ライフサイエンスコーパス: orexin receptor

1 hey resulted from activation of postsynaptic orexin receptors.

2 ulin contain OXA and both cell types express orexin receptors.

3 like immunoreactivity and express functional orexin receptors.

4 rexin receptor 2 (HcrtR2/OX(2)R) or the Hcrt/orexin receptor 1 (HcrtR1/OX(1)R) but not to Kirsten mur

5 duced drug-seeking behavior is attenuated by orexin receptor 1 (OX(1)R) antagonists.

6 in wakefulness, and focal antagonism of the orexin receptor 1 (OX(1)R) in two central chemoreceptor

7 significantly reduced in the presence of the orexin receptor 1 (OX1R) antagonist SB334867A at concent

8 C57BL/6J mice received the orexin receptor 1 (Ox1r) antagonist, SB-334867, prior to

9 locus coeruleus, an area that also expresses orexin receptor 1 (OX1R) messenger RNA (mRNA).

10 We hypothesized that orexin receptor-1 (OX(1)R) in the retrotrapezoid nucleus

11 n of lateral hypothalamic orexin neurons and orexin receptor-1 signaling in the mesolimbic dopamine s

12 nese hamster ovary cells containing the Hcrt/orexin receptor 2 (HcrtR2/OX(2)R) or the Hcrt/orexin rec

13 on histochemistry to map the distribution of orexin receptor 2 (OX2R) mRNA within the rat brainstem.

14 reas of the brain, while the mutation of the orexin receptor 2 gene has been implicated in canine nar

15 y is caused by disruption of the hypocretin (orexin) receptor 2 gene (Hcrtr2).

16 llele for rs7767652, upstream of hypocretin (orexin) receptor-2 (HCRTR2), were less likely to have im

17 Exon skipping mutations of the Hypocretin/Orexin-receptor-2 (Hcrtr2) gene were identified as the c

18 Orexin receptor agonists would be of potential value for

19 It has been proposed that OX(1) orexin receptors and CB(1) cannabinoid receptors can for

20 say and western blot measurement of orexins, orexin receptors and CRH in multiple brain regions.

21 that this effect is signaled by postsynaptic orexin receptors and expressed presynaptically, presumab

22 lly distinct subset of ARC neurons coexpress orexin receptors and glutamate decarboxylase-67 and are

23 accumbens shell (AccSh) and the presence of orexin receptors and varicosities within the AccSh, we h

24 ss species, similarly to that seen with dual orexin receptor antagonism.

25 triction significantly increased, and a dual orexin receptor antagonist decreased, Abeta plaque forma

26 roval of suvorexant as a first-in-class dual orexin receptor antagonist for the treatment of insomnia

27 Suvorexant is an orexin receptor antagonist for treatment of insomnia.

28 Conversely, an orexin receptor antagonist inhibits food consumption.

29 okinetics in a leading HTS-derived diazepane orexin receptor antagonist led to the identification of

30 Suvorexant (MK-4305) is an orexin receptor antagonist shown to be efficacious for i

31 xazole to provide 3 (MK-4305), a potent dual orexin receptor antagonist that is currently being teste

32 ors using an orally administered potent dual orexin receptor antagonist, almorexant, in SHRs and norm

33 ) Antagonism of orexin receptors with a dual orexin receptor antagonist, almorexant, normalizes the a

34 ral locations by an orally administered dual orexin receptor antagonist, almorexant, will substantial

35 Suvorexant, a dual (OX1/2R) orexin receptor antagonist, reduced cocaine-evoked prema

36 usion, but decreased with infusion of a dual orexin receptor antagonist.

37 Dual orexin receptor antagonists (DORAs) induce sleep by bloc

38 etic nerve activity, which can be blocked by orexin receptor antagonists.

39 y neuropeptides orexins A and B by design of orexin receptor antagonists.

40 cies higher than the range observed for dual orexin receptor antagonists.

41 ults directly show, for the first time, that orexin receptors are able to generate potent endocannabi

42 Importantly, intra-VTA blockade of orexin receptors attenuated food intake induced by LV gh

43 unsuspected mechanism by which postsynaptic orexin receptors can modulate glutamatergic synaptic tra

44 Blockade of orexin receptors can normalize the augmented CO2 chemore

45 However, orexin receptor-expressing cells somehow override the HI

46 stigated the relationship between orexin and orexin receptor expression in specific brain regions ass

47 t the brain, but a systematic examination of orexin receptor expression in the brain has not appeared

48 We found that targeted restoration of orexin receptor expression in the dorsal raphe (DR) and

49 number of serotonergic neurons restored with orexin receptor expression in the DR, while the consolid

50 Blocking orexin receptors had no effect on blood pressure and sym

51 Expression of the hypocretin/orexin receptor HCRTR2, which has been implicated in nar

52 leep features and brain levels of orexin and orexin receptors in adult rats neonatally subjected to e

53 halamus orexin neurons and ventral tegmental orexin receptors in reward-based learning and memory.

54 Finally, blockade of orexin receptors in the RVLM abolished the increase in A

55 in the locus coeruleus (LC) of mice lacking orexin receptors inhibited cataplexy-like episodes and p

56 s of narcolepsy and cataplexy; inhibition of orexin receptors is an effective therapy for insomnia.

57 The differential distribution of orexin receptors is consistent with the proposed multifa

58 rostral ventrolateral medulla, and blocking orexin receptors markedly lowered blood pressure (from 1

59 contrast, was involved in the activation of orexin receptor-operated Ca(2+) influx.

60 phanin FQ opioid receptor (NOP), MCHR1, both orexin receptors (ORX), somatostatin receptors 1 and 2 (

61 a positive correlation with amygdalar Type I orexin receptor (Orx1) mRNA and depressive behavior.

62 in-releasing hormone receptor (TRHR1) or the Orexin receptor (Orx1R), agonist stimulation induced rob

63 that acute and selective inhibition of both orexin receptors (OX(1)R and OX(2)R) at all central loca

64 Two orexin receptors (OX(1)R and OX(2)R) have been identifie

65 innervation and expression of genes encoding orexin receptors (OX1 and OX2) in the mouse SCN, with OX

66 in neuropeptides regulate sleep/wake through orexin receptors (OX1R, OX2R); OX2R is the predominant m

67 instatement of cocaine CPP depends on type 1 orexin receptors (OX1Rs), type 1 cannabinoid receptors (

68 Dual orexin receptor (OXR) antagonists (DORAs) such as almore

69 ffects of systemic or centrally administered orexin receptor (OXR) antagonists on measures of impulsi

70 port that the down-regulation of hippocampal orexin receptors (OXRs) and GPR103 particularly in the c

71 lacking orexin peptides, orexin neurons, or orexin receptors recapitulate human narcolepsy phenotype

72 We showed previously that OX(1) orexin receptor stimulation produced a strong (3)H overf

73 Orexin fibers and both orexin receptor subtypes are distributed in cholinergic

74 the patterns of expression of mRNA for both orexin receptors throughout the brain.

75 Here we show that signaling at orexin receptor type 1 (OxR1) in the VTA is required for

76 ked gene cassette disrupts production of the orexin receptor type 2 (OX2R; also known as HCRTR2), but

77 l ventrolateral medulla and antagonized both orexin receptors using an orally administered potent dua

78 that the peptides orexin A and B, acting on orexin receptors, which are GTP-binding-protein coupled,

79 (iii) Antagonism of orexin receptors with a dual orexin receptor antagonist,