ライフサイエンスコーパス: optineurin

1 hromosome 10p14 and designated it OPTN (for "optineurin").

2 uitin and subsequent recruitment of Nemo and Optineurin.

3 Here, we found that optineurin actively suppressed receptor-interacting kina

4 Optineurin and alphaB-crystallin levels remained unchang

5 . cerevisiae Atg19, Atg34 and the human p62, Optineurin and NDP52 cargo receptors interact with the E

6 LUBAC-synthesized polyubiquitin recruits Optineurin and Nemo for xenophagy and local activation o

7 Optineurin and p62/SQSTM1 are independently recruited to

8 In contrast, optineurin and/or its Ub-binding function was necessary

9 g misfolded proteins in foci with ubiquitin, optineurin, and LC3.

10 apoptosis-induced ligand, thrombospondin-1, optineurin, and palladin.

11 functional complex consisting of myosin VI, optineurin, and probably the GTPase Rab8 plays a role in

12 dimeric cargo adaptor protein of myosin VI, optineurin, and the myosin VI-binding segment from a mon

13 uilin 2, p62, valosin-containing protein and optineurin are all linked to aggrephagy, a cargo-specifi

14 of optineurin in mitophagy, as mutations in optineurin are causative for amyotrophic lateral scleros

15 Myocilin and optineurin are two genes linked to glaucoma, a major bli

16 rs previously linked to xenophagy, NDP52 and optineurin, are the primary receptors for PINK1- and par

17 In a yeast 2-hybrid screen we identified optineurin as a binding partner for myosin VI at the Gol

18 our study establishes an important role for optineurin as an autophagy receptor in parkin-mediated m

19 ucose-transporter binding protein (GIPC) and optineurin binding and a site that binds specifically an

20 On the other hand, the overexpression of optineurin blocks the protective effect of E3-14.7K on c

21 d by expression of siRNA-resistant wild-type optineurin, but not by an ALS-associated mutant in the u

22 PINK1 recruits NDP52 and optineurin, but not p62, to mitochondria to activate mit

23 complex containing IKKalpha and IKKbeta, and optineurin cannot substitute for NEMO in lipopolysacchar

24 found three genes associated with glaucoma, optineurin, cochlin, and CYP1B1 (cytochrome P450, family

25 Optineurin competitively antagonized NEMO's binding to p

26 Transfection with the wild-type optineurin construct, but not with that of the wild-type

27 In contrast, neither transfection of the optineurin constructs pOPTN(WT)-EGFP and pOPTN(E50K)-EGF

28 The autophagy cargo receptors p62, NDP52 and Optineurin detect incoming bacteria that have become ass

29 ed that the two glaucoma genes, myocilin and optineurin, exhibited differential effects on neurite ou

30 The optineurin gene and protein are evolutionary conserved b

31 n is a homolog of NEMO, and mutations in the optineurin gene are found in a subset of patients with g

32 Here we show that optineurin has a K63-linked polyUb-binding region simila

33 encoding myocilin and the gene OPTN encoding optineurin have been identified to harbor causal mutatio

34 Two further binding partners for optineurin have been identified: huntingtin and Rab8.

35 utes for protein clearance, in processing of optineurin in a retinal ganglion cell model line RGC5 an

36 These results reveal a physiologic role for optineurin in dampening TNFalpha signaling, and this rol

37 We examined the role of optineurin in mitophagy, as mutations in optineurin are

38 Depletion of endogenous optineurin inhibits LC3 recruitment to mitochondria and

39 static situation, the turnover of endogenous optineurin involves mainly UPP.

40 Optineurin is a gene linked to amyotrophic lateral scler

41 Optineurin is a homolog of NEMO, and mutations in the op

42 Optineurin is a widely expressed polyubiquitin-binding p

43 When optineurin is depleted from cells using RNA interference

44 Therefore, endogenous optineurin is dispensable for NF-kappaB activation but n

45 Optineurin is expressed in trabecular meshwork, nonpigme

46 When optineurin is up-regulated or mutated, the UPP function

47 It was found that the endogenous optineurin level in neuronal cells was increased by trea

48 These results show that optineurin links myosin VI to the Golgi complex and play

49 Akin to C-terminal optineurin mutations found in patients with certain neur

50 -expressed wild-type and mutant myocilin and optineurin on neurite outgrowth in neuronal cells, we tr

51 al sclerosis (ALS)-associated genes, such as optineurin (OPTN) and angiogenin (ANG), showed that the

52 in innate immunity and autophagy, including optineurin (OPTN) and p62 (SQSTM1/sequestosome), both of

53 Mutations in optineurin (OPTN) are linked to the pathology of primary

54 We recently identified optineurin (OPTN) as a novel gene for glaucoma and deter

55 It has been shown that mutations in the optineurin (OPTN) gene are involved in the etiology of a

56 Mutations in the optineurin (OPTN) gene have been implicated in both fami

57 Optineurin (OPTN) has recently been linked to glaucoma,

58 explored the role of the autophagy receptor optineurin (Optn) in autophagosome formation.

59 SOD1, TDP-43, FUS and optineurin (OPTN) proteins were identified to form intra

60 NEMO)-related polyubiquitin-binding protein, optineurin (OPTN), as a novel binding partner of TBK1.

61 Optineurin (OPTN), implicated genetically in glaucoma an

62 ed mitochondria requires autophagy receptors optineurin (OPTN), NDP52 (CALCOCO2), TAX1BP1, and p62 (S

63 Mitophagy receptors, including optineurin (OPTN), nuclear dot 52 kDa protein (NDP52), a

64 nce binding to candidate mitophagy receptors optineurin (OPTN), sequestosome-1 (p62), and nuclear dot

65 A and protein expression patterns for murine optineurin (Optn).

66 s not required for the recruitment of either optineurin or LC3 to damaged mitochondria.

67 FP-N1 (mock control) as well as myocilin and optineurin plasmids including pMYOC(WT)-EGFP, pMYOC(P370

68 sion and tissue distribution between the two optineurin proteins suggests that this nonhuman primate

69 oreactive to anti-ubiquitin were seen in the optineurin pulldown, indicating that optineurin was ubiq

70 Once recruited to mitochondria, NDP52 and optineurin recruit the autophagy factors ULK1, DFCP1 and

71 Following optineurin recruitment, the omegasome protein double FYV

72 protein levels because microRNA silencing of optineurin resulted in markedly enhanced TNFalpha-induce

73 Although optineurin shares considerable homology with NEMO, in re

74 FP and pOPTN(E50K)-EGFP nor the myocilin and optineurin small-interfering RNA treatments induced sign

75 oversial, with in vitro studies finding that optineurin suppressed TNF-mediated NF-kappaB activation

76 In cells overexpressing wild type and E50K optineurin, the level of the proteasome regulatory beta5

77 Optineurin then induces autophagosome formation around d

78 onstrate the parkin-dependent recruitment of optineurin to mitochondria damaged by depolarization or

79 er mitochondrial membrane proteins, allowing optineurin to stably associate with ubiquitinated mitoch

80 evealed recruitment of p62, ubiquilin-2, and optineurin to TDP-43 aggregates.

81 The foci formed after optineurin transfection were increased upon treatment of

82 in binding domain; in the absence of parkin, optineurin transiently localizes to damaged mitochondria

83 Moreover, the level of optineurin-triggered apoptosis was reduced by rapamycin.

84 ed macrophages (BMDMs) from mice carrying an optineurin Ub-binding point mutation had normal TLR-medi

85 ion, we generated a mouse in which wild-type optineurin was replaced by the polyubiquitin binding-def

86 in the optineurin pulldown, indicating that optineurin was ubiquitinated.

87 s implicated in glaucoma (PITX2, CYP1B1, and optineurin) were also represented.

88 the ubiquitin binding domain (E478G), or by optineurin with a mutation in the LIR domain.