ライフサイエンスコーパス: optogenetics

1 Nagel 'for their invention and refinement of optogenetics'.

2 lar functions with light sensitive proteins (Optogenetics).

3 ion channels with extensive applications in optogenetics.

4 opy, optical coherence tomography (OCT), and optogenetics.

5 of the alteration of synaptic physiology by optogenetics.

6 ular pathways is an important application of optogenetics.

7 c LOV-based photosensors with application in optogenetics.

8 logy, various neural imaging modalities, and optogenetics.

9 fast and powerful hyperpolarizing tools for optogenetics.

10 g integration of new genetic approaches into optogenetics.

11 in host cells resulted in the development of optogenetics.

12 ned cells in living systems, defining modern optogenetics.

13 wake, behaving mice using cell type-specific optogenetics.

14 ctivity in targeted cells is a major goal of optogenetics.

15 s have found application as photoswitches in optogenetics.

16 onal connectivity we have investigated using optogenetics.

17 to label D2R+ neurons for calcium imaging or optogenetics.

18 etworks using light in the emerging field of optogenetics.

19 ndwork for future therapeutic application of optogenetics.

20 ch-clamp recordings with calcium imaging and optogenetics.

21 a novel tool for flexible, high-conductance optogenetics.

22 an be used as efficient inhibitory tools for optogenetics.

23 netics: a non-invasive, US-based analogue of optogenetics.

24 V1 activation pattern as the one elicited by optogenetics.

25 may be important for CrChR2 applications in optogenetics.

26 ich make them efficient inhibitory tools for optogenetics.

27 Why optogenetics?

28 article is part of a Special Issue entitled Optogenetics (7th BRES).

29 Optogenetics, a widely used technique in neuroscience re

30 ramework for multiscale modelling of cardiac optogenetics, allowing both mechanistic examination of o

31 Optogenetics allows for phototactic guidance, steering,

32 Optogenetics allows rapid, temporally specific control o

33 Optogenetics allows the manipulation of neural activity

34 Optogenetics also offers the translational promise of re

35 Through a combination of physiology, optogenetics, anatomy, and circuit mapping, we elaborate

36 between layer 5 pyramidal cells by combining optogenetics and 2-photon calcium imaging in mouse neoco

37 Here we use optogenetics and a computational simulation to determine

38 Using optogenetics and a multichannel optrode, we investigated

39 e new GPCR approaches enhance the utility of optogenetics and allow for discrete spatiotemporal contr

40 , ultrastructural analysis, calcium imaging, optogenetics and behavioral analyses, we uncovered a cir

41 We use cell-type-specific optogenetics and chemogenetics (DREADDs) to modulate act

42 This review highlights how optogenetics and designer receptors can be applied in th

43 fundamental question by taking advantage of optogenetics and directly examining the functional effec

44 Here we compare cell-targeted optogenetics and electrical microstimulation in the maca

45 Klein et al. (2016) used cell-type-specific optogenetics and electrical microstimulation to characte

46 Optogenetics and electron microscopy reveal an ultrafast

47 d on this fact by combining pathway-specific optogenetics and electrophysiology in behaving rats to s

48 Using optogenetics and electrophysiology, we find that in juve

49 Combining optogenetics and electrophysiology, we found that this a

50 Here we use optogenetics and ex vivo electrophysiology to reveal the

51 fundamental question by taking advantage of optogenetics and examining directly the functional effec

52 Using optogenetics and fast-scan cyclic voltammetry, we show t

53 develop in vivo optical sensors, such as for optogenetics and force transduction.

54 We used optogenetics and in vivo juxtacellular recording and lab

55 sing a novel "opto-dialysis" probe to couple optogenetics and in vivo microdialysis, we report that o

56 e dynamics of acetylcholine release, we used optogenetics and paired recordings from CHIs and medium

57 y cell type-specific transgenic mouse lines, optogenetics and patch-clamp recordings, we found that d

58 arch Meeting in New Orleans in October 2012, Optogenetics and Pharmacogenetics in Neuronal Function a

59 hole-cell recordings, two-photon microscopy, optogenetics and pharmacogenetics to show how repeated c

60 PA dramatically reduces the entry barrier to optogenetics and photobiology experiments.

61 ivo deep tissue noninvasive optical imaging, optogenetics and photodynamic therapy.

62 dings have applications as an alternative to optogenetics and potentially for therapies involving neu

63 tructions by briefly stopping the heart with optogenetics and resolved nonperiodic phenomena by high-

64 tion of mixed populations of interneurons by optogenetics and study their impact on ongoing epileptif

65 rneurons [LTSIs]), we apply a combination of optogenetics and viral tracing approaches to dissect str

66 Here, using optogenetics and whole cortex electrophysiology, we show

67 Using optogenetics and whole-cell recordings in brain slices,

68 Using a combination of optogenetics and whole-cell recordings in mice, we now p

69 P mice, we applied a combination of in vivo (optogenetics) and multiple in vitro techniques to furthe

70 Using mutant analysis, laser ablation, optogenetics, and Ca2+ imaging, we observed that followi

71 f nociception, using novel transgenic lines, optogenetics, and calcium imaging in behaving larval zeb

72 Live-cell imaging, optogenetics, and cell ablation experiments show skin ce

73 ysiological recording methods, combined with optogenetics, and discuss directions for progress.

74 nipulating circuit function using mutations, optogenetics, and drugs.

75 omputational simulation, two-photon imaging, optogenetics, and dual-color uncaging of glutamate and G

76 and in vivo electrophysiological recordings, optogenetics, and fiber-photometry-based calcium imaging

77 nohistochemical assays, in vitro physiology, optogenetics, and in vivo video electroencephalographic

78 Using a combination of pharmacology, optogenetics, and linear regression methods, we estimate

79 ection of cardiomyocyte subpopulations using optogenetics, and opens new frontiers of exploration int

80 t few years, the combination of transgenics, optogenetics, and other technologies has allowed neurosc

81 ombination of patch-clamp electrophysiology, optogenetics, and pharmacology to confirm that Dlxi12b-l

82 P-16.48 Using a combination of pharmacology, optogenetics, and phenotypic analyses we determine that

83 sing a combination of in vivo chemogenetics, optogenetics, and retrograde tracing, we determine that

84 Using in vivo intracellular physiology, optogenetics, and sound playback, we also found that dir

85 iod activity modulation via odorant stimuli, optogenetics, and transgenic tetanus toxin neurotransmis

86 e mPFC and BLA, using whole-cell recordings, optogenetics, and two-photon microscopy.

87 ned single- and two-photon microscopy-based, optogenetics- and imaging-assisted, stable, simultaneous

88 ing applications in bioenergy production, in optogenetics applications in neuroscience, and as fluore

89 friendly technology with broad potential for optogenetics applications.

90 in vivo using a combined viral-infection and optogenetics approach to drive expression of channelrhod

91 In this study, we used an optogenetics approach to either globally stimulate AcbSh

92 Here we use the optogenetics approach to selectively stimulate neurons i

93 lectrical microstimulation and more recently optogenetics are widely used to map large-scale brain ci

94 ical infusions and tethered fiber optics for optogenetics, are not ideal for minimally invasive, unte

95 s fields such as in vivo optical imaging and optogenetics, are spearheading their popularity in biolo

96 Our results demonstrate the power of optogenetics as a viable alternative to electrical micro

97 irtual experimentation in neural and cardiac optogenetics at the cell and organ level and provide gui

98 Its blue-shifted absorption enables optogenetics at wavelengths even below 400 nm.

99 ed a loss-of-function behavioral screen with optogenetics-based clonal gain-of-function manipulations

100 Optogenetics-based defibrillation has been proposed as a

101 s necessary for the development of effective optogenetics-based defibrillation therapy using LED arra

102 Optogenetics-based defibrillation, a theoretical alterna

103 Furthermore, by optogenetics-based specific CST stimulation, we show a d

104 R", is particularly promising for inhibitory optogenetics because of its combination of larger curren

105 Optogenetics can also be used to study changes in these

106 Thus, optogenetics can be used to activate very specific sets

107 Specifically, optogenetics can be used to label and excite neurons tha

108 of the LGN konio neurons with CamK-specific optogenetics caused selective electrical current inflow

109 Using optogenetics, cell-specific ablation, whole cell patch-c

110 uire action potentials with precise temporal optogenetics control, achieving a long-sought flexibilit

111 e, we present a suite of technologies to use optogenetics effectively in primates and apply these too

112 Furthermore, combining immunohistochemistry, optogenetics, electrophysiology, and fast-scan cyclic vo

113 l cells in Drosophila using a combination of optogenetics, electrophysiology, and pharmacology, we fo

114 Moreover, two-photon optogenetics enable the possibility of artificially impr

115 tionships in ChRs and potentially useful for optogenetics, especially for combinatorial applications

116 tuning can further broaden their utility in optogenetics experiments.

117 Here, we combined optogenetics, fMRI, electrophysiology, and video-EEG mon

118 Finally, we employed CaMPARI and optogenetics for functional circuit mapping in ex vivo a

119 brane potential with light is fundamental to optogenetics for research and clinical applications.

120 Despite common use of ChR2 in optogenetics for selective control and monitoring of ind

121 By adapting optogenetics for use in non-neural cells in embryos, we

122 Here, we use pharmacology, optogenetics, genetics, and electrophysiology to investi

123 We found that optogenetics greatly improves the study of thalamocortic

124 Optogenetics has become an important research tool and i

125 Over the last 10 years, optogenetics has become widespread in neuroscience for t

126 ever, outside of neuroscience, the impact of optogenetics has been limited by a lack of user-friendly

127 To date, cardiac optogenetics has been studied with patch-clamp, multiele

128 Optogenetics has been widely adopted by the neuroscience

129 KEY POINTS: Optogenetics has emerged as a potential alternative to e

130 ABSTRACT: Optogenetics has emerged as a potential alternative to e

131 Optogenetics has emerged as an alternative method for el

132 tools are rapidly improving, in part because optogenetics has helped galvanize broad interest in neur

133 Optogenetics has provided a revolutionary approach to di

134 Optogenetics has significantly improved our understandin

135 rial version phycocyanobilin, often used for optogenetics, has a dramatically stabilized Pfr state.

136 vent of powerful perturbation tools, such as optogenetics, has created new frontiers for probing caus

137 Recent advances in optogenetics have enabled simultaneous optical perturbat

138 Recent advances in optogenetics have opened new routes to drug discovery, p

139 Recent studies using optogenetics have shown that "selective" stimulation of

140 onal ensemble recordings, microdialysis, and optogenetics, here we show that the block of the thalami

141 Here, we use intersectional genetics, optogenetics, high-throughput behavioral analysis, singl

142 of Neuron, using in vivo optical imaging and optogenetics, Hill et al. (2015) report that arteriolar

143 In vivo pharmacology and optogenetics hold tremendous promise for dissection of n

144 t only demonstrate, for the first time using optogenetics, how the spinal modules follow linearity in

145 me, closed-loop, response system and in vivo optogenetics in a mouse model of temporal lobe epilepsy.

146 oundwork for future applications of cochlear optogenetics in auditory research and prosthetics.

147 in the SNc controls mouse behavior, we used optogenetics in awake behaving mice and found that activ

148 Recent advances in the use of optogenetics in awake behaving rodents has added an addi

149 Thus, application of optogenetics in cell therapy can link transplantation, a

150 her with GFP-based reporters, and the use of optogenetics in combination with calcium imaging.

151 hibiting the retrotrapezoid nucleus (RTN) by optogenetics in conscious rats.

152 probes for advanced in vivo pharmacology and optogenetics in freely moving rodents.This protocol is a

153 address this issue, we used activity-guided optogenetics in male Sprague Dawley rats to silence IL p

154 in vitro and in vivo electrophysiology with optogenetics in mice and found the following: (1) the IG

155 We used optogenetics in mice to simulate CSTC hyperactivation ob

156 Using DREADDs and optogenetics in mice, we show that the output of the bas

157 ombination of in vitro electrophysiology and optogenetics in mouse brain slices, we found that 5-HT d

158 Using in vitro electrophysiology and optogenetics in mouse brain slices, we found that ACh ge

159 Applications of optogenetics in multicellular organisms, however, have n

160 ound that selective stimulation of SChIs via optogenetics in normal mice robustly and reversibly ampl

161 In neuroscience generally, and in optogenetics in particular, the ability to insert light

162 Here, we used optogenetics in Th::Cre rats to selectively stimulate VT

163 bining quantitative behavioral analysis with optogenetics in the head-fixed setup, we established a n

164 Using single-unit recordings and optogenetics in this task, we show that activity generat

165 Here, we used optogenetics in transgenic mice expressing ChannelRhodop

166 e identified with single unit recordings and optogenetics in vivo.

167 highlight key emergent principles about how optogenetics, in conjunction with more established modal

168 Optogenetics, in vivo ganglion imaging, and genetically

169 iguration of cortical circuits by two-photon optogenetics into neuronal ensembles that can perform pa

170 Optogenetics is a powerful research approach that allows

171 Optogenetics is a powerful technique to control cellular

172 Optogenetics is a recently developed method in which neu

173 Optogenetics is a revolutionary tool to assess the roles

174 Optogenetics is another area that shows promise for rest

175 Optogenetics is now a widely accepted tool for spatiotem

176 Cell assemblies manipulation by optogenetics is pivotal to advance neuroscience and neur

177 Despite recent advances in optogenetics, it remains challenging to manipulate gene

178 With the rise of ChR2 use in optogenetics, it will be critical to identify residues t

179 el technologies, including chemogenetics and optogenetics, live cell two-photon imaging, cell fate re

180 This synthesis of regenerative medicine and optogenetics may be a successful strategy to restore mus

181 In this way, optogenetics may serve to 'fill in the gaps' between gen

182 eyond 700 nm would generate new prospects in optogenetics, membrane sensor technology, and complement

183 t that repetitive activation with two-photon optogenetics of neuronal populations from ensembles in t

184 While optogenetics offers great potential for linking brain fu

185 Optogenetics offers the ability to selectively manipulat

186 research and future clinical applications of optogenetics outside the brain.

187 Specifically, an integrative approach of optogenetics, pharmacology, electrophysiology, and behav

188 Finally, optogenetics presents the opportunity to achieve cell-ty

189 Optogenetics promises precise spatiotemporal control of

190 Optogenetics promises to deepen our understanding of how

191 -vessel fMRI method and its combination with optogenetics provide a platform for mapping the hemodyna

192 Optogenetics provides a means to dissect the organizatio

193 Optogenetics provides an alternative to electrical stimu

194 The development of optogenetics provides increased precision in the control

195 Optogenetics provides new ways to activate gene transcri

196 In vivo optogenetics provides unique, powerful capabilities in t

197 In optogenetics, researchers use light and genetically enco

198 late identified inhibitory interneurons with optogenetics, revealing powerful control of the flow of

199 oach and recent advances in gene therapy and optogenetics seem likely to provide further routes to ef

200 e conclude that recent technical advances in optogenetics should provide a means to understand the ro

201 Combining optogenetics, slice electrophysiology and pharmacologica

202 Using in vivo optogenetics, the brain region-specific inputs to the NA

203 eation of new proteins for illuminating, via optogenetics, the fundamentals of brain function.

204 Optogenetics, the selective excitation or inhibition of

205 Together with subcellular optogenetics, the spatiotemporal sensitivity of the gamm

206 Using a combination of in vitro and in vivo optogenetics, this work demonstrates that interglomerula

207 KR2 is a promising tool for optogenetics, thus directed engineering to modify ion se

208 oor for applying the technical advantages of optogenetics to a systematic attack on the causal relati

209 Here we used optogenetics to activate or inhibit mouse STN to test it

210 affect the local circuits, we use two-photon optogenetics to activate them individually in mouse visu

211 To address this question, we used optogenetics to acutely silence CA3 pyramidal neurons in

212 Using optogenetics to augment dopamine concentration, we found

213 synapses and suggest an approach that allows optogenetics to be applied in a manner that helps to avo

214 Using optogenetics to control both the location and the timing

215 ion-specific circuit mechanisms, we employed optogenetics to control mesopontine cholinergic neurons

216 ion of whole-cell patch-clamp recordings and optogenetics to demonstrate that ethanol potently depres

217 We used optogenetics to demonstrate that the pedunculopontine te

218 Here we used subcellular optogenetics to determine how Cdc42 activation at one si

219 In conclusion, we used cell-specific optogenetics to determine with high spatial resolution a

220 use genetics, electrophysiology, imaging and optogenetics to directly target major classes of spinal

221 re, we review several studies that have used optogenetics to dissect circuits implicated in schizophr

222 Here, we use optogenetics to dissect the excitatory and inhibitory ne

223 We used optogenetics to drive individual mouse CA1 hippocampal n

224 rk highlights the potential for implementing optogenetics to drive nerve growth in specific cell popu

225 d induction of DeltaFosB in striatum, we use optogenetics to enhance activity in limbic brain regions

226 Here we combine targeted recordings and optogenetics to examine the synaptic underpinnings of th

227 ns of ventral pallidal neurons, we next used optogenetics to examine whether changes in synaptic plas

228 We used optogenetics to excite vasopressin terminals, originatin

229 ArchaerhodopsinT3.0 (ArchT) loss-of-function optogenetics to explore BP regulation by C1 neurons in i

230 ve circuit, we used AgRP-neuron ablation and optogenetics to explore connectivity in acute slice prep

231 used Archaerhodopsin-based loss-of-function optogenetics to explore the contribution of these neuron

232 A recent study has used optogenetics to identify the source of excitatory drive

233 se anterior cingulate cortex (ACC), by using optogenetics to induce oscillations in activity, can pro

234 A new study deploys optogenetics to induce the yeast bud on demand, at a sit

235 To this end, the current study used optogenetics to inhibit the BLA during specific task pha

236 of tdTomato or cre recombinase together with optogenetics to investigate whether hypothalamic arcuate

237 ates to movement and motor learning, we used optogenetics to manipulate spontaneously firing Purkinje

238 dy combines neuronal ensemble recordings and optogenetics to map a functional gradient in rodent pref

239 y somatosensory cortex (S1) of mice by using optogenetics to map the connections between parvalbumin

240 Here we use optogenetics to modulate in real time electrophysiologic

241 its in action, and hints at the potential of optogenetics to open up entirely new avenues in the trea

242 egrating personalized immunoengineering with optogenetics to overcome critical hurdles in cancer immu

243 cium imaging in head-fixed flying flies with optogenetics to overwrite the existing population repres

244 under more physiological conditions, we used optogenetics to release DA from ventral tegmental area i

245 To circumvent these barriers, we used optogenetics to selectively activate neurons that expres

246 To address this, we used optogenetics to selectively activate single, genetically

247 We used optogenetics to selectively activate the GABAergic nigro

248 Here, we used optogenetics to selectively stimulate either ChIs or dop

249 l-type and projection-pathway specificity of optogenetics to show that enhanced phasic firing of thes

250 Here we used optogenetics to silence neurons in the PL mPFC of rats d

251 Here we use optogenetics to stimulate cultured hippocampal neurons w

252 the Cre-recombinase/loxP system in mice with optogenetics to structurally and functionally characteri

253 gs, two-photon microscopy, GABA uncaging and optogenetics to study dendritic inhibition at layer 5 (L

254 stigates short-term recognition memory using optogenetics to target glutamatergic neurons within the

255 cal mapping and characterization followed by optogenetics to test their functional connectivity at do

256 this study, we use channelrhodopsin-2 (ChR2) optogenetics to test whether the C1 cells are also capab

257 However, few studies have applied optogenetics to the auditory brainstem.

258 oduces the precise spatiotemporal control of optogenetics to the molecular control of synaptic functi

259 tion discrimination task in mice while using optogenetics to transiently silence adult-born neurons a

260 Here we apply optogenetics to understand how subpopulations of beta-ce

261 on two-photon calcium imaging and two-photon optogenetics, to detect, characterize, and manipulate ne

262 , 2-photon microscopy, electrophysiology and optogenetics, to identify a novel population of glutamat

263 It has generated excitement as an optogenetics tool for the manipulation of cyclic nucleot

264 Here, we expand the optogenetics toolbox in the form of a tunable, high-cond

265 nterrogation tools, including CLARITY, COLM, optogenetics, viral tracing, and fiber photometry, we ex

266 Three recent studies use optogenetics, virtual 'odor-scapes' and mathematical mod

267 We review recent advances in optogenetics, visual prosthesis and electrostimulation t

268 half (2005-2009) of this 10-year period, as optogenetics was being created, there were difficulties

269 Using optogenetics we demonstrate that activation of Channelrh

270 Using optogenetics we show that at increased firing rates tect

271 Using optogenetics, we demonstrate that activation of 5-HT ter

272 Using optogenetics, we demonstrate that adult-born granule cel

273 Using optogenetics, we directly assessed both the excitability

274 Using optogenetics, we examined the role of the basal ganglia

275 Using optogenetics, we found that dopamine and glutamate were

276 By harnessing the temporal specificity of optogenetics, we found that FEF contributes to memory-gu

277 , electron microscopy, electrophysiology and optogenetics, we found that proliferating adult mouse hi

278 lectrophysiology, respiratory physiology and optogenetics, we identify a surprising new role for the

279 asks and determining axonal projections with optogenetics, we observed subsets of neurons changing fi

280 Using optogenetics, we probe yeast polarization and find that

281 try, to ex vivo and in vivo pharmacology and optogenetics, we provide compelling evidence identifying

282 By activating V1 directly via optogenetics, we replicated the effects of wakefulness i

283 Using optogenetics, we show that activation of a molecularly d

284 Using chemogenetics and optogenetics, we show that the output of the basal gangl

285 , by combining in vivo neural recordings and optogenetics, we unexpectedly find that both suppressing

286 n (ChR) set the stage for the novel field of optogenetics, where cellular processes are controlled by

287 regulated actuators, photoreceptors underpin optogenetics, which denotes the noninvasive, reversible,

288 ith new research methodologies, particularly optogenetics, which have provided scientists with an unp

289 zure suppression has only been achieved with optogenetics, which requires invasive light delivery.

290 dopamine release in Drosophila larvae using optogenetics, which verified the utility of CNPEs for in

291 chronized Kiss1(ARH) neuronal activity using optogenetics, whole-cell electrophysiology, molecular ph

292 The full impact of optogenetics will emerge only when other toolsets mature

293 Combining optogenetics with a closed-loop stimulation approach in

294 We combined optogenetics with calcium imaging and pharmacology to de

295 voltammetry, electrophysiology, and in vivo optogenetics with localized pharmacology to identify neu

296 Optogenetics with microbial opsin genes, and pharmacogen

297 By combining optogenetics with microelectrode array recording, we sho

298 Here we used a combination of optogenetics with multisite electrode recordings to simu

299 t fly are combining conditional genetics and optogenetics with pharmacology to map the effects of sle

300 ermed three-dimensional scanless holographic optogenetics with temporal focusing (3D-SHOT), which all