1 interactome using environmental factors and
organismal abundance profiles and found that environment
2 ocols and subsequently estimating biomass or
organismal abundance.
3 tive of a critical energetic requirement for
organismal activity.
4 remarkably controllable pathway facilitating
organismal adaptation to new environments.
5 We propose that cellular and
organismal ageing are intertwined through the effects of
6 The existence of an
organismal ageing dynamics that is invariant across gene
7 development [3, 4], tissue repair [5-8], and
organismal aging [9].
8 mportance, the critical understanding of how
organismal aging affects lifetime neuronal mitochondrial
9 sis that have a conserved role in modulating
organismal aging and fitness.
10 Environmental fluctuations influence
organismal aging by affecting various regulatory systems
11 CRTCs have been shown to modulate
organismal aging in Caenorhabditis elegans and to impact
12 glycogen, resistance to oxidative stress and
organismal aging in Caenorhabditis elegans.
13 However, how sensory neurons coordinate
organismal aging in response to changes in environmental
14 l as some normal transcripts, have a role in
organismal aging remains unexplored.
15 icate an uncoupling of cellular, tissue, and
organismal aging through inhibition of ISC proliferation
16 le to the potentially deleterious effects of
organismal aging.
17 separable from the effect of DAF-16/FOXO on
organismal aging.
18 cellular and genetic mechanisms that control
organismal aging.
19 e are intimately linked to each other and to
organismal aging.
20 By integrating molecular and
organismal analyses, our study suggests potential therap
21 omyosin ring coordinates epiboly on both the
organismal and cellular scales.
22 show that hydraulic fracturing provides the
organismal and chemical inputs for colonization and pers
23 enetic adaptations and their consequences at
organismal and ecological scales are often lacking.
24 he relationship between repeated measures of
organismal and environmental changes over short time sca
25 etabolic engineering, antibiotic design, and
organismal and enzyme evolution.
26 molecular, cellular, tissue, organ, system,
organismal and even psychological levels, trigger the on
27 r poorly understood eukaryote-specific inter-
organismal and inter-genomic conflicts.
28 Models that predict
organismal and population responses to climate change ma
29 ersy by noting that selection can operate on
organismal and sub-organismal 'entities' such that partn
30 We conducted multiple cellular and
organismal assays on wild type as well as four long-live
31 is known about the mechanisms underlying the
organismal balance of Mg(2+).
32 sm for controlling intestinal fat stores and
organismal behavioral states in C. elegans, and establis
33 Our results show that incorporating key
organismal behaviours with well-known biological mechani
34 ne potential (Deltapsi), which is central to
organismal bioenergetics, has been successfully measured
35 molecular damage while ignoring protective,
organismal biologic responses.
36 losophy and methodology between evolutionary/
organismal biologists and developmental geneticists ofte
37 delta(13)C records-a key measure of holistic
organismal biology and of the global carbon cycle.
38 ial applications, including studies of plant
organismal biology and the evolutionary innovations requ
39 ts applications in structural, cellular, and
organismal biology are clearly poised to massively expan
40 Body shape is a fundamental expression of
organismal biology, but its quantitative reconstruction
41 zation of cell-cell interactions relevant to
organismal biology.
42 ers, as opposed to producers, often dominate
organismal biomass.
43 ifies the fraction of network edges crossing
organismal boundaries.
44 physiological shifts leading to compromised
organismal capacity to respond to additional stressors.
45 A coordinated reaction at the
organismal,
cellular and gene/genome levels is thought t
46 We report here the
organismal,
cellular, and molecular phenotypes of varian
47 alysis to track melanoma-derived vesicles at
organismal,
cellular, and molecular scales to show that
48 uses a population approach to understand how
organismal changes in form or function are linked to und
49 ects might depend on interactions with other
organismal characteristics (here: colour morph).
50 To measure
organismal coherence in a pelagic ecosystem, we used moo
51 transporters in remote inter-organ and inter-
organismal communication: The Remote Sensing and Signali
52 families are causally linked to increases in
organismal complexity.
53 of the mechanisms that produce this form of
organismal complexity.
54 nt explosive diversification of cellular and
organismal complexity.
55 yotic lineages consistent with intense inter-
organismal conflict.
56 To understand the cellular and
organismal consequences of aneuploidy, it is important t
57 onstrates that depending on the cellular and
organismal context, orthologous proteins may exert both
58 ntestinal cells transport copper to maintain
organismal copper homeostasis are poorly understood.
59 Here, we identify a mechanism by which
organismal copper homeostasis is maintained by intestina
60 ated in a tissue-specific manner to maintain
organismal Cu homeostasis.
61 functions associated with cell survival and
organismal death rather than inflammatory pathways.
62 ricardial nephrocytes supporting its role in
organismal defence and detoxification.
63 if not all tissues and have diverse roles in
organismal development and cell differentiation, functio
64 minantly affects the genes involved in early
organismal development and cell differentiation.
65 rd a holistic and realistic understanding of
organismal development and evolution.
66 proliferation is critical for understanding
organismal development and identifying high-value target
67 Copper is an essential element for proper
organismal development and is involved in a range of pro
68 Epigenetic regulation is important for
organismal development and response to the environment.
69 final-exon-truncating mutations in REST for
organismal development and the association with the HGF
70 biology and possible common contribution to
organismal development and tissue homeostasis of all Jmj
71 devo) attempts to explain how the process of
organismal development evolves, utilizing a comparative
72 uently reused later in embryogenesis, during
organismal development or in the adult.
73 Organismal development requires the precise coordination
74 y to understanding cellular differentiation,
organismal development, and the evolution of cancer.
75 and assembly are increasingly used to model
organismal development, even when the underlying cellula
76 gely unknown whether K-to-M mutations impact
organismal development.
77 ggest that ABL1 has an important role during
organismal development.
78 ssembly is critical for mitotic fidelity and
organismal development.
79 ate the behaviour of individual cells during
organismal development.
80 ue growth are recognized as key processes in
organismal development.
81 e morphogenesis is critical to understanding
organismal development.
82 -influenced processes impact many aspects of
organismal development.
83 esponse, cellular immune signaling, and even
organismal development.
84 some-mediated control of gene expression and
organismal development.
85 pects of the epigenomic landscape throughout
organismal development.
86 e origin and evolvability of this feature of
organismal development.
87 n coordinating regenerative disc growth with
organismal developmental timing.
88 among the most conserved proteins known, but
organismal differences do exist.
89 rentiation could also be driving dynamics of
organismal diversity across time and space.
90 rait relationships and their role in shaping
organismal diversity.
91 Here we demonstrate that lncRNAs guide the
organismal DNA damage response.
92 etic and molecular evolutionary statistics),
organismal (
e.g. tissue-specific gene and protein expres
93 nomes do indeed contain detectable signal of
organismal ecology, and the methods described in the pap
94 effects of complex exposures at higher level
organismal effects without prior mechanistic knowledge o
95 circulating factors that act through a meta-
organismal endocrine axis to impact CVD risk.
96 challenges that lie ahead in targeting meta-
organismal endocrinology for CVD prevention.
97 ction) is critical for any general theory of
organismal energetics.
98 AC5) as a regulator of leptin signalling and
organismal energy balance.
99 -tissue communication is critical to control
organismal energy homeostasis in response to temporal ch
100 evidence suggests peripheral 5-HT may affect
organismal energy homeostasis.
101 lity feedback and partner choice between sub-
organismal entities, in addition to being promoted by pa
102 selection can operate on organismal and sub-
organismal '
entities' such that partner fidelity feedbac
103 using in vitro treatments as a proxy for the
organismal environment.
104 C. elegans hermaphrodite is sensitive to the
organismal environment.
105 frequent undertaking of biologists studying
organismal evolution through comparative genomic approac
106 Cancer evolution is different from
organismal evolution, however, and we discuss where conc
107 dition to revealing the impact of viruses on
organismal evolution, such studies can help us better un
108 nked to myriad diseases but also facilitates
organismal evolution.
109 crucial insights into extinct body plans and
organismal evolution.
110 h large fat reserves, when opportunities for
organismal experimental work are limited.
111 bal warming scenarios; for example, reducing
organismal feeding rates by 50% will reduce resource pro
112 enerationally inherited epigenetic states to
organismal fitness remains unknown as well-documented ex
113 hromosome-typically has an adverse impact on
organismal fitness, manifest in conditions such as Down
114 y-associated costs, which, in turn, enhances
organismal fitness.
115 event in yeast, having a two-faceted role in
organismal fitness.
116 ithin C. elegans providing a new measure for
organismal fitness.
117 an also act as mutation buffers that enhance
organismal fitness.
118 degradation of proteins, a process vital to
organismal fitness.
119 enylate kinase is an evolutionary driver for
organismal fitness.
120 ng of gene interaction networks that provide
organismal form and function as well as resilience to pe
121 ntial to understanding adaptive evolution in
organismal form and function.
122 opment is essential for establishing correct
organismal form and function.
123 While beneficial effects of fasting on
organismal function and health are well appreciated, we
124 ion is of fundamental importance to maintain
organismal function and integrity and requires a multifa
125 rstanding cellular specialization as well as
organismal function and organization.
126 Organismal function is, to a great extent, determined by
127 However, it is unknown whether
organismal function requires that every cell maintain a
128 folding is essential for proper cellular and
organismal function.
129 Organismal functions are size-dependent whenever body su
130 ght-mediated control of diverse cellular and
organismal functions such as neuronal activity, intracel
131 ical approaches in the study of cellular and
organismal functions, discuss current challenges, and pr
132 Protein 1a (HP1a), and is essential for many
organismal functions.
133 Phagocytosis is key for many
organismal functions.
134 ell polarization underlies many cellular and
organismal functions.
135 selected set of gene targets across multiple
organismal genomes.
136 unrepaired genome alterations and preserves
organismal genomic integrity during the early critical s
137 ts illustrate how epigenetic factors such as
organismal geometry and shape impact facial morphogenesi
138 nd is important for maintaining cellular and
organismal glucose homeostasis.
139 dentification and genome sequencing of novel
organismal groups can reduce the gap between the sequenc
140 , genome-scale datasets for a broad range of
organismal groups.
141 hermore, under such conditions, no effect on
organismal growth rate or loss of the reddish colony phe
142 ed to increased PI3K-AKT signaling, enhanced
organismal growth, and cancer development.
143 bility, and stress, to regulate cellular and
organismal growth.
144 ach can increase scientific understanding of
organismal-
habitat relationships, maintain natural biodi
145 res an understanding of spatially connected,
organismal-
habitat relationships.
146 rs of control has important implications for
organismal health and could offer new therapeutic approa
147 tion of cellular functions is lost, reducing
organismal health and fitness.
148 search into how protein restriction improves
organismal health and lengthens lifespan has largely foc
149 llular, tissue, and systemic level to ensure
organismal health and longevity.
150 f Drp1, in midlife, is sufficient to improve
organismal health and prolong lifespan, and observe a mi
151 between RNA binding proteins in maintaining
organismal health, and will serve as a paradigm applicab
152 homeostasis, or proteostasis, is crucial for
organismal health.
153 y that affects normal metabolism and overall
organismal health.
154 vity contributes to proper host immunity and
organismal health.
155 th great impact on biogeochemical cycles and
organismal health.
156 arily conserved and paramount for tissue and
organismal health.
157 ts reinforce the need to consider individual
organismal histories and indicate that barriers and refu
158 nutrient signals to control cell growth and
organismal homeostasis across eukaryotes.
159 Microbial infection poses a threat to
organismal homeostasis and therefore must be efficiently
160 tively help to preserve cellular, organ, and
organismal homeostasis at low temperature.
161 urological development, normal cognition and
organismal homeostasis in humans.
162 er impact of synthetase editing reactions on
organismal homeostasis, and based on effects in bacteria
163 tical role in promoting genome integrity and
organismal homeostasis.
164 a second major function: the maintenance of
organismal homeostasis.
165 crucial for the maintenance of cellular and
organismal homeostasis.
166 stributions and diverse roles in maintaining
organismal homeostasis.
167 ponses that are critical for re-establishing
organismal homeostasis.
168 ADAR1-mediated editing is not essential for
organismal homeostasis.
169 in reduced survival, locomotor deficits and
organismal hypersensitivity to oxidative stress.
170 ages and contributes to shaping cellular and
organismal immune responses.
171 We demonstrate
organismal impact of hpRNA activity, since knockout of h
172 The
organismal impact of systemic inhibition of Vps34 kinase
173 survival, cell population and organization,
organismal injury and abnormalities, molecular transport
174 al disease, psychological disorders, cancer,
organismal injury and skeletal and muscular disorders, a
175 ant functions as humoral immune response and
organismal injury/abnormalities.
176 ng evolved complex behavioral strategies and
organismal interactions that extend far beyond photosynt
177 rn rapidly converts the keratinocyte into an
organismal itch-generator cell.
178 At the same time,
organismal knowledge (morphology, ecology, physiology) h
179 he lens of forward genetics, starting at the
organismal level and proceeding to the locus level and,
180 cellular senescence was also observed at the
organismal level as shown by down-regulation of insulin-
181 entially PAH-resistant subpopulations showed
organismal level bioenergetic shifts in ER fish that are
182 ' such that partner fidelity feedback at sub-
organismal level can appear as partner choice at organis
183 ences of deficiency of its components at the
organismal level is largely limited to model organisms.
184 in vertebrate tissues, its functions at the
organismal level remain largely unknown.
185 However, the eIF4E dose requirement at an
organismal level remains unexplored.
186 (-/-) embryos died on E11.5, establishing an
organismal level synthetic lethal relationship between R
187 olites are integrated and coordinated at the
organismal level through hormonal signals.
188 gh cadmium elicited an adverse effect at the
organismal level, almost no genes were differentially ex
189 Such functional differences, read out at the
organismal level, are likely subserved by differences am
190 ions, but its functions, particularly at the
organismal level, are not well understood.
191 and difficult to measure and control at the
organismal level, as found in GWAS and epidemiological s
192 f intraguild species, well documented at the
organismal level, but not at the molecular level.
193 At the
organismal level, MDR may be controlled by clusters of R
194 rulence exclusively in specific cells at the
organismal level.
195 ces for studying stem cell regulation at the
organismal level.
196 rganizing proteins remains unexplored at the
organismal level.
197 is critical for survival at the cellular and
organismal level.
198 nismal level can appear as partner choice at
organismal level.
199 are turned on at a cellular (apoptosis) and
organismal level.
200 surveillance systems are also active at the
organismal level: Nutrient and stress sensing in one tis
201 f whole-animal vertebrate clonality (asexual
organismal-
level reproduction), both in the laboratory a
202 ses reduced fitness at both the cellular and
organismal levels but is also a hallmark of human cancer
203 interacts with the host at the cellular and
organismal levels is still limited.
204 rosis), metabolism (at both the cellular and
organismal levels), behavior and neurological function,
205 the regulation of aging at the cellular and
organismal levels, delineate the mechanistic links betwe
206 tion at the molecular, neuropathological and
organismal levels.
207 ts that operate at the cellular, tissue, and
organismal levels.
208 ystems may undergo senescence independent of
organismal life span.
209 and timing of stressors found in nature with
organismal life-history traits.
210 extends chronological lifespan in yeast and
organismal lifespan in worms and flies.
211 er improved cellular health and extension of
organismal lifespan or due to specific neural mechanisms
212 and dietary restriction in the regulation of
organismal lifespan, thus suggesting new strategies for
213 is inextricably tied to cellular health and
organismal lifespan.
214 e stress response, cellular homeostasis, and
organismal lifespan.
215 One of the original hypotheses of
organismal longevity posits that aging is the natural re
216 ated decline in the activity of cellular and
organismal maintenance mechanisms enables the emergence
217 of hepatic lipid metabolism is critical for
organismal metabolic fitness.
218 identified, the overall function of SIRT5 in
organismal metabolic homeostasis remains unclear.
219 ardiovascular health via temporal control of
organismal metabolism and physiology.
220 genetic manipulations that link cellular and
organismal metabolism to aging.
221 These findings link
organismal metabolism to local Hedgehog signaling and su
222 of cell adhesion and migration, cellular and
organismal metabolism, and regulation of TAU stability.
223 physiological situations of cell growth and
organismal metabolism.
224 s of peptides and discusses the relevance to
organismal metabolism.
225 ctors and coregulators in the fine tuning of
organismal metabolism.HDAC3 is a critical mediator of he
226 Hence, maintenance of
organismal Mg(2+) balance by TRPM6 is crucial for prenat
227 rated mechanistic model of the regulation of
organismal Mg(2+) balance during prenatal development an
228 PM6 is required in the intestine to maintain
organismal Mg(2+) balance, but is dispensable in the kid
229 of PRL deletion in a genetically controlled,
organismal model.
230 cal components and processes contributing to
organismal morphogenesis, but the mathematical and physi
231 ulted in a dramatic reduction in the rate of
organismal movement that was caused by a switch in the m
232 ng for sufficient concentrations of iron for
organismal needs while sequestering the metal from infec
233 role and function depending on cellular and
organismal needs.
234 e to the levels of dietary carbohydrates and
organismal oleic acid and is coupled to activation of th
235 c controls and environmental dependencies of
organismal ontogeny.
236 and is one of the primary traits underlying
organismal performance.
237 Here, we provide an
organismal perspective of C. intestinalis, highlighting
238 genes, can exert broad-scale effects on the
organismal phenotype [2, 3].
239 Predicting
organismal phenotypes from genotype data is important fo
240 The
organismal phenotypes of cell cycle, cell size, and phot
241 the molecular, gene-regulatory, cellular and
organismal phenotypes of these sub-threshold loci, demon
242 Future work linking molecular effects to
organismal phenotypes will broaden our understanding of
243 a link between variation in DNA sequence and
organismal phenotypes, and its abundance can be measured
244 gulation of mitochondrial genetic effects on
organismal phenotypes.
245 tional processing underlie many cellular and
organismal phenotypes.
246 NA nucleotide, resulting in an alteration of
organismal physiological behaviour, and linking rRNA-med
247 and progenitor cells are highly sensitive to
organismal physiological changes.
248 We further show that changes in
organismal physiology affect mitotic progression in germ
249 oss the natural world, with consequences for
organismal physiology and behaviour and the abundances a
250 oding genes has left the roles of Pol III in
organismal physiology relatively unexplored.
251 tophagy is important for normal cellular and
organismal physiology, and both increased and decreased
252 molecular mechanisms contribute to cell and
organismal physiology.
253 ggest that Maf1 plays a more diverse role in
organismal physiology.
254 mporal states represent the full spectrum of
organismal pluripotency.
255 tabolic process, localization, multicellular
organismal process, response to stimulus, immune system
256 ains regulate a wide variety of cellular and
organismal processes, including DNA damage repair, signa
257 ed to affect a wide range of cellular and/or
organismal processes.
258 nisation (e.g. population or community), and
organismal properties (e.g. body size or number of troph
259 to man-made objects) can accurately predict
organismal radio scattering characteristics from an anat
260 he OAT transporters in inter-organ and inter-
organismal remote communication via transporter-mediated
261 e, and endocrine manner, thereby determining
organismal resilience to aging, disease, and environment
262 metabolism and signaling networks can expand
organismal resilience.
263 show that FAN1 is required for cellular and
organismal resistance to ICLs.
264 enic, we outline the molecular, cellular and
organismal response pathways that designer nucleic acid
265 and hence shoot and root growth, in a whole-
organismal response to ambient light fluctuations.
266 represent excellent models for investigating
organismal response to long-term environmental change.
267 We then discuss how, if and when
organismal responses (acclimate/migrate/adapt) may be al
268 ess, are often used in an attempt to predict
organismal responses to climate change.
269 mean change, provide valuable insights into
organismal responses to environmental heterogeneity.
270 Despite the abundance of literature on
organismal responses to multiple environmental stressors
271 Type 1 interferon (IFN) is a key mediator of
organismal responses to pathogens, eliciting prototypica
272 cids within the histone H3 alpha3 helix play
organismal roles in defining chromatin structure.
273 ly associated with differential growth on an
organismal scale [3].
274 r, they differ in the temporal, spatial, and
organismal scales addressed and the methodology used.
275 ially) many anatomical landmarks to describe
organismal shape.
276 e conserved, to a lesser extreme, across the
organismal spectrum.
277 Organismal stress initiates a tightly orchestrated set o
278 equirements of the germline and soma dictate
organismal stress resistance as animals begin reproducti
279 Obesity is a chronic
organismal stress that disrupts multiple systemic and ti
280 tory signaling pathways in managing cell and
organismal stresses from pathogen infection and sterile
281 s, it is also important to consider the role
organismal structure plays as a context for such respons
282 n processes, are fundamental to cellular and
organismal survival and are paramount to health.
283 e production of erythroid cells that ensures
organismal survival in homeostatic and stress contexts.
284 nd breaks outside the domain, as well as for
organismal survival when DNA repair is compromised.
285 ortant trophic factor promoting cellular and
organismal survival.
286 trol of plasma glucose level is essential to
organismal survival.
287 for maintaining tissue function and enabling
organismal survival.
288 ation, pancreatic function, and cellular and
organismal survival.
289 or of these cells and significantly improves
organismal survival.
290 nning predictions of large-scale patterns in
organismal thermal stress, species' ranges and distribut
291 ological responses to temperature scale from
organismal to ecosystem levels.
292 Organismal tolerances correlate roughly with absolute me
293 inked an expression difference to a specific
organismal trait.
294 demographic rates as continuous functions of
organismal traits (in this case body size).
295 e still debated, and the role played by most
organismal traits and their intraspecific variation is u
296 ism implies the hierarchical organization of
organismal traits into semiautonomous subsets, or module
297 Size and age are fundamental
organismal traits, and typically, both are good predicto
298 This spectacular
organismal transition requires nuclear reprogramming and
299 stress, a characteristic that is relevant to
organismal viability in evolution and in modern HSC tran
300 l regulators of gene expression critical for
organismal viability.