ライフサイエンスコーパス: optic nerve head

1 signaling and other immune responses in the optic nerve head.

2 of activated microglia was found within the optic nerve head.

3 ce the physiology and pathophysiology of the optic nerve head.

4 diagnosed ONHD and EDI SD OCT imaging of the optic nerve head.

5 ssing shape differences of the peripapillary optic nerve head.

6 cells (RGCs) and intensely immunostained the optic nerve head.

7 tching regions of the same eyes close to the optic nerve head.

8 al, superior, nasal, and inferior-around the optic nerve head.

9 les of 3.4- and 3.75-mm diameters around the optic nerve head.

10 and activity of SPCs in the human retina and optic nerve head.

11 5 were limited to the glia of the retina and optic nerve head.

12 respective of their location relative to the optic nerve head.

13 spectral Doppler blood flow analysis of the optic nerve head.

14 ed, then phagocytic, and redistribute in the optic nerve head.

15 tic nerve head and regions peripheral to the optic nerve head.

16 ly those that may influence perfusion of the optic nerve head.

17 hese disconnected axons terminate within the optic nerve head.

18 es in the third of the retina nearest to the optic nerve head.

19 tical coherence tomography of the macula and optic nerve head.

20 re detectable in the glaucomatous retina and optic nerve head.

21 nd included laminar cribriform plates in the optic nerve head.

22 overing a 6.7 x 6.7-mm2 area centered at the optic nerve head.

23 ssels as a function of the distance from the optic nerve head.

24 nulus, at least 0.6 mm wide, surrounding the optic nerve head.

25 at 10- or 20-microm intervals throughout the optic nerve head.

26 only at distances less than 1.5 mm from the optic nerve head.

27 ventral ganglion cell axon targeting to the optic nerve head.

28 ma, could cause proliferation of ONAs in the optic nerve head.

29 site the injection site, and adjacent to the optic nerve head.

30 active guidance cue which is secreted at the optic nerve head.

31 nt activation was observed in and around the optic nerve head.

32 albino, and relative to the position of the optic nerve head.

33 e cells may also be a source for ET-1 in the optic nerve head.

34 ssues of the eye angle, but increased in the optic nerve head.

35 f the eye angle, sclera, cornea, retina, and optic nerve head.

36 umed to be moving in axonal transport at the optic nerve head.

37 the transitional, or laminar, region of the optic nerve head.

38 ness (PCT) from circle scans centered on the optic nerve head.

39 c damage to the choroidal, outer retinal and optic nerve head.

40 lting in large scotomata that connect to the optic nerve head.

41 expression in retinal ganglion cells and the optic nerve head.

42 d on the angle of nerve fiber entry into the optic nerve head.

43 or sclera, and posterior pole containing the optic nerve head.

44 o an ischemic or neurotoxic mechanism at the optic nerve head.

45 alterations in mural cell phenotype near the optic nerve head.

46 l ocular tissues tested including sclera and optic nerve head.

47 ganglion cells and resulting changes in the optic nerve head.

48 trocytes migrate into the retina through the optic nerve head.

49 he retina, retinal nerve fiber layer and the optic nerve head.

50 and vertical cross-sectional EDI OCT of the optic nerve head.

51 We obtained OCT images of the optic nerve head (24 radial scans) and peripapillary ret

52 imaging optical coherence tomography of the optic nerve head (24 radial scans) was performed.

53 nerves on examination received SDOCT of the optic nerve head (24 radial scans).

54 geting of retinal ganglion cell axons to the optic nerve head, a phenotype consistent with reduced BM

55 ia, at the junction of the neural retina and optic nerve head and by glia within the optic nerve.

56 hat in glaucoma RGC axons are damaged at the optic nerve head and degenerate within the optic nerve b

57 ONC, propagating from the injury site to the optic nerve head and finally the entire retina within on

58 -independent, three-dimensional model of the optic nerve head and gives a score for the probability t

59 al ganglion cell axon pathfinding toward the optic nerve head and in midbrain targets.

60 Imaging of the optic nerve head and macula and retinal nerve fiber laye

61 rrus HD-OCT (Carl Zeiss Meditec, Dublin, CA; optic nerve head and macular scans were taken every 4 mo

62 red over the physiological blind spot at the optic nerve head and over equally eccentric temporal ret

63 A 6-mm-diameter specimen containing the optic nerve head and peripapillary sclera was trephined

64 ampling was performed along the VRI over the optic nerve head and regions peripheral to the optic ner

65 we used genome-wide expression profiling of optic nerve head and retina and a series of computationa

66 identify PACE4 isoform expression within the optic nerve head and retina.

67 res in vivo has applications in the study of optic nerve head and retinal disease mechanisms.

68 al vision loss and structural changes of the optic nerve head and retinal ganglion cells is the hallm

69 The optic nerve head and retinal nerve fiber layer was asses

70 th the 1-mm central retina thickness and the optic nerve head and retinal nerve fiber layer, and visu

71 Optic nerve head and retinal responses, including the de

72 Furthermore, optic nerve head and RNFL photography is time consuming,

73 n prelaminar and lamina cribrosa (LC) in the optic nerve head and the retrolaminar region, immediatel

74 imals with BOA showed temporal pallor of the optic nerve head and thinning of the retinal nerve fiber

75 of diseases characterised by cupping of the optic nerve head and visual-field damage.

76 y be caused by microvascular ischemia at the optic nerve head and/or at the posterior pole and may se

77 vaded the retina, subretinal space, choroid, optic nerve head, and anterior chamber of the eye.

78 ressing astrocytes were first present at the optic nerve head, and as development progressed, the cel

79 tive oxygen species, induced swelling of the optic nerve head, and induced apoptosis, with a progress

80 lly located ganglion cells fail to enter the optic nerve head, and instead, make abrupt turns in this

81 nts of the retinal nerve fiber layer (RNFL), optic nerve head, and macula for assessing glaucoma prog

82 ion of the retinal nerve fiber layer (RNFL), optic nerve head, and macula with Cirrus OCT.

83 gic agonists, and prostaglandin analogues on optic nerve head, and on retinal, choroidal, and retrobu

84 -papillary profile between the fovea and the optic nerve head, and point-by-point test-retest repeata

85 n by an ophthalmologist of anterior segment, optic nerve head, and retina after pupil dilation.

86 any GFP-expressing cells were present at the optic nerve head, and some GFP-labeled fibers were prese

87 of testing and evaluating visual fields, the optic-nerve head, and the retinal nerve fiber layer offe

88 d center and large fibrotic scars around the optic nerve head; and (3) yellow dots in areas of relati

89 oantibody concentrations against retinal and optic nerve head antigens in the serum of glaucoma patie

90 ation such as elevated intraocular pressure, optic nerve head appearance, central corneal thickness,

91 ) and ECM remodeling in ET-1-activated human optic nerve head astrocytes (hONAs) were determined.

92 e that regulation of immunogenic capacity of optic nerve head astrocytes by cytokines or ischemic str

93 roximately 3 times higher in the cultures of optic nerve head astrocytes exposed to simulated ischemi

94 These findings suggest that optic nerve head astrocytes function as antigen-presenti

95 upregulation of the HLA-DR expression in the optic nerve head astrocytes in glaucoma.

96 L1 interfered with elastic fiber assembly by optic nerve head astrocytes in vitro.

97 astin fiber assembly was assessed by primary optic nerve head astrocytes in vitro.

98 Reactive remodeling of optic nerve head astrocytes is consistently observed in

99 vestigators have shown functional changes in optic nerve head astrocytes subjected to elevated hydros

100 s astroglial proliferation in cultured human optic nerve head astrocytes through ET(A/B) receptor act

101 Expression of HLA-DR in optic nerve head astrocytes was studied using immunohist

102 ltrahigh-speed OCT imaging of the retina and optic nerve head at 249,000 axial scans per second is po

103 helial migration pathway is activated in the optic nerve head at the earliest stages of disease in an

104 The microvasculature of the rat optic nerve head bears several similarities to that of t

105 Transport persists through the optic nerve head before finally failing in the retina.

106 degeneration of axon portions distal to the optic nerve head but does not cause the immediate degene

107 All optic nerve head capillaries drain into the central reti

108 Intraocular pressure (IOP) and optic nerve head characteristics are used clinically to

109 ures, such as the individual retinal layers, optic nerve head, choroid, and lamina cribrosa.

110 glaucoma, which posits that the behavior of optic nerve head connective tissues (specifically within

111 The retina between fovea and optic nerve head could serve as a convenient, accessible

112 ls occupied approximately 20% of the central optic nerve head cross-sectional area, gradually shifted

113 d with the Humphrey C24-2 threshold test and optic nerve head cup-to-disc ratio (C/D) was determined

114 nd hence to prevent progressive glaucomatous optic nerve head damage.

115 ct as reinforcing rings to limit corneal and optic nerve head deformations, whereas equatorial meridi

116 f this in vivo study suggest that though the optic nerve head diameter increases by more than 50%, on

117 useful for treating a variety of retinal and optic nerve head disorders.

118 red within an annulus region centered at the optic nerve head divided into superior and inferior hemi

119 individual retinal layers, in patients with optic nerve head drusen (ONHD) and optic disc edema (ODE

120 To investigate the prevalence of optic nerve head drusen (ONHD) in clinically normal subj

121 nized as the most sensitive tool to diagnose optic nerve head drusen (ONHD).

122 D Ia), DiGeorge syndrome (DGS), cataract and optic nerve head drusen (ONHD).

123 FL thinning in ischemic optic neuropathy and optic nerve head drusen is more likely to mimic the patt

124 erior ischemic optic neuropathy (NAION), (4) optic nerve head drusen with NAION, and (5) systemic lup

125 litis optica, pseudotumor cerebri, migraine, optic nerve head drusen, compressive optic neuropathy, a

126 e of progressive retinal ganglion cell loss, optic nerve head excavation, and axon loss.

127 ter retinal thicknesses and to visualize the optic nerve head excavation.

128 h positive family history or with suspicious optic nerve head findings for complete ophthalmologic ex

129 with pLPC may present a higher proportion of optic nerve head findings frequently observed in glaucom

130 ECM remodeling (cupping) at the level of the optic nerve head, frequently associated with elevated in

131 ducible nitric-oxide synthase (NOS-2) in the optic nerve heads from human glaucomatous eyes and from

132 The optic nerve heads from three monkeys with unilateral EG

133 Cultures of rat retina and optic nerve head glia were treated with a mixture of ROS

134 ntigen-presenting function of the retina and optic nerve head glia.

135 OAG either through IOP or via changes to the optic nerve head; here we present evidence that some gen

136 on masked assessment of digital stereoscopic optic nerve head images by three glaucoma specialists.

137 de transport and accumulation of TrkB at the optic nerve head in acute and chronic glaucoma models su

138 9, which were undetectable in the retina and optic nerve head in any condition.

139 Spectral-domain OCT of the optic nerve head in both conventional (non-EDI) and EDI

140 elberg retina tomograph (HRT) imaging of the optic nerve head in glaucoma.

141 ivo lamina cribrosa (LC) position within the optic nerve head in glaucoma.

142 ossible structural changes of the macula and optic nerve head in the free eyes of unilateral cured re

143 s," and giving the glial architecture of the optic nerve head in transverse section a honeycomb appea

144 dients along anomalous communications in the optic nerve head induce migration of fluid into the adja

145 torial degeneration pattern suggestive of an optic nerve head insult.

146 erial horizontal and vertical B-scans of the optic nerve head (interval between images, approximately

147 Filling-in at the optic nerve head involves additional low-level processes

148 and MT1-MMP1 expression in the glaucomatous optic nerve head is specific to tissue remodeling due to

149 extracellular matrix (ECM) remodeling in the optic nerve head is still unknown.

150 n the load-bearing connective tissues of the optic nerve head is substantial even at low levels of IO

151 tudies suggest that several of the ocular or optic nerve head ischemic or ocular vascular disorders p

152 that when a patient is at risk for ocular or optic nerve head ischemic or ocular vascular disorders,

153 ngs revealed Hb expression in the retina and optic nerve head macroglia and RGCs, suggesting an appro

154 in the retinal nerve fiber layer (RNFL) and optic nerve head may show subclinical pathology in unaff

155 vations suggest that in glaucoma, retina and optic nerve head microglia activation may be a factor in

156 e magnitude of IOP-related stress within the optic nerve head, models that incorporate physiologic sc

157 Bim deficient mice exhibited altered optic nerve head morphology and significantly lessened i

158 The optic nerve head morphology was abnormal with significan

159 ancy between the visual field defect and the optic nerve head morphology, however, led us to a vascul

160 ned in histologic sections of the retina and optic nerve head obtained from 38 donor eyes with glauco

161 e whether ECM remodeling in the glaucomatous optic nerve head occurs in response to loss of axons or

162 uctural evidence of axonal disruption in the optic nerve head of sigmaR1(-)/(-) mice as early as 6 mo

163 enous RGCs, with axons orienting towards the optic nerve head of the host retina and dendrites growin

164 ds with experimental glaucoma but not in the optic nerve head of transected eyes.

165 ted IOP, NOS-2 appeared in astrocytes in the optic nerve heads of these eyes and persisted for up to

166 The optic nerve head (ONH) and overlying vessels in cynomolg

167 To ascertain deformation of the optic nerve head (ONH) and peripapillary tissues caused

168 ssure, Humphrey 24-2 perimetry, stereoscopic optic nerve head (ONH) and retinal nerve fibre layer (RN

169 The biomechanical effects of IOP on the optic nerve head (ONH) are believed to play a role in gl

170 imetry (SLP) and photographic imaging of the optic nerve head (ONH) are currently used to document ba

171 phical map to demonstrate how sectors of the optic nerve head (ONH) are related to locations in the v

172 , and aberrant regrowth were detected at the optic nerve head (ONH) as early as 4 days after treatmen

173 ed with automated perimetry or a clinician's optic nerve head (ONH) assessment.

174 h factor beta (TGFbeta) receptor pathways in optic nerve head (ONH) astrocyte migration.

175 We have previously shown that human optic nerve head (ONH) astrocytes and lamina cribrosa (L

176 Human optic nerve head (ONH) astrocytes and rat microglial cel

177 nd human embryonic skeletal muscle cells and optic nerve head (ONH) astrocytes at confluence.

178 Optic nerve head (ONH) astrocytes have been proposed to

179 or netrin-1 in vitro and are guided into the optic nerve head (ONH) by localized netrin-1.

180 at radii of 0.22, 0.33, and 0.44 mm from the optic nerve head (ONH) center.

181 pairs of stereoscopic fundus photographs and optic nerve head (ONH) centered spectral domain optical

182 nar neural tissue (prelaminar) components of optic nerve head (ONH) cupping in one bilaterally normal

183 s are implicated in changes occurring at the optic nerve head (ONH) in glaucoma.

184 the distribution of birefringence around the optic nerve head (ONH) in normal subjects.

185 hat reduced ocular perfusion pressure in the optic nerve head (ONH) increases the risk of glaucoma.

186 experimental observations indicate that the optic nerve head (ONH) is a major site of axon degenerat

187 Understanding the effects of IOP on the optic nerve head (ONH) is important in understanding gla

188 In glaucoma, the optic nerve head (ONH) is the likely site of initial inj

189 In glaucoma, the optic nerve head (ONH) is the principal site of initial

190 visual system in a nonhuman primate model of optic nerve head (ONH) ischemia caused by sustained unil

191 PS-OCT scans around the optic nerve head (ONH) of two healthy young volunteers w

192 tudy was to evaluate the association between optic nerve head (ONH) parameters and branch retinal vei

193 r (NFL) thickness, macula thickness map, and optic nerve head (ONH) parameters in normal eyes were st

194 inal nerve fiber layer (RNFL) thickness, and optic nerve head (ONH) parameters.

195 Discovery and description of heritable optic nerve head (ONH) phenotypes have been haphazard.

196 The optic nerve head (ONH) region of 17 eyes of 17 healthy s

197 that leads to characteristic changes in the optic nerve head (ONH) region, such as nasalization of v

198 eformation of load bearing structures of the optic nerve head (ONH) resulting from raised intracrania

199 The optic nerve head (ONH) shape, retinal nerve fiber layer

200 ular pressure (IOP) on retinal thickness and optic nerve head (ONH) structure in the rat eye by spect

201 ucoma, defined as the onset of CSLT-detected optic nerve head (ONH) surface change, in the treated ey

202 tinal nerve fiber layer (RNFL) thickening in optic nerve head (ONH) swelling, but does not provide in

203 ify genes with upregulated expression at the optic nerve head (ONH) that coincides with retinal gangl

204 rized cell lines from the human LC and human optic nerve head (ONH) tissue.

205 SPC enzyme activity within human retina and optic nerve head (ONH) tissues.

206 to predict the biomechanical response of the optic nerve head (ONH) to intraocular pressure (IOP) ele

207 y Carl Zeiss Meditec, Inc., Dublin, CA), and optic nerve head (ONH) topography with HRT-II (retinal t

208 evelop at birth, expanding radially from the optic nerve head (ONH) towards the retinal periphery.

209 Expression of NOS-2 in the retina and optic nerve head (ONH) was evaluated by immunohistochemi

210 The optic nerve head (ONH) was imaged with SD-OCT (1.5 x 1.5

211 Tissue sections through the optic nerve head (ONH) were labeled with neuron-specific

212 ness (RNFL), ganglion cell complex (GCC) and optic nerve head (ONH) were measured in one eye of 57 gl

213 between scans, approximately 30 mum) of the optic nerve head (ONH) were obtained in both eyes of cli

214 A) and central cross-sectional images of the optic nerve head (ONH) were obtained using EDI-SDOCT.

215 orizontal and one 10 mm vertical through the optic nerve head (ONH), and one 10 mm 5-degree-offset th

216 ll axons of WT mice shed mitochondria at the optic nerve head (ONH), and that these mitochondria are

217 Excavation of the optic nerve head (ONH), axon loss, and COX reduction wer

218 ould also consider axial length, size of the optic nerve head (ONH), blood vessel contribution, and d

219 erence tomography (SD OCT) of the macula and optic nerve head (ONH), infrared reflectance, fundus aut

220 luate the vessel density measurements of the optic nerve head (ONH), peripapillary, and macular regio

221 of 445 participants underwent SD-OCT of the optic nerve head (ONH), visual field testing, and clinic

222 suspect subjects were repeatedly imaged, and optic nerve head (ONH)-centered OCT image volumes (200x2

223 y and mid-peripheral regions surrounding the optic nerve head (ONH).

224 enter the optic nerve by passing through the optic nerve head (ONH).

225 ge distance of 3.5 mm from the center of the optic nerve head (ONH).

226 50 frames x 1024 samplings), centered on the optic nerve head (ONH).

227 s were circumferentially oriented around the optic nerve head (ONH).

228 ensional (3-D) reconstructions of the monkey optic nerve head (ONH).

229 ensional (3-D) reconstructions of the monkey optic nerve head (ONH).

230 mapping SAP visual field locations onto the optic nerve head (ONH).

231 ith disorganization of elastic fibers in the optic nerve head (ONH).

232 ountability of rim tissue orientation in the optic nerve head (ONH).

233 ent radii (0.22, 0.33, and 0.44 mm) from the optic nerve head (ONH).

234 -OCT devices on the same day: Cirrus HD-OCT (optic nerve head [ONH]) cube 200 x 200 protocol), RTVue-

235 l scans in a 6 x 6-mm region centered on the optic nerve head [ONH]) with high-speed, ultrahigh-resol

236 volume scans centered on and surrounding the optic nerve head [ONH]).

237 Perfusion-fixed optic nerve heads (ONHs) from 21 animals were digitally

238 The optic nerve heads (ONHs) of donor eyes fixed at either 5

239 he minimum distance of jPED to the border of optic nerve head (OPN) was 2.6 +/- 11.1 (range: 0-61.9)

240 using astrocyte cultures derived from human optic nerve head or fetal human brain.

241 om the temporal and nasal neural rims of the optic nerve head out to 1040 mum allowed the quantificat

242 gnificantly with increased distance from the optic nerve head (P < or = 0.004), whereas retinal venou

243 s demonstrated retinal vascular attenuation, optic nerve head pallor, and mottling of retinal pigment

244 lary nerve fiber layer (pRNFL) thickness and optic nerve head parameters compared to the control grou

245 Optic nerve head parameters measured by HRT 3 were compa

246 e and substantial interocular correlation in optic nerve head parameters measured by HRT 3.

247 the ganglion cell inner plexiform layer and optic nerve head parameters, also are useful for progres

248 nts of NFL thickness, macular thickness, and optic nerve head parameters.

249 atio (r = 0.61; P < 0.001) and several other optic nerve head parameters.

250 a larger interocular difference in the other optic nerve head parameters.

251 e sleep apnea syndrome (OSAS) may compromise optic nerve head perfusion and cause glaucomatous optic

252 GON, based on longitudinally gathered stereo optic nerve head photographs.

253 Optic-nerve-head photography is still a mainstay in eval

254 had greater BOLD response compared with the optic nerve head region for both challenges.

255 nflammatory changes in the retina and/or the optic nerve head reminiscent of those suggested for prec

256 Appearance of the optic nerve head, retinal vessels, and surrounding retin

257 on of scan path location with respect to the optic nerve head rim, caused by relative magnification.

258 Macula and optic nerve head SD-OCT volumes were obtained in 57 eyes

259 ls of LC3-II were found in both LC cells and optic nerve head sections from glaucoma donors.

260 fiber layer curvature) and three measures of optic nerve head shape (cup depth, rim steepness, and cu

261 ro patients, elevated IOP and changes in the optic nerve head should result in a high index of suspic

262 such measurements and clinical estimates of optic nerve head structure and visual function.

263 ss-sectional and longitudinal measurement of optic nerve head structures using 3-D SD-OCT.

264 bilateral visual field defects and bilateral optic nerve head swelling 2 weeks after first dose of do

265 trocytes has been identified in glaucomatous optic nerve head, their role on the activated immune res

266 sue oxygen transport in the inner retina and optic nerve head through the regulated expression of Hb

267 horoidal neovascularization) and optic disc (optic nerve head tilt, optic disc dimensions, and peripa

268 on of the SPC family in the human retina and optic nerve head tissues was evaluated by quantitative r

269 Retinal avascularity, distance from the optic nerve head to the vascular edge in the peripheral

270 Measurements of optic nerve head topography showed less IOP-induced chan

271 Measurements of optic nerve head topography were obtained from confocal

272 nd quantitative measurements of the RNFL and optic nerve head topography.

273 Although glial cells in the optic nerve head undergo a reactivation process in glauc

274 retinal tissue superior and inferior to the optic nerve head using confocal scanning laser Doppler f

275 tical coherence tomography of the macula and optic nerve head using the Heidelberg Spectralis (Heidel

276 RNFL thickness was measured around the optic nerve head using Zeiss Stratus optical coherence t

277 we show that six6b (associated with POAG and optic nerve head variation) alters the expression of cdk

278 Above the optic nerve head was a conical space corresponding to th

279 Swelling of the optic nerve head was followed by progressive demise of g

280 crease in the mean level of nitrate over the optic nerve head was observed in mature animals compared

281 y, and the characteristics of the retina and optic nerve head were analyzed.

282 , pigmentation, nerve fiber arrangement, and optic nerve head were clearly visible on the fundus imag

283 rresponding stereo fundus photographs of the optic nerve head were obtained from 68 eyes of 34 patien

284 oherence tomography (EDI OCT) B-scans of the optic nerve head were obtained from patients with glauco

285 al coherence tomographic (OCT) images of the optic nerve head were obtained from patients with glauco

286 oherence tomography (EDI OCT) B-scans of the optic nerve head were obtained prospectively from each p

287 sional (3D) imaging of the normal retina and optic nerve head were performed.

288 ense in the vicinity of veins and toward the optic nerve head whereas smaller cells are often more de

289 1- and 5.7-fold higher in retina compared to optic nerve head, whereas PACE4 was expressed 4.1-fold h

290 e optic nerve correlated with MEMRI-measured optic nerve head width (P < 0.05).

291 , iridocorneal angle, ciliary body area, and optic nerve head width were readily measured from MEMRI

292 inner retinal thickness, ciliary body area, optic nerve head width, and iridocorneal angle.

293 In all mice, eye perimeter, optic nerve head width, iridocorneal angle, ciliary body

294 we acquired 12 radial scans centered on the optic nerve head with 15 degrees of separation between s

295 , was relatively increased at and behind the optic nerve head with IOP elevation.

296 (RNFL), and volumetric OCT scans through the optic nerve head with standard spectral-domain (SD OCT)

297 B and BDNF was identified in axons of monkey optic nerve heads with chronic glaucoma.

298 markedly increased in reactive astrocytes in optic nerve heads with experimental glaucoma but not in

299 itially infiltrates the retina, vitreous, or optic nerve head, with or without central nervous system

300 epithelium, outer part of the retina and the optic nerve head within 24-hours, in both groups of anim