ライフサイエンスコーパス: organelle

1 tiple cAMP/PKA signalling domains within the organelle.

2 PP-mediated translocation of NaStEP into the organelle.

3 iption, trans-splicing, and a glycosome-like organelle.

4 that function as counterparts to eukaryotic organelles.

5 tissue homeostasis despite severe damage to organelles.

6 phrocytes also impaired the acidification of organelles.

7 ong different tissues, cells and subcellular organelles.

8 distribution of hundreds of proteins within organelles.

9 s cargo including dysfunctional proteins and organelles.

10 ation at membrane contacts between different organelles.

11 y by recycling intracellular proteins and/or organelles.

12 sociated membrane protein 1 (LAMP1)-positive organelles.

13 brane permeability of multiple intracellular organelles.

14 chondria and other important life supporting organelles.

15 ut recombination among genetically divergent organelles.

16 lace at the cell surface or in endolysosomal organelles.

17 aracterize channels pivotal for these acidic organelles.

18 eukaryotic plasma membrane and intracellular organelles.

19 allow for transfer of signals, vesicles, and organelles.

20 protein (RNP) bodies and other membrane-less organelles.

21 es in the distribution of megakaryocyte (MK) organelles.

22 eukaryotic plasma membrane or intracellular organelles.

23 he functions of these important and ubicuous organelles.

24 he membranes of bacteria and some eukaryotic organelles.

25 are not readily applicable to intracellular organelles.

26 ones of contact between the membranes of two organelles.

27 pithelia, and acidification of intracellular organelles.

28 ushing forces on intracellular membranes and organelles.

29 onally favour Ca(2+) transit between the two organelles.

30 ions in detecting this modification in these organelles.

31 x across membranes of cells or intracellular organelles.

32 eneralizable to the study of other mammalian organelles.

33 us to the lipid-based membrane of eukaryotic organelles.

34 ge by removing damaged proteins, lipids, and organelles.

35 s, lysosomes, and other familiar vesicles or organelles.

36 in nanoscale vesicles derived from specific organelles.

37 to the biogenesis of virus-induced membrane organelles.

38 rganization and dynamics of such liquid-like organelles.

39 afficking of lipids and ions between the two organelles.

40 nd characteristics in isolated endolysosomal organelles.

41 genuine signalling microdomain between these organelles.

42 ions with a potential to serve as artificial organelles.

43 and the membranes of nanoscale intracellular organelles, a result we found to be due to differences i

44 Measuring changes in protein or organelle abundance in the cell is an essential, but cha

45 Estimation of relative organelle abundance was found to be reproducible and con

46 trains defective in endosomal trafficking or organelle acidification but not those defective in autop

47 eukaryotic cell into discrete membrane-bound organelles allows for the separation of incompatible bio

48 posed local Ca(2+)-sensing mechanisms inside organelles and at the organellar interfaces, revealed ho

49 Knowledge of the development of organelles and attendant pathways under different metabo

50 Optimal distribution of heterogeneous organelles and cell types within an organ is essential f

51 Partitioning of cell organelles and cytoplasmic components determines the fat

52 le contacts facilitate communication between organelles and impact fundamental cellular functions.

53 Depletion of PAQR11 dispersed Golgi organelles and impaired anterograde vesicle transport to

54 h impacts the cellular distribution of other organelles and influences autophagic activity.

55 review of semi-automated probability maps of organelles and other features from 3D electron microscop

56 om the universal code exist, particularly in organelles and prokaryotes with small genomes, they are

57 VLPs represent a new class of extracellular organelles and share pathways for protein delivery with

58 Here, we discuss the contributions of organelles and the cytoskeleton to the plant's defense r

59 ts, the existence of cell walls, subcellular organelles and the lack of stable cell lines have preven

60 generation necessary for the distribution of organelles and the restructuring of the cytoskeleton wit

61 generate 3D reconstructions of intracellular organelles and their membrane appositions involving the

62 Accessibility to the specialized sensory organelles and their small dimensions have been limiting

63 direct interaction of the cytotoxin with the organelle, and are independent of the toxin vacuolating

64 , identify mitochondrial contacts with other organelles, and further unravel their communication.

65 go-binding domain with both microtubules and organelles, and hence plays an important role in control

66 organization select for similarly configured organelle- and transport-related machineries.

67 e Golgi, but its role and regulation at this organelle are only partially understood.

68 sed to mitochondria in such a way that the 2 organelles are able to communicate with each other, both

69 Many motility organelles are complex surface appendages that have evol

70 r show that mutants lacking lysosome-related organelles are defective in the production of all 4'-mod

71 s mitochondrial network, while some of these organelles are degraded through hydrolysis.

72 Membranous structures derived from various organelles are important for replication of plus-strande

73 of mitochondria is autophagy, where damaged organelles are marked for disposal via ubiquitylation by

74 Inside the cell, however, such organelles are multicomponent, with numerous intermolecu

75 pulation and dynamics of single molecule and organelles are reviewed.

76 The organelles are thought to sequester a private cofactor p

77 ndance and distribution of cholesterol among organelles are tightly controlled by a combination of me

78 III phosphatidylinositol-3-kinase from these organelles as they acidify.

79 pate in the reorganization of the respective organelles, as exemplified by the fragmentation of the G

80 ay that degrades cytosolic macromolecules or organelles, as well as intracellular pathogens.

81 or the correct formation of centrosomes, the organelles at the poles of the spindle that can persist

82 Intriguingly, organelles avoid clashing and entangling with each other

83 Proteins are assigned to organelles based on the similarity of their gradient dis

84 we targeted the expression of roGFP2 to this organelle besides the cytosol.

85 ellular processes such as energy metabolism, organelle biogenesis and stress responses.

86 ucial for regulating tissue architecture and organelle biogenesis during animal development.

87 nslocases into a large network that controls organelle biogenesis, function, and dynamics.

88 rocyte invasion, acting on rhoptry secretory organelle biogenesis.

89 d reveal that LBs are not only lipid storage organelles but also act as a relay center in metabolic t

90 they unite not only secretory and endocytic organelles but also the flagellum and nucleus.

91 are silent (off) inside the intact endocytic organelles, but can be turned on by redox activation aft

92 Likewise a cell in homeostasis contains many organelles, but none of these organelles work on their o

93 RNA genomes in novel, membrane-bounded mini-organelles, but the organization of viral proteins and R

94 NRAMP2 may act indirectly on downstream organelles by building up a cytosolic pool that is used

95 fixation occurs inside a non-membrane-bound organelle called the pyrenoid, which is found within the

96 ame cell the molecular profiles of different organelles can strongly correlate, reflecting tight coor

97 blood cells can synthesize H2S but, lacking organelles, cannot dispose of H2S via the mitochondrial

98 s, ensuring appropriate delivery of specific organelle cargoes to selected subcellular domains.

99 s of both organelle expansion and ultimately organelle closure around a particular cargo.

100 ess foci that are distinct from conventional organelles, colocalize with the ribosomal protein L22, a

101 these diverse cells and how these different organelles communicate with each other in time and space

102 mitochondria is central to metabolism, inter-organelle communication, and cell life/death decisions.

103 r of mitochondrial membrane fusion and inter-organelle communication.

104 requires the biogenesis of lysosome-related organelles complex-1 (BLOC-1) for ciliary delivery.

105 Many bacteria contain primitive organelles composed entirely of protein.

106 The high-throughput detection of organelle composition and proteomic mapping of protein e

107 It is increasingly recognized that organelle contacts have a vital role in diverse cellular

108 volumes, speeds, positions and dynamic inter-organelle contacts in live cells from a monkey fibroblas

109 The cytosol-facing membranes of cellular organelles contain proteins that enable signal transduct

110 th macromolecular complexes and intertwining organelles, continually transported and reshaped.

111 Kagan studies how organelles control innate immunity.

112 The development of 'designer' organelles could be a key strategy to enable foreign pat

113 inogen activation, decreased cell viability, organelle damage manifest by mitochondrial depolarizatio

114 uestration in mitochondria-derived vesicles, organelle degradation by mitophagy and macroautophagy, a

115 by calcium ions, leading to swelling of the organelle, disruption of the inner membrane and ATP synt

116 ain a mitochondrial reserve that affords the organelles distinct homeostatic sensing and regulatory a

117 These proteins help in organelle division, viral resistance, and mitochondrial

118 ukaryotes, including vesicle trafficking and organelle division.

119 The bacterial flagellum is a motile organelle driven by a rotary motor, and its axial portio

120 ell adhesion and transport of germ cells and organelles (e.g., residual bodies, phagosomes) across th

121 ess causes unfolded proteins to populate the organelle, eliciting the unfolded protein response.

122 eractions among six different membrane-bound organelles (endoplasmic reticulum, Golgi, lysosome, pero

123 he phagophore rim marks the progress of both organelle expansion and ultimately organelle closure aro

124 lack the Golgi apparatus (GA), an essential organelle for conventional secretory trafficking.

125 ges) have long tail structures that serve as organelles for DNA delivery to host targets.

126 Many intracellular membraneless organelles form via phase separation of intrinsically di

127 racellular membrane trafficking and specific organelle formation.

128 mes to remove protein aggregates and damaged organelles from the cytoplasm for recycling.

129 nation in plants and suggests a link between organelle functioning and plant development.

130 patibility, interactions between nuclear and organelle genomes that are proposed to be among the earl

131 ofingiensis chromosome-level nuclear genome, organelle genomes, and transcriptome from diverse growth

132 molog of ATP7A/B, localizes to lysosome-like organelles (gut granules) in the intestine under copper

133 ions between poxvirus membranes and cellular organelles has led to uncertainty regarding the origin o

134 Mitochondria organelles have small circular genomes with substantial

135 alytes in living cells, and when targeted to organelles have the potential to define distribution of

136 The primary cilium is a highly conserved organelle housing specialized molecules responsible for

137 nositide content are fundamental features of organelle identity.

138 The endoplasmic reticulum (ER) is a single organelle in eukaryotic cells that extends throughout th

139 Lipid droplet (LD), a ubiquitous organelle in mammalian cells, serves as a hub for lipid

140 sublocalization of these proteins within the organelle in most cases remains poorly defined.

141 the periplasm of bacteria to virtually every organelle in the human cell.

142 ut in fact makes dynamic contacts with these organelles in a time-dependent manner.

143 ave evolved to function as essential sensory organelles in animals.

144 At MCS, specific proteins tether the organelles in close proximity and mediate the nonvesicul

145 analyze the function of the microcompartment organelles in detail.

146 general mechanisms of dependency on plastid organelles in eukaryotes that have lost photosynthesis;

147 reported to localize to numerous subcellular organelles in heterologous expression studies, but there

148 ation; however, the functional role of these organelles in inflammatory responses of myeloid immune c

149 ation of giant lysosomes or lysosome-related organelles in several cell types.

150 artments are bacterial analogs of eukaryotic organelles in that they spatially segregate aspects of c

151 Receptors on the remaining organelles in the phloem, such as plastid, vacuole, mito

152 s) in the coral gastrodermal tissues are key organelles in the regulation of endosymbiosis and exhibi

153 recisely how it sustains itself and remodels organelles in this niche is unknown.

154 tion model for the formation of membraneless organelles in vivo by assessing the two features that co

155 tyltransferase (NAT) because it localizes to organelles, in particular the Golgi apparatus, and has a

156 Mitochondria are organelles indispensable for maintenance of cellular ene

157 tic, mechanisms for protein/lipid import and organelle inheritance during parasite replication.

158 Together, our findings unveil a role for organelle inheritance in mitosis, spindle alignment, and

159 e we present a systems-level analysis of the organelle interactome using a multispectral image acquis

160 Lipid droplets (LD) are dynamic organelles involved in intracellular lipid metabolism in

161 e in the formation of multiple membrane-less organelles involved in RNA metabolism, including stress

162 ion of the bacterial endosymbionts into cell organelles involved the massive translocation of genetic

163 lization of metabolic pathways to particular organelles is a hallmark of eukaryotic cells.

164 Correct positioning of organelles is essential to eukaryotic cells.

165 Protein homeostasis in these organelles is maintained by a proteostasis network conta

166 it traffics there and its function in these organelles is unknown.

167 he sarcoplasmic reticulum (SR), a Ca storage organelle, is critical for proper cardiac muscle functio

168 which shuttles phosphatidylinositol between organelles, is essential for platelet-mediated tumor met

169 e ACS-7, which localizes to lysosome-related organelles, is specifically required for the attachment

170 Enteric and other bacteria use subcellular organelles known as bacterial microcompartments to spati

171 accumulate many large neutral lipid storage organelles known as lipid droplets (LDs).

172 idarians, yet they have retained specialized organelles known as polar capsules, akin to the nematocy

173 which are enclosed by a plant membrane in an organelle-like structure called the symbiosome.

174 Lysosomes are membrane-bound organelles mainly involved in catabolic processes.

175 released from membrane-enclosed endocytotic organelles, mainly late endosomes (LEs).

176 opts its host cell is through hijacking host organelles, many of which have roles in immunomodulation

177 ient distribution to those of well-annotated organelle marker proteins.

178 ins were enriched in the plasma membrane and organelle membrane compartments.

179 y within submembrane compartments, different organelle membranes, and also between cells of different

180 ate in a ring at the vertex between apposing organelle membranes, the encircled area of membrane can

181 motor proteins kinesin and dynein transport organelles, mRNA, proteins, and signaling molecules alon

182 mical processes, but the activities of these organelles must be coordinated.

183 same time, like these cooperating cells and organelles, my research is constantly reshaped and trans

184 pipeline of five steps to achieve mapping of organelle numbers, volumes, speeds, positions and dynami

185 As these organelles occupy a critical position in the bioenergeti

186 The bacterial flagellum is the principal organelle of motility in bacteria.

187 Mitochondria are ATP-producing organelles of bacterial ancestry that played a key role

188 Weibel-Palade bodies (WPB) are secretory organelles of endothelial cells that undergo evoked exoc

189 ses are conserved between eubacteria and the organelles of eukaryotic cells.

190 nteract specifically with PI lipids in their organelles of residence.

191 a periplasmic flagella (PF), unique motility organelles of spirochetes, in stimulating an innate immu

192 Dr fimbriae are homopolymeric adhesive organelles of uropathogenic Escherichia coli composed of

193 malian sperm feature a specialized secretory organelle on the anterior part of the sperm nucleus, the

194 ucture and state, they can enable complexes, organelles or cytoskeletal structures to assemble around

195 protein molecules located at their different organelles or locations.

196 llular self-eating process by which unwanted organelles or proteins are delivered to lysosomes for de

197 including damaged mitochondria, other broken organelles, or pathogens for degradation to the lysosome

198 sponses in membrane dynamics may explain how organelles orderly cohabit in the crowded cytoplasm.

199 reening offers opportunities to explore this organelle organization and the gene network underlying i

200 the long-dormant endosymbiont hypothesis of organelle origins.

201 se eukaryotic algae that have photosynthetic organelles (plastids) acquired through multiple evolutio

202 Membraneless organelles play a central role in the organization of pr

203 stingly, many functions are dependent on the organelle position.

204 lobal picture of the cell is localization of organelle proteins by isotope tagging (LOPIT), which com

205 including organellar remodeling, protein and organelle quality control, prevention of genotoxic stres

206 how they are able to selectively target this organelle remains largely unknown.

207 ophagy and endocytosis pathways and supports organelle remodeling and biogenesis.

208 ochondria are multifaceted and indispensable organelles required for cell performance.

209 These processes occur in specialized organelles, requiring membrane-bound intracellular trans

210 ed reporting of dynamic maturation at single-organelle resolution over time.

211 promotes or terminates vesicle tethering to organelles, respectively.

212 ystem and also the most metabolically active organelle responsible for lipid synthesis.

213 To give insight into the organelle RNA editosome, we performed tandem affinity pu

214 Loss-of-function mutations in ORGANELLE RNA RECOGNITION MOTIF PROTEIN6 (ORRM6) result

215 distance transport of many cargos, including organelles, RNAs, proteins, and viruses, towards microtu

216 ith the sigma-1 receptor (sigma1R), an inter-organelle signaling modulator.

217 The cell wall is now recognized as a living organelle, since the composition and cellular localizati

218 tions in diseases and at different organ and organelle sites.

219 rming fluid domain to show that transport of organelle-sized particles between the cell periphery and

220 s has been advanced by live cell imaging and organelle specific analysis.

221 These organelle-specific nanovesicles revealed that one struct

222 hich we focus on selected pathways including organelle-specific regulation of jasmonate biosynthesis;

223 These interactions can transmit organelle-specific targeting or regulation information t

224 betes-induced autophagy impairment, cellular organelle stress and apoptosis, leading to an NTD reduct

225 ophagy and macroautophagy sequester specific organelles/substrates or bulk cytoplasm, respectively, i

226 the size of clusters but not on the types of organelle such as endosomes and lysosomes.

227 The hallmark of gram-negative bacteria and organelles such as mitochondria and chloroplasts is the

228 The biogenesis and maintenance of cell organelles such as mitochondria and chloroplasts require

229 ferent types of RNA editing factors in plant organelles suggests complex RNA editosomes within which

230 Organelle-targeted Ca(2+) imaging and direct patch-clamp

231 ntains cyanobacterium-derived photosynthetic organelles termed 'chromatophores' that originated relat

232 sterol ester, are stored within the cellular organelles termed lipid droplets (LDs).

233 Primary cilium is a solitary organelle that emanates from the surface of most postmit

234 Mutants of the fusome, an organelle that is known to facilitate intracyst communic

235 The endoplasmic reticulum, the cytoplasmic organelle that matures a massive amount of nascent secre

236 The primary cilium is a solitary organelle that responds to mechanical and chemical stimu

237 The bacterial flagellum is an organelle that self-assembles outside the cell body.

238 Organisms have evolved motility organelles that allow them to move to favourable habitat

239 Stress granules (SG) are membrane-less organelles that are condensates of stalled translation i

240 alities in the distribution of intracellular organelles that are correctable by pharmacological CK2 i

241 ys are sequestered in peroxisomes, conserved organelles that are essential for human and plant surviv

242 emia nuclear bodies (PML-NB) are sub-nuclear organelles that are the hub of numerous proteins.

243 ein (RNP) granules are membrane-less droplet organelles that are thought to regulate posttranscriptio

244 Nonmembrane-bound organelles that behave like liquid droplets are widespre

245 emes and rhoptries are specialized secretory organelles that deploy their contents at the apical tip

246 Mitochondria are essential cytoplasmic organelles that generate energy (ATP) by oxidative phosp

247 Primary cilia are organelles that have recently been implicated to play a

248 Mitochondria are essential organelles that host crucial metabolic pathways and prod

249 e in the formation of autophagosomes, unique organelles that replenish the cellular pool of nutrients

250 fatty acid breakdown occurs in peroxisomes, organelles that sequester oxidative reactions.

251 Mitochondria are dynamic organelles that undergo fusion and fission events.

252 nd nutrient sensing have been discovered for organelles that were once thought to be simple energy co

253 rotein or protein/nucleic acid "membraneless organelles" that regulate a host of biochemical processe

254 or proteolysis within the parasite lysosomal organelle (the vacuolar compartment or VAC) in turnover

255 lexan pathogens contain an essential plastid organelle, the apicoplast, which is a key anti-parasitic

256 of cellular self-eating by a double-membrane organelle, the autophagosome.

257 rnal turnover of a specialized membrane-rich organelle, the outer segment, which is the primary site

258 light into chemical energy occur in specific organelles, the chloroplasts.

259 Being homologous organelles, the primary cilium and the OS share common b

260 llular factors originating from the cytosol, organelles, the substrate, neighbors, and the nucleus.

261 bels on protein aggregates and dysfunctional organelles, thus promoting their autophagy-dependent deg

262 cell variations in the molecular profiles of organelles, thus providing a physiologically relevant se

263 riers transport proteins and lipids from one organelle to another, recognizing specific identifiers f

264 Viral components target subcellular organelles to access host machineries required for repli

265 cytoskeletal network compete for the moving organelles to accomplish directional transport on the cy

266 ns utilized the low-pH environment of acidic organelles to facilitate viral maturation.

267 ent DNA repair pathways are crucial in these organelles to fix damage resulting from endogenous and e

268 results indicate that autophagosomes are key organelles to help avoid C99 accumulation preventing its

269 ved in the clearance of proteins and damaged organelles to maintain intracellular homeostasis and cel

270 Intracellular pathogens manipulate host organelles to support replication within cells.

271 Molecular motors transport organelles to their proper destinations, yet little is k

272 is interaction is required to tether the two organelles together, thereby facilitating the lipid exch

273 es via retrograde signals from the disturbed organelles toward the nucleus.

274 r various physiological processes, including organelle trafficking and fusion.

275 tor neurons, suggesting that neither RNA nor organelles transfer, but mito-mCherry neurons received G

276 otic mammalian cells and serves as a sensory organelle, transmitting the mechanical and chemical cues

277 the spatial regulation of myosin V-dependent organelle transport and may reveal common mechanisms for

278 hence plays an important role in controlling organelle transport and microtubule dynamics.

279 s and degradation, membrane trafficking, and organelle transport are employed to enable the encoding

280 lso was observed in cells using an inducible organelle transport assay.

281 ations and roles in microtubule dynamics and organelle transport is not well understood.

282 or mitochondrial elimination, in which these organelles undergo Parkin-dependent sequestration into R

283 ein-1, a 1.4-MDa motor complex that traffics organelles, vesicles, and macromolecules toward microtub

284 sm as preproteins and then imported into the organelles via specialized machineries.

285 proto-Kranz" anatomy requires an increase in organelle volume in sheath cells surrounding leaf veins.

286 Increased organelle volume was accompanied by the accumulation of

287 reased and the proteolytic activity of these organelles was deranged.

288 micking the lipid compositions of eukaryotic organelles, we determined that anionic lipids, cholester

289 Mitochondria and other organelles were displaced to the periphery of vimentin a

290 e of F-actin, the sperm DNA, centrioles, and organelles were transported as a unit with the yolk gran

291 s and form membrane contact sites with other organelles, where membranes are tethered, but not fused.

292 This includes communication between organelles, which allows them to function and adapt to c

293 They regulate the release of Ca(2+) from organelles, which is important for various physiological

294 Mitochondria are essential organelles whose biogenesis, structure, and function are

295 plants showed major editing defects in both organelles with a very high PPR type specificity, indica

296 anoscopy of discrete cellular structures and organelles with high spatiotemporal resolution.

297 Mitochondria are essential organelles with numerous functions in cellular metabolis

298 ing lines show broad editing defects in both organelles, with predominant specificity for sites edite

299 er, the spatial and temporal organization of organelles within the cell remains poorly characterized,

300 contains many organelles, but none of these organelles work on their own.