ライフサイエンスコーパス: organ-specific

1 gnals controlling mesothelial cell entry are organ specific.

2 ting that the role of Bax in pathogenesis is organ specific.

3 unlike the protoepithelial one is tissue and organ specific.

4 The organ-specific accumulation, spatial distribution, and c

5 m imaging reveals sparse, taste-specific and organ-specific activation in the Kenyon cell dendrites o

6 porter to screen for mutants affected in the organ-specific activation of jasmonate (JA) signaling in

7 I diabetes, such as strong HLA association, organ-specific adaptive immune responses, viral involvem

8 ate postembryonic development, especially in organ-specific adult stem cells, is unclear.

9 A large number of transcripts show organ-specific, age-dependent or sex-specific differenti

10 ransplants, as they are not part of Canadian organ-specific allocation models at present.

11 cells in newly invaded microenvironments are organ specific and consequently demand distinct mechanis

12 DY-780 and DY-654 showed organ specific and determined elimination routes in both

13 and effector(s) of complement in IRI may be organ specific and remain to be fully characterized.

14 n, we discuss the data regarding the role of organ-specific and bone marrow-derived stem and progenit

15 ulation pattern of the hcn RNA degradants is organ-specific and can be affected by various endogenous

16 cells in newly invaded microenvironments are organ-specific and consequently demand distinct mechanis

17 etes mellitus is increased across a range of organ-specific and multisystem chronic inflammatory diso

18 cular disease are elevated across a range of organ-specific and multisystem chronic inflammatory diso

19 ntial AR effect on PTEN may begin to explain organ-specific and perhaps sex-specific neoplasia predis

20 y a unique role for ICER, which affects both organ-specific and systemic autoimmunity in a Th17-depen

21 Organ-specific and whole-body dosimetries for (68)Ga-DOT

22 major congenital malformations (overall and organ specific) and spontaneous abortions and during the

23 d to elucidate the mechanisms that determine organ-specific anemia tolerance.

24 Notably, we demonstrate that organ-specific angiocrine signaling is essential not onl

25 cently, Bmp2 has been identified by us as an organ-specific angiokine derived from LSECs.

26 autoimmune hepatitis is associated with non-organ-specific antibodies in the context of hepatic auto

27 metastasis-initiating cells need to overcome organ-specific antimetastatic signals in order to underg

28 ut downstream signaling events, which can be organ-specific, are incompletely understood.

29 h focused on one of the following general or organ-specific areas: death determination using neurolog

30 , thymoma, or both for clinical features and organ-specific autoantibodies characteristic of APS-I pa

31 consisting of T1D subjects with and without organ-specific autoantibodies.

32 technology was used to study islet and other organ-specific autoantibody responses in parallel.

33 autoantibodies perpetuate or even induce an organ specific autoimmune response are not yet fully und

34 gers of systemic autoimmunity, but a role in organ-specific autoimmune disease has not been demonstra

35 eg accumulation and function during an acute organ-specific autoimmune disease in vivo.

36 We now recognize that MN is an organ-specific autoimmune disease in which circulating a

37 ysis bullosa acquisita (EBA) is a prototypic organ-specific autoimmune disease induced by autoantibod

38 lerance have not been studied in spontaneous organ-specific autoimmune disease.

39 uction and skin blistering in a prototypical organ-specific autoimmune disease.

40 A-deficient mice did not develop systemic or organ-specific autoimmune disease.

41 of CD40 plays a key role in the etiology of organ-specific autoimmune disease.

42 Many human organ-specific autoimmune diseases are characterized by

43 ommon among patients with Down syndrome, but organ-specific autoimmune diseases are common.

44 Organ-specific autoimmune diseases are usually character

45 h can be customized for application to other organ-specific autoimmune diseases as well.

46 IL-23) play crucial roles in pathogenesis of organ-specific autoimmune diseases by inducing the diffe

47 te this, mice lacking DRAK2 are resistant to organ-specific autoimmune diseases due to defective auto

48 ffecting the skin, is one of the most common organ-specific autoimmune diseases in humans.

49 Recovery from organ-specific autoimmune diseases largely relies on the

50 ons are also critical in the pathogenesis of organ-specific autoimmune diseases that were previously

51 The target autoantigens in several organ-specific autoimmune diseases, including type 1 dia

52 in almost all of the animal models of human organ-specific autoimmune diseases, transplant rejection

53 s into the pathogenesis of both systemic and organ-specific autoimmune diseases.

54 ered as a model for an autoantibody-mediated organ-specific autoimmune disorder.

55 r for both systemic autoimmune disorders and organ-specific autoimmune disorders probably involves th

56 treatments that target adaptive immunity in organ-specific autoimmune disorders.

57 hyroid disorders (AITDs) are the most common organ-specific autoimmune disorders.

58 al importance during the priming phase of an organ-specific autoimmune response remains unclear.

59 ears stronger resemblance to T cell-mediated organ-specific autoimmune than to inflammatory diseases.

60 Systemic organ-specific autoimmunities (type 1 diabetes mellitus

61 ting, particularly in patients with systemic organ-specific autoimmunities.

62 nding how commensal microbiota contribute to organ-specific autoimmunity and for developing novel muc

63 suppression, or negative selection, leads to organ-specific autoimmunity in ALPS, IPEX, and APS1.

64 ent suppressors, which mediate resolution of organ-specific autoimmunity in mice.

65 nd deficiency in LYN spontaneously developed organ-specific autoimmunity in the eye.

66 fore, (i) Treg normally prevents spontaneous organ-specific autoimmunity induction by persistent endo

67 ry immunodeficiency disorder associated with organ-specific autoimmunity linked to NFAT5 deficiency.

68 1 had Hashimoto thyroiditis, suggesting that organ-specific autoimmunity might be linked to nonhemato

69 le in regulating autoreactive Th17 cells and organ-specific autoimmunity remains largely unknown.

70 ut why their activity can prevent (or allow) organ-specific autoimmunity remains poorly understood.

71 IL-15 is a potent cytokine that can promote organ-specific autoimmunity when up-regulated on tissue

72 noninfectious complications: hematologic or organ-specific autoimmunity, 28.6%; chronic lung disease

73 p to answer important lingering questions in organ-specific autoimmunity, as to what factors initiate

74 onomous role in central T cell tolerance and organ-specific autoimmunity, but play a redundant role i

75 ith increased susceptibility to systemic and organ-specific autoimmunity, but the mechanism by which

76 how vitiligo, an underappreciated example of organ-specific autoimmunity, helps to answer them.

77 can present as an inflammatory disease with organ-specific autoimmunity, suggesting a role for DNA-P

78 the T cell-specific response to IL-10 during organ-specific autoimmunity, we generated mice with a se

79 ilt for antigen specificity, tend to produce organ-specific autoimmunity.

80 on of immunopathology and the development of organ-specific autoimmunity.

81 germinal center formation in the absence of organ-specific autoimmunity.

82 uld combine with an Aire mutation to provoke organ-specific autoimmunity.

83 imaging was performed at 6, 12, and 24 h and organ-specific biodistribution at 24 h after probe injec

84 erentially expressed genes reflect the known organ-specific biological activities.

85 at phylogenetic trees across metastases show organ-specific branches.

86 Here, we show that the organ-specific BTB-POZ domain proteins BLADE-ON-PETIOLE1

87 rved mechanism emerges whereby epithelia use organ-specific BTNL/Btnl genes to shape local T cell com

88 Development of organ-specific calcium and calmodulin-dependent protein

89 We normalized organ-specific cancer incidence by organ weight and foun

90 ession across healthy organs correlates with organ-specific cancer incidence.

91 cer (NSSC), who are not eligible to enter an organ-specific cancer program.

92 in cancer mortality, or in the incidence of organ-specific cancers.

93 Consistent with a role for GlcCer in organ-specific cell differentiation, calli from gcs-1 mu

94 Surprisingly, XMRV infection showed organ-specific cell tropism, infecting CD4 T cells in ly

95 ves as a foundational scaffold that supports organ-specific cell types and enables normal organ funct

96 culminates in the differentiation of stable organ-specific cell types that perform specialized funct

97 to cover the energy demands of the different organ-specific cell types.

98 show that tumour-derived exosomes uptaken by organ-specific cells prepare the pre-metastatic niche.

99 s and be further differentiated into desired organ-specific cells.

100 ndent DC generation to adapt this process to organ-specific cellular environments encountered by DC p

101 OR=5.9, P=0.04) ii/ a more severe global and organ-specific cGvHD scoring (P<0.05), iii/ the presence

102 These organ-specific changes in manganese were recently recapi

103 irculate through most human tissues and that organ-specific chemokine expression patterns might affec

104 ations of accumulation patterns arising from organ-specific clearance mechanisms, particle size, and

105 tastatic action of platelets was found to be organ specific, clearly enhancing lung metastasis but no

106 anistic insight into the developing field of organ-specific clocks.

107 or viral ITAM-mediated signaling with likely organ-specific consequences in the host.

108 This model could be used to investigate organ-specific consequences of Sbds-associated ribosomop

109 t not in nonpulmonary, LCH cases, suggesting organ-specific contribution of oncogenic RAS to LCH path

110 The relative organ-specific contributions to the levels and effects o

111 uced in liver, but not muscle, suggesting an organ-specific defect.

112 ing secreted proteins and maize mutants with organ-specific defects confirmed organ-restricted tumori

113 entiated cells, the HGPS mutation results in organ-specific defects.

114 tiple organs and thus encounters a myriad of organ-specific defense mechanisms.

115 ic chromatin loop formation, with consequent organ-specific deficiency of PMM2 leading to the restric

116 destruction has become a promising tool for organ specific delivery of bioactive substance.

117 cent imaging provides spatially resolved and organ-specific detection of lymphoid cell death during p

118 trictions do not lead to the same changes in organ-specific DFA metabolism as those associated with w

119 Organ-specific DFA partitioning and cardiac and hepatic

120 ovide starting points for the development of organ-specific diagnostics and therapies.

121 fluoro-6-thia-heptadecanoic acid to quantify organ-specific dietary fatty acid partitioning, we demon

122 The organ-specific difference in cancer prevalence has been

123 d that NLR expression patterns could reflect organ-specific differences in effector challenge and tes

124 niche for bacterial replication, indicating organ-specific differences in net bacterial growth.

125 y broadened our understanding of tissue- and organ-specific differences in the regulation of inflamma

126 ts dynamic spatiotemporal expression, ensure organ-specific differentiation and proportional growth,

127 (i.e., arteries, veins, and lymphatics) and organ-specific differentiation.

128 Hazards were increased in organ-specific disorders, including severe psoriasis (1.

129 analysis of the Hoxa3 null mutant shows that organ-specific domains did undergo initial patterning, b

130 esponse is truly localised in the context of organ-specific drug toxicity.

131 Organ-specific ECs control their tissue microenvironment

132 ognition, and decreased physical fitness, to organ-specific effects such as severe hepatosplenism, pe

133 In addition to organ-specific effects, the absence of CXCL10 during inf

134 s whose differential expression may underlie organ-specific elongation.

135 The temporal and spatial control of organ-specific endoderm progenitor development is poorly

136 hyma and contributed to our understanding of organ-specific endothelial differentiation.

137 In addition, an organ-specific enhancement-to-noise ratio and background

138 ella Variation within this intron affects an organ-specific enhancer that regulates the level of STER

139 r distributions could allow new insight into organ-specific enrichment and possible transportation pr

140 erspecies blastocyst complementation enables organ-specific enrichment of xenogenic pluripotent stem

141 elements in pleiotropic genes contribute to organ-specific evolution.

142 ed at low levels and characterized by tissue/organ specific expression profiles.

143 yses indicate that 2 degrees effectors share organ-specific expression patterns with 1 degrees effect

144 A subset of lincRNA genes shows organ-specific expression, whereas others are responsive

145 Hence, growing demand by cell biologists for organ-specific extracellular mimics has led to the devel

146 induced skin damage; (iii) reinfection; (iv) organ specific failure of memory T cell responses; and (

147 burn patients to determine the incidence of organ-specific failure and outcome.

148 firmed the expected chronologic incidence of organ-specific failure and yield the long-term mortality

149 oups on the basis of the incidence of single-organ-specific failure, MOF, and non-MOF.

150 (urinary symptoms, psychosocial dysfunction, organ specific findings, infection, neurologic/systemic

151 These studies support a tissue- and organ-specific function for Yipf6 in the maintenance of

152 gs are different, a virulence factor with an organ-specific function in the colonization of the nasop

153 uniquely differentiated to fulfill important organ-specific functions in development, under homeostat

154 We review recent findings on the tissue- and organ-specific functions of SPs and KLFs in the digestiv

155 Organ-specific functions of tissue-resident macrophages

156 Many body surfaces harbor organ-specific gammadelta T cell compartments that contr

157 l cells (ECs) are increasingly recognized as organ-specific gatekeepers of their microenvironment.

158 hallmark of plant development that requires organ-specific gene activity to establish determinacy an

159 nt primordia into plant tumors would require organ-specific gene expression by both host and pathogen

160 xA transcription factors play major roles in organ-specific gene expression, regulating, for example,

161 f the posterior spiracles by coordinating an organ-specific gene network.

162 Organ-specific gene regulation by FoxA proteins is achie

163 he importance of DNA binding specificity for organ-specific gene regulation by modulating promoter ac

164 expression ratios within species, suggesting organ-specific hardwiring of NLR expression patterns in

165 However, the potential role of Bcl-3 in organ-specific host defense against bacteria has not bee

166 microbial pathogens evolved to subvert these organ-specific host immune mechanisms to survive and gro

167 a microfluidic 3D in vitro model to analyze organ-specific human breast cancer cell extravasation in

168 does not appear to play a pathogenic role in organ-specific illness, even in a highly immunocompromis

169 ing pathway of NKG2D and the pathogenesis of organ-specific immune disorders.

170 by DCs, implicating DCs as key mediators of organ-specific immune tolerance.

171 Organ-specific immunity is a feature of many infectious

172 e systemically administered TLR5 agonists as organ-specific immunoadjuvants, enabling efficient antit

173 We have previously reported on a novel organ-specific immunomodifying therapy that provides pro

174 ent, and we put forth the concept of focused organ-specific immunotherapy as an alternative option.

175 tion including fever, rashes, arthritis, and organ-specific inflammation and are caused by defects in

176 NOMID patients present with systemic and organ-specific inflammation of the skin, central nervous

177 e innate immunity, thus connecting stress to organ-specific inflammation.

178 ndings support the hypothesis that T1D is an organ-specific inflammatory disease.

179 > damage --> inflammation that manifests via organ-specific inflammatory switching networks.

180 es in CT, current management implications of organ-specific injuries depicted at multidetector CT are

181 as to quantify the changes in whole-body and organ-specific insulin sensitivities 12 weeks after perm

182 or 9 or 30 days, and changes in systemic and organ-specific insulin sensitivity and inflammation were

183 Recent advances in organ-specific iron imaging and the availability of oral

184 mportant to examine rejection pathways at an organ-specific level.

185 and root clocks can largely be explained by organ-specific light inputs.

186 We conclude that organ-specific, light-responsive transcriptional network

187 n the specification of neural and non-neural organ-specific lineages, as well as cell survival during

188 s modulate neuronal activity to give rise to organ-specific, long-lasting changes in vascular archite

189 esults indicate that the lacteal is a unique organ-specific lymphatic system and does not merely serv

190 eport on phosphatase dysregulation linked to organ-specific malignancies.

191 tative RT-PCR analysis to be expressed in an organ-specific manner in M. truncatula.

192 cardiac energy demand, AMPK functions in an organ-specific manner to maintain cardiac energy homeost

193 m of a major transcriptional regulator in an organ-specific manner, playing an environment-dependent

194 any of the miRNAs were regulated in a tissue/organ-specific manner.

195 pression of SAA proteins and cytokines in an organ-specific manner.

196 d with the photomorphogenic transition in an organ-specific manner.

197 . sojae infection as well as expressed in an organ-specific manner.

198 e B and kill target cells in an epitope- and organ-specific manner.

199 ription somewhere in the body, largely in an organ-specific manner.

200 re metastatic than non-CSC populations in an organ-specific manner.

201 ism during infection that is displayed in an organ-specific manner.

202 lung inflammation in Sf mice in an apparent "organ-specific" manner through two novel mechanisms: by

203 s, the thymus and parathyroids by E18.5, and organ-specific markers are absent or downregulated durin

204 In this study, we show that CXCL12 is an organ-specific maturation factor of particular relevance

205 f cell growth and biochemistry, critical for organ-specific metabolic functions and particularly rele

206 Thus, irrespective of cancer types, organ-specific metastases may share common genomic aberr

207 ssociated with cancer, but their function in organ-specific metastasis remains unclear.

208 was linked to elevated PTHLH expression and organ-specific metastasis to bone.

209 fferent mechanisms by which hypoxia promotes organ-specific metastasis, inhibition of HIF-1alpha with

210 exosomal integrins could be used to predict organ-specific metastasis.

211 ential role for 3q genes in the mechanism of organ-specific metastasis.

212 PET and computed tomography (CT) in terms of organ-specific metastatic lesion detection and radiation

213 increase the numbers of Ly6G+Ly6C+ cells in organ-specific metastatic sites and results in enhanced

214 How organ-specific metastatic traits arise in primary tumors

215 However, the molecular regulators that drive organ-specific microvascular transcriptional programs an

216 n exposure was projected by using a separate organ-specific model that accounted for anatomic coverag

217 approach was applied that integrates static organ-specific models with a whole-plant dynamic model.

218 Mammaglobin A (MGA) is an organ specific molecular biomarker for metastatic breast

219 This study provides organ-specific molecular resolution of genetic variation

220 n the context of the eventual development of organ-specific molecular signatures from peripheral flui

221 PET/MR imaging is to study how stand-alone, organ-specific MR imaging can be improved by PET/MR imag

222 ing a whole-body PET scan with whole-body or organ-specific MR imaging.

223 thematosus and rheumatoid arthritis) and two organ-specific (multiple sclerosis and type 1 diabetes)

224 All mature pancreatic cell types arise from organ-specific multipotent progenitor cells.

225 The organ-specific mutagenicity of SHS is most pronounced in

226 In mammals, most organ-specific N-glycosylation events occur in the brain

227 Regulation of organ-specific neutrophil entry occurs at two levels.

228 We report organ-specific NH(3) dose-dependent metabolic responses

229 ll as how they contribute to the spectrum of organ-specific or systemic autoimmunity.

230 al homeostasis, and they provide evidence of organ-specific pathobiology resulting from different mut

231 ffer new insights into organ homeostasis and organ specific pathology.

232 ndividual pathogen effectors, deployed in an organ-specific pattern, interact with host factors to re

233 rmal development, when they are expressed in organ-specific patterns.

234 organ hormone sensitivity might explain this organ-specific penetrance.

235 ), an activating ligand of CX3CR1, regulates organ-specific peritoneal colonization.

236 The dicotyledon seedling undergoes organ-specific photomorphogenic development when exposed

237 These findings demonstrate that organ-specific physiological responses differentiate emo

238 Priming of the organ-specific premetastatic sites is thought to be an i

239 rapy regimens and may also enable imaging of organ-specific processes such as spleen activation.

240 We show that the organ-specific processing of these compounds was consist

241 Three compounds were evaluated for organ-specific processing: terfenadine for pharmacokinet

242 the expression of NTRC under the control of organ-specific promoters in the ntrc mutant.

243 We identify an ampullary organ-specific proneural transcription factor, and candi

244 Accumulating evidence points to organ-specific properties of systemic inflammation and N

245 detection of PLCPs by identifying common and organ-specific protease activities and identify previous

246 It also provides organ-specific quantificative information about female p

247 (-/-)p53(R172P/R172P) mice were not prone to organ-specific, rapid tumorigenesis.

248 pecific, autoimmune Th1 cells fostered their organ-specific reactivity, as confirmed in an autoimmune

249 ering plants and is often associated with an organ-specific reduction in flower size.

250 its the identification of genes required for organ-specific regeneration and suggests an ancient func

251 The output from M1 could add precision and organ-specific regulation to descending visceromotor com

252 These findings identify an organ-specific role for RA in GVHD and provide evidence

253 of the brain to ischemic damage is due to an organ-specific role of NOX4 in blood-brain-barrier endot

254 lture platforms to interact outside of their organ-specific scientific community.

255 The DENVER2 score was used to assess organ-specific scores for lung, liver, kidney, and heart

256 Here, we suggest that this process ensures organ-specific self-antigens are displayed to circulatin

257 Organ-specific sequencing provided digital expression pr

258 that cell-free DNA can be used to detect an organ-specific signature that correlates with rejection,

259 Additionally, an analysis of organ-specific SOFA scores revealed higher scores in thr

260 Human tissues are an important link between organ-specific spatial molecular information, patient pa

261 SI patients, two (10.5%) were diagnosed with organ-specific SSIs, which eventually led to graft loss;

262 helminths) have been restricted to specific organs, specific stages, or secretomes.

263 gulated proliferation and differentiation of organ-specific stem and progenitor cells.

264 Adult organ-specific stem cells are essential for organ homeos

265 for organ maturation and formation of adult organ-specific stem cells during vertebrate postembryoni

266 (Eya1) is a conserved critical regulator of organ-specific stem cells.

267 Within the organ-specific subgroup, there was minimal overlap among

268 of human pluripotent stem cells (hPSCs) into organ-specific subtypes offers an exciting avenue for th

269 Secondary clinical outcomes included organ-specific symptoms, medication-free days, rhinitis

270 long wondered how some patients develop this organ-specific syndrome.

271 drives the thymic development of a subset of organ-specific T(regs), which are likely coopted by tumo

272 cts exhibited autoantibodies against several organ-specific targets including gastric ATPase (11%), t

273 utoantibody portraits derived from islet and organ-specific targets will likely be useful for enhanci

274 We envisage that organ-specific therapeutics and diagnostics can be devel

275 s (IFN-gamma, granzyme B, and IL-10) display organ-specific thresholds of maximum activation.

276 ivergent evolution of dio2 paralogs supports organ-specific timing of the TH-dependent events governi

277 l intestine, and skeletal muscle to quantify organ-specific tolerance of different levels of acute an

278 s and not readily predictable off-target and organ-specific toxicities and highlight the need for imp

279 tes, metastatic cancer cells need to acquire organ-specific traits.

280 ricana (avocado), in contrast to the largely organ-specific transcriptional cascades evident in Arabi

281 esults have been published regarding whether organ-specific transcriptional patterns dominate over sp

282 Consequently, the predominantly organ-specific transcriptional programs that characteriz

283 The organ-specific transcriptome adjustments reflected the d

284 role for dendritic cells (DCs) in regulating organ-specific Treg cell biology.

285 the development and peripheral regulation of organ-specific Treg cells are dependent on antigen prese

286 implications for enhancing the generation of organ-specific Treg cells in autoimmune diseases.

287 migratory DCs coordinated the activation of organ-specific Treg cells in the prostate-draining lymph

288 VHL loss-of-function mutations result in organ-specific tumors, such as hemangioblastoma of the c

289 iver and heart following T/HS, demonstrating organ-specific UPR transcriptome changes.

290 es for Notch signaling in the development of organ-specific vascular beds.

291 crovascular specification and acquisition of organ-specific vascular competence, which are indispensa

292 ndothelial Notch1 (Notch1DeltaEC) share some organ-specific vascular defects with Adam10DeltaEC mice,

293 m17DeltaEC), which survived postnatally with organ-specific vascular defects, resembled Adam10DeltaEC

294 otch signaling, survived into adulthood with organ-specific vascular defects.

295 ular ECs instruct neighboring cells in their organ-specific vascular niches through angiocrine factor

296 ht molecular asymmetries are translated into organ-specific vascular patterns.

297 Progression of organ-specific vasculopathy often precedes organ dysfunc

298 us as an advantageous model for the study of organ-specific vessel development and provide new insigh

299 l in which to investigate the early steps of organ-specific vessel formation.

300 r benefits in tuberculosis are thought to be organ specific, with clinicians using them routinely to