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   1 le other cytoplasmic domains had a competing opposing effect.                                        
     2 larified how the same receptor mediates such opposing effects.                                       
     3 ing, with Ala and Asp substitutions inducing opposing effects.                                       
     4 having profibrotic effects and others having opposing effects.                                       
     5  whereas inhibition by Dkk1 (Dickkopf-1) had opposing effects.                                       
     6 colon adenocarcinomas, consistent with their opposing effects.                                       
     7  differentiation, whereas overexpression has opposing effects.                                       
     8  should be carefully tested in vivo for such opposing effects.                                       
     9 sponsiveness, SLC1A5/38A2 knockdown elicited opposing effects.                                       
    10 ociated genes were observed, many times with opposing effects.                                       
    11 yclase to cAMP to protein kinase A--but with opposing effects.                                       
    12 an antisense selective against nNOS-2 had an opposing effect against the first phase, increasing its 
  
  
  
  
    17  noninvasive electrical stimulation, we show opposing effects at beta and gamma frequencies and inter
    18  invade the parenchyma during pathology; the opposing effects (beneficial or detrimental) of these ce
    19  DRG neuron activation by chloroform and the opposing effects chloroform has on different TRP channel
    20 and temporally regulated phosphorylation has opposing effects directly on overt circadian rhythms and
    21 n assays where anosmin-1 was shown to induce opposing effects during chemotaxis of human neuronal cel
  
    23 TOMM40, TCF7L2, and CETP variants, many with opposing effects (eg, the same rs7901695/TCF7L2 allele i
    24 iators of arthritis, suggesting reciprocally opposing effects either via NF-kappaB or at the genomic 
    25 tion was determined by a balance between two opposing effects: enhanced presynaptic vesicular release
  
    27 A, consistent with the recent recognition of opposing effects for these phytohormones on the microbia
    28  determined by nuclear stiffness, as well as opposing effects from actin and intermediate filaments. 
    29 phin release, which inactivates the DAP, the opposing effects generating successive periods of bursti
    30 has attracted considerable attention for its opposing effect in carcinogenesis as tumor suppressor (e
  
    32 ty acid (VLCFA) derangement has dramatically opposing effects in astrocytes and oligodendrocytes.    
    33 that NF-kappaB and p53, which generally have opposing effects in cancer cells, coregulate induction o
    34 ngs show that VAP-1 and alpha4 integrin have opposing effects in Con A-induced hepatic injury, which 
  
  
    37 riasis have distinct genetic mechanisms with opposing effects in shared pathways influencing epiderma
  
  
  
    41  is found that PEGylated DNA experiences two opposing effects: local excluded volume effect and chemi
    42 e find that the two residues have strong and opposing effects: N richness promotes assembly of benign
  
  
  
  
  
    48 actions through MOR and DOR may underlie the opposing effect of these receptor systems on anxiety and
    49   This is the first report of spatiotemporal opposing effects of a host lectin for a virus in one typ
    50 g RNAi to zebrafish and reveal unanticipated opposing effects of a seed mismatch with implications fo
  
    52 sms for regulating atRA biosynthesis and the opposing effects of atRA and insulin on gluconeogenesis,
    53 ional variability, which we attribute to the opposing effects of austral summer insolation and the te
  
  
    56 ncentration and composition, we observed the opposing effects of cardenolides on monarch fitness trai
  
    58 nscription-PCR (RT-PCR) validation indicated opposing effects of CGI methylation in transcriptional r
    59 ical pathways affected by 5AR inhibition and opposing effects of COX-2 on the tissue-protective actio
  
  
  
  
    64 evance of these findings is supported by the opposing effects of Flightless-I overexpression and knoc
    65 asma 8-isoprostane F2alpha analysis revealed opposing effects of FO (increased) and AO (reduced) comp
    66 y a pivotal role for polyadenylation and the opposing effects of Gld2 and Ngd in hippocampal synaptic
    67 sttranslational histone modifications on the opposing effects of glucose and cAMP on the L-PK gene is
    68 s sensitivity to image recurrence depends on opposing effects of glycinergic and GABAergic inhibition
  
  
    71 f virus adaptation that incorporates the two opposing effects of host immunity on the virus populatio
    72 r growth; rather, we found only additive and opposing effects of hypoxia (detrimental) and warming (b
  
    74 use transplantation models, possibly through opposing effects of increased TGF-beta1 on the respectiv
  
    76 ntent for high fat nanoemulsions, due to the opposing effects of lipid digestion and micelle solubili
    77  a novel epigenetic mechanism that underlies opposing effects of MLL4 and PRMT7 on cellular different
  
  
    80 Our results also call attention to potential opposing effects of NMDAR antagonists as a treatment for
  
  
    83 als of DG compared with CA1 PCs underlie the opposing effects of perisomatic GABAergic transmission. 
  
    85 ersible arginine methylation of TRAF6 by the opposing effects of PRMT1 and JMJD6 is, therefore, a nov
  
  
  
    89 1)-GATA2, and nuclear GATA2, which links the opposing effects of serine and tyrosine phosphorylations
  
  
    92 ing a Nanog-GFP reporter line, we discovered opposing effects of Snai1 and Snai2 depletion on Nanog p
    93 is temporally and spatially modulated by the opposing effects of specific phosphoinositide-metabolizi
    94   Here, we review findings that suggest that opposing effects of stress and/or depression and antidep
  
    96 immune responses are finely regulated by the opposing effects of Th17 and T regulatory (Treg) cells. 
    97 indings confirm and extend prior data on the opposing effects of the APOE epsilon4 and epsilon2 allel
    98 incoherent feedforward is implemented by the opposing effects of the domain size on the rate and dura
  
  
  
   102  interactions have been described, we report opposing effects of the same galectin family member on a
   103 Together, these findings reveal distinct and opposing effects of the T cell costimulatory pathway and
   104 tion and increases nNOS protein, showing the opposing effects of the two chaperones as they participa
  
  
  
  
  
  
  
   112  issue of Immunity, Yagi et al. describe the opposing effects of transcription factors Runx3 and GATA
   113 ment can indeed be obtained by balancing the opposing effects of varying the ratio and by carefully a
  
   115 harmacological experiments revealed that the opposing effect on these neurons is mediated by the acti
  
   117 se two post-translational modifications have opposing effects on 4.1N association with GluK2 kainate 
   118  that TGF-beta exerts distinct and sometimes opposing effects on a disease progression depending on t
  
  
   121     We demonstrate that TREM2 deficiency has opposing effects on AD-related pathologies at early and 
   122 n the frequency of the original host has two opposing effects on adaptation: an increase in the suppl
   123 , we conclude that miR-221 and miR-130a have opposing effects on airway and vascular morphogenesis of
  
   125 d secondary thiol metabolic routes by having opposing effects on APSK and APS reductase in plants.   
   126 ing plk4 and slimb mutations, balances their opposing effects on Asl reduction, restoring seemingly n
   127 eviously unreported pleiotropic alleles with opposing effects on atopic dermatitis and psoriasis risk
  
   129    In mice, ANP and mANP (10-100 nmol/L) had opposing effects on atrial myocyte AP morphology and ICa
  
  
  
  
  
  
  
  
   138  we unexpectedly found that tsl and tor have opposing effects on body size; tsl null mutants are smal
   139 Avpr1alpha) and the Oxt receptor (Oxtr) have opposing effects on bone mass: Oxtr(-/-) mice have osteo
   140 rane and soluble isoforms have diametrically opposing effects on both tumor growth and myeloid conten
  
   142 equence, through which vigilin and HuR exert opposing effects on c-fms expression, suggesting a role 
   143 he mechanism by which CPEB2 isoforms mediate opposing effects on cancer-related phenotypes, we used n
  
  
   146 iomyocyte numbers during development through opposing effects on cardiomyocyte proliferation mediated
   147 f ARNO/cytohesin 2 and GRP1/cytohesin 3 have opposing effects on cell adhesion and spreading on fibro
  
  
   150 tely regulates phenotypic modulation through opposing effects on chromatin accessibility at the promo
   151 osphorylation of activated PKCalpha but have opposing effects on degradation of the phosphorylated pr
  
  
   154 ates that dopamine (0.1-10 mm) exerts novel, opposing effects on different populations of mammalian (
   155 itative variation may impose diverse or even opposing effects on distinct lineages of T cells, an opt
  
   157 nd non-canonical Wnt/Frizzled signaling have opposing effects on ECM organization underlying PCP and 
  
   159 s suggested that canonical Wnt signaling has opposing effects on epidermal and hair follicle stem cel
  
   161 at CRF1 and CRF2 receptors in the BNSTAL had opposing effects on exploratory behavior in the elevated
  
   163 lopment comprising biological processes with opposing effects on FA, such as axonal myelination and p
   164 hat dorsal and ventral mPFC subregions exert opposing effects on fear, as do subregions of other stru
  
   166 ation and trans-SNARE complex zippering have opposing effects on fragment formation and verify that t
   167 smic poly(A) binding protein (PABPC) to have opposing effects on gene expression when concentrated in
   168 when the involved transcription factors have opposing effects on gene regulation, like P53 tumor supp
  
   170  cellular sites and inducers of ROS can have opposing effects on GSIS, perhaps explaining some of the
  
   172 s in maternal care in the rat associate with opposing effects on hippocampal function in the dorsal a
  
   174 enal glucocorticoid secretion, but they have opposing effects on hippocampal neurogenesis and mood.  
   175 s and proteins with varied, overlapping, and opposing effects on histological and behavioral recovery
  
  
  
  
   180 terning receptor expression were linked with opposing effects on inflammatory, procatabolic responses
   181 uing insight that obestatin and ghrelin have opposing effects on insulin secretion, and both are medi
  
   183 e for binding to the Lmo3 promoter and exert opposing effects on its transcription; repressing Lmo3 b
  
  
  
   187 ation of PPN cholinergic cell bodies exerted opposing effects on locomotor behavior and reinforcement
  
   189 -surface and secreted isoforms of CSF-1 have opposing effects on macrophage activation and disease pr
   190 tic selection--where alleles at a locus have opposing effects on male and female fitness ("sexual ant
   191 ing by only 16 amino acids, exhibit markedly opposing effects on mammary epithelium growth and differ
  
  
   194  in which a ligand-receptor system generates opposing effects on mitogenesis by differentially regula
   195 nt downstream basal ganglia targets and have opposing effects on motivated behavior, yet differential
   196 so-called direct and indirect pathways--have opposing effects on movement: activity of direct-pathway
  
  
   199  HD-ZIPIII transcription factor REVOLUTA has opposing effects on multiple components of the auxin pat
   200 vitro findings, fimbrin and tropomyosin have opposing effects on Myo1p function at actin patches.    
  
   202 nd modularity (how a group is clustered) had opposing effects on network efficiency, showing that tol
   203  of synaptic and intrinsic conductances with opposing effects on neuronal activity when temperature c
   204 ead to a model where proteoglycans can exert opposing effects on neuronal extension by competing to c
  
  
  
  
   209 vide evidence that endocannabinoids can have opposing effects on nociceptive vs. non-nociceptive path
  
  
  
  
  
  
   216 current MRI) had highly significant (p<0.01) opposing effects on pain scores (std. beta=-0.46 and 0.4
   217  illustrating that a single factor may exert opposing effects on pathogenesis in distinct host niches
  
  
  
   221 Intragenic 5-methylcytosine and CTCF mediate opposing effects on pre-mRNA splicing: CTCF promotes inc
  
   223     Moreover, loss of myosin II activity has opposing effects on protrusive activity in fibroblasts o
  
   225 nce of macronutrients has marked and largely opposing effects on reproductive and longevity outcomes.
  
  
   228 nosteroid (BR) hormone is shown here to have opposing effects on root meristem size, depending on its
  
  
   231 lations demonstrate that N addition can have opposing effects on separate soil C pools (particulate a
   232 apted and nonassociated polymorphisms showed opposing effects on set-point VL and the balance between
   233 results suggest that neurotrophins can exert opposing effects on SG neurons, the balance of competing
   234 c Ca(V)2.1 channels by CaBP1 and VILIP-2 has opposing effects on short-term synaptic plasticity in su
  
  
  
  
   239 in the stability of Glut4 mRNA, resulting in opposing effects on steady-state Glut4 mRNA levels.     
   240 101) are highly homologous alleles that have opposing effects on susceptibility to primary biliary ci
   241 ntaining proteins in hippocampal neurons has opposing effects on synaptic strength, decreasing and in
  
   243 ms of p38 activation converge on NFATc1 with opposing effects on T cell immunity, which may underlie 
   244 ion by the snail intermediate hosts, causing opposing effects on tadpole per capita exposure to trema
  
  
   247 subunits, the two phosphorylation sites have opposing effects on the ability of each hexamer to bind 
  
   249 mediated CARMA1 phosphorylation events exert opposing effects on the activation status of CARMA1.    
   250 Ai-mediated suppression of PTP1B resulted in opposing effects on the activity of BRK and SRC and have
   251  compete for the same binding site, but have opposing effects on the activity of the receptor protein
   252 -DeltaN100 and cTnT3-DeltaE101 mutations had opposing effects on the Ca(2+) sensitivity of force deve
  
  
   255 ow that TrkA and p75 signaling pathways have opposing effects on the firing properties of sympathetic
   256 y or circulating inflammatory cells can have opposing effects on the generation of inflammatory media
  
   258 dicate that BMPR1a and BMPR1b exert directly opposing effects on the initial reactive astrocytic hype
  
  
  
  
   263  effects depending on sex, but also can have opposing effects on the same tissue: across both species
   264  is a regulator of liver fat metabolism with opposing effects on the secretion of TRLs and hepatic li
   265  dramatically in different contexts and have opposing effects on the selection for non-cooperating ch
   266 opose that calcium and d-serine binding have opposing effects on the stability of the dimer interface
   267 s mRNA, and changes in -1 RF efficiency have opposing effects on the steady-state abundance of the ES
   268 y between, at least, two processes that have opposing effects on the tension output as the shortening
  
   270 Fgf and Wnt, the two pathways generally have opposing effects on the transcription of co-regulated ge
  
  
  
   274 ct that targeted pathway modulators may have opposing effects on tolerance based on their impact on e
  
  
  
  
  
   280 factor (VEGF) and Ang1 (Angiopoietin-1) have opposing effects on vascular permeability, but the molec
   281 rved ejection fraction, sildenafil displayed opposing effects on ventricular and vascular function.  
   282 r phosphaturic hormones, PTH and FGF23, have opposing effects on vitamin D production, placing vitami
  
   284 ted MLCP, the ROCK isoforms had distinct and opposing effects on VSMC morphology and ROCK2, but not R
  
   286 asion, metastasis, and vascularization, with opposing effects produced by ROBO1 silencing in tumor ce
   287  Computational modelling suggests that these opposing effects reflect a fast-slow timescale hierarchy
  
   289 larification of the mechanisms causing these opposing effects should provide a better guide for thera
   290    Variants in the TOM1L2/SREBF1 locus exert opposing effects TB-LM and TBLH-BMD, and have a stronger
   291  results from a delicate balance between two opposing effects: the loss of conformational entropy due
   292 nctionally divergent T cell subsets can have opposing effects -- they can trigger tumor rejection or 
  
   294  have elevated epoxy-oxylipins, demonstrated opposing effects to epoxI-treated mice: reduced Ly6c(hi)
  
  
   297 ization by Ral downstream pathways, based on opposing effects via the Ral effectors RalBP1 and phosph
  
   299 ellular actions of IL-2, its cooperative and opposing effects with other cytokines, and how both prom
   300 ive processes that may have distinct or even opposing effects with respect to insulin sensitivity.   
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