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1 re followed up with FD-OCT cube scans of the optic disc.
2 on the pathogenesis of rare diseases of the optic disc.
3 eering, Heidelberg, Germany) scanning of the optic disc.
4 led by retrograde biocytin labeling from the optic disc.
5 g the disease based on the appearance of the optic disc.
6 the natural break in Bruch's membrane at the optic disc.
7 ed the entire macula and often encircled the optic disc.
8 ding pituitary hypoplasia and absence of the optic disc.
9 that were near, touching, or surrounding the optic disc.
10 and depends on Shh for its expression at the optic disc.
11 s traction and adhesion above the macula and optic disc.
12 covering a 1.5 x 2-mm2 area centered at the optic disc.
13 ts of age, disease severity, and size of the optic disc.
14 than 4 times as often as progression in the optic disc.
15 1.3, 1.5, and 1.7 mm from the center of the optic disc.
16 l coherence tomography imaging of macula and optic disc.
17 ain axon growth into the fiber layer and the optic disc.
18 The scans were centered on optic discs.
19 tool for patients with glaucoma with myopic optic discs.
20 6.0, 10.1, 10.2 mm) (P < 0.001), distance to optic disc (3, 5, 5, 5 mm) (P < 0.001), distance to fove
21 nner (2.2 vs. 2.7 mm), more distant from the optic disc (3.2 vs. 2.5 mm) and foveola (4.0 vs. 2.0 mm)
22 87%, P < 0.001), increased mean distance to optic disc (3.3 vs. 5.0 mm, P < 0.001) and foveola (3.1
23 s (N = 80) strabismus (88% versus 64%), pale optic discs (65% versus 27%) and visual field defects (7
25 nd 6.19 +/- 1.80 mm(3), respectively, at the optic disc and 217.4 +/- 43.6 mum and 7.83 +/- 1.55 mm(3
26 The eye underwent 3 scans centered on the optic disc and another 3 scans centered on the macula th
27 red to control eyes was largest close to the optic disc and approximated the level of controls toward
28 rrhages, exudates, neovascularization in the optic disc and elsewhere, drusen, abnormal pigmentation,
29 t basal diameter, and tumor distances to the optic disc and fovea were 7.6, 12.8, 5.2, and 4.6 mm, re
31 ach ON at 2 locations (5 mm posterior to the optic disc and just posterior to the optic canal) in pat
32 l coherence tomography (SDOCT) images of the optic disc and macula regions at baseline and at 3 and 6
36 cle disrupts ERK signaling, which results in optic disc and nerve dysgenesis and, ultimately, ocular
38 izontal cross-sectional FD-OCT images of the optic disc and parapapillary retina were obtained in 24
42 itis (Uv-N) (n = 143), raised IOP and normal optic disc and/or visual field (Uv-H) (n = 233), and rai
43 ning of the posterior globe, swelling of the optic disc, and bilateral transverse sinus stenosis.
44 by optic nerve degeneration, cupping of the optic disc, and loss of retinal ganglion cells which cou
49 nal barrier to fluid migration from cavitary optic disc anomalies can be safely achieved in most pati
59 de in 74.1% of Group A and 75.9% of Group B, optic disc appearance in 85.4% of Group A, and 93% of Gr
60 rol group (CG), patients having glaucomatous optic disc appearance or ocular hypertension, and patien
62 nts were suspected to have glaucoma based on optic disc appearance, but the eyes were judged to be no
64 stalline appearance, and drusen nasal to the optic disc are more likely to have a rare variant in the
65 icant correlation between RNFL thickness and optic disc area (95% confidence interval [CI] = -0.9 to
66 t association between corneal hysteresis and optic disc area (P = .6), cup area (P = .77), vertical c
67 ly been shown to be strongly associated with optic disc area and vertical cup-to-disc ratio, which ar
70 s of VCDR variants suggesting that increased optic disc area can significantly contribute to POAG ris
73 s associated with central corneal thickness, optic disc area, and VCDR were genotyped in 876 OAG case
76 lynomial regression model, including age and optic disc area, which accounted for 83.3% of the variat
81 se had participated in the previous European Optic Disc Assessment Trial (EODAT), a trial on glaucoma
87 tal fundus photographs: (1) sharpness of the optic disc border, (2) discontinuity along major vessels
88 microglia persisted and concentrated in the optic disc, but also localized to the retinal periphery.
89 ee 360-degree circular scans centered on the optic disc by the same experienced examiner using the Ci
91 degrees -336 degrees ) 2.0 mm away from the optic disc center was the most frequent location where R
93 that reached POAG endpoints for both VF and optic disc change (n = 127) deteriorated more rapidly (-
94 change (n = 74; -0.29 +/- 0.31 dB/y) or only optic disc change (n = 158; -0.12 +/- 0.19 dB/y) had sig
96 es that reached endpoints due to both VF and optic disc change had worse MDRs than eyes displaying ch
98 l relationship between them and glaucomatous optic disc changes such as neuroretinal rim thinning/not
103 hat were noted during endoscopy included the optic disc characteristics, anatomic integrity of the re
104 oscopic photographs in the assessment of any optic disc characteristics, for example disc size (mono
106 (angio-OCT) in morning glory syndrome (MGS), optic disc colobomas, and optic disc pits, and to explor
107 by an automated algorithm from stereoscopic optic disc color photographs of a random sample of 172 s
109 erve fiber layer imaging with Cirrus SD-OCT (Optic Disc Cube 200x200) and Heidelberg Retina Tomograph
110 using the fast RNFL program by Stratus, the optic disc cube protocol by Cirrus, and the N-site axona
112 gnosis, and the comparative diameters of the optic disc cup, experienced observers separately compare
113 tween eyes with presumed large physiological optic disc cupping (pLPC) and eyes with minimal optic di
114 than doubled the known loci associated with optic disc cupping and will allow greater understanding
115 plete success), stable ocular dimensions and optic disc cupping, and no further glaucoma surgery (inc
116 steresis or CCT and quantitative measures of optic disc cupping, suggesting that corneal hysteresis a
119 f visual field change in patients with focal optic disc damage (mean -0.34, standard deviation [SD] 0
120 of optic disc change in patients with focal optic disc damage (mean -11.70, SD 25.5 x10(-3) mm(2)/ye
124 ure of more than 21 mm Hg and the absence of optic disc damage or abnormal visual field results at th
125 thickness (CCT), and presence of progressive optic disc damage were associated with faster rates of M
126 tic (mean -0.45, SD 20.6 x10(-3) mm(2)/year) optic disc damage, although the differences were not sta
127 red with patients with diffuse and sclerotic optic disc damage, despite similar IOP reductions during
128 ield abnormality or evidence of glaucomatous optic disc damage, or both when not present at baseline.
130 change and a tendency toward faster rates of optic disc deterioration when compared with patients wit
132 eral bowing included reduced distance to the optic disc (difference, 1.3 mm; 95% CI, -2.95 mm to 5.51
133 tion) and optic disc (optic nerve head tilt, optic disc dimensions, and peripapillary atrophy) change
134 Eye Study 10-year follow-up who did not have optic disc disease, including glaucoma, were included.
137 (19 eyes) with PPE owing to suspected buried optic disc drusen (ODD), and 3 children (6 eyes) with PP
138 tive correlation between the diameter of the optic disc drusen and the global retinal nerve fiber lay
139 demonstrated the internal characteristics of optic disc drusen and their relationship with the lamina
140 streaks, pattern dystrophy-like changes, and optic disc drusen are a consistent finding in seven stud
141 gative correlation between proportion of the optic disc drusen area occupied by optic nerve drusen as
143 EDI-OCT and swept source OCT showed multiple optic disc drusen at different levels; most were located
145 chemic fundus and retinal lesions and of the optic disc during the acute phase showed no statisticall
146 4%]), (sub)retinal hemorrhage (n = 6 [12%]), optic disc edema (n = 3 [6%]), chorioretinal lesions (n
147 ents with optic nerve head drusen (ONHD) and optic disc edema (ODE) compared with healthy participant
148 and presented with normal visual acuity but optic disc edema and an enlarged blind spot in the right
150 d the need for remediation for misdiagnosing optic disc edema during end-rotation funduscopic simulat
151 initial evaluation revealed severe bilateral optic disc edema with distal lower-extremity sensory and
153 hthalmic changes, including choroidal folds, optic disc edema, cotton-wool spots, globe flattening, a
154 dings have included unilateral and bilateral optic disc edema, globe flattening, choroidal and retina
155 from 1 degrees to 4 degrees temporal to the optic disc edge using a computer-aided, manual segmentat
158 on, including gonioscopy, dilated fundus and optic disc examination, visual fields, stereo disc photo
159 atures were found, including nonglaucomatous optic disc excavation (20%), relatively low (<10 mmHg) i
160 LPC and individuals with minimal excavation (optic disc excavation within normal limits; control grou
162 eripapillary circle (1.7-mm radius) and cube optic disc fdOCT scans were obtained on 208 eyes from 11
163 es), were selected to demonstrate a range of optic disc features from a total of 197 eyes of 197 pati
164 ssess image quality, the ease of visualizing optic disc features important for glaucoma diagnosis, an
165 eles previously associated with POAG or with optic disc features in other cohorts were compared betwe
166 Visual acuity (VA), pupillary reaction, and optic disc findings were assessed at presentation and 3
167 sual field first in 28 eyes (15%) and in the optic disc first in 34 eyes (18%); in 1 eye (1%), it occ
168 ual field first in 163 eyes (52%) and in the optic disc first in 39 eyes (12%); in 1 eye (0%), it was
169 ty, and normal population variability of the optic disc flow index were 1.2%, 4.2%, and 5.0% CV, resp
170 t retinal function in a wide zone around the optic disc, giving rise to massive enlargement of the ph
171 ocular hypertension (OHT) and glaucoma-like optic discs (GLD)- defined as a cup to disc ratio greate
172 ous features, and VF data were combined with optic disc grading to determine "disc plus field defined
174 sual acuity of worse than 6/12 or suspicious optic discs had detailed examination including Goldmann
175 ucoma progression, eyes with a history of an optic disc hemorrhage (DH) confirmed by stereophotograph
176 To determine the cumulative incidence of optic disc hemorrhage (ODH) before and after development
178 ffected individuals presented with excavated optic discs, high myopia (-1.00 to -16.00 diopters), and
179 (HR, 1.03; 95% CI, 1.01-1.04; P = .001) and optic disc (HR, 1.01; 95% CI, 1.00-1.01; P = .005), and
183 l in 133 eyes (94.3%), were noncontiguous to optic disc in 122 eyes (86.52%), and involved the macula
184 er was prominent on the temporal side of the optic disc in ADOA (P <0.0001), but there was considerab
187 l ganglion cell (RGC) axons grow towards the optic disc in the central retina, where they turn to exi
190 mation with indistinct borders, vascular and optic disc leakage, vessel wall staining, or capillary n
192 ns were independently evaluated for quality: Optic disc, macula, and superior and inferior vascular a
195 retinal rim assessment based on the clinical optic disc margin (DM) lacks a sound anatomic basis for
196 rane opening (BMO), rather than conventional optic disc margin (DM)-based assessment or retinal nerve
199 ripapillary retinal nerve fiber layer (RNFL)/optic disc measurements and a reliable 24-2 SITA-Standar
200 re than 3 mm (P = 0.002), mean distance from optic disc more than 4 mm (P<0.001), and mean maximal ba
201 s a diagnostic challenge because of atypical optic disc morphology and visual field defects that can
202 whereas glaucoma eyes without progression in optic disc morphology lost 1.18 mum per year in RNFL thi
204 D) (spherical equivalent) and typical myopic optic disc morphology, with and without glaucoma, were r
206 visual field mean deviation (MD) and global optic disc neuroretinal rim area with follow-up time.
208 B colorectal cancer, who developed bilateral optic disc oedema and associated left sided optic neurop
211 re was impaired perfusion and leakage at the optic disc on fluorescein angiography immediately after
213 and myopic choroidal neovascularization) and optic disc (optic nerve head tilt, optic disc dimensions
215 , shorter distance between the tumor and the optic disc (P=0.026), subretinal fluid (P=0.035), thickn
216 e posterior globe [p=0.491], swelling of the optic disc [p=0.881], and bilateral dural sinus stenosis
218 me-wide association meta-analysis of IOP and optic disc parameters and validated our findings in mult
219 erated by the new SSADA, repeatably measures optic disc perfusion and may be useful in the evaluation
220 rence tomography (FDOCT) was used to measure optic disc, peripapillary retinal nerve fiber layer (NFL
222 ane opening (BMO) algorithm and stereoscopic optic disc photograph readings by glaucoma specialists.
223 tographs for glaucoma likelihood, monoscopic optic disc photographs did not appear to represent a sig
224 For expert observers in the evaluation of optic disc photographs for glaucoma likelihood, monoscop
227 thalmologists correctly matched stereoscopic optic disc photographs to their corresponding visual fie
228 ologists for correctly matching stereoscopic optic disc photographs to their visual fields was 58.7%.
229 ntral corneal thickness (CCT) were measured; optic disc photographs were analyzed; and multivariable
240 nitored by VF testing, quantitative imaging, optic disc photography, and tonometry at 11 visits.
241 testing included bilateral color fundus and optic disc photography, fundus autofluorescence, automat
244 analyze the morphologic changes seen in the optic disc pit and evaluate the source of subretinal flu
245 was performed on a 15-year-old boy with deep optic disc pit and foveal detachment, before and for 10
246 partial thickness fenestration radial to the optic disc pit was associated with retinal anatomic and
248 he gap in the lamina cribrosa present in the optic disc pit, supporting the hypothesis of cerebrospin
253 ry syndrome (MGS), optic disc colobomas, and optic disc pits, and to explore possible correlations be
254 The rate of rim area loss in eyes with an optic disc POAG endpoint was significantly faster than i
255 litative analysis of the optic nerve sheath, optic disc, posterior globe, and pituitary gland morphol
256 Evaluation of visual field progression and optic disc progression during an 8-year follow-up period
258 illedema, 37 eyes with congenitally elevated optic disc (pseudopapilledema), and 34 normal eyes met t
261 e Ocular Hypertension Treatment Study (OHTS) Optic Disc Reading Group and the OHTS Endpoint Committee
265 ous visual field loss combined with matching optic disc rim thinning and an enlarged cup-to-disc (C:D
266 ON was determined based on morphology of the optic disc, rim and retinal nerve fiber layer at the tim
268 ng was the most common artifact on 3D scans (optic disc scan, 7%; macula scan, 9%), whereas segmentat
269 ty-two normal subjects underwent macular and optic disc scanning in both eyes with Cirrus high-defini
270 inating the closure of the optic fissure and optic disc specification, which is necessary for the out
271 uded change in corneal diameter and clarity, optic disc status, refraction, need for anti-glaucoma th
273 igher proportion of eyes with progression by optic disc stereophotographs compared with the OLS metho
275 annually with standard automated perimetry, optic disc stereophotographs, and scanning laser polarim
276 ed with standard achromatic perimetry (SAP), optic disc stereophotographs, confocal scanning laser op
278 nic uveitis (9 patients), isolated bilateral optic disc swelling (1 patient), and Parinaud syndrome (
280 tracranial pressure to findings in eyes with optic disc swelling caused by optic neuritis and nonarte
281 tive afferent pupillary defect, (4) observed optic disc swelling, and (5) no other etiology being fou
282 included anterior and intermediate uveitis, optic disc swelling, and white-yellowish choroidal lesio
283 tereoscopic photographs and OCT scans of the optic discs taken during the same visit were compared.
284 im health according to the appearance of the optic disc, the clinically visible surface of the ONH.
286 uxtapapillary choroidal melanoma (</=1 mm to optic disc) treated with plaque radiotherapy from Octobe
287 er and thickness, distance to the foveola or optic disc, tumor calcification, central macular thickne
288 underwent circular OCT scans centred at the optic disc using a Spectralis OCT (Heidelberg Engineerin
290 d for three definitions of glaucoma based on optic disc, visual field, and a combination of both.
293 Severe PCO was defined if the view of the optic disc was obscured, or neodymium-yttrium-aluminum-g
294 A curved demarcation line inferior to the optic disc was observed on SW-AF images in 31/32 subject
295 papillary RNFL circular scan centered on the optic disc was obtained from right eyes of 25 preterm ch
296 optical coherence tomography scanning of the optic disc, was carried out between January 2013 and Nov
299 l coherence tomography scans surrounding the optic disc were performed in each eye of patients and su
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