ライフサイエンスコーパス: organic cation

1 ddition of an aqueous solution containing an organic cation.

2 on-phonon coupling to phonons located on the organic cation.

3 he receptor pore permeable to NMDG+, a large organic cation.

4 rganic solar absorber based on a photoactive organic cation.

5 quaternary or primary nature of the cobound organic cation.

6 ons of ionic interactions to the sorption of organic cations.

7 s; both are characteristic of highly charged organic cations.

8 s but lost their transport activities toward organic cations.

9 transport, they also bind and transport some organic cations.

10 tively charged silica surface and a layer of organic cations.

11 the I(2) state that is readily permeable to organic cations.

12 ing anions, sugars, purines, amino acids and organic cations.

13 ange of both simple and complex metallic and organic cations.

14 cations, soluble polycations and amphipathic organic cations.

15 thiamine transport is not inhibited by other organic cations.

16 mediates the transport of a wide spectrum of organic cations.

17 inusoidal uptake of endogenous and exogenous organic cations.

18 ery and for environmental risk assessment of organic cations.

19 of alternating inorganic TiS2 monolayers and organic cations.

20 li cations and are permeable also to several organic cations.

21 y to various reported soil sorption data for organic cations.

22 he large cavities contain pairs of the bulky organic cations.

23 onic neurotoxins and other potentially toxic organic cations.

24 n absorption, distribution, and excretion of organic cations.

25 inhibition hampers the release of the toxic organic cation 1-methyl-4-phenylpyridinium from astrocyt

26 mperature-dependent uptake of the quaternary organic cation [14C]-tetraethylammonium ([14C]-TEA), wit

27 However, decynium-22 (600 mug kg(-1) ), an organic cation 3 transporter (OCT3)/plasma membrane mono

28 he cRNA of hOCT1, the specific uptake of the organic cation 3H-1-methyl-4-phenylpyridinium (3H-MPP+)

29 ct1/Slc22a1-injected oocytes transported the organic cations [3H]-1-methyl-4-phenylpyridium and [3H]-

30 central role in mediating renal secretion of organic cations, a structurally diverse collection of co

31 erovskites and the templating effects of the organic cations allow for fine structural control of the

32 MRP4 or MRP5, replacement of bath Na(+) with organic cations also hyperpolarized the cell membranes a

33 human transporter families, most notably the organic cation and anion transporters of the solute carr

34 sport proteins, in particular with mammalian organic cation and anion transporters.

35 nt, which is composed of a large, asymmetric organic cation and inorganic (or organic) anion that loo

36 Describing organic cation and zwitterion interaction with dissolved

37 this study, sorption of a diverse set of 12 organic cations and 8 neutral aromatic solutes on two po

38 Experiments with large organic cations and anions showed that cation permeation

39 for the canalicular mdr1a and b are usually organic cations and are often sequestered in high concen

40 enter the I(2) state, which is permeable to organic cations and dye molecules.

41 This trend for competition between organic cations and exchangeable inorganic cations is co

42 e selectivity filter, and also permits large organic cations and inactivation peptides to enter the p

43 entified for the mode of association between organic cations and polar species in solution.

44 ic agents and xenobiotics, many of which are organic cations and substrates of the organic cation tra

45 lar permeability to monovalent inorganic and organic cations and to divalent cations but not to anion

46 ation-dependent binding of relatively large, organic cations and zwitterions (viz., the antibiotics c

47 ynamics, up to partial immobilization of the organic cation, are observed in the mixed MAPb(ClxBr1-x)

48 With available alkaline, alkaline earth, and organic cations as partners, four series of 5-nitrotetra

49 ls of known molecular composition with large organic cations as probes.

50 ead reflect the involvement of more unstable organic cations at their transition states.

51 id-water sorption coefficients (Kd) for four organic cations (benzylamine, 2,4-dichlorobenzylamine, p

52 The metal ion/organic cation binding properties of the newly synthesiz

53 In contrast, 1.5 mM tetraethylammonium, an organic cation, blocked uptake of 1 microM OTA by only 7

54 orting 1-methyl-4-phenylpyridinium (MPP+, an organic cation) but not uridine (a nucleoside), suggesti

55 of both agents was inhibited by a variety of organic cations, but the pattern of inhibition was diffe

56 s [PbBr4 (2-)]infinity are surrounded by the organic cations C4N2H14 (2+) to form the bulk assembly o

57 The organic cations can be completely exchanged with sodium

58 Toxic organic cations can damage nigrostriatal dopaminergic pa

59 transport was competitively inhibited by the organic cations carnitine, diphenhydramine, and verapami

60 transporters, confirming that defects in the organic cation/carnitine transporter OCTN2 are responsib

61 OCTN2 is an organic cation/carnitine transporter that is responsible

62 is condition maps to 5q31.2-32 and OCTN2, an organic cation/carnitine transporter, also maps to the s

63 vel organic cation transporter (OCTN2) is an organic cation/carnitine transporter, and two missense m

64 Na+, Cs+ and, to a lesser degree, the organic cation choline served as charge carriers, but Cl

65 metal nuclearity concomitant with increasing organic cation contribution supports the hypothesis that

66 Apart from TEA, the organic cations did not block from the outside.

67 ADP.3Na(+) structure indicated that 1) bound organic cations differentially distorted the ion binding

68 These findings suggest that the organic cation, DNR, is largely sequestered in cells suc

69 TEA uptake was inhibited by several other organic cation drugs, but was not inhibited by the organ

70 monium and N1-methylnicotinamide and bulkier organic cations (e.g., vecuronium and decynium-22) inhib

71 ), Hg(2+), and a large, synthesized divalent organic cation, ((Et)(3)N)(2)Bu(2+).

72 The divalent organic cation, ethyl diamine, inhibited PMCA but was no

73 Though highly selective organic cation exchange resins have been developed for m

74 Consistently, the organic cations exhibited little to no antagonism to cyt

75 o(III)(+) or Cp(*)2Co(+)] as an ultra-stable organic cation for polymer HEMs.

76 ased on the binding affinities of the tested organic cations for Oat3 was generated.

77 Polyamines are small organic cations found in all cells, and the biosynthetic

78 transporter that mediates the uptake of many organic cations from the blood into the liver where the

79 lium, consistent with a role of transporting organic cations from the CSF into CP epithelial cells.

80 tion of a metal cation and even of the large organic cation guanidinium, reminiscent of Shaker's omeg

81 nous organic cations, including two distinct organic cation:H+ exchanges and a separate carrier-media

82 bI3 is an all-inorganic analog to the hybrid organic cation halide perovskites, but the cubic phase o

83 CP, but its specific role in CP transport of organic cations has not been clearly defined.

84 ize-tunable, ion-exchangeable extraframework organic cations have been prepared.

85 cells (AFCs); however, the commonly employed organic cations have limited alkaline stability.

86 which transports amino acids, polyamines and organic cations in a multitude of biological roles, incl

87 natural mutation abolished the transport of organic cations in addition to carnitine.

88 us a potentially relevant sorption phase for organic cations in many soils.

89 s still debated, with the role played by the organic cations in the light-harvesting process remainin

90 diating both epithelial uptake and efflux of organic cations in the secretory cells of salivary gland

91 ransporter that transports a wide variety of organic cations including biogenic amines, cationic drug

92 bidirectional, multispecific transporters of organic cations (including 5-HT, dopamine, and norepinep

93 c exchange ions, sorption coefficients of 10 organic cations (including eight pharmaceuticals and two

94 e, dehydroascorbic acid, alditols) and small organic cations (including polyamines) also lacked consi

95 1 microM) and was inhibited significantly by organic cations, including cimetidine and N1-methylnicot

96 racts with a variety of structurally diverse organic cations, including clinically used drugs as well

97 wide enough to allow the permeation of large organic cations, including natural ones.

98 ansport process recognizes a large number of organic cations, including the neurotoxin 1-methyl-4-phe

99 inusoidal uptake of endogenous and exogenous organic cations, including two distinct organic cation:H

100 annel decreased as the ionic diameter of the organic cation increased.

101 lar dynamics simulations indicate that bound organic cations induce minor distortion of the binding s

102 Hepatic uptake of organic cations is essential for the metabolism and secr

103 d on how similar the charge density in these organic cations is to that in the proton removed.

104 Certain inorganic and organic cations known to activate the Ca2+ receptor were

105 er of inorganic atomic layers in between the organic cation layers.

106 The organic cations (MA(+)) interact with Au atoms, forming

107 cholesterol on the molecular transport of an organic cation, malachite green (MG), across large unila

108 These findings suggest that amino acids and organic cations may interact with the transporter throug

109 mains (TM) 1-6, and interaction of PMAT with organic cations may involve aromatic residues.

110 Previous reports have shown that the organic cations methylamine, dimethylamine, ethylamine,

111 of band-edge charge carriers by rotation of organic cation molecules can be a major contribution to

112 pertaining to the lead-halide framework and organic cation motions, respectively.

113 T3-R454DK370A preferentially transported the organic cation, MPP(+), in comparison to PAH (MPP(+) upt

114 c cation drugs, but was not inhibited by the organic cation n-methyl-nicotinamide (NMN), being instea

115 First, we compared the permeation of organic cations of different sizes.

116 Organic cations of increasing size were used as current

117 The impact of intercalated organic cations on the diffusion dominated mass transpor

118 The effects of three classes of organic cations on the inhibition of the plasma membrane

119 tial replacement of extracellular Na(+) with organic cations or sucrose induced a rapid and reversibl

120 22 subfamily members (including those of the organic cation, organic carnitine, and unknown substrate

121 determinant of inorganic ion selectivity and organic cation permeation.

122 e-evolution behavior of FA1-x MAx PbI3 mixed-organic-cation perovskite (MOCP) is studied.

123 ofen, were not removed from water, while the organic cation propranolol showed biouptake similar to t

124 the inorganic layers and then stabilized by organic cations, providing n-type carriers for current a

125 s shown that the mechanism of melting of the organic cation regenerated bR is different than for the

126 1575A had negligible effects on inorganic or organic cation selectivity and block by tetrodotoxin (TT

127 Our data on ion-exchange affinities for 80 organic cations show many examples where specific chemic

128 al k(IAM) values presented in this study for organic cations show that the net IAM surface charge is

129 re is a need for robust predictive models of organic cation sorption coefficients (Kd).

130 Organic cation sorption coefficients exhibited consisten

131 f natural exchange ions in the prediction of organic cation sorption coefficients for environmental s

132 To better understand how organic cation sorption is influenced by surface-associa

133 tography was evaluated as a method to obtain organic cation sorption isotherms for environmental soli

134 identity and abundance for the prediction of organic cation sorption to soils and soil minerals.

135 actors derived from this literature model of organic cation sorption, along with phenyltrimethylammon

136 s indispensable for optimal interaction with organic cation substrates.

137 ated transport of four structurally distinct organic cation substrates: the commonly used drugs: 1) m

138 We also demonstrate that mOat3 transports organic cations such as 1-methyl-4-phenylpyridinium and

139 Both small monovalent organic cations such as tetraethylammonium and N1-methyl

140 ntly show that the presence of intracellular organic cations (such as n-methyl-D-glucamine) induces a

141 For each organic cation tested, the currents were inhibited by ga

142 ters retained their ability to transport the organic cation tetraethylammonium indicating that their

143 on with other organic anions, but not by the organic cation tetraethylammonium, by the multidrug resi

144 e endogenous substrate (l-carnitine) and the organic cation tetraethylammonium, three variants showed

145 The prototype for organic cations tetraethylammonium (TEA) was also transp

146 Unexpectedly, also the organic cations Tetraethylammonium and Acetylcholine wer

147 The latter is an organic cation that combines the properties of good solu

148 The polyamines are small organic cations that are absolutely required for eukaryo

149 The amino acid-derived polyamines are organic cations that are essential for growth in all mam

150 r study showed that PMAT interacts with many organic cations that have heterogeneous chemical structu

151 toberberines represent a structural class of organic cations that induce topoisomerase I-mediated DNA

152 any endogenous compounds and xenobiotics are organic cations that rely on polyspecific organic cation

153 As an organic cation, the binding of methonium to protein rece

154 Even though thiamine is an organic cation, the cDNA-induced thiamine transport is n

155 or by physically gating the pores with large organic cations, thus demonstrating how metal-organic fr

156 yish soils, the model shows that sorption of organic cations to clay minerals accounts for more than

157 The sorption data for organic cations to clay showed several regular trends wi

158 n of Kd values for more structurally complex organic cations to homoionic montmorillonites and to het

159 expression assays, we have tested binding of organic cations to Oat1 and Oat3 in ex vivo assays by an

160 -exchange model that defines the sorption of organic cations to soil as a summed contribution of sorp

161 Sorption of organic cations to soil organic matter was studied using

162 We use organic cations to template the solution-state assembly

163 imated by fitting relative permeabilities of organic cations to the Renkin equation, was 0.41 nm.

164 from the ability of ACh, over that of other organic cations, to trigger the subsequent channel-openi

165 arge at Glu(206) (E206Q) resulted in loss of organic cation transport activity, whereas conserving th

166 h phenylalanine or tryptophan fully restored organic cation transport activity.

167 Pump-mediated K(+)-like organic cation transport challenges the concept of rigid

168 on the carnitine transport function and the organic cation transport function of OCTN2.

169 f these mutations may not interfere with the organic cation transport function.

170 rt function but significantly stimulated the organic cation transport function.

171 st to our understanding of the mechanisms of organic cation transport in rat liver, little is known a

172 ul tool for elucidation of the mechanisms of organic cation transport in the human liver and understa

173 ver, little is known about the mechanisms of organic cation transport in the human liver.

174 cation transporter, which may play a role in organic cation transport in vivo.

175 rnitine transport is Na(+)-dependent whereas organic cation transport is Na(+)-independent, we invest

176 d rat and human organic cation transporters, organic cation transport kinetics differed markedly.

177 A carrier-mediated organic cation transport process appears to exist in the

178 etylcholine, but not by substrates for other organic cation transport processes identified in blLPM v

179 ed that the carnitine transport site and the organic cation transport site were not identical.

180 In peripheral tissues, organic cation transport via some OCTs is inhibited by c

181 eft and contributes to forming a pathway for organic cation transport.

182 e interaction with the human ortholog of the organic cation transporter (hOCT1).

183 other multidrug transporters, including the organic cation transporter (OCT) 2, is influenced by the

184 To determine whether organic cation transporter (OCT) family members might me

185 catinib resembles the pharmacophore of known organic cation transporter (OCT) inhibitors and reduced

186 encode proteins with similarity to mammalian organic cation transporter (OCT) proteins.

187 s actively transported into the liver by the organic cation transporter (OCT)1 (encoded by SLC22A1).

188 cleotide polymorphisms (SNPs) mapping to the organic cation transporter (OCTN) genes, SLC22A4 and SLC

189 Novel organic cation transporter (OCTN2) is an organic cation/

190 In the rat organic cation transporter (rOct1), voltage- and ligand-

191 sence of a functional, alternatively spliced organic cation transporter (rOCT1A) in rat kidney.

192 ing the hypothesis that genetic variation in organic cation transporter 1 (OCT1) affects the response

193 ized that reduced transport of metformin via organic cation transporter 1 (OCT1) could increase metfo

194 Organic cation transporter 1 (OCT1) plays a critical rol

195 Organic cation transporter 1 (OCT1) plays a role in the

196 ch are organic cations and substrates of the organic cation transporter 1 (Oct1, Slc22a1).

197 olymorphism (SNP) mapping to intron 1 of the organic cation transporter 1 (OCTN1; SLC22A4) gene was a

198 We found that the organic cation transporter 2 (OCT2) is expressed on dors

199 pounds were found to be potent inhibitors of organic cation transporter 2 (OCT2), which contributes t

200 C content, and muscle carnitine transporter [organic cation transporter 2 (OCTN2)] messenger RNA and

201 This transporter, known as OCTN2 (novel organic cation transporter 2), is expressed in most tiss

202 Organic cation transporter 3 (OCT3) is a high-capacity,

203 The organic cation transporter 3 (OCT3) is emerging as an im

204 Here, we show that the organic cation transporter 3 (Oct3) is expressed in nond

205 duced blockade of dopamine clearance via the organic cation transporter 3 (OCT3).

206 Organic cation transporter 3 (OCT3, SLC22A3) is a polysp

207 on to DAT, PQ(+) is also a substrate for the organic cation transporter 3 (Oct3, Slc22a3), which is a

208 Expression of organic cation transporter 3, a corticosterone-sensitive

209 ne, Solute Carrier DmSLC22A, a member of the organic cation transporter family, enhances olfactory me

210 substrate for the known members of mammalian organic cation transporter family.

211 acterization of the first human polyspecific organic cation transporter from liver (hOCT1).

212 s) is 78% identical to the previously cloned organic cation transporter from rat, rOCT1.

213 noamine transporter (PMAT) is a polyspecific organic cation transporter in the solute carrier 29 (SLC

214 The presence of organic cation transporter inhibitors also does not sign

215 nthetic constructs suggest that a functional organic cation transporter is encoded by the larger open

216 by mutations in the Na+-dependent carnitine/organic cation transporter OCTN2.

217 porter (PMAT, SLC29A4) is a new polyspecific organic cation transporter that transports a wide variet

218 Here we demonstrate that expression of the organic cation transporter type 3 (OCT3, SLC22A3), which

219 "extraneuronal monoamine transporter," and "organic cation transporter type-3."

220 Oct1/Slc22a1 encodes for a hepatic and renal organic cation transporter which may be important for th

221 This potential-sensitive organic cation transporter, designated as OCT3, represen

222 protein-altering variants of the human liver organic cation transporter, OCT1, in Xenopus oocytes.

223 The organic cation transporter, OCT1, is a major hepatic tra

224 The organic cation transporter, OCT2, plays a role in renal

225 is caused by mutations in the Na+-dependent organic cation transporter, OCTN2.

226 Originally described as a monoamine/organic cation transporter, we found that both human and

227 ude that PMAT can function as a polyspecific organic cation transporter, which may play a role in org

228 could be attributed to the presence of human organic cation transporter-1 (hOCT1) single nucleotide p

229 hat express two point mutations of the human organic cation transporter-1 (hOCT1), R488M and G465R, h

230 Down-regulation of SLC22A1 encoding the organic cation transporter-1 (OCT1) may affect the respo

231 .001) and expression of the molecular human organic cation transporter-1 (RR, 1.79; P = .038) as the

232 t deterioration in tubule membrane function (organic cation transporter-1 transport activity) was obs

233 glands selectively and highly express OCT3 (organic cation transporter-3), a polyspecific drug trans

234 these alternative transcripts has been named Organic cation transporter-like (Orct).

235 rters; hence, we designate this gene ORCTL2 (organic cation transporter-like 2).

236 1-3, PMAT mainly functions as a polyspecific organic cation transporter.

237 Organic cation transporters (OCT), including multidrug a

238 orter is distinct from the previously cloned organic cation transporters (OCT1, OCT2, NKT, NLT, RST,

239 The activities of exogenous organic cation transporters (OCT2 and OCT3), organic ani

240 pacity transporters for 5-HT in brain [i.e., organic cation transporters (OCTs) and plasma membrane m

241 Organic cation transporters (OCTs) are involved in the r

242 Organic cation transporters (OCTs) are members of the so

243 Organic cation transporters (OCTs) in the kidney proxima

244 Organic anion transporters (OATs) and organic cation transporters (OCTs) mediate the flux of x

245 re organic cations that rely on polyspecific organic cation transporters (OCTs) to traverse cell memb

246 KT, since the Oats share close homology with organic cation transporters (Octs), it is possible that

247 We initially found that organic cation transporters (OCTs), uptake carriers of m

248 fluid by acting on corticosterone-sensitive organic cation transporters (OCTs).

249 able to the inhibition of 5-HT transport via organic cation transporters (OCTs).

250 rough the action of corticosterone-sensitive organic cation transporters (OCTs).

251 etformin uptake depends on the expression of organic cation transporters (OCTs).

252 Recently, two organic cation transporters (rOCT1 and rOCT2) were clone

253 Both groups had increased organic cation transporters (SLC22A4 and SLC16A9) activi

254 Recently the clinical importance of human organic cation transporters 1 (hOCT1/SLC22A1) and 2 (hOC

255 This compound is an excellent substrate for organic cation transporters 1 and 2, also designated SLC

256 thers Fmo1, Cyp2d2, Cyp2d4, Nqo2, as well as organic cation transporters and organic anion transporte

257 Organic cation transporters are membrane potential-depen

258 Several hepatic organic cation transporters have been kinetically define

259 Polyspecific organic cation transporters in the liver mediate the eli

260 Polyspecific organic cation transporters in the renal proximal tubule

261 dopamine transporter (DAT) and polyspecific organic cation transporters OCT-1 and OCT-3.

262 Organic cation transporters play a critical role in the

263 to cells, Glc-Pt 1 exploits both glucose and organic cation transporters, both widely overexpressed i

264 omologous to previously cloned rat and human organic cation transporters, organic cation transport ki

265 s a critical role in binding of substrate to organic cation transporters.

266 endothelium is non-vesicular and occurs via organic cation transporters.

267 lap in substrate specificity between the two organic cation transporters.

268 ript indicated homology to integral membrane organic cation transporters; hence, we designate this ge

269 ontribution supports the hypothesis that the organic cations used in the synthesis play an important

270 (SOM) has been studied for a wide variety of organic cations using a flow through method with fully a

271 onite has been studied for a wide variety of organic cations using a flow-through method with fully a

272 f PMAT with a series of structurally diverse organic cations using MDCK cells stably expressing human

273 consisted of the clay framework, interlayer organic cation, water, and organic sorbate.

274 The recognition properties toward various organic cations were also determined.

275 In the simulations, organic cations were intercalated and benzene molecules

276 The weak permeabilities to organic cations were resolved by looking at inward tails

277 Large RyR-permeable organic cations were used to interfere with Ca(2+) condu

278 dilates, making the cell permeable to large organic cations, which eventually leads to cell death.

279 Methonium (N(+)Me3) is an organic cation widely distributed in biological systems.

280 ction factors were derived from the data for organic cations with polar functional groups.

281 lead-halide perovskite absorbers RPbX3 (R = organic cation; X = Br(-) or I(-)), the toxicity of lead