ライフサイエンスコーパス: optimization

1 ic HERs, resulting in a "catalytic site self-optimization".

2 ted liabilities that may require significant optimization.

3 tly hardware-based computation and algorithm optimization.

4 nsitivity and specificity without individual optimization.

5 nk communities, which is suitable for global optimization.

6 inducible transcription with split construct optimization.

7 e models for systematic materials design and optimization.

8 mall molecule screening, identification, and optimization.

9 atrix were estimated by using particle swarm optimization.

10 community structures than partition density optimization.

11 and outputs in mammalian cells with minimal optimization.

12 nts of growth parameters crucial for process optimization.

13 osis induction in Raji cells to allow system optimization.

14 ity, and evaluated its applicability for AVD optimization.

15 how efficiencies of approximately 8% without optimization.

16 rification and/or extensive rounds of design optimization.

17 tion of the current concepts in pediatric CT optimization.

18 l formation and illuminate a path for future optimization.

19 lans was significantly better than graphical optimization.

20 lectronic structure calculations or geometry optimizations.

21 Through structure-activity relationship optimization, a 3-(N-piperidinyl)methylbenzamide derivat

22 After the analytical parameters optimization, a linear detection response from 0.01pg/mL

23 After comprehensive synthetic optimizations, a broad substrate scope is achieved and f

24 Under the umbrella of WOC optimization, advanced in situ/operando analytical techn

25 poses may enable productive structure-based optimization along multiple divergent pathways.

26 The optimization, analytical characterization and validation

27 teraction should have profound impact on the optimization and de novo design of new NM with better in

28 ilies of forest insects would facilitate the optimization and development of intercept traps for use

29 An arsine in nitrogen standard was used for optimization and evaluation of the system.

30 Through systematical optimization and evaluation using N-glycans released fro

31 can be chosen to not only solve problems of optimization and inference but also to implement precise

32 Here, we report the optimization and operationalization of a process called

33 is, especially machine learning, algorithmic optimization and parallel computing.

34 rranting further investigations of algorithm optimization and performance with different radiotracers

35 nse has long been explored to facilitate the optimization and personalization of cancer therapy.

36 e aid of a mathematical model combining both optimization and queuing can reduce the time to AED arri

37 Optimization and realization of stochastic patterns have

38 e constraints on the structure to help guide optimization and reconstruct underlying structure from v

39 Further optimization and representative scope of azide arylation

40 sion of the software package MOST (Metabolic Optimization and Simulation Tool), satisfies (i), and by

41 ng the subtle order achieved by evolutionary optimization and the possibility of an amorphous gyroid'

42 The aims of this study were the optimization and validation of a new ultrasound assisted

43 tion of the protein transport pathway, codon optimization, and co-expression of molecular chaperones

44 IPSA2 achieved similar results as graphical optimization, and none of the other IPSA plans was signi

45 manufacturing, and production for screening, optimization, and robustness testing.

46 auxetic structures through rational design, optimization, and taking inspiration from nature.

47 structure-based design, medicinal chemistry optimization, and unique ADME assays of our irreversible

48 Herein, we report the design, optimization, and validation of double-click stapled pep

49 o better understand polymer solar cell (PSC) optimization approaches.

50 mputational design, utilizing electric field optimization as guidance.

51 em we report here is also highly amenable to optimization, as each of its components can be fine-tune

52 After optimization, best results were achieved using a injecti

53 Structural homology and geometry optimization calculations enabled the identification of

54 -based screening approaches followed by drug optimization, chemical genetics in plant systems tends t

55 erformance was also found to be sensitive to optimization conditions and blend morphologies, which ar

56 Accordingly, codon optimization correlates with host range across the funga

57 Surprisingly, optimization could be achieved in a single attempt, and

58 It also implements different optimization criteria, such as edit distance, that can i

59 ancy, data consistency, and transparency for optimization, design, and decision making in WM.

60 Global sensitivity analysis and constrained optimization determined the set of parameters that minim

61 We show that DFT structural optimizations do not give accurate structural models, as

62 Design and optimization, driven with a TNBC tumor cell assay, ident

63 A focused screening and lead optimization effort identified 4b (GS-5734) with anti-EB

64 dition high throughput screen and subsequent optimization effort identified the first orally bioavail

65 Concurrent with our in vivo optimization effort using 9, we further improved LLE as

66 pelled by the convenient synthesis, the lead optimization effort yielded a number of potent antiviral

67 Herein, we present initial optimization efforts and structure-activity relationship

68 the interaction, which is key to direct lead optimization efforts in drug discovery.

69 We describe our optimization efforts to improve the physicochemical prop

70 Unconstrained optimization eliminates intermediate metastable states,

71 le structure-based design and multiparameter optimization enabled the development of compounds with p

72 pled with molecular dynamics and QM geometry optimization enabling the construction of an ensemble of

73 Optimization focused mainly on solubility, brain penetra

74 ines (MCF-7:5C and MCF-7:TAM1) were used for optimization, followed by validation in the parent endoc

75 be of great help in lead identification and optimization for early drug discovery.

76 rgy perturbation method (MD/FEP) in fragment optimization for the A2A adenosine receptor, a pharmaceu

77 g RGENs should enhance their engineering and optimization for therapeutic and other applications.

78 l application of SBDD paves the way for lead optimization for VEEV antivirals, and is an exciting pro

79 ween sampler and sensor, hinting towards an 'optimization' for efficient chemoreception.

80 In this study, we introduce the SteadyCom optimization framework for predicting metabolic flux dis

81 Structure-based optimization guided by predicted binding modes and analo

82 otein features evolved because of functional optimization, historical constraint, or blind chance.

83 Lead optimization identified selective sub-100-nM inhibitors

84 ymous substitutions underpin increased codon optimization in a generalist but not a specialist fungal

85 dence between biological neural circuits and optimization in structured architectures, allowing us to

86 Optimization in the sulfolane series led to compound 4,

87 i likely increase natural selection on codon optimization in these species.

88 Modulation optimization involved a systematic investigation of heat

89 FLUX's architecture is suitable for geometry optimization is rigorously demonstrated.

90 Structural optimization led to compound 28, which was 4-fold more p

91 Preliminary optimization led to compound 90, which inhibited the enz

92 Lead optimization (LO) is essential to fulfill the efficacy a

93 rozen accidents or optimization, though this optimization may also be for systems-level reasons, e.g.

94 ith Analysis of variance (ANOVA) and Taguchi optimization method for optimizing the performance of se

95 (CCA) and a stochastic gradient decent (SGD) optimization method give the best representation of the

96 as a flexible system, namely by the ensemble optimization method, which enables a distribution of con

97 Here, we introduce a filter-optimization method, which utilizes an expression for th

98 Our findings establish an optimization methodology for triboelectric nanogenerator

99 The drawbacks of global stochastic optimization methods are: (i) no guarantee of finding gl

100 Optimization methods with these features can substantial

101 is for each patient using maximum likelihood optimization methods.

102 ssessment (LCA), we develop a multiobjective optimization model to systematically identify the enviro

103 quential, cross-realm integration in spatial optimization modeling we highlight lands and waters that

104 We then formulate optimization models to determine optimal abatement strat

105 SOC models, adaptation plays no role, and no optimization occurs.

106 Further optimization of 25 to mitigate pH-dependent absorption r

107 Chemical optimization of 3 using SBDD culminated in the discovery

108 Structural optimization of 3-hydroxy-N'-arylidenepropanehydrazonami

109 Optimization of a multivariate calibration process has b

110 describe the identification and hit-to-lead optimization of a novel class of tricyclic sulfonamides

111 Optimization of a protein's pharmaceutical properties is

112 Herein, we report the discovery and optimization of a series of atropisomeric quinolinone su

113 The optimization of a series of internal NaV1.7 leads that a

114 the structure-guided design and group-based optimization of a series of VHL inhibitors with low nano

115 ive analysis of protein evolution and in the optimization of alignments for comparative modelling and

116 rally nonuniform background requires complex optimization of an emission filter-the main element of s

117 Herein, we describe optimization of an initial hit 2, resulting in identific

118 e marrow-derived MSC or dendritic cells) for optimization of appropriate conditioning or maintenance

119 gerbils and their absence in mice suggest an optimization of axonal and synaptic properties to the sp

120 catalytically upon reduction, permitting the optimization of azobenzene switching in new as well as i

121 neidensis as a model biocatalyst without any optimization of bacterial culture.

122 vity and may be a promising modification for optimization of biological properties of siRNAs.

123 Here, we report that optimization of caloric loading in B6 mice subject to HF

124 nd its cleavage mechanism can enable further optimization of Cas9-based genome-editing specificity an

125 Finally, the challenges related to the optimization of charge transfer kinetics in both oxides

126 lyze chemical reactions are critical for the optimization of chemical conversion processes.

127 vo enzymes since it is largely restricted to optimization of chemical positioning in the active site,

128 ded periods of time, and can be used for the optimization of combined chemo-radiation scheduling and

129 rated models for the successful, prospective optimization of crystallographically intractable fragmen

130 control is a necessary precondition for the optimization of desired properties.

131 eceived by hospital staff, inspiring further optimization of device function.

132 This study describes a stepwise optimization of DFG (1-deoxy-1-fructosylglycine) formati

133 that swarm intelligence may also benefit the optimization of diagnostics readout of other liquid biop

134 Optimization of early lead matter focused on removal of

135 on functionality, the system enables on-chip optimization of electroporation parameters for cells wit

136 In addition, an optimization of end wall resistance with plant height wa

137 Protein engineering has enabled the optimization of existing enzymes and the invention of en

138 al cell and to enable the interpretation and optimization of experiments.

139 The optimization of extraction of free polyphenols was perfo

140 Further optimization of fermentation conditions led to the isola

141 We report the optimization of fragment hit 5b to 13-d as a biased, pot

142 l become a powerful tool in structure-driven optimization of fragments to lead candidates.

143 onships and principles can help guide future optimization of functional organic/inorganic hybrid nano

144 The optimization of high-energy-storage dielectrics will hav

145 ovements in technology for the discovery and optimization of high-potency antibodies have greatly inc

146 Initial optimization of high-throughput screening (HTS) hit 1 le

147 ened experimentally and can enable efficient optimization of hits to potent leads.

148 o ensure reduction of radiation exposure and optimization of image quality.

149 -cell activity, with potential impact on the optimization of immune-modulatory therapies.

150 h pathogen escape mechanisms and will aid in optimization of immunization strategies to induce V2 ape

151 fish SIRT5, which provide insight for future optimization of inhibitors with more "drug-like" propert

152 ention, which is supported by motor-mediated optimization of input across saccades and pupil dilation

153 ion of potential inhibitor-binding sites and optimization of interactions of hits using the structure

154 ing of the synergetic effects leading to EET optimization of light-harvesting antenna systems while e

155 Benchmark studies demonstrate that global optimization of Link Surprise yields meaningful and more

156 f microcirculation perfusion is critical for optimization of microvascular perfusion and to define wh

157 Optimization of microwave-assisted extraction (MAE) of w

158 The functional optimization of neural ensembles is central to human hig

159 tailoring the microstructure can lead to the optimization of new high-performance solid electrolytes.

160 tures and, therefore, shed light on possible optimization of nuclear waste administration.

161 f PDE1B and PDE10A were determined, allowing optimization of PDE1B potency and PDE selectivity.

162 m within even short peptides, the design and optimization of peptidic catalysts by rational structura

163 The efficacy and optimization of poststroke physical therapy paradigms is

164 der structure comparison, as well as for the optimization of protein chemical modification reactions.

165 Further optimization of proton therapy, particularly intensity-m

166 Therefore, optimization of radiation doses with the use of specifie

167 After optimization of rate control, patients underwent cardiac

168 Optimization of reaction conditions, with respect to pH

169 igns and Doehlert matrix) often utilized for optimization of sample preparation procedures and also i

170 The effect of environmental factors on the optimization of segmented TEGs is also studied.

171 Optimization of sensing algorithms is required to ensure

172 e proposed framework can also be adapted for optimization of separation selectivity in various 2D com

173 we outline simple design principles for the optimization of shift currents for frequencies near the

174 sphodiesters may be useful modifications for optimization of siRNAs.

175 ology and software for efficient interactive optimization of spin parameters against experimental 1D-

176 magnetic insulators and spin liquids and aid optimization of spintronic devices.

177 We anticipate that with further optimization of structure design, strand synthesis and a

178 A), and delta (D), which might guide further optimization of substituents around the NH group and phe

179 The optimization of supported metal catalysts predominantly

180 Despite advances in the treatment of asthma, optimization of symptom control remains an unmet need in

181 These results will help facilitate the optimization of TCE-bioremediation at contaminated sites

182 t could provide important guidelines for the optimization of TERS experiments.

183 Here, we describe the optimization of the 2-anilino quinazoline class as antim

184 The optimization of the aryl substitution then identified a

185 Optimization of the ATC series gave improvements in pote

186 or several of these approaches should allow optimization of the beneficial effects of D1R stimulatio

187 reports on inhibitors of ATX derived by lead optimization of the benzene-sulfonamide in silico hit co

188 ture-based hit identification and subsequent optimization of the center (S)-proline-based lead 7 has

189 Optimization of the core and aryl appendages was perform

190 The optimization of the denticity, and steric and electronic

191 Future studies are warranted into optimization of the dosing and frequency of AD-MSC thera

192 actions could more productively benefit from optimization of the electrostatics of the protein scaffo

193 A Box-Behnken (BBD) design was used for optimization of the extraction and elution steps.

194 A complete optimization of the graphite furnace temperature program

195 g period and the fill-factor, along with the optimization of the grating coupler etching depth.

196 in small air-conditioning systems, including optimization of the heat exchangers.

197 Optimization of the inert shell coating surrounding the

198 Structure optimization of the isolated guest molecules demonstrate

199 model protein, we carry out an experimental optimization of the ITP-based immunoassay and demonstrat

200 rk in which long-term plasticity performs an optimization of the postsynaptic response statistics tow

201 The optimization of the potentiometric sensor presented here

202 Since no particular optimization of the probe design was applied, this metho

203 ithin the coordinate descent framework where optimization of the regularized logistic loss function i

204 y X-ray photoelectron spectroscopy (XPS) and optimization of the RIMS setup for this purpose, as well

205 Optimization of the series for potency and increased dur

206 Optimization of the spectral characteristics of each loc

207 e" control is critical for understanding and optimization of the thin-film morphology and charge-tran

208 We outline the discovery and chemical optimization of the THIQ scaffold leading to THIQ 40 and

209 d by gBGC in mammalian genomes precludes any optimization of the tRNA pool to the demand in codon usa

210 conductance regulator (CFTR) is key for the optimization of therapeutics as well as obtaining insigh

211 Optimization of thermosonication showed significant impr

212 Despite optimization of these factors, nonresponse to CRT may oc

213 To further the understanding and optimization of these materials, solution-based methods

214 Further evaluation and optimization of these molecules requires characterizatio

215 e of each factor by Pareto chart followed by optimization of these significant factors using central

216 tructures have been used for structure-based optimization of this series of compounds.

217 Further optimization of this system may allow noninvasive detail

218 tment of M. intracellulare lung disease, but optimization of treatment regimens is required to preven

219 In the present study an optimization of trienzyme treatment combining alpha-amyl

220 Through careful optimization of vaporization temperature and nebulizer g

221 be useful for development, benchmarking and optimization of VC algorithms and for the relative compa

222 Density functional theory geometry optimizations of an active site model reveal that the in

223 After systematic optimizations of experimental parameters (the components

224 Optimizations of various probe fabrication parameters ar

225 stem allows functional mapping and multiplex optimization on a genome scale for diverse phenotypes in

226 ch to guide this type of medicinal chemistry optimization once it has been validated for the system u

227 RNA sequence modification, delivery optimization, or concurrent use of appropriate compounds

228 ple and low-cost methods as well as flexible optimization parameters in terms of pixel density and de

229 Previously, using an output-driven optimization platform and an in vitro macrophage model o

230 n of clinical surfaces, but requires further optimization prior to widespread use.

231 we formulate TAD identification as a network optimization problem and propose an algorithm, MrTADFind

232 Coordination in groups faces a sub-optimization problem and theory suggests that some rando

233 We formulate our underlying combinatorial optimization problem as an integer linear program, and d

234 supervised learner is employed in an inverse optimization problem for estimating the scattering param

235 gs-signal-versus-background machine learning optimization problem, mapped to a problem of finding the

236 This is a typical big optimization problem, since the number of variables need

237 degrees of freedom are added to the overall optimization problem.

238 twork harnesses the natural analogue between optimization problems and energy minimization processes

239 Solving combinatorial optimization problems is challenging.

240 Besides solving optimization problems, polariton graphs can simulate a l

241 A two dimensional topology optimization procedure is employed to find the binary la

242 Herein, we report the optimization process for a hit compound that has emerged

243 5, and the benzothiadiazine derivative 6, an optimization process utilizing the simple benzofuran tem

244 An important feature of the optimization process was the successful application of r

245 The echocardiography-driven cardiac output optimization protocol led to a significant reduction of

246 the exploration of coherent quantum enhanced optimization protocols accessible with state-of-the-art

247 high throughput screening (HTS) followed by optimization provided a 4-phenyl-3-aryl-sulfoquinoline l

248 y pattern synthesis (APS) and particle swarm optimization (PSO) algorithm, the selection and distribu

249 er presents a novel two-stage particle swarm optimization (PSO) for the maximum power point tracking

250 Here we demonstrate that particle-swarm optimization (PSO)-enhanced algorithms enable efficient

251 phs, belonging to the class of combinatorial optimization, represents one such problem.

252 A round of optimization resulted in 11 new submicromolar KOR binder

253 Medicinal chemistry optimization resulted in 83, an orally bioavailable inhi

254 rmionic Hamiltonians and a robust stochastic optimization routine.

255 ntee of finding global optima, (ii) no clear optimization run termination criteria and (iii) no crite

256 (iii) no criteria to detect stagnation of an optimization run.

257 GRACE uses a novel optimization scheme to integrate regulatory evidence and

258 orted by analytical methods, and a heuristic optimization scheme, we identify a material geometry tha

259 h in this field, where the components of the optimization set are modeled as artificial spin units.

260 The study covers all the optimization steps for hybridization procedure and elect

261 gically distinct classes requiring different optimization strategies.

262 Herein, we report further optimization studies in which potential metabolically la

263 Constraint-based optimization, such as flux balance analysis (FBA), has b

264 Current methods based on optimization techniques are strongly sensitive to initia

265 After optimization, the 16-QAM OFDM data with and without side

266 Optimization, the ability to select the functionally bes

267 After further optimization, the discovery of a minor enantiomeric impu

268 After optimization, the method showed correlation coefficients

269 y is the more common strategy in selectivity optimization, the opposite strategy of subtracting the s

270 After proper optimizations, the OSCs with DF-PCIC as the acceptor and

271 pleted a de novo assembly and after assembly optimization, there were 113,329 transcripts representin

272 After two rounds of structural optimization, these design approaches led to small molec

273 With further optimization, this approach may enable clinical therapie

274 With further optimization, this new type of neuraminidase assay may b

275 d be due to evolutionary frozen accidents or optimization, though this optimization may also be for s

276 the applicability of S-LCC to SWM life-cycle optimization through a case study based on an average su

277 Further optimization through replacement of the amide with a var

278 With straightforward optimization to improve solar absorption, our work shows

279 ive models (GAM) and performed two-objective optimization to minimize the probability of poor mental

280 odify streptogramins would enable structural optimization to overcome these limitations as well as to

281 dapt biology's mechanisms for innovation and optimization to solving problems in chemistry and engine

282 f a direct multidimensional transition state optimization to the hydride transfer step in human dihyd

283 In this paper gradient based topology optimization (TO) is used to discover 3-D phononic struc

284 field: from lead discovery, to synthesis and optimization, to peptide drug delivery.

285 m, and a promising lead compound for further optimization toward the development of novel cancer ther

286 We present a framework for optimization under uncertainty for heterogeneous catalys

287 Here, we show that codon optimization underlies genome adaptation in broad host r

288 Further optimization using structure-based drug design approach

289 ough fragment-based screening and subsequent optimization using structure-based drug design, and para

290 Here, such optimization using ultrafast spectroscopy as a tool to o

291 The optimization was carried out using a simplex method.

292 Optimization was further guided by high-resolution cryst

293 The optimization was guided by structure-based design and fo

294 riched extracts and multivariate statistical optimization was performed to define the conditions for

295 A simultaneous optimization was performed to maximize TPC, ash and fibe

296 ng classification accuracy to guide platform optimization, we develop methods to standardize hologram

297 facilitate target identification and ligand optimization, we herein report a comprehensive structure

298 igh-impact design element for multiparameter optimization, wherein >/=10-, 100-, or 1000-fold improve

299 ing, reliable computational methods to guide optimization would be invaluable.

300 Typically, each round of optimization yields minor improvement in stability, and