocytes and oligodendrocytes.
31 that NF-kappaB and p53, which generally have opposing effects in cancer cells, coregulate induction o
32 ngs show that VAP-1 and alpha4 integrin have opposing effects in Con A-induced hepatic injury, which
36 riasis have distinct genetic mechanisms with opposing effects in shared pathways influencing epiderma
37 n species (ROS) and antioxidants, which have opposing effects in the cell, ultimately influence RAS-m
40 is found that PEGylated DNA experiences two opposing effects: local excluded volume effect and chemi
44 actions through MOR and DOR may underlie the opposing effect of these receptor systems on anxiety and
45 This is the first report of spatiotemporal opposing effects of a host lectin for a virus in one typ
46 g RNAi to zebrafish and reveal unanticipated opposing effects of a seed mismatch with implications fo
48 sms for regulating atRA biosynthesis and the opposing effects of atRA and insulin on gluconeogenesis,
49 ional variability, which we attribute to the opposing effects of austral summer insolation and the te
51 thesised that inhibin alpha may modulate the opposing effects of BMP and inhibin on androgen producti
52 ncentration and composition, we observed the opposing effects of cardenolides on monarch fitness trai
53 of Neuron, Griciuc et al. (2019) demonstrate opposing effects of CD33 and TREM2 on AD phenotypes, whe
54 nscription-PCR (RT-PCR) validation indicated opposing effects of CGI methylation in transcriptional r
55 CTCF clusters in living cells, uncovers the opposing effects of cohesin and transcription on CTCF cl
56 ical pathways affected by 5AR inhibition and opposing effects of COX-2 on the tissue-protective actio
60 asma 8-isoprostane F2alpha analysis revealed opposing effects of FO (increased) and AO (reduced) comp
61 y a pivotal role for polyadenylation and the opposing effects of Gld2 and Ngd in hippocampal synaptic
62 s sensitivity to image recurrence depends on opposing effects of glycinergic and GABAergic inhibition
65 f virus adaptation that incorporates the two opposing effects of host immunity on the virus populatio
66 r growth; rather, we found only additive and opposing effects of hypoxia (detrimental) and warming (b
68 use transplantation models, possibly through opposing effects of increased TGF-beta1 on the respectiv
69 ntent for high fat nanoemulsions, due to the opposing effects of lipid digestion and micelle solubili
70 a novel epigenetic mechanism that underlies opposing effects of MLL4 and PRMT7 on cellular different
74 Our results also call attention to potential opposing effects of NMDAR antagonists as a treatment for
78 als of DG compared with CA1 PCs underlie the opposing effects of perisomatic GABAergic transmission.
80 ersible arginine methylation of TRAF6 by the opposing effects of PRMT1 and JMJD6 is, therefore, a nov
85 1)-GATA2, and nuclear GATA2, which links the opposing effects of serine and tyrosine phosphorylations
88 ing a Nanog-GFP reporter line, we discovered opposing effects of Snai1 and Snai2 depletion on Nanog p
89 is temporally and spatially modulated by the opposing effects of specific phosphoinositide-metabolizi
90 Here, we review findings that suggest that opposing effects of stress and/or depression and antidep
92 indings confirm and extend prior data on the opposing effects of the APOE epsilon4 and epsilon2 allel
93 conditions is to find a balance between two opposing effects of the carboxylic acid in the reaction
94 incoherent feedforward is implemented by the opposing effects of the domain size on the rate and dura
97 interactions have been described, we report opposing effects of the same galectin family member on a
98 Together, these findings reveal distinct and opposing effects of the T cell costimulatory pathway and
99 tion and increases nNOS protein, showing the opposing effects of the two chaperones as they participa
106 ment can indeed be obtained by balancing the opposing effects of varying the ratio and by carefully a
107 C-Ar or N-Ar rings, which is ascribed to the opposing effect on metal-ligand sigma- and pai-bonding.
109 harmacological experiments revealed that the opposing effect on these neurons is mediated by the acti
111 se two post-translational modifications have opposing effects on 4.1N association with GluK2 kainate
112 that TGF-beta exerts distinct and sometimes opposing effects on a disease progression depending on t
113 d glycinergic antagonists in the BotC caused opposing effects on abdominal expiratory activity, sugge
115 We demonstrate that TREM2 deficiency has opposing effects on AD-related pathologies at early and
116 , we conclude that miR-221 and miR-130a have opposing effects on airway and vascular morphogenesis of
117 2-AG signaling in the ventral MHb and led to opposing effects on anxiety- and depressive-like behavio
119 d secondary thiol metabolic routes by having opposing effects on APSK and APS reductase in plants.
120 ing plk4 and slimb mutations, balances their opposing effects on Asl reduction, restoring seemingly n
121 eviously unreported pleiotropic alleles with opposing effects on atopic dermatitis and psoriasis risk
123 In mice, ANP and mANP (10-100 nmol/L) had opposing effects on atrial myocyte AP morphology and ICa
132 nin B2, two G protein-coupled receptors with opposing effects on blood vessel constriction, triggers
133 we unexpectedly found that tsl and tor have opposing effects on body size; tsl null mutants are smal
134 Avpr1alpha) and the Oxt receptor (Oxtr) have opposing effects on bone mass: Oxtr(-/-) mice have osteo
135 rane and soluble isoforms have diametrically opposing effects on both tumor growth and myeloid conten
137 he mechanism by which CPEB2 isoforms mediate opposing effects on cancer-related phenotypes, we used n
140 iomyocyte numbers during development through opposing effects on cardiomyocyte proliferation mediated
144 y homologous HSP70s, HSPA1A and HSPA1L, have opposing effects on cellular handling of various substra
145 tely regulates phenotypic modulation through opposing effects on chromatin accessibility at the promo
147 tion and plasticity in E. vaginatum thus had opposing effects on CO(2) fluxes, suggesting that warmin
149 osphorylation of activated PKCalpha but have opposing effects on degradation of the phosphorylated pr
151 ates that dopamine (0.1-10 mm) exerts novel, opposing effects on different populations of mammalian (
152 itative variation may impose diverse or even opposing effects on distinct lineages of T cells, an opt
155 nd non-canonical Wnt/Frizzled signaling have opposing effects on ECM organization underlying PCP and
156 s suggested that canonical Wnt signaling has opposing effects on epidermal and hair follicle stem cel
158 at CRF1 and CRF2 receptors in the BNSTAL had opposing effects on exploratory behavior in the elevated
159 lopment comprising biological processes with opposing effects on FA, such as axonal myelination and p
160 hat dorsal and ventral mPFC subregions exert opposing effects on fear, as do subregions of other stru
163 ation and trans-SNARE complex zippering have opposing effects on fragment formation and verify that t
164 when the involved transcription factors have opposing effects on gene regulation, like P53 tumor supp
165 criptional regulators Slx and Sly [3-7] have opposing effects on global transcription levels of the s
167 cellular sites and inducers of ROS can have opposing effects on GSIS, perhaps explaining some of the
169 s in maternal care in the rat associate with opposing effects on hippocampal function in the dorsal a
171 enal glucocorticoid secretion, but they have opposing effects on hippocampal neurogenesis and mood.
172 s and proteins with varied, overlapping, and opposing effects on histological and behavioral recovery
173 onists (PA452 and HX531) had independent and opposing effects on I (Ca) that were also time-dependent
176 ions by phosphorylation and methylation have opposing effects on in vitro translational regulation, w
179 uing insight that obestatin and ghrelin have opposing effects on insulin secretion, and both are medi
180 stria terminalis, and these projections have opposing effects on investigation or avoidance of threat
182 e for binding to the Lmo3 promoter and exert opposing effects on its transcription; repressing Lmo3 b
187 ation of PPN cholinergic cell bodies exerted opposing effects on locomotor behavior and reinforcement
188 Thus, cAMP-downregulation by CIRL exerts opposing effects on low-threshold mechanosensors and hig
190 -surface and secreted isoforms of CSF-1 have opposing effects on macrophage activation and disease pr
191 tic selection--where alleles at a locus have opposing effects on male and female fitness ("sexual ant
193 nt downstream basal ganglia targets and have opposing effects on motivated behavior, yet differential
194 onclusion, vitamin A and D deficiencies have opposing effects on mouse survival from BCR-ABL ALL.
195 so-called direct and indirect pathways--have opposing effects on movement: activity of direct-pathway
199 HD-ZIPIII transcription factor REVOLUTA has opposing effects on multiple components of the auxin pat
201 nd modularity (how a group is clustered) had opposing effects on network efficiency, showing that tol
202 of synaptic and intrinsic conductances with opposing effects on neuronal activity when temperature c
203 machinery and an F-box protein, MEC-15, have opposing effects on neuronal differentiation, and that t
208 vide evidence that endocannabinoids can have opposing effects on nociceptive vs. non-nociceptive path
211 ific niches has been implicated in mediating opposing effects on organotropic metastasis to the lungs
216 current MRI) had highly significant (p<0.01) opposing effects on pain scores (std. beta=-0.46 and 0.4
217 illustrating that a single factor may exert opposing effects on pathogenesis in distinct host niches
219 Our data thus show that FcgammaRIIb has opposing effects on pre-immune and post-immune tolerance
220 Intragenic 5-methylcytosine and CTCF mediate opposing effects on pre-mRNA splicing: CTCF promotes inc
222 Moreover, loss of myosin II activity has opposing effects on protrusive activity in fibroblasts o
223 nce of macronutrients has marked and largely opposing effects on reproductive and longevity outcomes.
225 uption of the MBD only or the entire CTT had opposing effects on ribosome binding, substrate-protein
227 nosteroid (BR) hormone is shown here to have opposing effects on root meristem size, depending on its
231 lations demonstrate that N addition can have opposing effects on separate soil C pools (particulate a
232 FtsZ filaments and lipid membranes have opposing effects on SepF polymerization, indicating that
233 apted and nonassociated polymorphisms showed opposing effects on set-point VL and the balance between
234 c Ca(V)2.1 channels by CaBP1 and VILIP-2 has opposing effects on short-term synaptic plasticity in su
238 in the stability of Glut4 mRNA, resulting in opposing effects on steady-state Glut4 mRNA levels.
240 101) are highly homologous alleles that have opposing effects on susceptibility to primary biliary ci
241 ntaining proteins in hippocampal neurons has opposing effects on synaptic strength, decreasing and in
243 ms of p38 activation converge on NFATc1 with opposing effects on T cell immunity, which may underlie
244 ion by the snail intermediate hosts, causing opposing effects on tadpole per capita exposure to trema
247 subunits, the two phosphorylation sites have opposing effects on the ability of each hexamer to bind
249 Ai-mediated suppression of PTP1B resulted in opposing effects on the activity of BRK and SRC and have
251 tion and/or overexpression of miR-511-3p has opposing effects on the expression levels of two key C-t
254 y or circulating inflammatory cells can have opposing effects on the generation of inflammatory media
255 at individual G186V and L194P mutations have opposing effects on the HA receptor-binding site (RBS),
261 effects depending on sex, but also can have opposing effects on the same tissue: across both species
262 is a regulator of liver fat metabolism with opposing effects on the secretion of TRLs and hepatic li
263 dramatically in different contexts and have opposing effects on the selection for non-cooperating ch
265 Fgf and Wnt, the two pathways generally have opposing effects on the transcription of co-regulated ge
271 ct that targeted pathway modulators may have opposing effects on tolerance based on their impact on e
277 factor (VEGF) and Ang1 (Angiopoietin-1) have opposing effects on vascular permeability, but the molec
278 rved ejection fraction, sildenafil displayed opposing effects on ventricular and vascular function.
279 r phosphaturic hormones, PTH and FGF23, have opposing effects on vitamin D production, placing vitami
281 mperatures and decreasing winter length have opposing effects on Wood Frog winter energy requirements
283 asion, metastasis, and vascularization, with opposing effects produced by ROBO1 silencing in tumor ce
284 e dysregulated, will lead to different, even opposing effects, producing prenatal as well as later ne
285 al populations and neuro-mediators can exert opposing effects, promoting or inhibiting tissue immunit
286 Computational modelling suggests that these opposing effects reflect a fast-slow timescale hierarchy
288 larification of the mechanisms causing these opposing effects should provide a better guide for thera
289 mal ploidy (aneuploidy) can have a number of opposing effects, such as unbalancing protein abundances
290 Variants in the TOM1L2/SREBF1 locus exert opposing effects TB-LM and TBLH-BMD, and have a stronger
291 results from a delicate balance between two opposing effects: the loss of conformational entropy due
292 d by the interplay between two currents with opposing effects: the rapid delayed rectifier potassium
294 have elevated epoxy-oxylipins, demonstrated opposing effects to epoxI-treated mice: reduced Ly6c(hi)
296 aride A-deficient BF failed to produce these opposing effects upon oral and systemic deliveries.
297 ization by Ral downstream pathways, based on opposing effects via the Ral effectors RalBP1 and phosph
299 ellular actions of IL-2, its cooperative and opposing effects with other cytokines, and how both prom
300 ive processes that may have distinct or even opposing effects with respect to insulin sensitivity.