ライフサイエンスコーパス: organellar

1 ruit, we demonstrate directly the unique sub-organellar accumulation sites of specific carotenoids us

2 show that treatments with drugs diminishing organellar acidification may reduce the inflammatory res

3 However, the individual contribution of organellar acidification to virulence and its associated

4 t of core intracellular functions, including organellar acidification, granule secretion, and microbi

5 lved in maintaining electroneutrality during organellar acidification.

6 channels are thought to represent defects of organellar acidification.

7 The V-ATPase is the main regulator of intra-organellar acidification.

8 Only one of the three eukaryotic organellar ACPs allowed growth.

9 als to the nucleus to coordinate nuclear and organellar activities.

10 lleviate pathological states associated with organellar alkalinization.

11 s that discriminate them from the termini of organellar amino acid transporters.

12 erstanding of molecular mechanisms shared by organellar and bacterial group II introns.

13 organisms requires an effective response to organellar and cellular damage either by repair of such

14 lar ion channels are essential regulators of organellar and cellular function, yet the molecular iden

15 in intracellular homeostasis, sterility, and organellar and cellular functionality.

16 which is accompanied by a more rapid loss of organellar and cytoplasmic proteins.

17 , including cytoplasmic, nuclear, nucleolar, organellar and endomembrane compartments.

18 pisomes, revealing a potential mechanism for organellar and foreign DNA acquisition.

19 However, translocation in organellar and in vivo demonstrates strong specificity t

20 re of high quality with low contamination by organellar and lambda-sequences.

21 for genome evolution through acquisition of organellar and mobile DNAs at DSB sites.

22 ng the distribution of genetic labor between organellar and nuclear genomes.

23 he membrane-binding motif is conserved among organellar and prokaryotic homologs.

24 at folate polyglutamylation is essential for organellar and whole-plant folate homeostasis.

25 ing or SNPs within the chromosomally encoded organellar (apicoplast) isoleucyl-tRNA synthetase.

26 Control of organellar assembly and function is critical to eukaryot

27 To determine the organellar basis of this process, we investigated the su

28 trient induces transcriptional repression of organellar biogenesis involving epigenetic alterations.

29 ses play key roles in apicomplexan invasion, organellar biogenesis, and intracellular survival.

30 isms that export drugs or toxins from cells, organellar biogenesis, and mechanisms that protect again

31 A build-up of degradative organellar by-products and decreased recycling of cellul

32 The only known example of non-organellar C to U editing of tRNAs occurs in trypanosoma

33 NAADP-regulated Ca(2+) channels that release organellar Ca(2+) in response to NAADP.

34 r hypo-osmotic shock) is inhibited, and (ii) organellar Ca(2+) release (induced by a fungally derived

35 of how the spatial organization of discrete, organellar Ca(2+) stores may underpin the generation of

36 fic probes demonstrated that major swings in organellar [Ca(2+)] parallel the changes occurring in th

37 ighlight some of the challenges in observing organellar Ca2+ and the alternative strategies researche

38 ting ATPases in the control of cytosolic and organellar Ca2+ levels are well established, but the phy

39 disruption of intracellular transport of key organellar cargo, such as mitochondria.

40 usly expressed in both animals and plants as organellar cation channels.

41 oreover, they show, for the first time, that organellar caveolin-1 significantly affects tissue funct

42 scription, thereby obviating the need for an organellar clock, at least for these rhythms.

43 Organellar clones comprised approximately 10% of each li

44 domains that emerged as a product of nuclear-organellar coevolution.

45 was small, such that in none of the nuclear-organellar combinations was the difference between obser

46 organization, subcellular dynamics and inter-organellar communication during the immune response.

47 ical mechanisms for membrane trafficking and organellar communication in mammalian cells.

48 Inter-organellar communication in plant-microbe interactions 1

49 Inter-organellar communication is vital for successful innate

50 nate protease domains by sensing pH of their organellar compartments as they transit the secretory pa

51 oncentration ([Cl-]) was measured in defined organellar compartments using fluorescently labeled tran

52 o reveal the organization of organelles, sub-organellar compartments, protein complexes, functional n

53 et was validated by (i) correlation with the organellar composition of SiEPs versus Paneth cells, (ii

54 d quantitative view of HeLa cell anatomy and organellar composition, at the protein level.

55 ces in our understanding of these remarkable organellar contact sites.

56 ize range between 123 and 161 kb, an average organellar content of 0.4%-4.1% and nonrecombinant conte

57 Maternal organellar cranberry inheritance was inferred by analyzi

58 lace via their sequestration into a specific organellar deposit site we termed intramitochondrial pro

59 and have similar pathological responses and organellar disorders with pancreatitis-causing treatment

60 olarized cells present unique challenges for organellar distribution and dynamics.

61 oking spatial Ca2+ responses that mirror the organellar distribution.

62 section of cell biological processes such as organellar division and cell motility, and for the ident

63 The evidence for efficient photorepair of organellar DNA contrasts with previous studies of irradi

64 several Geranium species containing foreign organellar DNA from diverse eudicots, including many tra

65 It also reduces contamination from organellar DNA in preparations of nuclear DNA.

66 cotiana tabacum, indicated that migration of organellar DNA into the F3galtase gene was an ancient ev

67 ments demonstrate that the nuclear influx of organellar DNA is a potentially a source of mutation for

68 aTI activity within the Arabidopsis thaliana organellar DNA polymerase gene POLgamma2.

69 eting and sequence alignment features of two organellar DNA polymerase genes from Arabidopsis thalian

70 Zea mays), white2 (w2), encoding a predicted organellar DNA polymerase.

71 Organellar DNA sequences are widely used in evolutionary

72 lear DNA suggests that the genetic impact of organellar DNA transfer to the nucleus is potentially fa

73 mounts of specific repeats and insertions of organellar DNA.

74 , and effectors of the cAMP cascade in these organellar domains remain largely undefined.

75 b cellular morphology, membrane traffic, and organellar dynamics and to trigger cell death.

76 consequence of alterations in molecular and organellar dynamics within the cellular milieu of cardio

77 l interface is central to calcium signaling, organellar dynamics, and lipid biosynthesis.

78 rvous system, including protein importation, organellar dynamics, and programmed cell death.

79 The intricate biogenesis of multimeric organellar enzymes of dual genetic origin entails severa

80 sesses only one each of the following likely organellar enzymes: polynucleotide phosphorylase, hydrol

81 that of MM PCs, associated with distinctive organellar features and expression patterns indicative o

82 docytosis, mitochondrial division, and other organellar fission and fusion events in eukaryotes.

83 chinery of bacteria and the dynamin-mediated organellar fission machineries of eukaryotes.

84 heRS enzymes, a cytoplasmic (ctPheRS) and an organellar form.

85 nt stripped off tBid from the membrane-bound organellar fraction of Bid plus Bcl-2-co-transfected cel

86 In a partially purified vesicular/organellar fraction, HPS1 and HPS4 are both components o

87 ion of Bax and Bak within the membrane-bound organellar fraction, shown by cross-linking experiments.

88 ing, tBid translocated to the membrane-bound organellar fraction.

89 slocation from cytosol to the membrane-bound organellar fraction.

90 Immunoblot analysis of organellar fractions showed that the location of NCLX is

91 lity of proteomics in the discovery of novel organellar functions and resulted in 1) a protein profil

92 ding quality control, analogous to the above organellar functions of higher eukaryotes.

93 demonstrated a role for Rab14 in stimulating organellar fusion between phagosomes and early endosomes

94 Nuclear-encoded maturases could regulate organellar gene expression and may reflect a step in the

95 e found in metazoans and plants and regulate organellar gene expression at different levels.

96 g factors that control almost all aspects of organellar gene expression.

97 to the organelle as a functional protein, an organellar gene must first be assimilated into the nucle

98 achieve a fitness level comparable with the organellar gene.

99 exity in establishing a nuclear copy, why do organellar genes end up in the nucleus?

100 on of the 5' region of other nucleus-encoded organellar genes suggests that several genes may incorpo

101 ng RNA pathway, and extensive RNA editing of organellar genes.

102 t the potential for independent evolution of organellar genes.

103 s are required for the correct expression of organellar genes.

104 Cells that lose their organellar genome ([rho(0)] cells) dramatically induce t

105 The Dual Organellar GenoMe Annotator (DOGMA) automates the annota

106 ticipate in maintenance or expression of the organellar genome at the inner surface of the inner memb

107 n the mitochondrion and plastid to influence organellar genome behavior and plant growth patterns.

108 nucleic acids, possibly representative of an organellar genome comparable with those described for mi

109 SWIB family members suggests a link between organellar genome maintenance and cell proliferation.

110 Organellar Genome Retrieval (OGRe) is a relational datab

111 MSH1 is a plant-specific protein involved in organellar genome stability in mitochondria and plastids

112 vansi, a form of the latter stage lacking an organellar genome.

113 lacement therapy have roused interest in the organellar genome.

114 of which are the largest of any green plant organellar genome.

115 The nontarget cytoplast organellar genomes and metabolites are removed by centri

116 Plant organellar genomes are complex compared with their anima

117 Instead, their organellar genomes are generally larger and more intron

118 Extant cytoplasmic organellar genomes contain very few genes compared with

119 velopment of transformation technologies for organellar genomes has made it possible to reconstruct t

120 It appears that organellar genomes have already been reduced in free-liv

121 number of codon reassignments in nuclear and organellar genomes highlights the importance of experime

122 ansfer complexes are consistently encoded by organellar genomes in multicellular organisms, suggestin

123 fects of the endosymbiotic transition on the organellar genomes of eukaryotes.

124 the endosymbiotic lifestyle has affected the organellar genomes of photosynthetic green algae, we gen

125 evidence that the coevolution of nuclear and organellar genomes spurred the evolution of diverse nonc

126 e translocation of genetic material from the organellar genomes to the nucleus.

127 rtunity to study possibly ancestral forms of organellar genomes, a unique glimpse into the evolutiona

128 enome assembly includes nuclear (~29 Mb) and organellar genomes, and contains 9,052 gene models.

129 ile group II introns, found in bacterial and organellar genomes, are both catalytic RNAs and retrotra

130 Initially identified in organellar genomes, group II introns are found in bacter

131 sociation were not consistent across loci or organellar genomes, suggesting that they are not the res

132 species and new combinations of nuclear and organellar genomes.

133 olecular function of proteins encoded in the organellar genomes.

134 nd thus far, only in certain eubacterial and organellar genomes.

135 and are particularly prevalent within plants organellar genomes.

136 omplexa are known to contain greatly reduced organellar genomes.

137 hough there is no doubt that prokaryotic and organellar group II introns are evolutionary related, th

138 In eukaryotes, these organellar gymnastics are controlled by numerous pathway

139 ate to the nucleus in response to changes in organellar homeostasis.

140 utophagy genes that function in immunity and organellar homeostasis.

141 Organellar Hsp-70 is required for post-translational tra

142 ern in a diverse subset of 165 bacterial and organellar Hsp70s.

143 sfunctional CFTR in cystic fibrosis leads to organellar hyperacidification in lung epithelial cells b

144 t the cellular level, CF is characterized by organellar hyperacidification, which results in altered

145 of the mammalian enzyme, may be involved in organellar import of the plant enzyme.

146 s two types of microscopically visible intra-organellar inclusions: a large crystalline lattice of me

147 ase pair mismatch, unique to eubacterial and organellar initiator tRNAs, may also be important for th

148 ystems ensuring maintenance of proteostasis, organellar integrity, function and turnover, and overall

149 e measurement and perturbation of ROS at the organellar interface has proven difficult.

150 sing mechanisms inside organelles and at the organellar interfaces, revealed how Ca(2+) binding might

151 Splicing of organellar introns requires the activity of numerous nuc

152 me complex, they function as two independent organellar ion channels and that TPCs, not TRPMLs, are t

153 de are discussed and put into the context of organellar ion homeostasis in general.

154 NHE6 and NHE9 are organellar isoforms that can appear transiently on plasm

155 In addition, the relative organellar localization of Psd1 is dynamically modulated

156 tail of Naa60, which is responsible for the organellar localization.

157 The rate of evolution in organellar loci is slower than for other liverwort linea

158 for Arabidopsis membrane-bound, nuclear, and organellar long coiled-coil proteins.

159 Dynamic Organellar Maps enable the proteome-wide analysis of phy

160 We have developed and applied Dynamic Organellar Maps, a proteomic method that allows global m

161 Through a comprehensive analysis of organellar markers in mouse models of Alzheimer's diseas

162 nthase, a ThPP-requiring enzyme found in the organellar matrix.

163 f many organisms, but the cell signaling and organellar mechanisms underlying this capability are unc

164 cold shock domain places RBP16 as the first organellar member of the highly conserved Y-box protein

165 solated cDNA clones for two nuclear-encoded, organellar members of the Arabidopsis hsp70 gene family,

166 member of the Omp85 family of bacterial and organellar membrane insertases, characterized by N-termi

167 These findings suggest that the organellar membrane potential may undergo large regulato

168 Cellular and organellar membranes are dynamic materials that underlie

169 uses have the ability to utilize alternative organellar membranes during infection that could increas

170 lysosomal membranes were unique among known organellar membranes in terms of cholesterol content, ch

171 nknown how localization of Sac1p to distinct organellar membranes is mediated.

172 y, facilitating protein translocation across organellar membranes, and ensuring proper folding of nas

173 or the translocation of many proteins across organellar membranes, presumably by providing energy in

174 cyte 15-lipoxygenase binds and permeabilizes organellar membranes, thereby releasing the lumenal cont

175 een organelles, and between microtubules and organellar membranes, to be accurately defined in 3-D an

176 the transport of Cl(-) ions across cell and organellar membranes.

177 s that regulate the association of GGA3 with organellar membranes.

178 tween those of the plasma membrane and other organellar membranes.

179 f sugar-containing molecules across cell and organellar membranes.

180 clear-encoded proteins after passage through organellar membranes.

181 Concurrently, copper and organellar metal homeostasis genes, which are functional

182 es various functional and structural data on organellar (mitochondrial and chloroplast) introns.

183 Currently, COPaKB features 8 organellar modules, comprising 4203 LC-MS/MS experiments

184 their functional integrity and cellular and organellar morphology using light, fluorescence, and ele

185 y with respect to its ambient cytoplasm; but organellar motion will raise that limit as a non-decreas

186 latter suggests a coordinated regulation of organellar multiple site editing through DYW2, which pro

187 Despite limited mitochondrial mass, organellar NAD(P)H is extensive because much of the sign

188 tive sulfur assimilation and plays a role in organellar nucleoid organization.

189 eolytic systems in Arabidopsis thaliana, the organellar oligopeptidase, OOP (At5g65620).

190 ts expression and is not found in either the organellar or cytoplasmic fractions.

191 In organellar or in vitro reconstitution studies have ident

192 spread in eukaryotes in which it can provide organellar or nuclear RNase P activities.

193 veral independent occasions and recruited as organellar or nucleo-cytoplasmic RNA modifiers, operatin

194 he effects of postendosymbiotic evolution on organellar pathway partitioning.

195 olic mosaics of ancestral and newly acquired organellar pathways.

196 nd to generate a coexpression network for 97 organellar peptidase baits (1742 genes, making 2544 edge

197 eview provides a systematic insight into the organellar peptidase network in Arabidopsis thaliana We

198 Neutralization of organellar pH by chloroquine or bafilomycin A resulted i

199 ispensable for many organisms in maintaining organellar pH homeostasis.

200 ly, we report that fertilization also alters organellar pH in a spatio-temporally complex manner.

201 Generation of low organellar pH is primarily driven by the V-ATPases, prot

202 ous PC paralogues are activated at different organellar pH values.

203 ion of their protease domains by sensing the organellar pH within the secretory pathway.

204 omised in their vesicular zinc uptake, their organellar pH, and their total and surface content of AP

205 The sum of these results shows that organellar pH, proteasome activity, and down-regulation

206 (2)(+) (Ca(2)(+) mito) is needed to maintain organellar physiology, Ca(2)(+) mito overload can lead t

207 nnotator (DOGMA) automates the annotation of organellar (plant chloroplast and animal mitochondrial)

208 teins, in mammals, the mechanism of how this organellar pool is generated has remained obscure.

209 oteins involved in endocytotic recycling and organellar positioning and an apicomplexan family.

210 recognition in vitro, preprotein binding in organellar, precursor binding in vivo, and the recogniti

211 survival in mammals, is enhanced by an inter-organellar process involving ER tubules encircling and c

212 presequences and the subunit composition of organellar processing peptidases evolved in concert.

213 We created Cardiac Organellar Protein Atlas Knowledgebase (COPaKB; www.Hear

214 Saccharomyces cerevisiae suggested that the organellar protein might lack the editing activity.

215 isciplines to retrieve and analyze pertinent organellar protein properties of interest.

216 hondria and the cytosol suggests that either organellar protein synthesis quality control is focused

217 findings change our view of the evolution of organellar protein synthesis.

218 Hsp70 activity and, hence, are essential for organellar protein translocation and folding.

219 an essential role for Magmas and DnaJC19 in organellar protein translocation and mitochondria biogen

220 log of the bacterial RecG translocase, is an organellar protein with multiple roles in mtDNA maintena

221 A significant proportion of nucleus-encoded organellar proteins are dual targeted, and the process b

222 d to occur not only on histones, but also on organellar proteins in plants and animals.

223 more constitutively expressed genes encoding organellar proteins.

224 phylogenetic distribution of the homologs of organellar proteins.

225 anslation, and support membrane targeting of organellar proteins.

226 ntified and characterized a component of the organellar proteolytic systems in Arabidopsis thaliana,

227 hloroplast protein import contributes to the organellar proteome changes that occur during plant deve

228 tal cues, enabling dynamic regulation of the organellar proteome, and suggest new approaches for impr

229 During evolution, organellar proteomes are modified by gene gain and loss,

230 Organellar proteomes therefore provide cumulative feedba

231 As a fuzzy organelle, it defies classical organellar proteomics and cannot be described by a singl

232 teomic imaging' as described here integrates organellar proteomics with multiple imaging techniques t

233 Using a large survey of organellar proteomics, we similarly classified human gen

234 of T. brucei as a first target for protozoan organellar proteomics.

235 peroxidase (APEX) that bypasses the need for organellar purification when applied to membrane-bound c

236 gy has emerged as a key cellular process for organellar quality control, yet this pathway apparently

237 nges compared to control can be modulated by organellar Ras signalling.

238 as other peptidase families were exclusively organellar; reasons for such biases are discussed.

239 as a much broader role in biology, including organellar remodeling, protein and organelle quality con

240 cterized recombination factors and extensive organellar remodeling.

241 ecificity being necessary to maintain larger organellar repertoires.

242 he analysis of individual LDs makes possible organellar resolution of molecular compositions and will

243 rmis provide a model system for the study of organellar response to osmotic stress within the context

244 tochondrial and chloroplast ribosomes (i.e., organellar ribosomes).

245 ments from bacterial, archaeal, eukaryal and organellar ribosomes, using nucleotide numbers from repr

246 of eubacterial or eukaryotic (cytoplasmic or organellar) ribosomes to our knowledge.

247 Organellar RNA abundance exhibited marked changes during

248 in the most global, yet opposite, effects on organellar RNA abundance, changes that were dissected fu

249 useful for characterizing the specificity of organellar RNA accumulation mutants.

250 nuclear genomes encode hundreds of predicted organellar RNA binding proteins, few of which have been

251 ite recognition and proteins of the multiple organellar RNA editing factor (MORF) family as cofactors

252 The here identified family of multiple organellar RNA editing factor (MORF) proteins provides a

253 ain RNA editing interacting protein/multiple organellar RNA editing factor (RIP/MORF) boxes, which ar

254 The MEF10 protein interacts with multiple organellar RNA editing factor 8 (MORF8) but not with oth

255 >U plant organellar RNA editing is required for the translation o

256 or which are amplified in plant species with organellar RNA editing.

257 A prominent enzyme in organellar RNA metabolism is the exoribonuclease polynuc

258 r findings implicate several PPR proteins in organellar RNA metabolism, but the biological functions

259 l repeat proteins that bind RNA and modulate organellar RNA metabolism.

260 ns, several of which have been implicated in organellar RNA metabolism.

261 nts and are thought to be mostly involved in organellar RNA metabolism.

262 s data for the evolution and function of the organellar RNA polymerases is discussed.

263 The organellar RNAPs appear to use this surface in an altern

264 processing, stability, and/or translation of organellar RNAs.

265 POP5*RPP30 reconstituted with bacterial and organellar RPRs suggests functional overlap of this bina

266 efficiency of VSG transport and fidelity in organellar segregation during cytokinesis.

267 wed by capturing of additional A-derived and organellar sequences and amplification of B-specific rep

268 Finally, there is substantial plasticity in organellar shape, with extensions such as stromules, per

269 genome is indisputable, it is now clear that organellar signals can have profound effects, not just o

270 elles.It is yet unknown whether vesicular or organellar sites perform this function in mammals.

271 An organellar SRP identified in chloroplasts (cpSRP) is unu

272 subjected to proteolytic maturation prior to organellar storage and discharge.

273 tion, prompting the activation of a specific organellar stress-response mechanism, the mitochondrial

274 to the influence of gravity on cellular and organellar structure.

275 t contribute to pre-protein unfolding at the organellar surface.

276 The karyomastigont organellar system, common in extant amitochondriate prot

277 Reconstructions of pathways and organellar systems revealed that ST1 has a relatively co

278 , which suggests communication between these organellar systems.

279 isrupts the entire complex, interfering with organellar targeting and subsequent trafficking.

280 ghlight the exquisite in vivo specificity of organellar targeting mechanisms.

281 ge, the first evidence of splicing-regulated organellar targeting of a plant ion channel and identify

282 CML30 in other plants further indicates that organellar targeting of these CMLs is not a specific fea

283 d epimerase sequences examined had predicted organellar targeting peptides with a potential second st

284 -terminal extensions with characteristics of organellar targeting peptides.

285 llar bodies (LB) in lung epithelium, and its organellar targeting sequence has been identified.

286 including transfer of genetic material from organellar to nuclear genomes, de novo sequence manufact

287 Organellar trafficking and import, in addition to quater

288 imentally identified sites of RNA editing in organellar transcriptomes from several species, but thes

289 d frequently contribute to the maturation of organellar transcripts.

290 ections and the establishment of nuclear and organellar transformation methods has opened the way for

291 rsion on phagosomes, allowing or disallowing organellar transition into a late endosomal compartment.

292 side, where it could participate directly in organellar translation and localize Cox2p synthesis by v

293 Defects in organellar translation are the underlying cause of a num

294 regulating both the levels and locations of organellar translation.

295 d-base transporters involve plasmalemmal and organellar transporters of H(+), HCO3(-), and Cl(-).

296 er (RhaT) families as well as the eukaryotic organellar triose phosphate transporter (TPT) and nucleo

297 diting has only been previously described in organellar tRNAs.

298 cause autophagy is the primary mechanism for organellar turnover, these results offer insights into p

299 Organellar two-pore channels (TPCs) contain two copies o

300 ells have an "awareness" of their volume and organellar volumes, and maintain a nuclear size that is