ライフサイエンスコーパス: optimism

1 Bootstrapping validation showed negligible optimism.

2 individuals who scored high and low on trait optimism.

3 ailure to code for errors that should reduce optimism.

4 estionnaire, measuring predisposition toward optimism.

5 approaches are providing grounds for renewed optimism.

6 ting characteristic curve (AUC) adjusted for optimism.

7 ultiple sclerosis has generated considerable optimism.

8 as new methodologies are cause for continued optimism.

9 enome-wide association, however, has revived optimism.

10 ts in healthy individuals, and is related to optimism.

11 illion people can be confronted with renewed optimism.

12 standing of likelihood of cure compared with optimism.

13 r cingulate cortex was correlated with trait optimism.

14 the rapid pace of research offers reason for optimism.

15 ourts to date in these cases gives cause for optimism.

16 disciplinary treatment team, and therapeutic optimism.

17 d immune tolerance provide further cause for optimism.

18 s as well as cancers is viewed with cautious optimism.

19 should be grounds for continuing therapeutic optimism.

20 vel approaches for which there is particular optimism.

21 sely related past experiences or unrealistic optimism.

22 Despite this, there are reasons for optimism.

23 a subset of patients at risk is a cause for optimism.

24 among people with the highest versus lowest optimism.

25 potential HIV-1 cure have generated renewed optimism.

26 luate different approaches to adjustment for optimism.

27 can trypanosomiasis, giving rise to cautious optimism.

28 ment at this conference brought about by the optimism about applying new sequencing techniques, genom

29 testosterone operates by inducing increased optimism about future price changes.

30 d a large, earlier body of data suggest that optimism about outcome from schizophrenia is justified.

31 This review will assess whether optimism about outcome from serious mental illness and o

32 These discoveries led to optimism about prophylactic HCV vaccines, and several st

33 Key tenets of the recovery model - optimism about recovery from schizophrenia, the importan

34 The findings offer cause for tempered optimism about the accuracy of strategic intelligence fo

35 of tumor immunology in the past decade, but optimism about the clinical application of currently ava

36 n the chimpanzee challenge model has allowed optimism about the development of at least a partly effe

37 ve attempted to identify the reasons why the optimism about the Patient Self-Determination Act has no

38 Our results suggest guarded optimism about the prospects of using genetic data in SW

39 However, any optimism about the resilience of these ecosystems is pre

40 Overall, there is far more optimism about the use of drugs in HIV infection than th

41 Concerns about safety are balanced by optimism about their potential role in delaying the prog

42 le model for 6-month mortality showed strong optimism-adjusted discrimination (concordance index, 0.7

43 out cross-validation) all generated unbiased optimism-adjusted estimates of the C statistic and had s

44 n, and leave-1-out cross-validation produced optimism-adjusted estimates of the C statistic that were

45 The optimism-adjusted Harrell C statistic for the combined s

46 associated with stressful life events, less optimism, ambivalence over expressing negative emotions,

47 This may also be influenced by personal optimism and a belief that patients are unable to predic

48 l prosthesis must be performed with cautious optimism and attention to general biomechanical and biol

49 re were no significant relationships between optimism and biomarkers.

50 If associations between optimism and broader health outcomes are established, it

51 study, we evaluated the association between optimism and cause-specific mortality in women after con

52 t current research indicates causes for both optimism and concern depending upon the content of the t

53 sicians may possibly be explained by patient optimism and confidence; however, the discrepancies in r

54 Optimism and cynical hostility are independently associa

55 Effects of optimism and cynical hostility were independent.

56 linding), and normal human tendencies toward optimism and denial.

57 cation, smoking status, personality trait of optimism and evidence of mental health care/treatment.

58 hired and promoted, having higher degrees of optimism and extraversion, and less neuroticism.

59 imed to investigate associations of baseline optimism and gratitude with subsequent physical activity

60 ovascular outcomes, the relationship between optimism and heart failure has not been examined.

61 Participants with low optimism and high anxiety had associations that were 3-4

62 ss and were characterized by lower levels of optimism and higher anxiety traits compared to the other

63 techniques, both of which heralded premature optimism and hubris, I urge open-minded skepticism.

64 fits of donation were associated with higher optimism and lower mental health; expected consequences

65 ences of donation were associated with lower optimism and lower physical and mental health.

66 cancer on public health, there is cause for optimism and room for hope.

67 ngs in the literature related to unrealistic optimism and self-beliefs, it does not appear to influen

68 f features of positive mental health such as optimism and self-confidence; a return to one's usual, n

69 Optimism and speculation require a counterweight.

70 After adjusting for physical health, optimism, and demographics, donors' SWL was significantl

71 echanisms of reward and motivation (hedonia, optimism, and learned helpfulness), fear responsiveness

72 However, grounds for optimism are provided by progress in implementation of t

73 Positive psychological constructs, such as optimism, are associated with beneficial health outcomes

74 These results give some cause for optimism as to the possibility for patients to adapt to

75 tive framework, to directly assess how trait optimism, as classically measured using self-report ques

76 Additionally, there was optimism associated with the diagnostic and prognostic u

77 ydroxy-L-phenylalanine; L-DOPA) increases an optimism bias.

78 nitoring emotional salience in mediating the optimism bias.

79 mined how the brain generates this pervasive optimism bias.

80 Post-ACS optimism, but not gratitude, was prospectively and indep

81 dispose to type 2 diabetes was launched with optimism, but progress has been slower than was hoped.

82 away from this Series with a great sense of optimism, but with specific recommendations that are bas

83 in this study displaying a form of parental optimism by allocating greater resources at birth to mal

84 eterminate has the potential for unrealistic optimism by both physicians and families.

85 been demonstrated in randomized trials that optimism can be learned.

86 Whether interventions that target optimism can successfully increase optimism or improve c

87 Reason for optimism comes from a recent study of mutant flies with

88 euroticism to more disengagement coping; and optimism, conscientiousness, and agreeableness to less d

89 A general sense of optimism continues to exist that there will be further p

90 th in the ages provided and in the degree of optimism conveyed.

91 ST-elevations-had excellent discrimination (optimism corrected C-Statistic, 0.88) and calibration (H

92 -terminal pro-brain natriuretic peptide, the optimism-corrected area under curve of the ARIC HF risk

93 d showed good discriminatory ability with an optimism-corrected C statistic of 70.1%.

94 lization showed good discrimination, with an optimism-corrected C-index of 0.79.

95 ariables (c-statistic = 0.84 [0.82 to 0.86]; optimism-corrected c-statistic = 0.83; pFEV1 = 3.4 x 10(

96 discriminate well when applied to new data (optimism-corrected c-statistic = 0.84).

97 How people maintain unrealistic optimism, despite frequently encountering information th

98 powering outcomes were identified: increased optimism, emotional well-being, social well-being, being

99 ry model refers to subjective experiences of optimism, empowerment and interpersonal support, and to

100 une responses, has been replaced by cautious optimism engendered by the RV144 trial outcome, the isol

101 ental treatments to the clinic, momentum and optimism exist for the translation of candidate experime

102 Meta-analyses link optimism, extraversion, conscientiousness, and openness

103 paleoenvironmental and genetic data provide optimism for a fuller understanding of the initial colon

104 ansmission is encouraging and has stimulated optimism for achieving a dramatic change in the trajecto

105 or treatments for this devastating disorder, optimism for developing RTT treatments derives from a un

106 ation and stem-cell therapy suggest cautious optimism for finding an effective treatment in the not-t

107 These advances provide optimism for improvements in the diagnosis, staging, and

108 Optimism for the concordance index and calibration slope

109 These exciting recent results provide optimism for the development of mAbs that bind novel tar

110 e pathogenesis, there is reason for cautious optimism for the future.

111 nucleic acid technologies, have given great optimism for the impact of 'genomic medicine'.

112 optimized treatment strategies provide much optimism for the treatment of more heart failure patient

113 scovery in this system, as well as providing optimism for the usefulness of inferences from mRNA expr

114 asis of ear morphogenesis offers grounds for optimism for translational research toward intervention

115 Newer pharmacological approaches provide optimism for treatment for this common problem.

116 r to question many of the foundations of the optimism GWAS prompted.

117 ociodemographic factors, each SD increase in optimism had an odds ratio of 0.74 (95% confidence inter

118 Although higher optimism has been linked with an array of positive healt

119 That optimism has been tempered by the potential risks of the

120 obust biomarkers with predictive value, some optimism has come from the identification and study of i

121 e limited progress toward this goal, renewed optimism has followed the recent success of the RV144 va

122 antation into medical practice, progress and optimism have been abundant.

123 ssociated with reduced social support, lower optimism, higher hostility, and greater early life adver

124 Early optimism, however, was soon tempered by the hard realiti

125 ficiency of endovascular cooling has offered optimism in cerebral protection during neurovascular sur

126 pling on only the clusters for estimation of optimism in model performance when data are clustered.

127 r only clusters showed accurate estimates of optimism in model performance.

128 emes in clustered data for the estimation of optimism in model performance.

129 iently with bootstrapping to assess possible optimism in model performance.

130 The 2-step approach overestimated the optimism in model performance.

131 has created real excitement and justifiable optimism in recent years among rheumatologists and among

132 tivated protein C (APC) has led to a renewed optimism in targeted biotherapies for this syndrome.

133 rsity in antigenic proteins may be cause for optimism in the difficult fight to control global tuberc

134 ned this trend: surrogates' need to register optimism in the face of a poor prognosis and surrogates'

135 e costimulatory pathways provide reasons for optimism in the search for a cure for devastating autoim

136 There is reason for optimism in the struggle against global blindness in lar

137 A novel approach stimulates new optimism in the struggle to eliminate the burden of mala

138 There is optimism in the surgical treatment of children with Down

139 ese obstacles, there is increasing cause for optimism in the treatment of diabetic and other chronic

140 Renewed optimism in this area of research comes in part from the

141 The experiments reported here encourage optimism in this respect by demonstrating targeted corre

142 ional stability, determination, control, and optimism-in 8,119 men and women aged 52 and older (mean

143 As optimism increased, risk of developing heart failure dec

144 Unfortunately, despite early optimism, inhaled nitric oxide has several significant l

145 y improve the prognosis; and the surrogate's optimism, intuition, and faith.

146 Unrealistic optimism is a pervasive human trait that influences doma

147 This is the first study to suggest that optimism is associated with a lower risk of heart failur

148 Failure to account for this inherent optimism is especially pernicious when the number of pos

149 These findings indicate that optimism is tied to a selective update failure and dimin

150 Cautious optimism is warranted regarding the use of high-dose Epo

151 This well-known bias, termed unrealistic optimism, is observed across age, culture, and species,

152 riers of the "A" allele have lower levels of optimism, mastery, and self-esteem, relative to G/G homo

153 Psychological resources--optimism, mastery, and self-esteem--buffer the deleterio

154 This increased optimism may represent an optimal foraging strategy for

155 Optimism measured using the Life Orientation Test scale,

156 ingly resistant to evidence, suggesting that optimism might also influence how new information is sel

157 sex, social constraint, survivor depression, optimism, multiple life changes, and social support.

158 These advances allow optimism not only for the advancement of our understandi

159 f 0.768 (95% CI 0.735-0.801) with an average optimism of 0.037.

160 tive nature of LO decisions and the inherent optimism of project teams, very few attempts have been m

161 reasing sample size did not correct the over optimism of single-arm studies.

162 The optimism of surrogate decision makers should be balanced

163 The optimism of the early period of antimicrobial discovery

164 There is cause for optimism on this difficult problem: the prebiotic chemic

165 at target optimism can successfully increase optimism or improve cardiovascular outcomes in post-ACS

166 t were 3-4 times larger than those with high optimism or low anxiety.

167 modified by psychological factors including optimism or pessimism, anxiety, and depression.

168 his latter issue, there is cause for current optimism owing to rapid increases in our knowledge of co

169 Among family member characteristics, greater optimism (p = 0.001, Hospital Anxiety and Depression Sca

170 Effects of optimism persisted even after adjusting for a wide range

171 Trait optimism (positive future expectations) and cynical, hos

172 0.21; 95% CI, -0.38 to -0.03), dispositional optimism (r = 0.20; 95% CI, 0.01 to 0.37), and spiritual

173 ntly more likely to report the importance of optimism regarding prognosis (79% vs 62%, P < 0.0001) an

174 st a profound misperception of and unfounded optimism regarding societal race-based economic equality

175 There is also an increased optimism regarding the use of supervisory ratings and re

176 We find that trait optimism relates to an a priori belief about the likelih

177 hic characteristics, numeracy, dispositional optimism, religiousness/spirituality, understanding of r

178 Optimism remains guarded as additional evidence accumula

179 Optimism remains that these RIT approaches will improve

180 ain family characteristics of coping such as optimism, resilience, and social support to be associate

181 estionnaires to assess SWL, physical health, optimism, retrospective evaluation of the donation exper

182 and COPD should be interpreted with cautious optimism since much of the evidence has been published o

183 ors associated with trait anxiety were trait optimism, state anxiety, evidence of mental health care/

184 ound in news media and on the Internet, with optimism tempered by evidence to support the ethical tra

185 Optimism that a highly effective malaria vaccine can be

186 Nevertheless, recent advances justify optimism that a licensed malaria vaccine is within reach

187 derstanding of fold determination, engenders optimism that a solution to the folding problem for memb

188 novel strategies under development engenders optimism that a successful candidate will emerge.

189 ng knowledge from these three areas provides optimism that additional acute stroke therapies can be d

190 Nevertheless, there is reason for optimism that advances in long-acting antiretroviral the

191 The workshop concluded on a cautious note of optimism that antibody-based treatment and prevention fo

192 Earlier results provide the initial optimism that CD44 isoform expression may be a marker fo

193 n synthetic lethal drug combinations inspire optimism that CDK inhibitors will become important weapo

194 he Human Genome project has sparked hope and optimism that cures for debilitating conditions can be a

195 Recent findings have brought optimism that development of a successful human immunode

196 These data thus provide optimism that development of nonliving vaccines which ca

197 There was considerable optimism that genetic linkage and genome-wide associatio

198 s memantine and ketamine have helped sustain optimism that glutamate receptors represent viable targe

199 d the ability to culture them in vitro lends optimism that high-throughput screenings of large chemic

200 f many adolescent disorders gives reason for optimism that interventions that shorten the duration of

201 derstanding of the ageing process and raised optimism that interventions to slow ageing may be on the

202 There is now cautious optimism that isoform-selective PI3K inhibitors will pro

203 d the inferred abundance of water reinforced optimism that Mars was once habitable.

204 g in their own right, songbirds also provide optimism that mature brains have recourse to plasticity.

205 r biology of these genes provide grounds for optimism that meaningful therapies for ALS are attainabl

206 the biology of ALS provides new reasons for optimism that meaningful therapies will be identified.

207 There is also optimism that pretargeting procedures, including new mol

208 pment of vaccine candidates provide cautious optimism that preventive measures are possible.

209 ransplantation biotechnologies, have created optimism that previously blinding retinal conditions may

210 agents available for evaluation provides new optimism that progress will be made over the next decade

211 tained, such patterns provide some cause for optimism that rapid evolution of PCV escape strains with

212 The original authors' optimism that RCM would provide material for future gene

213 These results increase our optimism that simulations in atomic detail may provide a

214 The current rapid advances create realistic optimism that the establishment of RNAi as a new and pot

215 ple techniques by many laboratories provides optimism that the field is advancing toward elucidating

216 There is justified optimism that the full potential of biofuel production f

217 as and strategies, but also will reflect our optimism that the next generation of approved platinum c

218 These new findings have stimulated optimism that the progression of heart failure can be pr

219 There is considerable optimism that the targeted molecular approach being appl

220 ation in the inner ear of birds provides new optimism that there may be a treatment for hearing and b

221 ssues they have colonized has raised immense optimism that these cells may provide functional recover

222 Recent studies provide cause for optimism that this ambitious goal is achievable.

223 ransfer of tumor-specific T cells has fueled optimism that this approach may find a place as a target

224 nomodulatory approaches, there is reason for optimism that we can markedly improve survival for all p

225 ly examine subjective health assets, such as optimism, that are a core focus of positive psychology,

226 t of these findings are grounds for cautious optimism, the same cannot be said for issues of cost; re

227 After initial optimism, there is increasing recognition of the limitat

228 inked positive psychological attributes like optimism to a lower risk of poor health outcomes, especi

229 d phenomena, provided sufficient grounds for optimism to allow more extensive toxicologic evaluation.

230 y for HCV infection has brought considerable optimism to the HCV sector, with the realistic hope that

231 ical applications range from unsubstantiated optimism to undeserved pessimism.

232 mber of recent advances have spurred renewed optimism toward initiating clinical trials and developin

233 aboratory based studies justifies a cautious optimism towards the successful translation of remyelina

234 such methods, and those that do correct for optimism use diverse methods, some of which are known to

235 Baseline optimism was also associated with lower rates of cardiac

236 Optimism was assessed by the Life Orientation Test-Revis

237 ard models, we found that a higher degree of optimism was associated with a lower mortality risk.

238 Higher optimism was associated with a lower risk of incident he

239 Given that optimism was associated with numerous causes of mortalit

240 egression models were used to assess whether optimism was independently associated with incident hear

241 Therefore, we examined whether higher optimism was linked with a reduced incidence of heart fa

242 Dispositional optimism was measured in 2004; all-cause and cause-speci

243 Baseline optimism was significantly associated with greater physi

244 f the physician, the most common reasons for optimism were a need to maintain hope to benefit the pat

245 outcome measures for PA/IVS may give way to optimism with the refinement of early diagnosis and earl

246 ompared with women in the lowest quartile of optimism, women in the highest quartile had a hazard rat