ライフサイエンスコーパス: oral administration

1 travenous administration) and 18.1 muSv/MBq (oral administration).

2 ) were tested as Lf encapsulation system for oral administration.

3 rs with overall ADME properties suitable for oral administration.

4 nanoencapsulants and their performance upon oral administration.

5 n colorectal carcinoma xenograft model after oral administration.

6 low adverse reaction rate when compared with oral administration.

7 ich can be an advantageous route compared to oral administration.

8 in the dose range of 5-100 mg/kg x 4 days by oral administration.

9 ability and suitable physical properties for oral administration.

10 low permeability, and degradation following oral administration.

11 ch potentially makes it a good candidate for oral administration.

12 tic study in rats for detection of GLB after oral administration.

13 lability of pinometostat relative to CIV and oral administration.

14 mice in the absence or presence of rofecoxib oral administration.

15 in a rat model of neuropathic pain following oral administration.

16 d in the stomach lining up to 24 h after the oral administration.

17 ty of encapsulated resveratrol for potential oral administration.

18 and pharmacokinetic properties suitable for oral administration.

19 ue to common systemic side effects following oral administration.

20 ic acid (MPA), to the lymphatic system after oral administration.

21 b) in vivo on tumor growth in mice following oral administration.

22 pertensive double-transgenic rat model after oral administration.

23 t partial conversion of 4c was observed with oral administration.

24 oid (Abeta) in Sprague-Dawley rats following oral administration.

25 and pharmacokinetic properties suitable for oral administration.

26 sevenfold lower dose of BYL719 compared with oral administration.

27 , and improve patient compliance by enabling oral administration.

28 ,4-dinitrobenzenesulfonic acid in rats after oral administration.

29 7) proof of biological effects in mice after oral administration.

30 with improved pharmacokinetic profile after oral administration.

31 ovir diphosphate to lymphoid cells following oral administration.

32 cant delay and diminished symptoms of EAE by oral administration.

33 t 230 appears rapidly in the blood following oral administration.

34 After oral administration (15 mg/kg), intestinal absorption of

35 ology and edible crops for fish vaccines for oral administration, (3) regulatory constraints and (4)

36 al and T cell-mediated immune responses upon oral administration and may be used as a safe oral vacci

37 Frequency of medication (oral administration and nasal spray) was also evaluated.

38 pes of xenograft models of human cancer with oral administration and represents the most potent and e

39 icient PC3 prostate tumor bearing mice after oral administration and showed complete inhibition of tu

40 Hsp90 inhibition, good pharmacokinetics upon oral administration, and an excellent pharmacokinetic/ph

41 MX-1 breast cancer xenograft model following oral administration as a single-agent or in combination

42 le to significantly enhance cognition, after oral administration, at doses as low as 0.3 mg/kg.

43 , rabbits, monkeys and dogs following repeat oral administrations by gavage.

44 owever, miltefosine's long half-life and its oral administration could make it a good option for main

45 olonic epithelial cells and macrophages, and oral administration decreases the severity of colitis in

46 Compound 15 exhibited in vivo efficacy after oral administration, determining a 62% increased surviva

47 ophilicity required for cell penetration and oral administration for chemical probes or therapeutics

48 trated in vivo antiplasmodial activity after oral administration in a P. berghei malaria model, altho

49 from poor systemic availability (14%) after oral administration in addition to other side effects on

50 ch afforded excellent release of 1 following oral administration in both mice and dog.

51 ugates with activated nucleoside analogs for oral administration in cancer chemotherapy.

52 dulatory effects in vitro, but not following oral administration in humans.

53 General behavior after oral administration in mice was also analyzed.

54 After oral administration in mice, ARN2508 engages its intende

55 t ultrahigh optical densities and, following oral administration in mice, passed safely through the g

56 ure and desired bioavailability of 45% after oral administration in rats.

57 OP receptor occupancy in the brain following oral administration in rats.

58 wn some efficacy and fewer side effects than oral administration in some trials, yet neither approach

59 ibutes to a concentration-time profile after oral administration in the cynomolgus monkey that showed

60 efore levels of full length SMN protein upon oral administration in two mouse models of SMA.

61 13)C18]-oleic acid following intravenous and oral administration in vivo.

62 ic and antidepressant activity in rats after oral administration, in the absence of cognitive or moto

63 Additionally, following oral administration, inhibitor 12 was found in rat liver

64 short- and long-term inhibition of CSF1R by oral administration leads to a robust decline in nerve m

65 odialysis experiments also demonstrated that oral administration of (+)-67 significantly elevated ext

66 C]carfentanil PET scans, before and after an oral administration of 0.5 mg/kg of d-amphetamine.

67 5-fold higher plasma levels of 1 compared to oral administration of 1 itself.

68 Oral administration of 1 lowered 24 h nonfasting glucose

69 on-transferrin-bound iron resulting from the oral administration of 1) a supplemental dose of iron (6

70 lasmatic concentrations 24h after the single oral administration of 10, 25 and 50 mg/kg of maslinic a

71 In P. berghei-infected mice, oral administration of 1o drastically reduces parasitaem

72 Oral administration of 2-((4-chloro-2,6-difluorobenzyl)a

73 nt protocol recommended either the immediate oral administration of 2.5 mg bisoprolol (within 30 min

74 Patients were randomized to receive either oral administration of 20 mg of doxycycline or matching

75 Oral administration of 200 mg/kg per day Brd4 inhibitor

76 Oral administration of 28 significantly reduced fibrosis

77 Notably, the oral administration of 3-amino-4-(4-fluorophenylamino)-1

78 vivo object recognition test with CD1 mice, oral administration of 36c was found to significantly im

79 The oral administration of 3d to mice translated into prefer

80 ss in the murine CT26 syngeneic model, after oral administration of 400 mg/kg.

81 ions well above its IC50 for GCPII following oral administration of 5 in rats.

82 ects repeated the exercise 150 minutes after oral administration of 50 mg sildenafil.

83 Oral administration of 6 in mice increased the plasma ex

84 Small bowel distention was achieved by oral administration of 600-1000 ml of hyperosmotic solut

85 dren at high risk for type 1 diabetes, daily oral administration of 67.5 mg of insulin, compared with

86 Oral administration of 69 to rats reduced food intake in

87 ses 1 and 2 (DGAT1 and DGAT2) inhibitors, an oral administration of 6f exhibited inhibition of the in

88 Chronic oral administration of 7,8-DHF activated TrkB signaling

89 In tumor bearing mice, oral administration of 71 causes rapid accumulation of m

90 Repeated oral administration of 83 caused marked inhibition of tu

91 man hepatocyte chimeric mice after 7 days of oral administration of 9.

92 Human studies employed oral administration of [2-(13) C]-glycine and (13) C spe

93 stered encapsulated, stimulates GAS, whereas oral administration of a caffeine solution delays GAS in

94 ination half-life (T1/2el = 135 h) following oral administration of a commercial formulation (CF).

95 ent and can be mostly reversed by long-term, oral administration of a positive allosteric modulator o

96 In this study, we report that oral administration of a selective ROCK2 inhibitor, KD02

97 A 30-d course of oral administration of a semipurified extract of the roo

98 Oral administration of a single dose of decoquinate effe

99 of multiple doses, and bioavailability after oral administration of a single dose of different PB for

100 We found that oral administration of a SIRT1-activating compound essen

101 Oral administration of ABT263 to either sublethally irra

102 Further, oral administration of AEA to NOD mice provides protecti

103 Oral administration of Ag induces regulatory T cells tha

104 In this study, we demonstrate that upon oral administration of Ag, lamina propia (LP) DCs engage

105 Oral administration of all major SCFAs, such as acetate,

106 CD was achieved by oral administration of alpha-methyl-para-tyrosine (AMPT)

107 together with gastric emptying studies after oral administration of an appropriately radiolabeled mea

108 e (LD) of ticagrelor, 180 mg, vs traditional oral administration of an equal dose enhances platelet i

109 ing an LD of ticagrelor, 180 mg, or standard oral administration of an equal dose.

110 Oral administration of an ErbB2-targeted CL-387,785 for

111 te restriction can be overcome chemically by oral administration of an ERK pathway inhibitor or genet

112 of FGFR kinase corrects the aneuploidy, and oral administration of an FGFR inhibitor prolongs surviv

113 Oral administration of an HIF-P4H inhibitor, FG-4497, to

114 In addition, oral administration of an inclusion compound of alamandi

115 We observed that oral administration of ANC improved fasting blood glucos

116 Oral administration of anti-CD3 ameliorated the enteropa

117 Oral administration of anti-CD3 protected the mice from

118 Oral administration of anti-CD3 to mice induces changes

119 Oral administration of anti-CFA/I minor pilin subunit (C

120 in NOD animals with depleted microbiota via oral administration of antibiotics.

121 on two occasions, but they disappeared after oral administration of antihistamines.

122 ET/CT images were acquired 24 and 96 h after oral administration of approximately 28 MBq of (124)I-so

123 After the oral administration of aqueous solutions of ferrous sulf

124 telemetered mice, acute intraperitoneal and oral administration of azithromycin caused effects consi

125 Oral administration of azithromycin definitively decreas

126 ess Abeta40 levels in brain and plasma after oral administration of BACE1 inhibitors SCH1682496 or LY

127 Moreover, daily oral administration of bardoxolone methyl to monkeys for

128 Moreover, in YFV-infected hamsters, oral administration of BDAA protected 90% of the animals

129 Oral administration of Bifidobacterium alone improved tu

130 Oral administration of canagliflozin activated AMPK in m

131 ate drug-delivery system is designed for the oral administration of cancer therapeutics.

132 eres in vitro and to initiate tumors in vivo Oral administration of CBL0137 to mice bearing orthotopi

133 Oral administration of CCX168, a small molecule antagoni

134 Oral administration of CDDO-Me to mice with SMAD4-defici

135 amined in vivo in duodenum of mice following oral administration of CE.

136 plete oral absorption was observed following oral administration of celecoxib (F% = 56-110%) and mava

137 Oral administration of CFI-402257 in monotherapy or in c

138 Oral administration of chalcone 16, at a concentration o

139 ive transplant recipients from 27 centers to oral administration of CMX001 or placebo.

140 In a murine model of HAT, oral administration of compound 1 cured the disease.

141 Oral administration of compound 28 to athymic nude mice

142 Oral administration of Cu(II)(atsm) delayed the onset of

143 There is a preclinical evidence that the oral administration of d,l-sulforaphane (SFN) can decrea

144 cans with [(11)C]-(+)-PHNO, before and after oral administration of d-amphetamine.

145 a levels of D-serine in mice compared to the oral administration of D-serine alone, demonstrating its

146 ated plasma D-serine levels in monkeys after oral administration of D-serine in the presence or absen

147 magnetic resonance imaging (fMRI) following oral administration of delta-9-THC, CBD, or a placebo ca

148 r intestinal homeostasis abnormalities after oral administration of dextran sodium sulfate (DSS).

149 Experimental chronic colitis was induced by oral administration of dextran sodium sulfate.

150 In vivo, oral administration of DF2593A effectively reduced mecha

151 Here we show that oral administration of DHA to normal adult mice as lysop

152 ium sulfate-induced colitis, with or without oral administration of DHA.

153 Oral administration of DHED elicits a significant reduct

154 Tissue analysis following intravenous and oral administration of discretely and cassette-dosed com

155 ntinuous infusions, multiple inhalations, or oral administration of drugs that act on various pathway

156 al colonization in 2-day-old (P2) rats after oral administration of E. coli K1 strain A192PP and a vi

157 Oral administration of either PBA or TUDCA reduced featu

158 Oral administration of ERG240 reduces the severity of co

159 Particularly, passive oral administration of ETEC anti-fimbrial antibodies pre

160 Oral administration of fenofibrate significantly amelior

161 (PUFAs), by use of fat-1 transgenic mice and oral administration of fish oil, significantly promote i

162 Furthermore, oral administration of GA significantly increased the pa

163 In acute sleep disturbance, oral administration of glycine-induced non-rapid eye mov

164 Oral administration of green tea extract at doses of 125

165 Our study found that oral administration of green tea extract prevented CCl(4

166 Short-term oral administration of GS-9620 provided long-term suppre

167 Oral administration of GSK2656157 to mice shows a dose-

168 e maximum absorption site of the organ after oral administration of HDTA conjugates.

169 We investigated whether oral administration of human commensal bacteria engineer

170 Furthermore, oral administration of human milk-derived HA to adult, w

171 Oral administration of I-BET726 to mouse xenograft model

172 line and at 2 d and 6-7 d after the start of oral administration of imatinib (400 mg/d).

173 Oral administration of Imm124E hyperimmune colostrum ame

174 Oral administration of Imm124E improved bowel histology.

175 Oral administration of Imm124E promoted Tregs and allevi

176 Oral administration of intestinal AP could be a valid th

177 After the oral administration of iron, the production of circulati

178 l-F2 fraction increased glucose uptake while oral administration of KCl-F1 and final FPH decreased sy

179 om a phase 1 clinical trial demonstrate that oral administration of KD025, a selective ROCK2 inhibito

180 Oral administration of KPT-330 to mice reduced growth of

181 Most importantly, oral administration of KPT-9274 reduces tumorigenesis in

182 The results of this trial indicate that oral administration of L. rhamnosus SP1 resulted in simi

183 Oral administration of L. salivarius PS2 during late pre

184 Previous studies have shown that oral administration of lactobacilli can be an efficient

185 Four weeks of oral administration of live E. coli expressing LigA7-13

186 We found that oral administration of low-dose miglustat (120 mg/kg onc

187 Oral administration of LPS led to reduced IL-6 productio

188 Additionally, oral administration of lysophosphatidic acid (LPA) incre

189 Conversely, daily oral administration of lysozyme prevented expansion of E

190 Strikingly, 3 days or more of oral administration of Maraviroc to healthy volunteers c

191 nd memory-enhancing neural correlates of the oral administration of methylene blue in the healthy hum

192 Oral administration of mibefradil inhibited growth of GS

193 Oral administration of milligram amounts of YLLIP2 signi

194 uding plateau plasma PB concentrations after oral administration of multiple doses, and bioavailabili

195 Oral administration of multiple LXR agonists suppressed

196 In vivo investigation demonstrated that oral administration of Myr at 300 mg/kg/day for 8 weeks

197 Long-term oral administration of myricetin demonstrated glucoregul

198 Moreover, oral administration of NaPB increased the levels of BDNF

199 Oral administration of NaPB reduced nigral activation of

200 Moreover, the combined oral administration of NDI and 2DG reduced in vivo melan

201 In vivo oral administration of Nos (100 mg/kg) followed by intra

202 Finally, oral administration of NTR1 improved the learning perfor

203 In vivo results demonstrated that oral administration of NTZ (50 mg/kg) in an acute MPTP m

204 The oral administration of olives to rats and its determinat

205 Upon oral administration of our small molecules, the levels o

206 Oral administration of ovalbumin (OVA) in Was(-/-) mice

207 illus rhamnosus L34 in a new sepsis model of oral administration of pathogenic bacteria with GI leaka

208 Oral administration of Pep19 into diet-induced obese Wis

209 In mice with chemical-induced CAC, oral administration of plant-type sphingolipids called s

210 sue inflammation were analysed in mice after oral administration of Porphyromonas gingivalis, a repre

211 ch is the potential new delivery carrier for oral administration of probiotics.

212 Oral administration of proteases that can rapidly degrad

213 Oral administration of protein antigens is a preferred m

214 As with the ACN, oral administration of pure D3S5G dose-dependently decre

215 Oral administration of PWH (3 and 10mg/kg) reduced the g

216 However, oral administration of recombinant CCL20 to neonatal mic

217 Oral administration of regacin to mice, commencing 15 mi

218 Daily oral administration of resolvin D1, a downstream metabol

219 Oral administration of resveratrol is able to improve gl

220 Oral administration of reversible CRM1 inhibitors in pre

221 Oral administration of RG7112 to human xenograft-bearing

222 Oral administration of rolofylline for 2-wk to 14-mo-old

223 Consistent with in vitro results, oral administration of rosiglitazone to ob/ob mice for 2

224 ed Adams gene expression that was blocked by oral administration of SB 525334.

225 Oral administration of selinexor (15 mg/kg p.o. QoDx3/we

226 ally or completely, after intraperitoneal or oral administration of several indenes.

227 Finally, oral administration of simvastatin or the antioxidant ap

228 se studies in the mdx mouse demonstrate that oral administration of SMT022357 leads to increased utro

229 f the functional importance of our findings, oral administration of sodium bicarbonate was sufficient

230 Indeed, oral administration of specific microbial metabolites to

231 Furthermore, oral administration of specific-sized HA fragments promo

232 treatment with metronidazole or vancomycin, oral administration of spores of NTCD-M3 was well tolera

233 ) mice, a model of intestinal tumorigenesis, oral administration of SQ-CDDP NP curtailed spontaneous

234 Thus, the oral administration of Sr-containing medications has bee

235 Oral administration of synbiotic has been proposed as an

236 needed to clearly define the intervention as oral administration of synbiotics (combination of probio

237 se of 50-300-fold of these metabolites after oral administration of T undecanoate was observed, provi

238 st function, and in B12-deficient offspring, oral administration of taurine rescued their growth reta

239 Oral administration of tenapanor or other intestinal sod

240 ly elevated or repressed in adult animals by oral administration of tetracycline.

241 Oral administration of TGF-beta1 therefore can potential

242 Oral administration of the 11betaHSD inhibitor carbenoxo

243 emic exposure of the parent drug 1 following oral administration of the amminium salt 2 when compared

244 of anti-CD3 monoclonal antibody 2 days after oral administration of the antibody.

245 Furthermore, oral administration of the clinically approved histone d

246 These effects were also observed upon oral administration of the clinically evaluated NOS smal

247 Oral administration of the drug to mice reduces growth o

248 art and kidney decreased significantly after oral administration of the ethyl acetate extract, compar

249 In this study, we report that following oral administration of the independent GP forms, only Mo

250 In an NEC animal model, oral administration of the isoform TGF-beta1 activated t

251 Oral administration of the lead compound 54 effectively

252 Oral administration of the NAD(+) precursor nicotinamide

253 Oral administration of the phages up to 24 h before V. c

254 Oral administration of the plasmid DNA (pDNA) encoding G

255 Oral administration of the prodrug 14 induces sustained

256 Oral administration of the serotonin receptor type 1A ag

257 d for CD103(+) DC migration to the MLN after oral administration of the TLR7 agonist R848, it was not

258 (11)C-metformin uptake was pronounced after oral administration of the tracer, with tissue-to-blood

259 Oral administration of the TRPV1 agonist, capsaicin, sup

260 ject was a success at the preclinical level: oral administration of the ultimate analogue obtained wa

261 Finally, oral administration of the VEGFR2 kinase inhibitor Vande

262 Oral administration of this compound markedly diminishes

263 gly, even 24 hours after lethal IR exposure, oral administration of TMC mitigated myelosuppression an

264 Oral administration of tofacitinib prevented GVHD-like d

265 Oral administration of UNC1999 prolongs survival of a we

266 y hypertensive rats (SHR) also revealed that oral administration of Val-Glu-Leu-Tyr-Pro can decrease

267 Oral administration of vancomycin greatly dampened both

268 to determine the immunomodulatory effect of oral administration of vitamin D-enriched mushrooms extr

269 Oral administration of vitamin-D enriched mushrooms extr

270 Oral administration of VLX103 also decreased hepatotoxic

271 Importantly, oral administration of WA effectively inhibited HepG2-xe

272 Oral administration offers a potential alternative to in

273 Following oral administration, plasma BCAA concentrations showed a

274 nd energetic agent, acetyl-l-carnitine (LAC, oral administration), rapidly rescued the depressive- an

275 Treatment with (R)-14c by oral administration resulted in significant increases in

276 ith MDA-MB-231 cells, with inhibitor 38u via oral administration robustly inhibits breast cancer lung

277 Five minutes after oral administration, she developed a heat sensation and

278 geable safety profile and the convenience of oral administration suggest that afatinib could be an ad

279 tion of tumor burden, particularly following oral administration, suggesting a potential role as an a

280 properties of this tracer mean that through oral administration, the turnover and flux through a num

281 ors in nude mice by both intraperitoneal and oral administration, thus demonstrating its in vivo effi

282 in-1(2H)-yl)acet amide (PF-06282999, 8) upon oral administration to lipopolysaccharide-treated cynomo

283 d the number of circulating lymphocytes upon oral administration to male Wistar rats.

284 vitro and blocked AP activity ex vivo after oral administration to monkeys as demonstrated by inhibi

285 ded that of phenobarbital and phenytoin upon oral administration to rats.

286 able to decrease the plasma LPA levels upon oral administration to rats.

287 After oral administration to rodents, P(HEMA-co-SS) was predom

288 After oral administration to spontaneously hypertensive rats,

289 sulfonamides were also found effective upon oral administration to Wistar rats and inhibited MES ind

290 ivered locally to the jejunum or ileum or by oral administration to young male rats.

291 udy was to evaluate the fate of prions after oral administration, using highly purified radiolabeled

292 Bioavailability after oral administration vs. intraperitoneal injection was al

293 In vivo efficacy of 14 following oral administration was demonstrated in D54 glioma and A

294 isplayed good bioavailability, as once daily oral administration was sufficient to maintain blood con

295 As opposed to oral administration, we propose that maximum anticancer

296 estive tract and must be stabilized to allow oral administration, which can be accomplished by nanoen

297 NEFA) pool predicts brain uptake of DHA upon oral administration, which enters the plasma NEFA pool a

298 cular tissue distribution and efficacy after oral administration while minimizing systemic exposure.

299 Oral administration with diosgenin markedly restored the

300 e in acute toxicity experiment in rats after oral administration with LD50 exceeding 2000 mg/kg of bo