ライフサイエンスコーパス: organ of Corti

1 r papilla (the avian analog of the mammalian Organ of Corti).

2 f the prosensory domain destined to form the organ of Corti.

3 ear growth, cell fate, and patterning of the organ of Corti.

4 eafness, and progressive degeneration of the organ of Corti.

5 d damage or death of outer hair cells in the organ of Corti.

6 ssed precisely at the neural boundary of the organ of Corti.

7 normal mechanical stimulation, or an intact organ of Corti.

8 n cells affects efferent fiber growth to the organ of Corti.

9 o the hair cells and supporting cells of the organ of Corti.

10 maintain normal innervation patterns to the organ of Corti.

11 naptic terminal segments beneath IHCs in the organ of Corti.

12 s (IPCs)] in whole-mount preparations of rat organ of Corti.

13 mmalian cochlea that constitutes the nascent organ of Corti.

14 pt, afferent fibers are disoriented near the organ of Corti.

15 loss due to progressive degeneration of the organ of Corti.

16 ) molecules are clearly expressed within the organ of Corti.

17 rcular canals and auditory hair cells in the organ of Corti.

18 he supporting cells and Schwann cells of the organ of Corti.

19 olarized subcellular localization across the organ of Corti.

20 ferentially affected supporting cells in the organ of Corti.

21 hlear epithelium encompassing the primordial organ of Corti.

22 nd ligament, and supporting cells within the organ of Corti.

23 entally for continued function of the mature organ of Corti.

24 s the predominantly expressed isoform in the organ of Corti.

25 iters' cells, a non-sensory cell type of the organ of Corti.

26 expression in the sensory epithelium of the organ of Corti.

27 's, Claudius, and inner sulcus cells) in the organ of Corti.

28 f the sensory epithelium in the cochlea, the organ of Corti.

29 ls that act like force generators within the organ of Corti.

30 stibular system as well as to the developing organ of Corti.

31 ia vascularis, spiral ganglion cells and the organ of Corti.

32 tility in OHCs of the apical turn of the rat organ of Corti.

33 iral ganglion and were projecting toward the organ of Corti.

34 necessary for the normal development of the organ of Corti.

35 rase staining of surface preparations of the organ of Corti.

36 s and a disruption in the development of the organ of Corti.

37 ifferentiated supporting cells of the mature organ of Corti.

38 e tectorial and basilar membranes within the organ of Corti.

39 no evidence of any hair cell recovery in the organ of Corti.

40 system, and a range of abnormalities of the organ of Corti.

41 18.6 kDa peptide abundantly expressed in the organ of Corti.

42 lls (OHCs) in undissociated tissues from the organ of Corti.

43 table in >85% of supporting cells within the organ of Corti.

44 ying the hearing organ of the inner ear, the organ of Corti.

45 the human and mouse spiral ganglia (SG) and organ of Corti.

46 ed by hair cells and supporting cells of the organ of Corti.

47 p63 (TAp63) protein is normally found in the organ of Corti.

48 s migrating from the outermost region of the organ of Corti.

49 constituent of the hair cell tip link in the organ of Corti.

50 s hair cell formation in the differentiating organ of Corti.

51 by loss or damage to outer hair cells in the organ of Corti.

52 ) and lateral compartments in the developing organ of Corti.

53 spiral ligament, and supporting cells of the organ of Corti.

54 its mechanical effect via deformation of the organ of Corti, a complex assembly of sensory and suppor

55 afness that include surgical ablation of the organ of Corti, acoustic trauma, ototoxic drugs, and her

56 acid signaling during the development of the organ of Corti, activation of retinoid receptors was blo

57 olds that three different cochlear elements (organ of Corti, afferent neurons, and stria vascularis)

58 l ganglion, lateral wall of the cochlea, and organ of Corti, all targets for acoustic trauma.

59 In neonatal rat organ of Corti, ALMS1 was localized to the basal bodies

60 e mammalian inner ear detects sound with the organ of Corti, an intricately patterned region of the c

61 hysical interaction of these two proteins in organ of Corti and brain.

62 The signals that induce the organ of Corti and define its boundaries in the cochlea

63 l limbus may promote pathology of the medial organ of Corti and eventual loss of afferent neurons, wi

64 for establishing the cytoarchitecture of the organ of Corti and for hearing.

65 These hair cell receptors reside in the organ of Corti and function to transduce mechanical stim

66 of Math1 protein in supporting cells of the organ of Corti and in adjacent nonsensory epithelial cel

67 egins in the epithelial support cells of the organ of Corti and is accompanied by changes in cellular

68 tein is expressed in outer hair cells of the organ of Corti and is colocalized with CGRP-containing e

69 results from damage to the hair cells of the organ of Corti and is irreversible in mammals.

70 signaling that first set the boundary of the organ of Corti and later regulate hair cell development.

71 ities in the patterning of hair cells in the organ of Corti and missing ampullae, structures that hou

72 ttenuated by (+)-MK-801 and PD 174494 in the organ of Corti and modiolar core, by L-NAME in the later

73 the appearance of immature hair cells in the organ of Corti and new hair cells adjacent to the organ

74 rane vibration, the internal workings of the organ of Corti and of the tectorial membrane have resist

75 tional regulation are observed in the mature organ of Corti and retina, suggesting that this mechanis

76 )-permeable CNGA3 expressed in the mammalian organ of Corti and saccular hair cells was found to inte

77 ssion patterns along the length of the mouse organ of Corti and spiral ganglion neurons.

78 ame transcripts were found in microdissected organ of Corti and spiral ganglion samples.

79 uditory system in particular in the cochlear organ of Corti and stria vascularis.

80 by BDNF, in promoting SGN axon growth in the organ of Corti and synaptogenesis on IHCs.

81 tional deformation in a cross section of the organ of Corti and tectorial membrane in the mammalian c

82 ervation deficiencies, the morphology of the organ of Corti and the development of inner and outer ha

83 The micromechanics of the organ of Corti and the tectorial membrane is then analyz

84 In both the organ of Corti and the vestibular organ, impaired termin

85 re coupled to a micromechanical model of the organ of Corti and to electrical potentials in the cochl

86 ng in the auditory inner hair cells from the organ of Corti and to investigate molecular differences

87 ally to the death of outer hair cells in the organ of Corti and ultimately to deafness.

88 chanism based on the cytoarchitecture of the organ of Corti and using the time-averaged Lagrangian me

89 it is found in the sensory epithelium of the organ of Corti and vestibular end organs as well as in c

90 the sensory and non-sensory epithelia in the organ of Corti and vestibular end organs.

91 3 and CAMSAP3/Marshalin are expressed in the organ of Corti, and carry several protein-protein intera

92 IBC/IPhC regeneration is lost in the mature organ of Corti, and consequently IHC survival and hearin

93 hair/supporting cell damage in the mammalian organ of Corti, and emphasize the importance of transcri

94 tochastic events; and 5) Independent strial, organ of Corti, and neural pathology.

95 rise to both the auditory sensory organ, the organ of Corti, and SG neurons.

96 motile, sensorimotor outer hair cells of the organ of Corti, and that the amplification and frequency

97 he sensory and supporting cells (SCs) of the organ of Corti are derived from a limited number of prog

98 lacement by cells from the outer side of the organ of Corti are factors that may need to be considere

99 nsory hair cells and supporting cells of the organ of Corti are generated by a precise program of coo

100 Unique specializations in the organ of Corti are required to make this conversion, suc

101 r cells, most likely supporting cells of the organ of Corti, are the main source of SGN survival fact

102 nsory primordium from which the cells of the organ of Corti arise, but instead is limited to a role i

103 d and demonstrate altered innervation to the organ of Corti, as well as fewer sensory hair cells.

104 The sensory cells of the mammalian organ of Corti assume a precise mosaic arrangement durin

105 ip1) expression is induced in the primordial organ of Corti between E12 and E14, correlating with the

106 Synaptogenesis in the organ of Corti between the primary receptors, the inner

107 form, and remains in close proximity to the organ of Corti, but is detached from the limbal surface.

108 t expressed in all support cell types in the organ of Corti, but is restricted to developing Deiters'

109 and the level of 8-isoprostane formed in the organ of Corti, but not in the lateral wall tissues.

110 bohydrate on CTL2 and presumably damages the organ of Corti by blocking the transporter function of t

111 ional model to illustrate deformation of the organ of Corti by the two active processes.

112 indings indicate that the quiescent neonatal organ of Corti can replenish specific supporting cells c

113 of birds, unlike hair cells in the mammalian organ of Corti, can regenerate following sound-induced l

114 degeneration in a restricted portion of the organ of Corti cause changes in a corresponding region o

115 els in the inner and outer hair cells of the organ of Corti, cells lining the inner sulcus, and suppo

116 12, the prosaposin KO mice showed histologic organ of Corti changes including cellular hypertrophy in

117 Early models considered the organ of Corti complex (OCC) as a succession of spring-m

118 Second, the local stiffness of the organ of Corti complex felt by individual outer hair cel

119 ative changes in outer hair cells and in the organ of Corti, conforming to human sensory ARHL.

120 The mammalian organ of Corti consists of a highly organized array of h

121 The mammalian auditory sensory organ, the organ of Corti, consists of sensory hair cells with unif

122 e mammalian auditory sensory epithelium (the organ of Corti) contains a number of unique cell types t

123 ory epithelium in the mammalian cochlea (the organ of Corti) contains four rows of mechanosensory hai

124 e mammalian auditory sensory epithelium, the organ of Corti, contains sensory hair cells and nonsenso

125 feed-backward approximation representing the organ of Corti cytoarchitecture.

126 f SPRY2 results in dramatic perturbations in organ of Corti cytoarchitecture: instead of two pillar c

127 2(-/-) mice, stria vascularis abnormalities, organ of Corti degeneration, and profound hearing loss w

128 In the organ of Corti, deletion of Atoh1 at E15.5 led to the de

129 The organ of Corti derives from a prosensory domain that run

130 pression gradient in supporting cells of the organ of Corti deserves attention, given the role of sup

131 of N-Myc (using Pax2-Cre), hair cells in the organ of Corti develop and remain until at least seven d

132 g hair cell differentiation during embryonic organ of Corti development ex vivo.

133 Outer hair cells (OHCs) in the mammalian organ of Corti display electromotility, which is thought

134 lear microphonic potentials suggest that the organ of Corti does continue to move after the end of a

135 (outer hair and supporting cells) within the organ of Corti during a specific developmental time.

136 vation and enabled diagnostic imaging of the organ of Corti, even 30 hours after death.

137 ACAM16 are consistent with the idea that the organ of Corti evolved to maximize the gain of the cochl

138 Dexamethasone treatment of organ of Corti explants challenged with an ototoxic leve

139 iral ganglion neuron (SGN) cell cultures and organ of Corti explants from P3 rats were used to test t

140 This study examines the response of naive organ of Corti explants to treatment with dexamethasone.

141 Three-day-old rat organ of Corti explants were cultured for 1, 2, or 4 day

142 It is not known if naive organ of Corti explants will respond in a similar manner

143 o 2.03 times greater than untreated, hypoxic organ of Corti explants.

144 Prosaposin demonstrates diffuse organ of Corti expression at birth, with gradual localiz

145 helia shows numerous fibers overshooting the organ of Corti, followed by a reduction of those fibers

146 on of both outer and inner hair cells in the organ of Corti, following two reciprocal longitudinal gr

147 point deflection, and the deformation of the organ of Corti for current injection, as well as display

148 pling; and 3), the Y-shaped structure in the organ of Corti formed by the outer hair cell, the Deiter

149 or ablating the hair bundles in the cultured organ of Corti from neonatal gerbils.

150 he sensory primordium that gives rise to the organ of Corti from within the cochlear epithelium is pa

151 ion were decreased in hair cells in cultured organs of Corti from Va(J)/+ and Va(J)/Va(J) mice.

152 In organ of Corti hair cell cultures (UB/OC-1 cells), cispl

153 ns of DT resulted in nearly complete loss of organ of Corti hair cells within 1 week of injection reg

154 We demonstrate that the organ of Corti has the intrinsic capacity to replenish I

155 how that Ca(2+)-dependent interaction of the organ of Corti HCN1 and protocadherin 15 CD3 is mediated

156 t hair cell model, the amino terminus of rat organ of Corti HCN1 was found by yeast two-hybrid analys

157 cular type of fiber did not project into the organ of Corti; however, the nonperivascular type could

158 In vitro studies in UB/OC-1 cells, an organ of Corti immortalized cell line, showed that R-PIA

159 fibers, as seen in confocal analysis of the organ of Corti immunostained for presynaptic and postsyn

160 In the organ of Corti, immunostaining was restricted to the sec

161 hair cell formation and morphogenesis of the organ of Corti in developing mammals, the changing statu

162 Here we measured the 2-D motion of the organ of Corti in mice and found that the structures tha

163 he spiral ganglia or supporting cells of the Organ of Corti in the human cochlea.

164 Sensory hair cells of the mammalian organ of Corti in the inner ear do not regenerate when l

165 of Corti and new hair cells adjacent to the organ of Corti in the interdental cell, inner sulcus, an

166 g and analyzed the cellular integrity of the organ of Corti in two mouse models of this disease with

167 ound-induced 2-D vibrations within the mouse organ of Corti in vivo Our goal was to determine the tra

168 te loss of the cochlear neuroepithelium (the organ of Corti) in adult mutant mice.

169 cx30 colocalised in supporting cells of the organ of Corti, in the basal cell region of the stria va

170 rotein, Fbx2 is also highly expressed in the organ of Corti, in which it has been called organ of Cor

171 analyses of the postnatal development of the organ of Corti, including supporting cells and the basil

172 n the cochlear ganglion, cochlear nerve, and organ of Corti, including the type I and type II ganglio

173 ial transcriptional events in the developing organ of Corti, including those involving Atoh1, has bee

174 n made in identifying the signals regulating organ of Corti induction and differentiation, less is kn

175 e data indicate that supporting cells in the organ of Corti initiate electrical activity in auditory

176 Here we show that the organ of Corti is formed from a thicker and shorter post

177 ts show that the expression of delta1 in the organ of Corti is intense and restricted to the inner ha

178 After P15, GFAP expression in the organ of Corti is mostly restricted to supporting cells

179 Our analysis demonstrates that the organ of Corti is nearly optimized to receive maximum so

180 n jc mutants, the cellular patterning of the organ of Corti is severely disrupted, exhibiting supernu

181 The organ of Corti is the mechanosensory transducing apparat

182 e mammalian auditory sensory epithelium, the organ of Corti, is a highly ordered cellular structure t

183 The organ of Corti, located within the mammalian cochlea, co

184 Since no regeneration occurs in the mature organ of Corti, loss of hair cells leads to deafness.

185 that GJs connecting supporting cells in the organ of Corti mainly provide ionic pathways for rapid r

186 from P6 rat pups consisting of a portion of organ of Corti maintained intact with the corresponding

187 Thus, location-dependent signals within the organ of Corti may set the "address" of neurons within t

188 ating as a wave through support cells in the organ of Corti, may constitute a fundamental mechanism t

189 An underlying assumption was that organ of Corti mechanics are governed by rigid body kine

190 ibration measurement techniques reveals that organ of Corti mechanics are too complicated to be fully

191 We show that the organ of Corti mechanics dictate the longitudinal trend

192 el without alteration to outer hair cell and organ of Corti mechanics or to mechanoelectric transduct

193 he active feedback are considered explicitly-organ of Corti mechanics, and outer hair cell electro-me

194 back of outer hair cells, facilitated by the organ of Corti microstructure, can control the tuning an

195 In the mouse organ of Corti MOR was expressed in inner and outer hair

196 after birth onward and related to changes in organ of Corti morphology.

197 r-vibrations are driven by energy added into organ of Corti motion after the end of an acoustic stimu

198 In the organ of Corti, Nav1.6 was localized in the short segmen

199 voked motion of hundreds of cells within the organ of Corti (OC).

200 sed sequence tag (EST) database of the mouse organ of Corti (OC).

201 ch afferent dendrites must pass to reach the organ of Corti (OC).

202 sound into auditory signals in the mammalian organ of Corti (OC).

203 d from hair cells or supporting cells in the organ of Corti (OC).

204 ost vestibular hair-cell model and mammalian organ of Corti (OC).

205 ion of cellular and functional repair in the organ of Corti of a mature deaf mammal.

206 Histological observations made in the organ of Corti of homozygous Cx26 and Cx30 gene knockout

207 cally active cells are still observed in the organ of Corti of postnatal day 6 animals, suggesting th

208 and Hensen's cells has been described in the organ of Corti of several mammalian species and has been

209 ctural analysis of sensory hair cells in the organ of Corti of the inner ear indicates that the whirl

210 In the organ of Corti of the inner ear, TJs of the reticular la

211 talized cell line UB/OC-2 developed from the organ of Corti of the transgenic H-2Kb-tsA58 mouse (the

212 tly from age-related pathology of either the organ of Corti or cochlear neurons.

213 of selected populations of cells within the organ of Corti or spiral ganglion cells rather than a mi

214 ve relied upon either microdissection of the organ of Corti or the generation of serial sections of t

215 The only sensory neurons innervating the organ of Corti originate from the spiral ganglion, rough

216 In the organ of Corti, Panx1 labeling was found in supporting c

217 Intense noise damages the cochlear organ of Corti, particularly the outer hair cells (OHCs)

218 gically assessed noise-induced damage to the organ of Corti, predominantly basal turn row 1 outer hai

219 We used electrical stimulation in an excised organ of Corti preparation to examine evoked release of

220 They had no recognizable organ of Corti, presented >90% loss of spiral ganglion c

221 sified as exemplifying sensory (referring to organ of Corti), "primary" neural (loss of afferent neur

222 organ of Corti, in which it has been called organ of Corti protein 1.

223 Here, we provide evidence for organ of Corti proteins, of Ca(2+)-dependent binding of

224 al modes due to the complex structure of the organ of Corti provide optimal phases for outer hair cel

225 thway, is crucial for the development of the organ of Corti, providing a molecular explanation for th

226 The cellular mosaic of the mammalian organ of Corti represents one of the most highly ordered

227 g of cell cycle withdrawal in the developing organ of Corti requires p27(Kip1), a cyclin-dependent ki

228 edge to the spiral limbus and lies over the organ of Corti, retains its general form, and remains in

229 Examination of the BWC's organ of Corti revealed numerous dysmorphologies: 1) hai

230 Immunostaining of adult mouse organ of Corti revealed that myosin XV protein is concen

231 This partition, comprising the organ of Corti sandwiched between the basilar and tector

232 data argue that passive mechanics within the organ of Corti sharpen frequency selectivity by defining

233 ed nitration of cellular proteins within the organ of Corti, spiral ganglion, and stria vascularis, w

234 f cells from the various functional domains (organ of Corti, spiral ganglion, etc.) by LCM.

235 rogressive hair cell loss in the base of the organ of Corti, starting between 6 and 13 weeks of age,

236 The present study attempts to relate organ of Corti structure and auditory nerve activity to

237 not reach hair cells and remain outside the organ of Corti, suggesting a chemotactic role for neurot

238 bB3 are expressed by supporting cells of the organ of Corti, suggesting that these molecules mediate

239 ferent innervation of these cells within the organ of Corti suggests that regulation of outer hair ce

240 In the organ of Corti, tenascin-C lines the neural pathways alo

241 ic motor was more effective in deforming the organ of Corti than in displacing the basilar membrane.

242 A guinea pig organ of Corti (the mammalian hearing organ) cDNA librar

243 The organ of Corti, the auditory neuroepithelium of the inne

244 The organ of Corti, the auditory organ of the inner ear, con

245 n-induced hearing loss and cell death in the organ of Corti, the auditory sensory epithelium of mamma

246 ring loss and sensory hair cell death in the organ of Corti, the mammalian auditory sensory epitheliu

247 In the organ of Corti, the pattern of noise-induced lipid perox

248 The organ of Corti, the sensory epithelium of hearing in mam

249 MYH9 was immunolocalized in the organ of Corti, the subcentral region of the spiral liga

250 ect micromechanical interactions between the organ of Corti, the tectorial membrane and the subtector

251 ndolymphatic and perilymphatic spaces of the organ of Corti; the separation from one another by epith

252 fness functionally uncouples the TM from the organ of Corti, thereby minimizing energy losses during

253 ions regulate cellular patterning within the organ of Corti through the induction of one cell fate (P

254 s limited by the extensive remodeling of the organ of Corti throughout postnatal development and asso

255 fluence the micromechanical responses of the organ of Corti to acoustic stimuli during this period.

256 The morphological study of the Odontocete organ of Corti, together with possible alterations assoc

257 not assembled in the supporting cells of the organ of Corti until 3 days after birth in mice and then

258 voked OHC somatic motility within the gerbil organ of Corti using an excised cochlear preparation.

259 that distinct low-frequency forward waves of organ of Corti vibration are launched simultaneously at

260 In contrast, Nav1.2 in the organ of Corti was localized to the unmyelinated efferen

261 The organ of Corti was microdissected, and indirect immunohi

262 A cDNA library from guinea pig organ of Corti was screened by using this oocyte-CFTR as

263 l imaging of FM1-43 in excised strips of the organ of Corti, we show that the time constants of fluor

264 All cells in the middle turn organ of Corti were lost 1 month after birth, and degene

265 Tissue cultures of the organ of Corti were prepared from the cochleas of newbor

266 The auditory sensory epithelium (organ of Corti), where sound waves are converted to elec

267 tic equilibration in epithelial cells in the organ of Corti, which are subject to large K(+) fluxes d

268 ory inner and outer hair cells (OHCs) of the organ of Corti, which convert mechanical deflections of

269 her constitute the sensory epithelium of the organ of Corti, which is the hearing apparatus of the ea

270 imally excites the sensory hair cells of the organ of Corti, which transduce it into electrical signa

271 ctal cells and inner border cells of the rat organ of Corti with a tonotopic expression gradient.

272 null mice show morphological defects of the organ of Corti, with supernumerary hair cells, as also r

273 sduction of sound by hair cells (HCs) in the organ of Corti within the cochlea of the inner ear.