ライフサイエンスコーパス: optic cup

1 y close, giving rise to a healthy, spherical optic cup.

2 ing (cVax) within the ventral but not dorsal optic cup.

3 bdividing dorsal and ventral portions of the optic cup.

4 trols tissue specification in the developing optic cup.

5 steps before the formation of the definitive optic cup.

6 of the eye arrests prior to formation of an optic cup.

7 f the bimetallic strip, the curvature of the optic cup.

8 pithelial flow around the distal rims of the optic cup.

9 ayered cortical neuroepithelium or an entire optic cup.

10 s that originate from the inner layer of the optic cup.

11 thereby suppress apoptosis in the developing optic cup.

12 involute around the rim of the invaginating optic cup.

13 retinal neuroepithelium (RNE), a part of the optic cup.

14 expressed in the mesenchyme surrounding the optic cup.

15 o regulate the morphogenesis of the lens and optic cup.

16 the transition of the optic vesicle into the optic cup.

17 nted epithelium are not contained within the optic cup.

18 nts that lead to ventral invagination of the optic cup.

19 in timing and apposition of two poles of the optic cup.

20 lens ectoderm is not sufficient to create an optic cup.

21 s that underwent invagination and formed the optic cup.

22 rm that induces the optic vesicle to form an optic cup.

23 folds, caudal branchial arch, hindbrain, and optic cup.

24 ls (RPCs) residing in the inner layer of the optic cup.

25 the formation of small and abnormally shaped optic cups.

26 ntified in the anterior portion of lens-less optic cups.

27 11 resulted in structurally normal lens and optic cup, although the latter showed abnormal expressio

28 that is derived from the anterior rim of the optic cup, an extension of the neural tube.

29 Ventral closure of the optic cup and choroid fissure does not occur.

30 Pax6 may promote cell surface changes in the optic cup and control the fate of the ectoderm from whic

31 ic vesicle formation, transformation into an optic cup and integration with neighboring tissues are e

32 h placodes invaginate to form the definitive optic cup and lens, respectively.

33 acting directly and cell autonomously in the optic cup and lens.

34 embryonic fissure as it forms in the ventral optic cup and optic stalk.

35 ural tube, urogenital system, optic vesicle, optic cup and optic tract.

36 rogenital system, neural tube, otic vesicle, optic cup and optic tract.

37 ive Wnt receptor expressed in the eye field, optic cup and retina - causes all of these defects with

38 her sex and found that the morphology of the optic cup and stalk and the closure of the optic fissure

39 of Wnt/beta-catenin target molecules in the optic cup and stalk may underlie the molecular and morph

40 expression in the intermediate mesoderm, the optic cup and stalk, and the otic vesicle, Pax2, a membe

41 h signals persist after the formation of the optic cup and suggest that the early vertebrate optic pr

42 differentiation begins in the dorso-central optic cup and sweeps peripherally and ventrally.

43 Krd/+ embryos, Pax2+ cells in the posterior optic cup and the optic stalk undergo abnormal morphogen

44 iameter and perimeter of each optic disc and optic cup and the width of the neuroretinal rim were dra

45 A larger optic cup and/or a more damaged visual field are predict

46 entiated photoreceptors in three-dimensional optic cups and retinal pigment epithelium (RPE) from iPS

47 rying a null allele of this gene do not form optic cups and so do not develop eyes.

48 the development of the renal epithelia, the optic cup, and the inner ear.

49 ere higher for vertical optic disc, vertical optic cup, and vertical cup-to-disc ratio than for intra

50 ONH parameters (including optic disc area, optic cup area, neuroretinal rim area, cup volume, rim v

51 g the specification of cells along the inner optic cup as retinal tissue, polarity of the retinal neu

52 e inner and outer segments of the developing optic cup at embryonic days 10.5 to 11.5.

53 tly its expression becomes restricted to the optic cup by reciprocal transcriptional repression of pa

54 undergo optic cup morphogenesis; and (2) the optic cup can form in the absence of lens formation.

55 surface fish embryonic lens into a cavefish optic cup can restore a complete eye.

56 2alpha mutants also exhibited defects in the optic cup consisting of transdifferentiation of the dors

57 or abnormal development leading to defective optic cup, cornea, and eyelid morphogenesis.

58 and induced pluripotent stem cell (iPSC) 3D optic cups derived from a patient carrying an RP2 nonsen

59 iPSCs differentiated normally into RPE and optic cups, despite abnormal CEP290 splicing and cilia d

60 RA signaling in the optic cup, detected by using a RARE-lacZ transgene, is n

61 us demonstrate a role for Bcor during normal optic cup development in preventing colobomata.

62 l (RPE) compartment during optic vesicle and optic cup development.

63 enetic proteins (BMPs) also regulate ventral optic cup development.

64 d in the smaller optic discs controlling for optic cup diameter as well as age, systolic and diastoli

65 55, 0.57, and 0.48 for intraocular pressure, optic cup diameter, optic disc diameter, and cup-to-disc

66 Absolute (anterior or posterior) optic cup displacement (OCD) averaged 41 +/- 7 mum in 30

67 e is overproliferation of the outer layer of optic cup (E10.5) immediately after the initial specific

68 cation of the eye anlage, growth rate of the optic cup, establishment of retinal stratification, spec

69 splicing and cilia defects were observed in optic cups, explaining the retinal-specific manifestatio

70 mc1 function impairs basal contractility and optic cup folding.

71 Later aspects of distal optic cup formation (i.e. retina development) are normal

72 f Vax1 and Vax2, known regulators of ventral optic cup formation and choroid fissure closure, and tha

73 de evidence that Tbx2 is required for proper optic cup formation and plays a critical early role in r

74 rocedure quantifies eye field specification, optic cup formation and retinal differentiation in 3D cu

75 sis needs to be tightly regulated for normal optic cup formation and that Bcl6a, Bcor, Rnf2 and Hdac1

76 We investigated the role of Tbx2 in optic cup formation by analysing mice with a targeted ho

77 esis occur, but development arrests prior to optic cup formation in both the optic neuroepithelium an

78 icle to optic cup transition and after early optic cup formation in chick embryos.

79 mburger Hamilton (HH) stage 10, there was no optic cup formation, and lens development was abortive d

80 orebrain hemisphere fusion, ventricle shape, optic cup formation, neural tube closure, and layering o

81 nation of RNE cells and consequently impairs optic cup formation.

82 optic vesicle position but caused arrest of optic cup formation.

83 or, is required to prevent colobomata during optic cup formation.

84 coordinates the multiple pathways leading to optic cup formation.

85 The hemispheric, bi-layered optic cup forms from an oval optic vesicle during early

86 nsgene is expressed within the domain of the optic cup from which RPE arises, and Yap immunoreactivit

87 inarily that the most anterior layers of the optic cup have a retained retinal and neuroglial differe

88 n of all lines resulted in the generation of optic cups in a self-organising manner after 100 days in

89 ification of normal ciliary body, we created optic cups in which the lens had been removed while stil

90 essed in the non-neuronal derivatives of the optic cup, including the pigment epithelium, optic stalk

91 ce fish lens is transplanted into a cavefish optic cup, indicating that cavefish optic tissues have c

92 e lens tissue in inducing and/or maintaining optic cup invagination in ovo.

93 The formation of the vertebrate optic cup is a morphogenetic event initiated after the o

94 The driving element within the optic cup is almost certainly the retinal pigmented epit

95 per dorsal--ventral pattern formation of the optic cup is essential for vertebrate eye morphogenesis

96 Later, in the optic cup, it is restricted to the prospective dorsal ci

97 Optic cup morphogenesis (OCM) generates the basic struct

98 ior and actomyosin dynamics during zebrafish optic cup morphogenesis by live imaging.

99 added, a neural retina does not develop and optic cup morphogenesis fails, although lens formation a

100 m line Pax6 inactivation, and the failure of optic cup morphogenesis indicates the importance of ecto

101 Our work shows that optic cup morphogenesis is driven by a constriction mech

102 re or in some instances, more severe ventral optic cup morphogenesis phenotypes.

103 inding transcription factors govern lens and optic cup morphogenesis.

104 n with pre-lens ectoderm in order to undergo optic cup morphogenesis; and (2) the optic cup can form

105 ris, two tissues derived from the peripheral optic cup (OC).

106 tion of a surface fish lens into a cave fish optic cup or lens extirpation.

107 ectopic Pax2 expression in the chick ventral optic cup past the normal developmental period when Pax2

108 entral retinal pigment epithelium, defective optic cup periphery, and closure defects of the eyelid,

109 rise to four basic tissues in the vertebrate optic cup: pigmented epithelium, sensory neural retina,

110 ormation and highlight the key role that the optic cup plays in this process.

111 pressed in the anterior optic vesicle and/or optic cup, respectively, did not affect the rod pattern.

112 ent after transplantation into the cave fish optic cup, restoring optic tissues lost during cave fish

113 We show that genetic ablation of SOX2 in the optic cup results in complete loss of neural competence

114 ectroporation of Pax2 into the chick ventral optic cup results in the formation of colobomas, a condi

115 igment epithelium (RPE) progenitors near the optic cup rim.

116 ess consistent and not significant for small optic cup sizes.

117 At the optic cup stage, Pax6, Tbx5 and Bmp4 are ectopically exp

118 At optic cup stages, however, noggin overexpression caused

119 ficant effects on the development of ventral optic cup structures.

120 genes is lost following early removal of the optic cup, suggesting a role for this tissue in inducing

121 tiation protocol, allowing three-dimensional optic cups to form.

122 In the POAG group, optic cup-to-disc ratio (CDR) was positively correlated

123 irements for Shh during the optic vesicle to optic cup transition and after early optic cup formation

124 The ventral region of the chick embryo optic cup undergoes a complex process of differentiation

125 c consequences that included a saucer-shaped optic cup, ventral coloboma, and a deficiency of periocu

126 The morphology of the optic cup was also severely affected in these chimeras;

127 Human 3D organoid optic cups were used to investigate REEP6 expression and

128 Treating optic cups with an antisense morpholino effectively bloc