ライフサイエンスコーパス: opt

1 representative sample from 19 opt-out and 10 opt-in consent countries from across Europe.

2 ir organs in a representative sample from 19 opt-out and 10 opt-in consent countries from across Euro

3 ARL participants (35.3%) as controls (17.6%) opted to receive a dental injection after the interventi

4 unique HCV-unaware baby boomers, 289 (12.7%) opted out of HCV screening.

5 3052 individuals (88%) opted for investigation in their first vignette.

6 In 47 primary care participants, 96% opted for testing of three single nucleotide polymorphis

7 AAV8G9-opt-IDUA administered to human corneas via intrastromal

8 se in each choice set between 2 meals and an opt-out choice, with different combinations of attribute

9 joined the collaborative and implemented an opt-out protocol for nurses and respiratory therapists t

10 National Health Service England uses an opt-in incentive scheme to encourage annual health check

11 physicians consented to participate with an opt-in or opt-out mechanism; patient consent was waived

12 ased relative, support the transition to an "opt-out" policy, or donate a kidney while alive.

13 sed relative, or support a transition to an "opt-out" policy.

14 o donate their organs in opt-in (58.63%) and opt-out (59.23%) countries.

15 s did not differ between opt-in (65.97%) and opt-out (66.37%) countries.

16 Implementing risk-based and opt-out screening could diagnose 41,900 to 122,700 new H

17 needed in addition to provider-initiated and opt-out HIV testing in adolescents, Sheri Weiser and col

18 transmission network, reinfection rate, and opt-out HCV screening rate are lacking.

19 ), although the association between risk and opting for investigation was strong when colorectal canc

20 pted out more often on difficult trials, and opting out improved their proportion of successful trial

21 nts ( approximately 90%) who were approached opted to undergo molecular testing.

22 Bees opted out more often on difficult trials, and opting out

23 o donate their organs did not differ between opt-in (65.97%) and opt-out (66.37%) countries.

24 A multidisciplinary board opted for a second endovascular attempt, this time with

25 don optimized idua cDNA expression cassette (opt-IDUA) was validated for IDUA production and function

26 Centers opted for one dose (70, 74, or 78 Gy).

27 Resistant cells also co-opt developmental pathways and display stem-like propert

28 e the perivascular space for invasion and co-opt existing vessels as satellite tumour form.

29 occupying the brain microenvironment and co-opt GABA as an oncometabolite.

30 Tumors routinely attract and co-opt macrophages to promote their growth, angiogenesis, a

31 encode ethologically relevant stimuli and co-opt midbrain reward circuits to promote prosocial behavi

32 from their normal B-cell counterpart and co-opt them for their own oncogenic purpose, which is usual

33 pport to the following scenario: bacteria co-opt the host transporter SLC35D2 to import UDP-glucose i

34 Brain tumor initiating cells (BTICs) co-opt the neuronal high affinity glucose transporter, GLUT

35 studies suggest that squirrels and camels co-opt a common molecular strategy to adapt to hot environm

36 ich striatal cholinergic interneurons can co-opt dopamine terminals to drive GABA release and rapidly

37 n and demonstrate that an oncoprotein can co-opt HA biosynthesis to drive malignancy.

38 Similar to how a growing tumour can co-opt normal soluble signalling pathways, our findings dem

39 Our findings demonstrate that EBV can co-opt Rad18 as a novel accessory factor in the production

40 onverge to demonstrate that androgens can co-opt the AMPK-PGC-1alpha signaling cascade, a known homeo

41 chitinase A is a unique way an insect can co-opt the plant's defense proteins for its own benefit.

42 e concept that tumor-initiating cells can co-opt the self-renewal program of endogenous stem cells as

43 et al., (2017) demonstrate how host cells co-opt sequential action of autophagy proteins and IFN-indu

44 How cancer cells co-opt this process to promote tumorigenesis remains unclea

45 147R) that enables an N1 NA to completely co-opt the receptor-binding function normally performed by

46 liovirus (PV), and enterovirus 71 (EV71), co-opt the host cell secretory pathway, which controls the

47 Venoms frequently co-opt host immune responses, so study of their mode of act

48 Glioblastomas co-opt stem cell regulatory pathways to maintain brain tumo

49 a (CML) by showing that these 2 leukemias co-opt miR-486 functions in normal erythroid progenitor pro

50 ow that chemotherapy-resistant CD36+ LSCs co-opt gonadal adipose tissue to support their metabolism a

51 MCs co-opt their secretory granules for antigen processing and

52 peutics, small hairpin RNAs (shRNAs) must co-opt sufficient quantities of the endogenous microRNA mac

53 Thus, nanotherapeutics co-opt TAMs for drug delivery, which has implications for T

54 umerous strategies to combat, subvert, or co-opt host immunity.

55 ed exquisite virus-host interactions that co-opt or evade a number of host pathways to enable the vir

56 ogenes include transcription factors that co-opt the general transcriptional machinery to sustain the

57 imension, wherein cancer cells themselves co-opt NKG2D for their own benefit to complement the presen

58 g capacity and are therefore obligated to co-opt a significant amount of cellular factors to translat

59 host specialization can enable aphids to co-opt both the phytohormonal responses and defensive compo

60 nd have therefore developed strategies to co-opt cellular processes to optimize infection and counter

61 ecture provides an efficient mechanism to co-opt conserved signaling networks for diverse purposes in

62 mechanism for the malignancy in order to co-opt the microenvironment and suggest separate mesenchyma

63 and Neospora use a conserved mechanism to co-opt these host organelles, which suggests that lipid dro

64 Solid tumors co-opt developmental cues to promote formation of tumor ves

65 lity to break down the shield that tumors co-opt for their defense.

66 Thus, tumors co-opt the ancient survival functions of HSF1 to orchestrat

67 erscores why eukaryotic viruses typically co-opt eukaryotic genes and bacteriophages commonly harbour

68 RNA viruses co-opt a large number of cellular proteins that affect viru

69 Viruses have also co-opted the MHC fold for immune-evasive functions.

70 ation complexes by sequestering viral and co-opted host proteins to reach high local concentrations a

71 involved in immune cell homeostasis, are co-opted by cancer cells to thwart the development of effec

72 Wild-type cells are co-opted into new hair growths by beta-catenin mutant cells

73 ctivation, identifying functions that are co-opted or abated to drive human cancers and developmental

74 is whether host cytosolic components are co-opted to transport the viral particle into the cytosol.

75 he distributions of sequences that can be co-opted are biased with respect to codons, and phasing of

76 t natural selection are more likely to be co-opted as mating cues, leading to the appearance of magic

77 maintaining self-tolerance, which can be co-opted by cancer to evade immune attack.

78 g anti-microbial immune responses, can be co-opted by cancer to evade immune destruction.

79 lergic inflammatory circuitry that can be co-opted by metastatic cancer cells to facilitate lung colo

80 tion through Irs2 induction, which can be co-opted by Vegf inhibitors to modulate glucose metabolism.

81 pose that larger BS in C3 lineages may be co-opted for C3 -C4 and C4 biochemistry requirements.

82 SPR-Cas system in Escherichia coli can be co-opted for programmable transcriptional repression.

83 atures that activate transcription can be co-opted to participate in the regulation of the splicing o

84 d shell has another function and has been co-opted as a defense system to encase and kill parasitic n

85 y example of an exoskeleton that has been co-opted as an immune system.

86 hese transcription units, which have been co-opted as gene regulatory mechanisms.

87 ll puncturing nanomachines that have been co-opted by bacteria for self-defense against both bacteria

88 single molecular mechanism may have been co-opted by synaptic partners to ensure joint laminar restr

89 em for lysosome homeostasis that has been co-opted by the autonomous defense program to clear recalci

90 genes of retroviral origin that have been co-opted for a role in placentation and likely contribute t

91 ures in vertebrate evolution, having been co-opted for an enormous array of functions.

92 response to ultrasonic bat calls has been co-opted for mate location.

93 nes for insect pathogenesis may have been co-opted from genes involved in endophytic colonization.

94 These results suggest that Ubx has been co-opted into a novel eyespot gene regulatory network, and

95 This process has been co-opted into a range of developmental events, and it also

96 suggest that TE proteins have often been co-opted or 'domesticated' by their host as adaptations to

97 vior in an ancestral protist may had been co-opted to develop some multicellular properties currently

98 polarity determination mechanism has been co-opted to different functions during evolution.

99 suggest that a lamin derivative has been co-opted to enhance tissue stability in tardigrades, a func

100 st that different HPAT homologs have been co-opted to function in diverse species-specific developmen

101 n some contexts, but rather RISC has been co-opted to negatively regulate toxic host antiviral effect

102 ue chemistry that cyanobacteria have been co-opted to perform.

103 d the promoters for these genes have been co-opted to produce selective transgene expression within t

104 This trait may have then been co-opted to provide cancer resistance and longevity to this

105 how common metabolic regulators have been co-opted to the plant-pathogenic lifestyle as well as how n

106 in the earliest seed plants before being co-opted to control transpiration and CO2 exchange in deriv

107 season, and concurrent temporally driven co-opted mechanisms that sense spatial signals, i.e. nitrat

108 nts, which might have been evolutionarily co-opted as an essential part of the adaptive genetic reper

109 Inhibition of host factors co-opted during active infection is a strategy hosts use to

110 Frequently co-opted to pattern new structures, the pathway is conserve

111 -microRNA regulatory circuits are further co-opted by plants to regulate both beneficial and pathogen

112 We propose that Caulobacter has co-opted a nucleoid-associated protein with high AT recogni

113 Primates have co-opted a viral gene to produce an envelope protein that p

114 Our data indicate that neurons have co-opted an ancient RNA modification mechanism to regulate

115 ion of the somatic nucleus, and they have co-opted different DNA recombination mechanisms-some previo

116 production and spread, some viruses have co-opted prosurvival genes from the host.

117 We propose that herpesviruses may have co-opted the MTC functionality of UL37 to bring capsids to

118 helial-to-mesenchymal transition (EMT) is co-opted by cancer cells to metastasize to distant sites.

119 ibility is that this feedback response is co-opted by the learning system and used as a template to i

120 Here we describe how ingested nicotine is co-opted for larval defense by a unique mechanism.

121 The other splice site is co-opted from the gene sequence that is duplicated upon tra

122 lator of Caulobacter crescentus, SpmX, is co-opted in the genus Asticcacaulis to specify stalk synthe

123 mulation in most cells that express it is co-opted to negatively regulate pDC IFN-I production and li

124 e regulation, and that the gill was later co-opted for its central role in gas exchange in more deriv

125 e ancestor and that smooth myocytes later co-opted the striated contractile module repeatedly - for e

126 However, a subgroup of genes was likely co-opted de novo early in the Pooideae.

127 Endogenous viruses are occasionally co-opted by their hosts to combat other viruses.

128 this study, we dissected the functions of co-opted cellular ESCRT-I (endosomal sorting complexes requ

129 ealed intriguing and complex functions of co-opted cellular translation factors, heat shock proteins,

130 Although the important roles of co-opted host proteins in RNA virus replication have been a

131 erilluminating photophores were partially co-opted for bioluminescent signalling, leading to complex

132 P32A represents an essential host partner co-opted to support influenza virus replication and is a ca

133 The vesicular trafficking pathways co-opted by C. burnetii for PV development are poorly defin

134 idea that these elements are pervasively co-opted for the regulation of host genes.

135 yeast also leads to reduction of several co-opted host factors in the viral replicase complex (VRC).

136 tion of (+)RNA viruses depends on several co-opted host proteins but is also under the control of cel

137 the viral p33 RNA chaperone, and several co-opted host proteins.

138 tein that acts as a "don't eat me" signal co-opted by cancers to evade innate immune surveillance, is

139 othesise that WIP genes were subsequently co-opted in the control of morphogenesis of novel multicell

140 target in stem chordates and subsequently co-opted into the development of many novel traits in verte

141 Homeotic genes were subsequently co-opted to suppress growth of some dorsal flaps in the tho

142 strategy of the virus may be successfully co-opted by autonomous host cells and play a role in lesion

143 tor of jawless and jawed vertebrates that co-opted different antigen receptor supertypes.

144 independently evolved fungal complex that co-opted useful activities from bacterial neighbours within

145 By using TBSV RdRp, we show that the co-opted cellular Hsp70 chaperone and neutral phospholipids

146 Taken together, the results show that the co-opted cellular Rpn11 is a critical host factor for tombu

147 ular heat shock protein 70 (Hsp70) as the co-opted host factor required for the activation of an N-te

148 The emerging picture is that many of the co-opted host factors are from highly expressed and conserv

149 The co-opted PK generates high levels of ATP within the viral r

150 The ATP generated by the co-opted PK is used to promote the helicase activity of rec

151 Overall, this work demonstrates that the co-opted Rpn11p, which is involved in the assembly of the f

152 , demonstrating the requirement for these co-opted cellular factors in tombusvirus replicase formatio

153 This stress adaptation mechanism is thus co-opted for growth by cancers, and its inhibition may repr

154 ome editing to determine the roles of two co-opted transcription factors that are expressed during ea

155 can be controlled by the activity of two co-opted transcription factors.

156 e expression patterns of haplotypes using co-opted transposon-derived sequences as regulatory element

157 emission served another function and was co-opted as an aposematic signal later in the diversificati

158 w that the karilysin catalytic domain was co-opted by competent bacteria through horizontal gene tran

159 We conclude that (1) ABA was co-opted early in plant evolution to regulate functionally

160 de that multicellular cAMP signalling was co-opted from PKA regulation of protist encystation with pr

161 Finally, Ultrabithorax was co-opted to uncouple the morphology of T2 and T3 wings and

162 We co-opted Escherichia coli for biomolecular synthesis and as

163 teins derived from Camelid antibodies, we co-opted GFP as a scaffold for inducing formation of biolog

164 f lateral openings that subsequently were co-opted as pharyngeal gills.

165 ant ARABIDILLO germination functions were co-opted early into both gametophyte and sporophyte, with a

166 volved as chromosomal scaffolds that were co-opted for a similar purpose in striated muscles.

167 fish kank genes suggested KANK genes were co-opted for vertebrate vascular development.

168 tivation of signaling pathways that, when co-opted, enable cancer cells to survive drug treatments.

169 t may later contribute to adaptation when co-opted--e.g., following a mutation increasing expression

170 own, however, about how, or even whether, co-opted genes function in eyespot development.

171 his new nutrient niche contingent on both co-opting and overcoming a history of prior adaptation.

172 These viruses make sfRNAs by co-opting a cellular exonuclease via structured RNAs called

173 s its niche through oncogenic mutation by co-opting an underlying homeostatic process.

174 ual deception, pollination is achieved by co-opting and regulating two independent biosynthetic pathw

175 ing hermaphrodites became self-fertile by co-opting either of the two redundant male programs.

176 ot built from scratch, but rather form by co-opting preexisting gene networks.

177 ceptor impinges on a signaling pathway by co-opting protein kinase docking sites to constitutively ac

178 BTICs outcompete for glucose uptake by co-opting the high affinity neuronal glucose transporter, t

179 s from polarized host intestinal cells by co-opting the host vesicle trafficking system and escaping

180 increased ELF5 levels drive metastasis by co-opting the innate immune system.

181 the ribosome and initiate translation by co-opting the translation elongation cycle.

182 (b) regulation of PKR activation, and (c) co-opting of RNA granule factors for new roles in viral rep

183 e the complexities of the mammalian cell, co-opting mechanisms of cellular physiology while defeating

184 and to present CMV antigen to TH1 cells, co-opting MC secretory granules for antigen processing and

185 ure was human imposed and involved humans co-opting functions of defense and reproductive security.

186 oach to targeted therapy that is based on co-opting the cellular quality-control machinery-the ubiqui

187 ti-tumoral immunity and escape, revealing co-opting of tissue-specific immune development in the tumo

188 rculating proteins to their own surfaces, co-opting the host protein functions as a mechanism of viru

189 Rather than co-opting pain circuitry, rejection involves distinct affec

190 Our results also show that co-opting the sulphur-delivery machinery of primary metabol

191 n complexes and provide an example of the co-opting of cellular processes by CMV.

192 racellular helminths, in part through the co-opting of tissue repair and remodeling mechanisms, they

193 We propose that the 'co-opting' of sour and bitter neural pathways evolved as a

194 We have shown that C. albicans co-opts amino acid catabolism to generate and excrete ammon

195 NPM-ALK co-opts several intracellular signal transduction pathways,

196 e pathogen Hyaloperonospora arabidopsidis co-opts the host cell's nuclear import machinery.

197 mechanisms through which the tumour cell co-opts a normal fibroblast.

198 The viral polymerase complex co-opts the nuclear RNA exosome complex and cellular RNAs e

199 In conclusion, the stress hormone CRH co-opts mechanisms that contribute to the plasticity and in

200 an immunodeficiency virus polyprotein Gag co-opts this process for budding of virus-like particles.

201 intracellular parasite Toxoplasma gondii co-opts critical functions of its host cell to avoid immune

202 This study examined whether HIV co-opts the normal T cell activation process through the so

203 s, we found that the type III-B machinery co-opts type I-F CRISPR-RNAs.

204 its association with MAL and Rab11b, Nef co-opts Lck switchlike function driving the formation Ca(2+

205 f evidence suggests that cancer mimics or co-opts developmental processes to facilitate tumor initiat

206 In this way, the parasite co-opts an immune response in a way that enhances its own s

207 We find that TBSV co-opts the cellular glycolytic ATP-generating pyruvate kin

208 paper, the authors demonstrate that TBSV co-opts the guanosine triphosphate (GTP)-bound active form

209 Tomato bushy stunt virus (TBSV) co-opts cellular ESCRT (endosomal sorting complexes require

210 One route by which Toxoplasma co-opts its host cell is through hijacking host organelles,

211 To induce the degradation of SAMHD1, Vpx co-opts the cullin4a-based E3 ubiquitin ligase, CRL4.

212 With most countries opting for one dose of IPV in routine immunisation sched

213 The current "opt-in" strategy for anti-EGFR therapy in all patients w

214 therapy, but some women with Graves disease opt to receive definitive therapy with RAI or surgery pr

215 e reasons why potential living kidney donors opt out of the donor evaluation process for nonmedical r

216 absorption between 600 and 940 nm with an Eg(opt) of 1.32 eV.

217 were randomly assigned (1:1) to offer either opt-out rapid HIV testing to newly registering adults or

218 newly engineered GluCl opt alpha-mXFP L9'F + opt beta-mXFP Y182F RSR_AAA receptor in dissociated neur

219 e other control parameters; this yields an f(opt)(g) that is universal for different types of gates.

220 Expression of the newly engineered GluCl opt alpha-mXFP L9'F + opt beta-mXFP Y182F RSR_AAA recept

221 minal propensities across population groups, opting for a facultative view of life history evolution

222 d over, suffered from chronic back pain, had opted in to the clinic and had sufficient ability to rea

223 acteristics and whether or not practices had opted in to the incentivised scheme.

224 the states and the District of Columbia have opted to expand Medicaid starting in 2014, many states c

225 illing to donate their organs was greater in opt-out (85.26%) than opt-in (80.72%) countries.

226 rgans for transplant purposes was greater in opt-out than opt-in countries and whether such effects w

227 ople's willingness to donate their organs in opt-in (58.63%) and opt-out (59.23%) countries.

228 In opting for perceptual realism over social constructivism

229 tion than ever before, with many individuals opting to consume content through social channels rather

230 tandard of care included health information, opt-out HIV testing, infant feeding counselling, referra

231 me clinicians delaying treatment and instead opting for continued surveillance for additional or long

232 we describe early experience with integrated opt-out HCV antibody (Ab) screening of medically stable

233 V case-finding (achieved through introducing opt-out HCV testing in UK pilot prisons) and increasing

234 ountries are considering whether introducing opt-out consent would increase the availability of donor

235 on (PMTCT) guidelines, compared to those not opting in.

236 f early eluting metabolites are not noticed; opt for a RP column for superior retention of highly pol

237 tand the factors that moderate the effect of opt-out consent legislation on organ donation.

238 Promotion of opt-out rapid testing in general practice led to increas

239 Bees could also transfer the concept of opting out to a novel task.

240 bles associated with increased likelihood of opting for investigation were shorter travel times to te

241 The greatest predictor of opting out of donation was high ambivalence.

242 ted number of centers have reported rates of opting out between 0.2% and 22%; the reasons for declini

243 Many men with indolent prostate cancer often opt for radical prostatectomy or radiotherapy treatment

244 to join forces in collaboration-people often opt for engaging in corrupt collaboration.

245 n southwestern Harare implemented optimised, opt-out PITC for all attendees aged 6-15 years.

246 an email with the active choice to opt in or opt out (active choice), or the active choice email plus

247 s consented to participate with an opt-in or opt-out mechanism; patient consent was waived with IRB a

248 Fourteen participants opted for a 16 week moderate intensity supervised exerci

249 rcise intervention, while seven participants opted for control.

250 ho did not receive chemotherapy, 12 patients opted for watchful waiting and four patients received ra

251 We compared survival of patients opting for an HLAi kidney transplant with that of simila

252 tRNA(Pyl-opt) facilitated a 5-fold increase in AcK incorporation

253 yses revealed that the mutations in tRNA(Pyl-opt) had no significant effect on the catalytic efficien

254 Thus tRNA(Pyl-opt) should be an excellent replacement of wild-type tRN

255 Using tRNA(Pyl-opt) with PylRS and various PylRS variants facilitated e

256 ionally evolved tRNA(Pyl) to create tRNA(Pyl-opt) with six nucleotide changes.

257 , an informed consent was obtained after she opted for medical termination of pregnancy.

258 An informed consent was obtained after she opted for medical termination of pregnancy.

259 esponds to a figure of merit sigma(dc)/sigma(opt) = 1,400, significantly higher than any other contin

260 , and even risk-averse individuals sometimes opt for riskier alternatives.

261 nts; the optimum temperature for tenacity (T(opt)) increased from 1.0 degrees C (N. concinna) to 14.3

262 organs was greater in opt-out (85.26%) than opt-in (80.72%) countries.

263 nsplant purposes was greater in opt-out than opt-in countries and whether such effects were moderated

264 will change the proportion of patients that opt for surgery.

265 Although states that opt in to the expansion will secure additional federal f

266 For states that opt into the expansion, it is important to understand wh

267 ical merits of a recycled water project that opted for an inland release of tertiary-treated recycled

268 Patients were excluded if they opted out this service after the initial assessment, suf

269 d HCV testing in UK prisons (such as through opt-out testing) is borderline cost-effective compared t

270 We thus opted to investigate the association of adiposity with a

271 initially only generics, with the ability to opt out.

272 Policies to remove parents' ability to opt-out from school immunization requirements on the bas

273 noisy display and were sometimes allowed to opt out of the direction choice if their confidence was

274 control), an email with the active choice to opt in or opt out (active choice), or the active choice

275 ho viewed a video of CPR were less likely to opt for CPR than those who listened to a verbal narrativ

276 0-69 years were significantly more likely to opt for investigation than were those aged 40-59 years,

277 idence that participants were more likely to opt for investigation with a 1% increase in risk of canc

278 to continue toward potential donation or to opt out of the registry.

279 n, there are one or several possibilities to opt out from the game by adopting loner strategies.

280 dge, attitudes, and behavior with respect to opting out of NBS or DBS for their child.

281 r could avoid choosing by exiting the trial (opting out).

282 outcome trials in diabetes, but most trials opted for non-inferiority designs aiming primarily to sh

283 suppressed with an optimized o-tRNA (o-tRNA(opt)) that was evolved to be better recognized by Ef-Tu.

284 Universal opt-out HCV screening in prisons is highly cost-effectiv

285 Risk-based and universal opt-out hepatitis C screening in prisons, followed by tr

286 different examples of a single situation, we opt for model-based learning and adaptive flexibility.

287 The negative impact of hiding holds whether opting not to disclose unflattering (drug use, poor grad

288 ther research on potential living donors who opt out of donation.

289 The experiences of individuals who opt out of donation may reveal avenues for enhancing don

290 tissue expander or the implant for women who opt for a two-stage expander-implant reconstruction.

291 Army soldiers (n = 143) who opted for refractive surgery.

292 BCT was successful in 93% of patients who opted for it, but 31% of BCT-eligible patients still cho

293 After AF ablation, all 61 patients who opted for RFM and 88 control subjects were assessed ever

294 ical correlation was done in 31 patients who opted for surgical treatment.

295 l of 692 patients were enrolled, 84% of whom opted to receive bevacizumab.

296 abel Extension collected DBS routinely, with opt-in hair collection; concentrations were measured wit

297 The most consistent factor associated with opting out of the registry across all race/ethnic groups

298 The vast majority of women opted for the same place of childbirth for their success

299 The lower breast cancer incidence in women opting for chemoprevention highlights the potential for

300 Participants were asked whether they would opt for diagnostic testing on the basis of the informati