ライフサイエンスコーパス: organic cation transporter

1 1-3, PMAT mainly functions as a polyspecific organic cation transporter.

2 lap in substrate specificity between the two organic cation transporters.

3 endothelium is non-vesicular and occurs via organic cation transporters.

4 s a critical role in binding of substrate to organic cation transporters.

5 ing the hypothesis that genetic variation in organic cation transporter 1 (OCT1) affects the response

6 ized that reduced transport of metformin via organic cation transporter 1 (OCT1) could increase metfo

7 Organic cation transporter 1 (OCT1) plays a critical rol

8 Organic cation transporter 1 (OCT1) plays a role in the

9 ch are organic cations and substrates of the organic cation transporter 1 (Oct1, Slc22a1).

10 olymorphism (SNP) mapping to intron 1 of the organic cation transporter 1 (OCTN1; SLC22A4) gene was a

11 Recently the clinical importance of human organic cation transporters 1 (hOCT1/SLC22A1) and 2 (hOC

12 This compound is an excellent substrate for organic cation transporters 1 and 2, also designated SLC

13 could be attributed to the presence of human organic cation transporter-1 (hOCT1) single nucleotide p

14 hat express two point mutations of the human organic cation transporter-1 (hOCT1), R488M and G465R, h

15 Down-regulation of SLC22A1 encoding the organic cation transporter-1 (OCT1) may affect the respo

16 .001) and expression of the molecular human organic cation transporter-1 (RR, 1.79; P = .038) as the

17 t deterioration in tubule membrane function (organic cation transporter-1 transport activity) was obs

18 We found that the organic cation transporter 2 (OCT2) is expressed on dors

19 pounds were found to be potent inhibitors of organic cation transporter 2 (OCT2), which contributes t

20 C content, and muscle carnitine transporter [organic cation transporter 2 (OCTN2)] messenger RNA and

21 This transporter, known as OCTN2 (novel organic cation transporter 2), is expressed in most tiss

22 Organic cation transporter 3 (OCT3) is a high-capacity,

23 The organic cation transporter 3 (OCT3) is emerging as an im

24 Here, we show that the organic cation transporter 3 (Oct3) is expressed in nond

25 duced blockade of dopamine clearance via the organic cation transporter 3 (OCT3).

26 Organic cation transporter 3 (OCT3, SLC22A3) is a polysp

27 on to DAT, PQ(+) is also a substrate for the organic cation transporter 3 (Oct3, Slc22a3), which is a

28 Expression of organic cation transporter 3, a corticosterone-sensitive

29 glands selectively and highly express OCT3 (organic cation transporter-3), a polyspecific drug trans

30 thers Fmo1, Cyp2d2, Cyp2d4, Nqo2, as well as organic cation transporters and organic anion transporte

31 Organic cation transporters are membrane potential-depen

32 to cells, Glc-Pt 1 exploits both glucose and organic cation transporters, both widely overexpressed i

33 This potential-sensitive organic cation transporter, designated as OCT3, represen

34 ne, Solute Carrier DmSLC22A, a member of the organic cation transporter family, enhances olfactory me

35 substrate for the known members of mammalian organic cation transporter family.

36 acterization of the first human polyspecific organic cation transporter from liver (hOCT1).

37 s) is 78% identical to the previously cloned organic cation transporter from rat, rOCT1.

38 Several hepatic organic cation transporters have been kinetically define

39 ript indicated homology to integral membrane organic cation transporters; hence, we designate this ge

40 e interaction with the human ortholog of the organic cation transporter (hOCT1).

41 noamine transporter (PMAT) is a polyspecific organic cation transporter in the solute carrier 29 (SLC

42 Polyspecific organic cation transporters in the liver mediate the eli

43 Polyspecific organic cation transporters in the renal proximal tubule

44 The presence of organic cation transporter inhibitors also does not sign

45 nthetic constructs suggest that a functional organic cation transporter is encoded by the larger open

46 these alternative transcripts has been named Organic cation transporter-like (Orct).

47 rters; hence, we designate this gene ORCTL2 (organic cation transporter-like 2).

48 dopamine transporter (DAT) and polyspecific organic cation transporters OCT-1 and OCT-3.

49 other multidrug transporters, including the organic cation transporter (OCT) 2, is influenced by the

50 To determine whether organic cation transporter (OCT) family members might me

51 catinib resembles the pharmacophore of known organic cation transporter (OCT) inhibitors and reduced

52 encode proteins with similarity to mammalian organic cation transporter (OCT) proteins.

53 s actively transported into the liver by the organic cation transporter (OCT)1 (encoded by SLC22A1).

54 Organic cation transporters (OCT), including multidrug a

55 orter is distinct from the previously cloned organic cation transporters (OCT1, OCT2, NKT, NLT, RST,

56 protein-altering variants of the human liver organic cation transporter, OCT1, in Xenopus oocytes.

57 The organic cation transporter, OCT1, is a major hepatic tra

58 The activities of exogenous organic cation transporters (OCT2 and OCT3), organic ani

59 The organic cation transporter, OCT2, plays a role in renal

60 cleotide polymorphisms (SNPs) mapping to the organic cation transporter (OCTN) genes, SLC22A4 and SLC

61 by mutations in the Na+-dependent carnitine/organic cation transporter OCTN2.

62 Novel organic cation transporter (OCTN2) is an organic cation/

63 is caused by mutations in the Na+-dependent organic cation transporter, OCTN2.

64 pacity transporters for 5-HT in brain [i.e., organic cation transporters (OCTs) and plasma membrane m

65 Organic cation transporters (OCTs) are involved in the r

66 Organic cation transporters (OCTs) are members of the so

67 Organic cation transporters (OCTs) in the kidney proxima

68 Organic anion transporters (OATs) and organic cation transporters (OCTs) mediate the flux of x

69 re organic cations that rely on polyspecific organic cation transporters (OCTs) to traverse cell memb

70 KT, since the Oats share close homology with organic cation transporters (Octs), it is possible that

71 We initially found that organic cation transporters (OCTs), uptake carriers of m

72 fluid by acting on corticosterone-sensitive organic cation transporters (OCTs).

73 able to the inhibition of 5-HT transport via organic cation transporters (OCTs).

74 rough the action of corticosterone-sensitive organic cation transporters (OCTs).

75 etformin uptake depends on the expression of organic cation transporters (OCTs).

76 omologous to previously cloned rat and human organic cation transporters, organic cation transport ki

77 Organic cation transporters play a critical role in the

78 In the rat organic cation transporter (rOct1), voltage- and ligand-

79 Recently, two organic cation transporters (rOCT1 and rOCT2) were clone

80 sence of a functional, alternatively spliced organic cation transporter (rOCT1A) in rat kidney.

81 Both groups had increased organic cation transporters (SLC22A4 and SLC16A9) activi

82 porter (PMAT, SLC29A4) is a new polyspecific organic cation transporter that transports a wide variet

83 Here we demonstrate that expression of the organic cation transporter type 3 (OCT3, SLC22A3), which

84 "extraneuronal monoamine transporter," and "organic cation transporter type-3."

85 Originally described as a monoamine/organic cation transporter, we found that both human and

86 Oct1/Slc22a1 encodes for a hepatic and renal organic cation transporter which may be important for th

87 ude that PMAT can function as a polyspecific organic cation transporter, which may play a role in org