1 ule real-time sequencing and high-resolution
optical mapping.
2 subtracted) during AF in vivo and in ex vivo
optical mapping.
3 tle fine-scale Ca(2+) alternans, captured by
optical mapping.
4 ce alignment, with modifications specific to
optical mapping.
5 ective myocardial conduction was detected by
optical mapping.
6 ysis was performed on each preparation after
optical mapping.
7 icular conduction velocity, as determined by
optical mapping.
8 mice using high-resolution, dual-wavelength
optical mapping.
9 typic sequenced strain by using the tools of
optical mapping.
10 acteristics of the PVs using high-resolution
optical mapping.
11 tential plateau, and DeltaVm was measured by
optical mapping.
12 strain 2.4.1 were constructed using shotgun
optical mapping.
13 ships were assessed using immunostaining and
optical mapping.
14 ivation spread recorded simultaneously using
optical mapping.
15 which utilize molecular fixation, including
optical mapping.
16 fingerprinting, radiation hybrid mapping and
optical mapping.
17 nesthetized Thy1-GCaMP mice using wide-field
optical mapping.
18 al locations on the molecules generated from
optical mapping.
19 recording depolarization in the scar through
optical mapping.
20 Activation was recorded with
optical mapping.
21 We addressed this gap with
Optical Mapping,
a high-throughput, high-resolution sing
22 ip system has drawn from critical aspects of
Optical Mapping,
a single-molecule system that enables t
23 Here, we describe how
optical mapping,
a single-molecule system, was used to i
24 In this study, we present the application of
optical mapping,
a single-molecule, whole-genome analysi
25 hromosome 2 DNA as the starting material for
optical mapping,
a system for making ordered restriction
26 s were removed during the integration of the
optical mapping and chromosome conformation capture data
27 Despite their technical differences,
optical mapping and chromosome conformation capture perf
28 se assemblies, we generated BioNano Genomics
optical mapping and Dovetail Genomics chromosome conform
29 Finally, using
optical mapping and electrophysiological analyses, we pr
30 c animals and incorporating information from
optical mapping and fiber-FISH.
31 Here we used
optical mapping and Fourier analysis to determine the di
32 ethod relieves a long-standing limitation of
optical mapping and has potential to enhance new studies
33 We applied biatrial
optical mapping and immunoblot mapping of various atrial
34 Optical mapping and immunohistochemistry indicate that p
35 Electrophysiological effects were studied by
optical mapping and patch-clamping.
36 in the intact non-failing rabbit heart using
optical mapping and pharmacological manipulation of RyRs
37 e isolated rabbit heart experimentally using
optical mapping and superconducting quantum interference
38 Using ratiometric
optical mapping and video microscopy, we discovered that
39 ent Na(+)-channel block mathematical models,
optical mapping,
and action potential recording were use
40 able by pulsed-field gel electrophoresis and
optical mapping,
and harbored a novel pmrC1A1B allele.
41 d Pitx2c mRNA by electrophysiological study,
optical mapping,
and patch clamp studies.
42 Using a new
optical mapping approach, we measured action potentials
43 study, using next-generation sequencing and
optical mapping approaches, a 24.1-Mb complete genome of
44 natal rat ventricular myocytes and performed
optical mapping at high temporal and spatial resolution.
45 In
optical mapping,
at 4 mM [K(+)](o), 17 null hearts showe
46 Using in vivo
optical mapping/
calcium imaging, we determined that the
47 We discuss how
optical mapping can be used as a validation tool for gen
48 Given the rapid spread of the use of
optical mapping,
careful evaluation must be made in term
49 We used epicardial and endocardial
optical mapping,
chemical subendocardial ablation with L
50 Subsequent
optical mapping confirmed a DF gradient from posterior L
51 Optical mapping confirmed that treatment with each compo
52 We generated and used stimulated
optical mapping data for loblolly pine and F.tularensis
53 loblolly pine and F.tularensis and used real
optical mapping data for rice and budgerigar.
54 Analysis of lacZ expression and
optical mapping data highlight important differences bet
55 Analysis of
optical mapping data reveals that VF excitation frequenc
56 The
optical mapping data were in good agreement with theory.
57 from the sequence data were compared to the
optical mapping data, and good correspondence was found.
58 Using the real
optical mapping data, we correctly identified 75% of ext
59 akpoints using paired-end sequence reads and
optical mapping data.
60 n source computational methods for analyzing
optical mapping data.
61 re few publicly available tools for aligning
optical mapping datasets.
62 Optical mapping demonstrated that current delivered with
63 sing CLC Genomics Workbench read mapping and
Optical mapping developed by OpGen.
64 Simultaneous endocardial and epicardial
optical mapping (
di-4-ANEPPS) was performed in isolated,
65 Optical mapping (
Di-4-ANEPPS, 300 frames/sec) of the pos
66 In preparations with z(0) <700 microm,
optical mapping during epicardial stimulation revealed u
67 Optical mapping during VF showed that activity often beg
68 High-resolution
optical mapping employing seven enzymes places these clo
69 Optical mapping enabled spatial characterization of exci
70 assive number of individual DNA molecules by
optical mapping enables assembly of physical maps spanni
71 Optical mapping experiments allow investigators to view
72 METHODS AND Biochemical, patch clamp, and
optical mapping experiments demonstrate that PKP2 associ
73 Finally,
optical mapping experiments in AnkG-silenced cells demon
74 We performed
optical mapping experiments in isolated Langendorff-perf
75 Here, we simulate dual voltage-calcium
optical mapping experiments using a monodomain-Luo-Rudy
76 Optical mapping experiments were performed on Langendorf
77 In simulations and
optical mapping experiments, virtual PentaRay recordings
78 combination of microelectrode recordings and
optical mapping experiments.
79 maging and enriched the model with data from
optical mapping experiments.
80 and by abolishing contraction, also prevent
optical mapping from being used to study coupling betwee
81 Optical mapping has become an indispensible tool for stu
82 Cardiac
optical mapping has proven to be a powerful technology f
83 Recent advances in the automation of
optical mapping have enabled us to map a set of 16 BAC c
84 microelectrode recordings and more recently
optical mapping have ushered in new periods of significa
85 estion, we conducted simultaneous voltage/Ca
optical mapping in atrial tissue and one-/two-dimensiona
86 mon understanding of the basic principles of
optical mapping in complex 3D anatomic structures.
87 METHODS AND Using
optical mapping in isolated perfused canine atrial prepa
88 rther confirmed by electric measurements and
optical mapping in Langendorff-perfused hearts.
89 propagation was assessed by high-resolution
optical mapping in monolayers of neonatal rat ventricula
90 By allowing high-resolution
optical mapping in the absence of electromechanical unco
91 iefly look into the possible future roles of
optical mapping in the development of regenerative cardi
92 A good example of this is the use of
optical mapping in the sinoatrial node (SAN): when micro
93 Optical mapping is a new tool that creates a high-resolu
94 Optical mapping is a technique for capturing fluorescent
95 Optical mapping is an accessible and relatively mature t
96 Optical mapping is an emergent technology for genomic an
97 r study that may be used, until such time as
optical mapping is clinically feasible, to improve mecha
98 lysis which may facilitate the automation of
optical mapping is presented.
99 An important limitation of conventional
optical mapping is that contraction is usually arrested
100 Panoramic
optical mapping is the primary method for imaging electr
101 Traditional
optical mapping lacks the spatial resolution to assess c
102 but MI differences are amplified by current
optical mapping methods.
103 In
optical mapping,
molecules are elongated and fixed onto
104 gated using a combination of high-resolution
optical mapping (
n = 5) and extracellular bipolar and in
105 underlying PV tachycardias was confirmed by
optical mapping (
n = 5).
106 By using high-resolution
optical mapping,
numerical simulations and metaanalysis
107 We used
optical mapping of action potentials and ratiometric cal
108 Notably,
optical mapping of action potentials in atrial fibrillat
109 Here, we make progress by combining
optical mapping of action potentials with concurrent act
110 Optical mapping of arrhythmias and defibrillation provid
111 Optical mapping of Ca(2+) transients revealed that rat A
112 t this hypothesis, we performed simultaneous
optical mapping of Ca(i) and membrane potential (V(m)) i
113 Optical mapping of cardiac electrical activity using a v
114 So far, the
optical mapping of cardiac electrical signals using volt
115 he excitation and emission of photons during
optical mapping of cardiac tissue.
116 Optical mapping of chimeric hearts by use of voltage-sen
117 Optical mapping of coronary-perfused atria (n=24) reveal
118 Novel intramural
optical mapping of coronary-perfused right atrial prepar
119 Optical mapping of cytosolic calcium transients in intac
120 Optical mapping of DeltaSIV hearts revealed that ventric
121 diagnostic applications, DNA sequencing and
optical mapping of epigenetic markers.
122 While over the last two decades
optical mapping of excitation (voltage and calcium dynam
123 Thus,
optical mapping of genetically engineered mice may help
124 Optical mapping of HFpEF hearts demonstrated prolonged a
125 Optical mapping of intact cardiac tissue reveals that, i
126 or improved interpretation of the results of
optical mapping of intact heart preparations.
127 Optical mapping of intracellular Ca (Ca(i)) and voltage
128 Simultaneous
optical mapping of intracellular Ca(2+) and membrane pot
129 At 4 weeks,
optical mapping of intracellular Ca2+ and ROS was perfor
130 In vitro, high-resolution near-infrared
optical mapping of intramural SAN activation was perform
131 neonatal cell pairs from mutant hearts, and
optical mapping of isolated-perfused hearts with voltage
132 Simultaneous voltage-calcium
optical mapping of Langendorff-perfused SHR hearts revea
133 Optical mapping of membrane voltage (V(m)) and intracell
134 y ganglia in vivo, opening the door to rapid
optical mapping of neuronal excitability.
135 s of AF drivers in a 2-dimensional model and
optical mapping of ovine atrial scar-related AF.
136 Optical mapping of perfused hearts confirmed slowed cond
137 Optical mapping of the epicardial electrical activation
138 ion potential duration using high-resolution
optical mapping of the epicardial surface in 8 isolated,
139 Optical mapping of the epicardial surface in ventricles
140 Detailed
optical mapping of the epicardial surface of guinea pig
141 Optical mapping of the first extrabeat with a coupling i
142 ultaneous voltage and intracellular Ca(+)(2)
optical mapping of the left ventricular epicardial surfa
143 Conduction velocity measurements from
optical mapping of the RBB revealed slow conduction in C
144 We used simultaneous
optical mapping of the right and left atria (RA and LA)
145 cts of ISO on LQT1 and LQT2 were verified by
optical mapping of the whole heart, suggesting that ISO-
146 Simultaneous
optical mapping of transmembrane potential and Ca(2+) tr
147 To validate this model, we used
optical mapping of transmembrane potential and calcium t
148 Optical mapping of transmembrane potential and intracell
149 ocity, measured by multisite high-resolution
optical mapping of transmembrane potential in strands of
150 ping ventricular myocardium using high-speed
optical mapping of transmembrane potentials and calcium
151 formed, and a 4-cm2 area of the PV underwent
optical mapping of transmembrane voltage to obtain 256 s
152 In addition, comparative
optical mapping of two other inbred maize lines revealed
153 Optical mapping of uniformly Kir2.1 gene-modified monola
154 Optical mapping of V(m) and Ca(i) in paced rabbit hearts
155 We used
optical mapping of V(m) in patterned cultures of neonata
156 Simultaneous
optical mapping of Vm (with RH237) and [Ca(2+)]SR (with
157 Simultaneous
optical mapping of voltage and [Ca(2+)]i in CPVT hearts
158 Programmed electric stimulation ex vivo and
optical mapping of voltage transients indicated that pep
159 nformation from the shape of the upstroke in
optical mapping recordings.
160 egmentation and tracking of cardiac waves in
optical mapping recordings.
161 Optical mapping revealed a loss of the normal elliptical
162 Optical mapping revealed cardiac refractoriness with los
163 solated, Langendorff-perfused rabbit hearts,
optical mapping revealed that dofetilide-induced arrhyth
164 Optical mapping revealed that selectively the transverse
165 ifferences similar to variations in I(Ca,L);
optical mapping revealed that the earliest EADs fired at
166 and long-read sequencing in conjunction with
optical mapping,
revealed a compact genome of approximat
167 First, we explore key components of a modern
optical mapping set-up, focusing on: (1) new camera tech
168 Optical mapping showed increased activation in the borde
169 High-resolution
optical mapping showed that epicardial wavefront expansi
170 Optical mapping showed that this effect also applied to
171 phasic action potentials and to conventional
optical mapping signals.
172 f electrical shocks within the heart, recent
optical mapping studies have revealed two major discrepa
173 Optical mapping studies have suggested that intracellula
174 Optical mapping studies in mice demonstrate that ANP spe
175 We then look at recent
optical mapping studies in single cells, cardiomyocyte m
176 Recent
optical mapping studies of cardiac tissue suggest that m
177 Moreover,
optical mapping studies of embryonic hearts demonstrate
178 We performed
optical mapping studies of VF in isolated swine right ve
179 Optical mapping studies showed that during rapid ventric
180 zation of the large-insert clones, e.g., for
optical mapping studies.
181 Optical mapping surfaces have been shown to be compatibl
182 The
Optical Mapping System discovers structural variants and
183 The
optical mapping system reported here is based on our phy
184 A multisite
optical mapping system was used to obtain 17 or 25 micro
185 tin using either a confocal microscope or an
optical mapping system.
186 dvances, we developed and validated low-cost
optical mapping systems for panoramic imaging using Lang
187 Optical mapping technique was used to assess effects of
188 ed preparations of left ventricle (LV) by an
optical mapping technique.
189 in geometrically defined cell cultures using
optical mapping technique.
190 hock-induced DeltaV(m) was measured using an
optical mapping technique.
191 s in DNA repair, were directly visualized by
optical mapping techniques after gamma irradiation.
192 studied ventricular defibrillation by use of
optical mapping techniques failed to observe an initial
193 We used
optical mapping techniques to study the effects of propr
194 Optical mapping techniques were used to determine the pa
195 To address these mechanisms, high-resolution
optical mapping techniques were used to measure action p
196 Imaging methods utilizing
optical mapping techniques will need to account for thes
197 By
optical mapping techniques, action potential duration (A
198 Using
optical mapping techniques, calcium transients and actio
199 g voltage-sensitive dyes and high resolution
optical mapping techniques, we found that uncoupling of
200 ion and contraction; (6) new multiparametric
optical mapping techniques; and (7) photon scattering ef
201 ating the potential benefit of more accurate
optical mapping technologies, such as nano-coding.
202 Previously, we used new
optical mapping technology to image VF wavefronts from n
203 e compared to sham mice by echocardiography,
optical mapping,
telemetry electrocardiographic monitori
204 onstrate the use of technology developed for
optical mapping to acquire DNA fingerprints from single
205 icroscopy, immunochemistry, patch-clamp, and
optical mapping to assess the interactions between AnkG,
206 We used
Optical Mapping to create genome-wide restriction maps o
207 We used
optical mapping to reconstruct patterns of activation du
208 The applicability of
optical mapping to this problem was enhanced by advances
209 Cardiac
optical mapping uses potentiometric fluorescent dyes to
210 Optical mapping using voltage-sensitive dye revealed slo
211 Optical mapping using voltage-sensitive fluorescent dyes
212 Thus
optical mapping was advanced to use simply extracted, un
213 Optical mapping was performed in 44 rat ventricular myoc
214 Optical mapping was performed on epicardial, endocardial
215 Optical mapping was performed to evaluate diastolic spon
216 Optical mapping was used to assess bidirectional conduct
217 Optical mapping was used to measure action potential dur
218 High-resolution
optical mapping was used to measure conduction velocity
219 High-resolution
optical mapping was used to study conduction in the righ
220 Using
optical mapping we observe increased dispersion of actio
221 using
optical mapping,
we investigated the effects of I(Kr) up
222 Illumina, 454 sequencing, and
optical mapping were used to obtain a complete genome se
223 Whole-genome
optical mapping (
WGM) (OpGen, Inc.) was performed on sel
224 Whole-genome mapping (formerly
optical mapping),
which is a high-resolution ordered res
225 ventricular arrhythmias (VA) were probed by
optical mapping,
whole-cell patch clamp to measure actio
226 High-resolution
optical mapping with correlative histological analysis o
227 etic and optogenetic fluorescent probes; (5)
optical mapping with motion and contraction; (6) new mul
228 Chromosome 2 was found to be 976 kb by
optical mapping with NheI, and 946 kb with BamHI, which
229 Optical mapping with the voltage-sensitive dye di-4 ANEP
230 d variation by integrating our findings from
optical mapping with those from DNA sequencing-based gen
231 Optical mapping with voltage-sensitive dyes provides a h
232 Using high-resolution
optical mapping with voltage-sensitive dyes, we measured
233 ing of impulse propagation, as determined by
optical mapping with voltage-sensitive dyes.