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1 or selective extraction (e.g., as applied to organic synthesis).
2  persists as a largely unsolved challenge in organic synthesis.
3 d manageability make them appealing tools in organic synthesis.
4 talysis plays a central role in contemporary organic synthesis.
5 d with molecular-scale information by simple organic synthesis.
6 chemistry that is very common in traditional organic synthesis.
7 ctural motif and versatile building block in organic synthesis.
8 ts a paradigm shift in the standard logic of organic synthesis.
9 led reactor capable of effecting a multistep organic synthesis.
10 nt aspects of the bromo-organic compounds in organic synthesis.
11 formations accessing heterocycles for use in organic synthesis.
12 ketones, another important building block in organic synthesis.
13 xploration of roles for Ni(IV) and Pd(IV) in organic synthesis.
14 esign and application of nonplanar amides in organic synthesis.
15 enes have become a central transformation in organic synthesis.
16 tions entice chemists to use biocatalysts in organic synthesis.
17 ility and practicality of these catalysts in organic synthesis.
18 d into a prominent and indispensable tool in organic synthesis.
19 reaching impact such reactions would have in organic synthesis.
20 importance in the context of drug design and organic synthesis.
21 free conditions is a challenging process for organic synthesis.
22  the use of alkenes as alkyne equivalents in organic synthesis.
23 sts for the activation of multiple bonds for organic synthesis.
24 ion metal-organic compounds and their use in organic synthesis.
25 s for heterogeneously catalyzed reactions in organic synthesis.
26 re unusually versatile C3 building blocks in organic synthesis.
27 tallic reagents occupy a central position in organic synthesis.
28 f aliphatic molecules remains a challenge in organic synthesis.
29 d holds potential for future applications in organic synthesis.
30 or SN2 reactions) is an ongoing challenge in organic synthesis.
31 ation techniques, applicable in the field of organic synthesis.
32 talyst control remains a challenge in modern organic synthesis.
33 alent p-block metal hydrides as catalysts in organic synthesis.
34 xyhydrocinnamic acid without any complicated organic synthesis.
35 ve as potentially useful building blocks for organic synthesis.
36 me broadly useful reactive intermediates for organic synthesis.
37 onylation reactions have been widely used in organic synthesis.
38 oxyacrylamides, which are useful synthons in organic synthesis.
39 tallic reagents a central position in modern organic synthesis.
40 useful motif has languished in the annals of organic synthesis.
41 whole-cell biocatalysts as powerful tools in organic synthesis.
42 ry and homogeneous catalysis directed toward organic synthesis.
43 constitutes one of the highest challenges in organic synthesis.
44 olefins employing common building blocks for organic synthesis.
45 use of low-valent group 9 metal complexes in organic synthesis.
46 ochemically pure building blocks for further organic synthesis.
47 oenriched materials of considerable value in organic synthesis.
48 processes have emerged as powerful tools for organic synthesis.
49 bons is regarded as a challenging problem in organic synthesis.
50  within the general context of efficiency in organic synthesis.
51 the evolution of the strategy and tactics of organic synthesis.
52 hey address both diversity and complexity in organic synthesis.
53 tertiary alcohols, valuable intermediates in organic synthesis.
54 one of the most important reducing agents in organic synthesis.
55 was possible by using HPLC-MS techniques and organic synthesis.
56 nd of methyl groups, as functional groups in organic synthesis.
57 which are highly valuable building blocks in organic synthesis.
58 nd of methyl groups, as functional groups in organic synthesis.
59  and have become attractive biocatalysts for organic synthesis.
60 were matched using isomers prepared by total organic synthesis.
61 d the potential for numerous applications in organic synthesis.
62 c pathways and chemical diversity enabled by organic synthesis.
63 e diastereomer generated in a solution-phase organic synthesis.
64 enign oxidants with numerous applications in organic synthesis.
65 roles such plumes may have played in abiotic organic synthesis.
66 to discover novel bond-forming strategies in organic synthesis.
67 yl rings is an area of great significance to organic synthesis.
68 methyl carbonate, which has extensive use in organic synthesis.
69 ave brought about "revolutionary" changes in organic synthesis.
70  of the greatest practitioners of the art of organic synthesis.
71 nts for this process are required for modern organic synthesis.
72 l organic azides and iodonium imides used in organic synthesis.
73  making them more accessible as reagents for organic synthesis.
74 tion and self-assembly to direct and conduct organic synthesis.
75 g protected phenolic ether intermediates for organic synthesis.
76 icroarrays, and complementing fluorous-phase organic synthesis.
77  cyclohexenones are useful intermediates for organic synthesis.
78 r (AT-RvD1) with compounds prepared by total organic synthesis.
79 c ring structures is of utmost importance in organic synthesis.
80 molecular architectures is a central goal in organic synthesis.
81 ed under the conditions used for traditional organic synthesis.
82 tible to the conditions used for traditional organic synthesis.
83  KH(P) should be a generally useful base for organic synthesis.
84 ws the promise of employing nanomaterials in organic synthesis.
85 s have on synthetic planning and strategy in organic synthesis.
86 ate constitutes a rare study in contemporary organic synthesis.
87 n use in a variety of applications including organic synthesis.
88 tified in human plasma and prepared by total organic synthesis.
89 '-trichloroamidines as starting materials in organic synthesis.
90 ions can lead to exciting new strategies for organic synthesis.
91 on (ROMP) and used as polymeric supports for organic synthesis.
92 yn-dihydroxylation with potential utility in organic synthesis.
93 immensely valuable building blocks in modern organic synthesis.
94 ialkyl amines remains an unsolved problem in organic synthesis.
95 potential of these reagents and catalysts in organic synthesis.
96 inaccessible single-site solid catalysts for organic synthesis.
97 eteroatom bonds are of central importance in organic synthesis.
98 ely been observed with flavoproteins used in organic synthesis.
99 ard the future of this promising subfield of organic synthesis.
100 pectives on using this feedstock chemical in organic synthesis.
101 ls-Alder reaction is a cornerstone of modern organic synthesis.
102 oxylic acids are ubiquitous intermediates in organic synthesis.
103 truction is one of the central challenges of organic synthesis.
104 tes that may prove to be of general value in organic synthesis.
105 s a highly challenging yet desirable goal in organic synthesis.
106 l systems but also are valuable catalysts in organic synthesis.
107  extend the utility of LiDBB as a reagent in organic synthesis.
108 titutes a green and sustainable strategy for organic synthesis.
109 ine and different bromo-organic compounds in organic synthesis.
110 yclic ketones is a longstanding challenge in organic synthesis.
111 r generating reactive inorganic radicals for organic synthesis.
112 xyl compounds is a contemporary challenge in organic synthesis.
113 rality render this method a valuable tool in organic synthesis.
114  to be potent catalysts for enantioselective organic synthesis.
115 nes, compounds that are of broad interest in organic synthesis.
116 tive processes has become a staple in modern organic synthesis.
117 m CO into organic reagents with potential in organic synthesis.
118 selectivity simultaneously is challenging in organic synthesis.
119 ical use of SF6 as a fluorinating reagent in organic synthesis.
120 actions have found important applications in organic synthesis.
121 iphatic C-H bonds remain a paramount goal of organic synthesis.
122 rea by presenting such newer applications in organic synthesis (175 references).
123 ional molecular design and function-oriented organic synthesis, a general design principle is present
124 hesis catalysts are used in laboratory-scale organic synthesis across chemistry, largely thanks to th
125 renes constitute valuable building blocks in organic synthesis and an essential skeleton ubiquitously
126 r new applications in several fields such as organic synthesis and bioconjugate formation.
127  groups can be applied in materials science, organic synthesis and biological systems.
128 one of the most important transformations in organic synthesis and can be carried out using bromine a
129  polymerization, their utility in mainstream organic synthesis and catalyst development has arguably
130 ally designed to have adequate stability for organic synthesis and characterization.
131                        We prepared PCTR1 via organic synthesis and confirmed that synthetic PCTR1 inc
132 adium catalysts have been widely adopted for organic synthesis and diverse industrial applications gi
133                                          Via organic synthesis and DNA photochemistry, we selectively
134                  Their broad applications in organic synthesis and drug discovery are demonstrated in
135 it can be used as a convenient tool to guide organic synthesis and drug discovery, particularly appli
136 Allenes are important 2pi building blocks in organic synthesis and engage as 2-carbon components in m
137 e analogues, which are important synthons in organic synthesis and for the preparation of a variety o
138 licenes to induce asymmetry and chirality in organic synthesis and in supramolecular chemistry.
139 n discovery approach that uses DNA-templated organic synthesis and in vitro selection to simultaneous
140  bonds is a fundamental bond construction in organic synthesis and is indispensable for the synthesis
141 ed from these reactions have applications in organic synthesis and materials chemistry, and in additi
142 is an important objective for fields such as organic synthesis and medicinal chemistry; however, ther
143 ward enhancing the robustness of enzymes for organic synthesis and other applications.
144 ombination of solution-phase high-throughput organic synthesis and parallel chromatographic purificat
145            Nitrones are key intermediates in organic synthesis and the pharmaceutical industry.
146                                The advent of organic synthesis and the understanding of the molecule
147 of alternative functional groups of value in organic synthesis and thus achieves a higher level of mo
148 ave recently emerged as a powerful means for organic synthesis and thus have generated significant in
149 nd easily synthesized starting materials for organic synthesis, and alkyl acrylates are among the mos
150  an increasingly attractive moiety in modern organic synthesis, and as such, they have been utilised
151 se library followed by rational drug design, organic synthesis, and biological testing.
152  hydrogels, dynamic combinatorial chemistry, organic synthesis, and chemical biology.
153 ttention as metal-free-arylation reagents in organic synthesis, and efficient access to these salts i
154 ransfer reagent with unparalleled utility in organic synthesis, and has emerged as a vital feedstock
155                     Computational chemistry, organic synthesis, and in vitro assays were employed to
156       Oxetanes are valuable intermediates in organic synthesis, and strategic manipulations of this s
157  structure of the molecule, the emergence of organic synthesis, and the art of total synthesis from t
158 Ten compounds were synthesized via multistep organic synthesis, and the corresponding Gd complexes we
159 defined GNRs can be made using a 'bottom-up' organic synthesis approach through solution-mediated or
160       Finally, key catalytic applications in organic synthesis are presented and how the molecular ar
161 2, CO2 and metal sulphides could have driven organic synthesis are uncertain, and theoretical ideas l
162  with these intermediates, a central goal of organic synthesis, are typically carried out with covale
163 alamin (1) has been successfully utilised in organic synthesis as a catalyst for Co-mediated reaction
164 bstituents in the chain and is often used in organic synthesis as a ring-closing effect.
165           These compounds are widely used in organic synthesis as selective oxidants and environmenta
166 bamates can serve as useful intermediates in organic synthesis as well as bioactive compounds in thei
167 en the critical importance of amino acids in organic synthesis as well as their myriad of application
168 ing reaction is a foundation stone of modern organic synthesis, as evidenced by its widespread use in
169 nidine, and related isothiourea catalysts in organic synthesis, as well as the evidence for the nucle
170                                       In the organic synthesis aspect, reaction of malononitriles and
171 ox catalysis has become an essential tool in organic synthesis because it enables new routes to impor
172 are ideal prospective starting materials for organic synthesis because they are manufactured on very
173 pplications for cerium(iv) compounds include organic synthesis, bioinorganic chemistry, materials sci
174 lasses of chemicals that are used broadly in organic synthesis, biological chemistry, and nanoscience
175 e potentially very useful in stereoselective organic synthesis but are relatively unexplored.
176 -directable reactions play a pivotal role in organic synthesis, but are uncommon in reactions proceed
177  constructions characteristic of traditional organic synthesis, but can be accomplished under environ
178 ransition-metal catalysis has revolutionized organic synthesis, but difficulties can often be encount
179      Epoxides are versatile intermediates in organic synthesis, but have rarely been employed in cros
180  boronate esters are useful intermediates in organic synthesis, but these reagents cannot be prepared
181             Although the early beginnings of organic synthesis came about serendipitously, organic ch
182                                              Organic synthesis can be used to produce pure standards,
183                                    Workup in organic synthesis can be very time-consuming, particular
184 bonding theory and have modern importance in organic synthesis, catalysis and organic spintronics.
185 ers industrial aspects, inorganic materials, organic synthesis, cocrystallisation, pharmaceutical asp
186 try represents a historical challenge to the organic synthesis community.
187 vators for C-H bond cleavage applied to fine organic synthesis conclude the review.
188 us advances in modern spectroscopic methods, organic synthesis continues to play a pivotal role in el
189                 Electrocatalytic methods for organic synthesis could offer sustainable alternatives t
190  alpha-imino esters and related compounds in organic synthesis, covering the literature from the last
191  cathode materials in the context of electro-organic synthesis (dehalogenation, deoxygenation) of pha
192 etones remains a largely unsolved problem in organic synthesis, despite the wide potential utility of
193 he major contributions of DESs in catalysis, organic synthesis, dissolution and extraction processes,
194                 Isoxazolidines are useful in organic synthesis, drug discovery, and chemical biology
195 idation method will find wide application in organic synthesis, drug discovery, and chemical biology.
196 nd use in most areas of chemistry, including organic synthesis, drug discovery, and supramolecular ch
197  choice enzymes for oxyfunctionalizations in organic synthesis due to their independence from a cellu
198 yl oxoboranes (RBO) are valuable reagents in organic synthesis due to their role in Suzuki coupling r
199 d one of the most important breakthroughs in organic synthesis during the past decade, but a rational
200                                DNA-templated organic synthesis enables the translation of DNA sequenc
201                                DNA-templated organic synthesis enables the translation, selection, an
202      A combined approach was taken featuring organic synthesis, enzymatic assaying, crystallography,
203 anesulfonamides have been investigated using organic synthesis, enzymatic assays, X-ray crystallograp
204             The protocol only requires basic organic synthesis equipment, and no silica gel column ch
205 utperforms typical chlorinating reagents for organic synthesis, facilitates workup and purification o
206 iew thus serves to showcase the potential of organic synthesis for (chemical) biology and immunology.
207 nditions has been a significant challenge in organic synthesis for more than a century.
208 )s with electrophiles is used extensively in organic synthesis for stereoselective C-C bond formation
209 nvironmentally benign alternative to classic organic synthesis for the oxidation or the reduction of
210 -catalysis is emerging as a powerful tool in organic synthesis for the stereoselective manipulation o
211 ry stereocenters is a challenging problem in organic synthesis for which only few solutions have been
212          These reactions are of interest for organic synthesis, for pharmaceutical and medicinal chem
213 The Diels-Alder reaction is a cornerstone in organic synthesis, forming two carbon-carbon bonds and u
214 autotrophy, or as a prelude to heterotrophy, organic synthesis from an environmentally available C1 f
215          The first catalytic use of Ga(0) in organic synthesis has been developed by using a Ag(I) co
216                 The scope of the protocol in organic synthesis has been examined preliminarily.
217 s three reactive sites, their application in organic synthesis has been limited because of the lack o
218 e use of small-molecule organic catalysts in organic synthesis has flourished over the past decade.
219                                 The field of organic synthesis has made phenomenal advances in the pa
220 t years, the combination of fermentation and organic synthesis has provided a new route for the produ
221 , a widely used C-C bond-forming reaction in organic synthesis, has no biological counterpart.
222 damental importance and paramount utility in organic synthesis have been reinvestigated, the Barton d
223            Recent advances in DNA-programmed organic synthesis have raised the possibility that evolu
224        Flow-system approaches, now common in organic synthesis, have not been utilized widely for the
225 w is to give an overview of their utility in organic synthesis, highlighting the variety of compounds
226 e application of these biocatalytic tools in organic synthesis, however, remains under-utilized due t
227 oxidation reactions exhibit broad utility in organic synthesis; however, they often feature high cata
228  of the first carbon-carbon bond, the art of organic synthesis improved to impressively high levels o
229  continue to design benign methodologies for organic synthesis in aqueous media under catalyst-free c
230 nthetic antibiotic demonstrates the power of organic synthesis in enabling design and comprehensive i
231  transformation is essential to the field of organic synthesis in order to promote excellence in qual
232 st time to our knowledge strong evidence for organic synthesis in the early solar system activated by
233 n two distinct reaction pathways for abiotic organic synthesis in the natural environment at the Von
234       This tutorial review briefly discusses organic synthesis in water with a Green Chemistry perspe
235  This study illustrates a powerful tactic in organic synthesis in which a structurally complex target
236  on transition metals have found wide use in organic synthesis, in particular for the functionalizati
237 versatility of these vinylogous amidines for organic synthesis, including the following: transaminati
238  the author's transition from small molecule organic synthesis into polymeric materials and nanotechn
239 e landscape of the strategies and methods of organic synthesis irreversibly changed for the modern ch
240                       Glycoside formation in organic synthesis is believed to occur along a reaction
241                                              Organic synthesis is changing; in a world where budgets
242 ons in other carbenium ion-based branches of organic synthesis is considered.
243 over a research area whose impact in current organic synthesis is constantly increasing in the chemic
244 ces as an important method for carbonylative organic synthesis is spreading.
245 enerated inorganic radical intermediates for organic synthesis is still small, future extension of th
246 f the concept of biomimetic chemistry, where organic synthesis is used to generate artificial molecul
247                  Use of molecular bromine in organic synthesis is well-known.
248                                             "Organic synthesis" is a compound-creating activity often
249 is anticipated to find wider applications in organic synthesis, its immediate application to the cons
250 widely accepted as a routine procedure in an organic synthesis laboratory, electrosynthesis needs to
251 ous-flow reactors, including applications in organic synthesis, material science, and water treatment
252 nstrate broad applications of this method in organic synthesis, medicinal chemistry, and chemical bio
253 or a long time and have wide applications in organic synthesis, medicinal chemistry, and material sci
254 he utilization of CO2 as a carbon source for organic synthesis meets the urgent demand for more susta
255 es have been synthesized through a multistep organic synthesis method and are further used as promisi
256           However, by combining the tools of organic synthesis, molecular biology, and electrophysiol
257 ics, machine learning, industrial expertise, organic synthesis, molecular characterization, device fa
258          Proven to be a valuable tool within organic synthesis, natural product, and medicinal chemis
259                                       Modern organic synthesis now requires efficient atom economical
260 thways may lead to biomimetic strategies for organic synthesis of such compounds.
261 view describes singlet oxygen ((1)O2) in the organic synthesis of targets on possible (1)O2 biosynthe
262 d biology sections; the former describes the organic synthesis of the caged IP(3), which requires 12
263 s in response to pH for use in, for example, organic synthesis or nitroxide-mediated polymerization.
264 tho to heteroatoms remains as a challenge in organic synthesis, particularly relevant to the construc
265 he ubiquity of organophosphorus compounds in organic synthesis, pharmaceutical discovery agrochemical
266                                              Organic synthesis played a major role in this revolution
267 e how the advent of machines is impacting on organic synthesis programs, with particular emphasis on
268                                        While organic synthesis provides access to many natural produc
269 rs at concentrations >0.01 M typical of most organic synthesis reactions and physical measurements.
270 re underexploited as photoredox catalysts in organic synthesis relative to their homogeneous, molecul
271 ue features of the WGSR, its applications in organic synthesis remain largely underdeveloped.
272                 However, its applications in organic synthesis remain largely unexplored.
273 ial of unactivated sp3 C-H bond oxidation in organic synthesis requires the discovery of catalysts th
274  the typical heterotransfer reagents used in organic synthesis show a greater tendency toward triplet
275  for the construction of cyclic compounds in organic synthesis, since these reactions are vital to ac
276 ctions using conventional building blocks of organic synthesis such as acetals, enolates, Michael acc
277 hough sulfur ylides are textbook reagents in organic synthesis, surprisingly little variation of subs
278 iazolinediones (TADs) are unique reagents in organic synthesis that have also found wide applications
279 es innovations and developments in selective organic synthesis that have used cooperative dual cataly
280 pments in organic chemistry and the field of organic synthesis that not only can molecules of this co
281     Here we present a traceless strategy for organic synthesis that uses a boronic ester as such a gr
282 ough C-C bond formation has been a staple of organic synthesis, the direct transfer of primary amino
283 iphenylphosphine as a reductant is common in organic synthesis, the resulting triphenylphosphine oxid
284 trophiles are emerging as a powerful tool in organic synthesis, there have been virtually no reports
285                            Enabled by modern organic synthesis, these studies provide a new class of
286 c carbene-based organocatalysis with electro-organic synthesis to achieve direct oxidation of catalyt
287 lysis has emerged as a powerful stratagem in organic synthesis to construct complex molecules primari
288 R(2) that play a role in topics ranging from organic synthesis to gas-phase oxidation chemistry.
289           Despite over a century of applying organic synthesis to the search for drugs, we are still
290 iaturization coupled with the flexibility of organic synthesis to tune the individual component.
291   The importance of microwave irradiation in organic synthesis today is unquestionable, but in many c
292  new simple procedure for microwave-assisted organic synthesis under continuous flow processing has b
293 y agree with results obtained by traditional organic synthesis, validating the method.
294 rsible imine formation is used to achieve an organic synthesis via the solid state.
295 spectrometry in combination with unambiguous organic synthesis, we confirm that oxPC-furans, ultimate
296  and the renaissance of radical chemistry in organic synthesis, we envision that new enzymatic and sy
297 hium metal reductions are widely employed in organic synthesis, where it is common to employ a "media
298 ic substitution reactions are widely used in organic synthesis, whereas the analogous reactions for s
299 carbon-carbon (C-C) bonds are the bedrock of organic synthesis, widely used across the chemical scien
300  have not likewise integrated reactions from organic synthesis with the metabolism of living organism

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