ライフサイエンスコーパス: organic anion

1 ower the concentration of uric acid, another organic anion.

2 monolayer is important to the uptake of the organic anion.

3 porters and implied that it may transport an organic anion.

4 +) signals and of secretion of a fluorescent organic anion.

5 artments (e.g. kidney, olfactory mucosa) via organic anions.

6 ly diverse array of endogenous and exogenous organic anions.

7 to assist in interaction with non-bile acid organic anions.

8 ti-cancer agents and transports a variety of organic anions.

9 atment impairs the biliary excretion of some organic anions.

10 was identified as one of several fluorescent organic anions.

11 e permeability of the blood-brain barrier to organic anions.

12 ss that is distinct from that of these other organic anions.

13 ane gradients by exchange with inorganic and organic anions.

14 aired hepatocyte transport of bile acids and organic anions.

15 OAT mediates hepatobiliary clearance of many organic anions.

16 stic epithelia retain the ability to secrete organic anions.

17 lly expressed metabolites were water-soluble organic anions.

18 as previously thought to primarily transport organic anions.

19 (G 1)(16).2Ba(2+).4A(-) containing different organic anions: 2,4,6-trinitrophenolate (2), 2,6-dinitro

20 Canalicular secretion of the organic anion 5-chloromethylfluorescein diacetate (CMFDA

21 The organic anion (99m)Tc-N-[2-[(3-bromo-2,4,6-trimethylphen

22 11), phospholipids (ABCB4), and nonbile acid organic anions (ABCC2), lack initial residence in the ba

23 dent transport of bile acid and nonbile acid organic anions across the canalicular membrane.

24 (MRP1/ABCC1) extrudes a variety of drugs and organic anions across the plasma membrane.

25 in (BCRP/ABCG2) mediates efflux of drugs and organic anions across the plasma membrane.

26 ential nephrotoxicity of clinically relevant organic anion agents.

27 d marked up-regulation of orthologs of known organic anion and bile salt transporters in the kidney,

28 ucts feature strong interactions between the organic anion and both Li(+) and AlH(3).

29 cetic acids, and various other inorganic and organic anions and are investigated.

30 ferent ABC family that transports conjugated organic anions and in which sequences of the two NBDs ar

31 ium-independent, saturable, and inhibited by organic anions and steroids, including the major skate b

32 The lifetimes of organic anions and their radicals produced by reduction

33 itions, and their role in the elimination of organic anions and therapeutic drugs.

34 ession may permit urinary excretion of toxic organic anions and xenobiotics under conditions in which

35 ted in understanding how bilirubin and other organic anions are transferred from the plasma through t

36 We conclude that organic anion/base exchange is an important, potentially

37 On the other hand, organic anion binding selectivity between Oat6 and Oat1

38 es that the structure and electronics of the organic anions, bound to the assembly's periphery, are c

39 t 4 degrees C, or upon incubation with other organic anions, but not by the organic cation tetraethyl

40 at Oatp2 mediates bidirectional transport of organic anions by a GSH-sensitive facilitative diffusion

41 ritical for recognition and translocation of organic anions by a member of the organic anion transpor

42 in the handling of endogenous and exogenous organic anions by excretory and barrier tissues.

43 nisms for impaired biliary excretion of some organic anions by PB treatment: 1) PBOH-glucuronide is a

44 lay a pivotal role in the clearance of small organic anions by the kidney, yet little is known about

45 s essential for recognition and transport of organic anions by the rat organic anion transporter, rOA

46 electron localization in nitrile-substituted organic anions by utilizing time-resolved infrared detec

47 Metal-organic anion channels based on Zn10 L15 pentagonal pris

48 uch anions and was accordingly comparable to organic anion-dependent regulatory volume decreases repo

49 of surfactant-protein and surfactant-protein-organic anion deposits is proposed on the basis of these

50 ystemic detoxification and in control of the organic anion distribution in cerebrospinal fluid.

51 protein (MRP1/ABCC1), transports conjugated organic anions (e.g. leukotriene C(4)) and also co-trans

52 chromate, arsenate, pertechnetate, etc.) or organic anions (e.g., salicylate, pharmaceuticals, and t

53 Fourth, besides PAH, other organic anions effectively cis-inhibited the uptake of 1

54 C4 have been identified as key physiological organic anions effluxed by MRP1, and an ever growing bod

55 icating the presence of apical dicarboxylate/organic anion exchange.

56 tion of organic anions through dicarboxylate/organic anion exchange.

57 d cotransporter, ntcp, and the multispecific organic anion exporter, mrp2.

58 ine, and verapamil, but penicillin and other organic anions failed to produce inhibition.

59 ubstrate for Mrp2 and may compete with other organic anions for biliary excretion and 2) Mrp2 protein

60 nd efficient procedure for the extraction of organic anions from aqueous samples.

61 TP-binding cassette transporters that export organic anions from cells.

62 nsporters that mediates the apical efflux of organic anions from hepatocytes, enterocytes, and renal

63 that they were involved in hepatic uptake of organic anions from plasma.

64 try (SIMS) was used to monitor the uptake of organic anions from solution by aminoethanethiol (AET) m

65 This carrier mediates uptake of organic anions from the bloodstream in exchange for intr

66 uent reuptake will drive placental uptake of organic anions from the fetal circulation.

67 In the case of the organic anion, furosemide, loss of renal secretion in th

68 activities directed toward large amphipathic organic anions have recently been identified on the vacu

69 Secretion of organic anions, however, does not appear to contribute i

70 The transport of organic anions in proximal convoluted tubules plays an e

71 ed the levels of approximately 60 endogenous organic anions in the plasma and urine of wild-type and

72 para-aminohippuric acid (PAH), a prototypic organic anion, in a time- and concentrationdependent man

73 n fractions, designated Y and Z, which bound organic anions including bilirubin, and thus we proposed

74 ssential role in eliminating a wide range of organic anions including endogenous compounds, xenobioti

75 ssential role in eliminating a wide range of organic anions including endogenous compounds, xenobioti

76 -sensitive, and inhibited by a wide range of organic anions including vitamins, anti-hypertensive dru

77 onstrated that both endogenous and exogenous organic anions, including biliverdin, bile salts, and BS

78 nd basolateral Mrp3 mediate the excretion of organic anions, including conjugated and unconjugated xe

79 ls which are permeable to a variety of small organic anions, including the excitatory amino acids (EA

80 VRAC are permeable to small inorganic and organic anions, including the excitatory neurotransmitte

81 Measurements of permeability ratios of organic anions indicated that the lysine mutant has an i

82 The excretion of various organic anions into bile is mediated by an adenosine tri

83 rters mediate exchange whereby uptake of one organic anion is coupled to efflux of a counter-ion.

84 re first-order, the canalicular secretion of organic anions is not altered by actin disruptive agents

85 eic hepatocytes metabolize and excrete human organic anions is unclear.

86 absence of renal excretion of metabolizable organic anions, leaving only the nonmetabolizable fracti

87 the high concentrations of K(+), Na(+), and organic anions like glutamate.

88 tive and was inhibited by several conjugated organic anions (MRP1 substrates) as well as the metalloi

89 in and the alkalinizing effect of potassium (organic anions), NEAP can be predicted with confidence f

90 this study was to determine the direction of organic anion (OA) transport across the ciliary body and

91 t, although only keratinocytes expressed the organic anion organic anion transporter protein (OATP) 2

92 al for the renal excretion of the prototypic organic anion, para-aminohippurate, as well as of a larg

93 rganic anions, we find a correlation between organic anion potency (pKi) and hydrophobicity (logP) su

94 The organic anions probenecid, octanoate, and alpha-ketoglut

95 and raise the possibility that it may be an organic anion pump relevant to cellular detoxification.

96 athic cations, phospholipids, and conjugated organic anions, respectively.

97 This study examined whether organic anion secretion contributes to fluid accumulatio

98 Renal organic anion secretion has been implicated in numerous

99 anic anion transporters (OATs), the study of organic anion secretion has entered the molecular age.

100 InsP(3)R2-mediated Ca(2+) signals enhance organic anion secretion into bile by targeting Mrp2 to t

101 is a canalicular transporter responsible for organic anion secretion into bile.

102 The "classical" organic anion secretory pathway of the renal proximal tu

103 bit renal proximal tubules is limited to the organic anion secretory pathway.

104 saturating concentration of the prototypical organic anion substrate para-aminohippurate (PAH) reduce

105 x = 20.6 pmol/106 cells min), a prototypical organic anion substrate.

106 reduced or eliminated the transport of five organic anion substrates by MRP1 and abrogated the bindi

107 In contrast to organic anions, substrates for the canalicular mdr1a and

108 ransporter, rOAT3, mediates the transport of organic anions such as p-aminohippurate (PAH) and estron

109 r that mediates Na+-independent transport of organic anions such as sulfobromophthalein and taurochol

110 taurine and chenodeoxycholyltaurine) and two organic anions (sulfobromophthalein and sulfolithocholyl

111 Luminal accumulation of the fluorescent organic anions sulforhodamine 101 and fluorescein methot

112 asymmetric organic cation and inorganic (or organic) anion that loosely fit together, is extending t

113 cient in mrp2, a canalicular transporter for organic anions), the isolated perfused rat liver, and he

114 for metabolic purposes and for secretion of organic anions through dicarboxylate/organic anion excha

115 evaluate the mechanism of renal clearance of organic anions, to assess potential drug-drug interactio

116 e knock-out mice manifest a profound loss of organic anion transport (e.g. para-aminohippurate) both

117 Basolateral and canalicular bile acid and organic anion transport are markedly impaired in endotox

118 e the first demonstration that regulation of organic anion transport by mOAT is likely to be tightly

119 henotype manifested by a substantial loss of organic anion transport capacity in kidney and CP was id

120 n of genes related to metabolic pathways and organic anion transport in cKO mice compared with contro

121 inked glycosylation, significantly inhibited organic anion transport in COS-7 cells expressing a mous

122 ons of non-radioactive ALA or probenecid (an organic anion transport inhibitor) and, therefore, appea

123 ls undergoing apoptosis was inhibited by the organic anion transport inhibitors MK571, sulfinpyrazone

124 To test whether organic anion transport is coupled to HCO3- extrusion, w

125 ecent studies implicate a role in hepatocyte organic anion transport of a plasma membrane protein tha

126 rates for the bile acid and the nonbile acid organic anion transport pathways, respectively.

127 Although many organic anion transport protein (Oatp) family members ha

128 The mRNA for organic anion transport protein (oatp) was previously sh

129 membrane protein that has been termed oatp1 (organic anion transport protein 1).

130 atic transport of (99m)Tc-mebrofenin through organic anion transport protein 1a and 1b (Oatp1a/1b) an

131 enopus laevis oocytes was used to isolate an organic anion transport protein from rat kidney.

132 In summary, OATP2 is a novel organic anion transport protein that has overlapping but

133 er the expression and/or function of hepatic organic anion transport proteins.

134 a indicating that DMPS is transported by the organic anion transport system and that this transport i

135 ent data have implicated at least one of the organic anion transport systems in the basolateral uptak

136 membrane localization of choroid plexus (CP) organic anion transport were determined in apical (or br

137 e the effects of probenecid, an inhibitor of organic anion transport, on K+-evoked SD in vivo.

138 Oat3, and Oat6 appear to function largely in organic anion transport, they also bind and transport so

139 (K370A) suggested that K370 is important for organic anion transport.

140 evealed that this amino acid is required for organic anion transport.

141 oximal cysts secreted sulfonefluorescein, an organic anion transported by the PAH system.

142 n 1 (MRP1) and the canalicular multispecific organic anion transporter (cMOAT or MRP2) are ATP-bindin

143 protein (MRP) and canalicular multispecific organic anion transporter (cMOAT) are closely related ma

144 ctive in the liver canalicular multispecific organic anion transporter (cMOAT) protein.

145 protein (MRP)1 and canalicular multispecific organic anion transporter (cMOAT)/MRP2 are ATP-binding c

146 The human organic anion transporter (hOAT1) is a key component in

147 translational modification of a mouse kidney organic anion transporter (mOAT), in a mammalian cell sy

148 transport in COS-7 cells expressing a mouse organic anion transporter (mOAT1), suggesting an importa

149 In vivo studies implicate the organic anion transporter (OAT) family as a pivotal comp

150 assessment of the contributions of specific organic anion transporter (OAT) family members to detoxi

151 rate) include two "drug" transporters of the organic anion transporter (OAT) family: OAT1 (SLC22A6, o

152 organic cation transporters (OCT2 and OCT3), organic anion transporter (OAT1), and monoamine transpor

153 Human organic anion transporter 1 (hOAT1) belongs to a superfa

154 Human organic anion transporter 1 (hOAT1) plays a critical rol

155 MDCK cells transfected stably with the human organic anion transporter 1 (hOAT1), the hypothesis that

156 cell line stably transfected with the human organic anion transporter 1 (hOAT1).

157 m a human renal library and designated human organic anion transporter 1 (hOAT1).

158 to other anionic substrates, the human renal organic anion transporter 1 (hOATI) is capable of transp

159 Organic anion transporter 1 (OAT1) mediates the body dis

160 Organic anion transporter 1 (OAT1), originally identifie

161 nces the kinetic interaction of ligands with organic anion transporter 1 (OAT1).

162 entially affected by the in vivo deletion of organic anion transporter 1 (Oat1, Slc22a6, originally N

163 Importantly, both hOAT1 and rat renal organic anion transporter 1 (rROAT1) mediated saturable,

164 droxylase (Cyp7a1) and the Na(+)-independent organic anion transporter 2 (Oatp2).

165 is the major regulator of the Na+-dependent organic anion transporter 2.

166 of compound in the kidneys mediated by human organic anion transporter 3 (hOAT3) was hypothesized as

167 ried out a targeted disruption of the murine organic anion transporter 3 (Oat3) gene.

168 In this study, mice lacking organic anion transporter 3 (Oat3) had a 10 to 15% lower

169 mate 80% decrease in the expression level of organic anion transporter 3 (SLC22a8).

170 Human organic anion transporter 4 (hOAT4) belongs to a superfa

171 ) (a substrate for canalicular multispecific organic anion transporter [cMOAT]).

172 These results identify an organic anion transporter composed of a putative seven-h

173 ing is independently correlated with hepatic organic anion transporter expression.

174 ily 10 member 1 (Slc10a1) and solute carrier organic anion transporter family member (Slco) 1a1 and 1

175 rritin light chain (FTL), and solute carrier organic anion transporter family member 2B1 (SLCO2B1), i

176 the structure-function relationships of the organic anion transporter family.

177 the structure-function relationships of the organic anion transporter family.

178 ocation of organic anions by a member of the organic anion transporter family.

179 We have previously cloned a cDNA encoding an organic anion transporter from mouse kidney (mOAT).

180 These cells had organic anion transporter function.

181 nce was associated with polymorphisms in the organic anion transporter gene SLCO1B1 (P = 2.1 x 10(-11

182 Human organic anion transporter hOAT1 belongs to a superfamily

183 Human organic anion transporter hOAT1 plays critical roles in

184 a role in the functional maturation of human organic anion transporter hOAT4.

185 7-kDa membrane-associated protein; cMOAT, an organic anion transporter implicated in multidrug resist

186 inhibited in the presence of probenecid, an organic anion transporter inhibitor.

187 The organic anion transporter OAT4 (SLC22A11) and organic an

188 gnificant associations were with SNPs in the organic anion transporter polypeptide, SLCO1B1.

189 Rat organic anion transporter polypeptide1 (Oatp1) is known

190 stance-associated protein 2 (Mrp2/Abcc2), an organic anion transporter present in the apical membrane

191 tance-associated protein 2 (Mrp2, Abcc2), an organic anion transporter present in the apical membrane

192 odium taurocholate cotransporter protein and organic anion transporter protein 1.

193 selectively taken up by a sodium-independent organic anion transporter protein-1B1 (OATP1B1) exclusiv

194 trolled by URAT1 (SLC22A12), a member of the organic anion transporter superfamily.

195 oatp1 is an hepatic sinusoidal organic anion transporter that mediates uptake of variou

196 ase in the expression of rOat2 (Slc22a7), an organic anion transporter that regulates, in part, the t

197 taurocholate cotransporter and multispecific organic anion transporter were more profoundly diminishe

198 substrates for the canalicular multispecific organic anion transporter whose activity has recently be

199 closely related to MRP, cMOAT, and the yeast organic anion transporter YCF1.

200 +) taurocholate cotransporter, multispecific organic anion transporter, and P-glycoprotein) were also

201 ferences and transport function of olfactory organic anion transporter, Oat6, in comparison with the

202 The rat organic anion transporter, rOAT3, mediates the transport

203 n and transport of organic anions by the rat organic anion transporter, rOAT3.

204 ids are substrates for the renal basolateral organic anion transporter-1 (Oat1) from rat kidney.

205 Notably, organic anion transporter-1 (OAT1) knockout mice express

206 Organic anion transporter-1 (OAT1) mediates the body dis

207 Organic anion transporter-1 (OAT1) mediates the body's d

208 nd non-steroidal anti-inflammatory drugs) is organic anion transporter-1 (OAT1), originally identifie

209 MDCK cells that were transfected with human organic anion transporter-1 were used.

210 c2), the principal canalicular multispecific organic anion transporter.

211 acids is an important function of the renal organic anion transporter.

212 inated by its interaction with the classical organic anion transporter.

213 s was effectively limited to the "classical" organic anion transporter.

214 mal tubule cells by the basolateral membrane organic anion transporters (Oat) 1 and Oat3.

215 Renal organic anion transporters (OAT) are known to mediate th

216 Organic anion transporters (OAT) play essential roles in

217 Organic anion transporters (OATs) and organic cation tra

218 Organic anion transporters (OATs) are believed to mediat

219 Organic anion transporters (Oats) are located in the bar

220 min, fatty acid binding proteins (FABPs) and organic anion transporters (OATs) have been identified a

221 Studies of the organic anion transporters (Oats) have focused mainly on

222 Given the selective expression of organic anion transporters (OATs) in renal proximal tubu

223 luding the proximal tubule-specific drug and organic anion transporters (OATs) OAT1 (SLC22a6) and OAT

224 Organic anion transporters (OATs) play a critical role i

225 Organic anion transporters (OATs) play a pivotal role in

226 With the cloning of multiple genes encoding organic anion transporters (OATs), the study of organic

227 s are secreted by the recently characterized organic anion transporters (OATs), which are expressed i

228 Organic anion transporters (OATs, SLC21) are important i

229 Organic anion transporters (OATs, SLC22) interact with a

230 uggests the presence of distinctly different organic anion transporters for the efflux of VPA at the

231 In contrast to the organic anion transporters identified to date, a transpo

232 Organic anion transporters in the kidney proximal tubule

233 ne of direct evidence implicating one of the organic anion transporters in the uptake of a mercuric c

234 city, and circumstantial evidence implicates organic anion transporters in these processes.

235 The organic anion transporters OAT1 (SLC22A6) and OAT3 (SLC2

236 The organic anion transporters OAT1 (SLC22A6, originally ide

237 Organic anion transporters play an essential role in eli

238 , as well as organic cation transporters and organic anion transporters Slc22a1 (Oct1), Slc22a2 (Oct2

239 The mechanisms that target organic anion transporters to different domains of the i

240 ransporter hOAT1 belongs to a superfamily of organic anion transporters, which play critical roles in

241 porter 1 (hOAT1) belongs to a superfamily of organic anion transporters, which play critical roles in

242 er fatty acid binding proteins (L-FABP), and organic anion transporters--determine the distribution,

243 ; 3) mRNA expression of hepatic transporters organic anion transporting polypeptide (Oatp) 1a1, Oatp1

244 Human organic anion transporting polypeptide (OATP) 1B1 and so

245 s for active liver uptake via members of the organic anion transporting polypeptide (OATP) family.

246 Organic anion transporting polypeptide (oatp) is an inte

247 kinetics were determined in wild-type (WT), organic anion transporting polypeptide (OATP) knockout m

248 Here, we investigated the role of organic anion transporting polypeptide (OATP) transporte

249 ispecific transporters, such as those of the organic anion transporting polypeptide (OATP, SLC21) and

250 Several members of the organic anion transporting polypeptide (OATP/Oatp) famil

251 n addition, protein mass and function of the organic anion transporting polypeptide (Oatp1), another

252 possibly due to the presence of T4-selective organic anion transporting polypeptide (OATP1C1).

253 Organic anion transporting polypeptide 1B3 (OATP1B3, SLC

254 Organic anion transporting polypeptide 2 (Oatp2) mRNA wa

255 ion of the basolateral membrane transporter, organic anion transporting polypeptide 2 (Oatp2), was no

256 The rat organic anion transporting polypeptide 2 (oatp2; Slc21a5

257 Human organic anion transporting polypeptide 2B1 (OATP2B1) is

258 Organic anion transporting polypeptide 4 (Oatp4; Slc21a1

259 on of mice with a targeted disruption of the organic anion transporting polypeptide Oatp1b2.

260 Organic anion transporting polypeptide OATP1B3 is a memb

261 rganic anion transporter OAT4 (SLC22A11) and organic anion transporting polypeptide OATP2B1 (SLCO2B1)

262 ilum specifically up-regulates I. scapularis organic anion transporting polypeptide, isoatp4056 and k

263 The human organic anion transporting polypeptide-C (OATP-C) (gene

264 Human organic anion transporting polypeptides (OATP) 1B1 and 1

265 Organic anion transporting polypeptides (Oatp) are trans

266 The hepatic organic anion transporting polypeptides (OATPs) influenc

267 ), multidrug resistance protein 1 (mrp1) and organic anion transporting polypeptides (oatps).

268 lt export pump (Bsep), and the expression of organic anion transporting polypeptides 1 and 2 (Oatp1 a

269 omplete and simultaneous deficiencies of the organic anion transporting polypeptides OATP1B1 and OATP

270 The organic anion transporting polypeptides, Oatp1 (Slc21a1)

271 Rat organic anion transporting protein 1a1 (oatp1a1), a hepa

272 describe here a gene reporter, based on the organic anion transporting protein Oatp1a1, which mediat

273 conjugated bile salts, a process mediated by organic anion-transporting polypeptide (OATP) 1B2.

274 Human organic anion-transporting polypeptide (OATP) 2B1 (OATP-

275 The organic anion-transporting polypeptide (OATP/Oatp) super

276 sion of the hepatic anion uptake transporter organic anion-transporting polypeptide 1A1 (Oatp1a1), th

277 Organic anion-transporting polypeptide 1A2 (OATP1A2) (ge

278 Organic anion-transporting polypeptide 1A2 (OATP1A2) is

279 The organic anion-transporting polypeptide 1b family (Oatp1b

280 inhibition of the hepatic transport proteins organic anion-transporting polypeptide 1B1 (OATP1B1) and

281 Ugt1a1), sulfotransferase 2a1 (Sult2a1), and organic anion-transporting polypeptide 2 (Oatp2) in live

282 ation of agonist-stimulated platelets via an organic anion-transporting polypeptide and is retained i

283 idrug resistance protein (ABCC/MRP), and the organic anion-transporting polypeptide protein (SLCO/OAT

284 ide polymorphism in the SLCO1B1 gene for the organic anion-transporting polypeptide that regulates st

285 ines expressed comparable MRP and OATP/SLCO (organic anion-transporting polypeptide) mRNA levels, and

286 Organic anion-transporting polypeptides (OATP) 1B1 and 1

287 Organic anion-transporting polypeptides (OATPs) mediate

288 hepatic disposition are OATP1B1 and OATP1B3 (organic anion-transporting polypeptides 1B1 and 1B3, res

289 The organic anion-transporting polypeptides represent an imp

290 us studies in rat hepatocytes suggested that organic anion uptake is associated with base exchange.

291 loss was paralleled by the activation of an organic anion uptake process, supporting the role of an

292 characterize the mechanism of oatp-mediated organic anion uptake, we examined transport of taurochol

293 g Oat3 does not play a major role in hepatic organic anion uptake.

294 Secretion may be inhibited by retained organic anions, urate, or acidosis.

295 No apparent transport of organic anions was observed.

296 Sodium-independent transport of organic anions was reduced by 40%-55%.

297 ansporters with over 40 structurally diverse organic anions, we find a correlation between organic an

298 In addition, small organic anions were tested as inhibitors.

299 membrane and transports structurally diverse organic anions with a wide spectrum of pH sensitivities.

300 dation for activation of persulfate by other organic anions without the toxicity of phenols, such as