ライフサイエンスコーパス: organizer

1 a large battery of target genes in the head organizer.

2 s essential for proper positioning of the DV organizer.

3 fluid flow inside the vertebrate left-right organizer.

4 motile and immotile cilia at the left-right organizer.

5 in-2 and not neuroligin-1 excitatory synapse organizer.

6 s initiates at the site of the morphogenetic organizer.

7 3K27 methylation in the embryonic left-right organizer.

8 competence and on Shh signaling from the ZLI organizer.

9 est a role for U-STAT3 as a chromatin/genome organizer.

10 al cells, which subsequently emerge from the organizer.

11 catenin marks the formation of the Nieuwkoop organizer.

12 criptional activator and a chromatin/genomic organizer.

13 ors regulate hhex expression in the gastrula organizer.

14 role in setting up and maintaining the head organizer.

15 iniscent of the Fgf8/Wnt1-expressing isthmic organizer.

16 defects as well as disruption of the isthmic organizer.

17 ping buds suggesting they play a role in the organizer.

18 try of the body in the vertebrate left-right organizer.

19 1 (beta-NRX1) via Cbln1, a C1q-like synaptic organizer.

20 al portal (AIP) endoderm as a putative heart organizer.

21 Centrosomes are important cell organizers.

22 d Ccdc151 expressed in vertebrate left-right organizers.

23 omplement the overall assessment by the CAFA organizers.

24 nisms orchestrated by regional morphogenetic organizers.

25 patterning is controlled by several discrete organizers.

26 esis is coordinated by single- or multi-cell organizers.

27 r and suggest similarity with other metazoan organizers.

28 performed by the participants and challenge organizers.

29 NOXO1beta [NOXO1 (Nox organizer 1) beta] is a cytosolic protein that, in conju

30 al side of the embryo and induces the dorsal organizer, a BMP signaling gradient patterns tissues alo

31 l interpretation of these data to aid future organizers achieve improved equity among the limited num

32 ds promise as a tool to discover other novel organizers acting during development.

33 embryonic day 14, at which time Fgf8 isthmic organizer activity is complete and the major output cell

34 Whether FGF8 also has organizer activity that generates the postnatal neocorti

35 whether the subcellular distribution of the organizer/adapter NOX p47(phox) subunit is altered in PV

36 Here, we asked whether the synaptic organizer agrin might regulate the metabolic stability a

37 which are required to exclude Vents from the organizer allowing hhex transcription.

38 and mouse to maintain Gsc expression in the organizer and along the axial midline, neural tube closu

39 rosstalk between mesenchymal lymphoid tissue organizer and hematopoietic lymphoid tissue inducer cell

40 d specifically in the dorsal Spemann-Mangold Organizer and is required for anterior development durin

41 After Spemann's organizer and its derivatives have endowed the neural pl

42 n the dorsal side, in cells of the embryonic organizer and its neighbors.

43 ter, MZdchs1b mutants exhibit altered dorsal organizer and mesendodermal gene expression, due to impa

44 tubules in wild-type embryos impaired dorsal organizer and mesodermal gene expression without percept

45 Ce-Punctin as a previously unknown synaptic organizer and show that presynaptic and postsynaptic dom

46 2-4 signaling is a key part of the spiralian organizer and suggest similarity with other metazoan org

47 brafish Ccr7 or Ccl19.1 expands the blastula organizer and the dorsoanterior tissues at the expense o

48 Wnt inactivation by the Tiki protease in the Organizer and the Notum deacylase in presumptive neuroec

49 ate consists of two outgrowths with distinct organizers and growth trajectories; a lower median fin t

50 cific FGFs act as target-derived presynaptic organizers and help to organize specific presynaptic ter

51 ncreasing our understanding of how extrinsic organizers and intracellular mechanisms contribute to pr

52 ate that replication origins are fundamental organizers and regulators of gene activity through embry

53 irect interaction between MDC1, a master DDR organizer, and a marker of DNA damage, histone gammaH2AX

54 HSV-1) localizes to ND10s, degrades the ND10 organizer, and disperses ND10 components in order to all

55 including a catalogue of trainers and course organizers, and an announcement service for training eve

56 Although signals from the isthmic organizer are known to specify cerebellar territory alon

57 for proteasome subunits and mitotic spindle organizers are enriched among the genes whose knock down

58 Here we review how these secondary organizers are established and how they exert their sign

59 Organizers are regions of the embryo that can both induc

60 ge, zona limitans intrathalamica and isthmic organizer-are present in the hemichordate Saccoglossus k

61 performed a method designed by the challenge organizers as well as predictions by ALS clinicians.

62 Atg11, the preautophagosomal structure (PAS) organizer, as a downstream effector of Ypt1 and show tha

63 The organizers assembled an amazing forum, which included 53

64 The expression patterns of the organizer-associated gene HyWnt3 and the hypostome-speci

65 ignals originated from the so-called isthmic organizer at the mid/hindbrain junction; however, the un

66 w approach, using chick embryos, to discover organizers based on a common gene expression signature,

67 ltaneous reduction of Nodal signaling and an organizer BMP (bone morphogenetic protein) antagonist, e

68 dence shows that these cells act as a tissue organizer by positioning the domain of oriented cell div

69 a novel instructive influence from an early organizer can impose normal asymmetry upon late organize

70 leus downregulates the glutamatergic synapse organizer Cbln1, which is needed for sociability in mice

71 important LTbetaR-dependent lymphoid tissue organizer cell population and indicates that continuous

72 ies a subset of murine fetal lymphoid tissue organizer cells that gives rise exclusively to adult mar

73 on of mesenchymal cells into lymphoid tissue organizer cells.

74 nment of lymph nodes gave rise to lymph node organizer cells.

75 ive imaging technique for Xenopus left-right organizer cilia and show that Galnt11-mediated Notch1 si

76 uded several previously unrecognized Spemann organizer components.

77 This was tested in mosaic organizers composed of motile and immotile cilia generat

78 Here we argue that the vertebrate genome organizer CTCF (CCCTC-binding factor) played an importan

79 regulator and three-dimensional (3D) genome organizer CTCF at cryptic binding sites, in conjunction

80 n restore trunk neural tube formation in the organizer-deficient ichabod(-/-) mutant.

81 Organizer-derived signals are responsible for establishi

82 ere we show that key ingredients of the head-organizer development, namely Nodal ligands, Nodal antag

83 twins produced by late induction of ectopic organizers did have normal asymmetry.

84 ling pathways, thus establishing the Spemann organizer domain.

85 has a well-established role as a microtubule organizer during mitosis and cytokinesis.

86 a functions as a potent endogenous circadian organizer (ECO), which rewires the pathophysiological di

87 tives of this first phase, the Pre-B Project organizers established 4 working groups (WGs) to address

88 As organizers explore new ways of sharing knowledge globall

89 rchin embryo relies on a ventrally-localized organizer expressing Nodal, a pivotal regulator of the D

90 expressing prechordal cells, which leave the organizer first, migrate and do not undergo CE like the

91 Thus, RA acts as a central organizer for coordinated homeostatic plasticity in both

92 ting molecular scaffold involving MreD as an organizer for optimal cell function and growth based on

93 dorsomedial telencephalon, is the embryonic organizer for the hippocampus.

94 morphogenetic proteins (BMPs) and acts as an organizer for the hippocampus.

95 hat normally differentiated HCs act as 'self-organizers' for OC development and that Atoh1 plays a cr

96 Sia and Twn induce organizer formation and expression of organizer-specific

97 The mechanisms promoting organizer formation are known to involve cooperation bet

98 Although roles of Wnt signaling during organizer formation have been studied extensively, it is

99 Organizer formation occurs in dorsal blastomeres receivi

100 c activation of Wnt signaling and subsequent organizer formation on the future dorsal side of the emb

101 terminants, the initiation of Wnt signaling, organizer formation, and ultimately results in ventraliz

102 rs initially responsible for germ layers and organizer formation, including Nodal itself.

103 integration of these signals is required for organizer formation.

104 ent with a redundant role for Sia and Twn in organizer formation.

105 nscriptional responses necessary for Spemann organizer formation.

106 steps in the signalling events that lead to organizer formation.

107 However, the organizer forms in a very restricted region, suggesting

108 at the MHB and that Fgf8, in addition to its organizer function, plays a crucial role in maintaining

109 Sia and Twn are required for all aspects of organizer function.

110 , to which current models assign a stem cell organizer function.

111 22 genes with expression in the ciliated LR organizer (gastrocoel roof plate), a marked enrichment c

112 ut not individually, results in a failure of organizer gene expression and a disruption of axis forma

113 iption initiation that involves mesoderm and organizer gene expression.

114 The MHB organizer gene Fgf8, which is expressed as a sharp trans

115 This suggests that, at organizer gene promoters, a stable transcriptional compl

116 nism for spatial and temporal restriction of organizer gene transcription by the integration of two m

117 oised chromatin architecture and marking key organizer genes for later expression.

118 and Nodal pathways in the activation of the organizer genes Goosecoid (Gsc), Cerberus (Cer), and Cho

119 tant of Sox3 can cause ectopic expression of organizer genes via a mechanism that activates all of th

120 ment to specifically modify the chromatin of organizer genes, poising them for rapid activation when

121 s is required for the expression of multiple organizer genes, suggesting that integration of these si

122 rgistically activates transcription of these organizer genes.

123 sum, we provide evidence that fetal stromal organizers give rise to adult marginal reticular cells a

124 We propose that in the organizer Gsc represses CE as well: Gsc-expressing prech

125 later embryogenesis, the role of Gsc in the organizer has remained enigmatic.

126 So far, surprisingly few organizers have been discovered, considering the number

127 ance and to be expressed in apical meristem "organizers." Here, we focus on the role of the WOX5 tran

128 transcription factor, serves as a chromatin organizer in building this complex chromatin structure b

129 o induce robust expression of markers of the organizer in ectopic positions in the animal pole, where

130 tor 22 (FGF22), a target-derived presynaptic organizer in the mouse hippocampus, induces the expressi

131 s, guidance signals emanating from a central organizer in the specific target tissue may act as an im

132 the results highlight the clamp as a central organizer in the structure and function of replication f

133 ptic scaffold protein liprin-alpha2 as a key organizer in this process.

134 play major roles in establishing the dorsal organizer in vertebrate embryos, overexpression of any o

135 (Gsc) expression marks the primary embryonic organizer in vertebrates and beyond.

136 (NL-NRX) complexes are fundamental synaptic organizers in the central nervous system.

137 Tetraspanins are master organizers in the plasma membrane, forming tetraspanin-e

138 anizer can impose normal asymmetry upon late organizers in the same cell field.

139 unctional experiments manipulating secondary organizers in zebrafish and mice.

140 culus in the absence of Fgf8 and the isthmic organizer, indicating that FGF and Mek1(DD) initiate qua

141 operly oriented the LR axis 90% of the time, organizers induced in any position at any time after the

142 n by anti-sense morpholinos causes defective organizer induction, patterning and differentiation of m

143 nipulating the timing and location of dorsal organizer induction: the primary dorsal organizer was ab

144 An organizer is a portion of the embryo producing signals t

145 Ontology Term Organizer is a user-friendly, web-based, consensus-promo

146 The Spemann organizer is an essential signaling center in Xenopus ge

147 o, we show that fluid flow in the left-right organizer is asymmetric and provides a good predictor of

148 Formation of the organizer is one of the most central patterning events i

149 The thalamic organizer is the zona limitans intrathalamica (ZLI), a t

150 The concept of an "organizer" is basic to embryology.

151 we also observed a decrease of the synaptic organizer laminin beta2 protein, an extracellular ligand

152 naptic VDCCs link the target-derived synapse organizer laminin beta2 to active-zone proteins and func

153 In an adult hydra the head organizer, located in the hypostome, is constantly activ

154 rate development is broken at the left-right organizer (LRO) by ciliary motility and the resultant di

155 We found that despite all left-right organizer (LRO) cells express foxj1a and the ciliary axo

156 ymmetry originates at a transient left-right organizer (LRO), a ciliated structure where cilia play a

157 Here we identify two synaptic organizers, Lrrtm1 and Lrrtm2, as targets of nuclear cal

158 lymphoid tissue inducer and lymphoid tissue organizer (LTo) cells.

159 tablishment of the dorsal Nieuwkoop blastula organizer, marked by the nuclear accumulation of materna

160 A key premise is that project organizers may be able to draw on underused human resour

161 ption factor combination is a novel synaptic organizer molecule, the single immunoglobulin domain pro

162 Furthermore, addition of the synaptic organizers, neuroligins, induces presynaptic differentia

163 and highlights the role of flow as a central organizer of actomyosin network architecture.

164 Reward seeking is a major motivator and organizer of behavior, and animals readily learn to modi

165 existence of a Hox-CTCF kernel as principal organizer of bilaterian body plans.

166 sphatidylserine-binding protein and critical organizer of caveolae (small microdomains in the plasma

167 reB based on evidence implicating MreB as an organizer of cell wall synthesis.

168 These data implicate FGF14 as an organizer of channel localization in the AIS and provide

169 dent LARG-RhoA signaling module as a central organizer of directed cell migration and invasion.

170 tranded DNA binding protein (SSB) acts as an organizer of DNA repair complexes.

171 Thus, alpha-DB emerges as a central organizer of dystrophin-associated protein in glial endf

172 in transcription factor Lhx2 is an essential organizer of early eye development and is subsequently e

173 Here, we propose that EphBs act as a central organizer of excitatory synapse formation and function,

174 Fibronectin is a master organizer of extracellular matrices (ECMs) and promotes

175 g protein beta (mAKAPbeta) serves as a nodal organizer of hypertrophic signaling.

176 t increase in the expression of gephyrin, an organizer of ligand-gated ion channels at inhibitory syn

177 ub for complex sphingolipids, but also as an organizer of membrane domains segregating receptors and

178 Caveolin-1 (Cav-1) is a key organizer of membrane specializations and a scaffold pro

179 PML, the organizer of NBs, is expressed as a number of splice var

180 he degradation and dissociation of the major organizer of ND10, a promyelocytic leukemia (PML) and ND

181 ase, thereby revealing a function of Rif1 as organizer of nuclear architecture.

182 fiber provides a robust spatial and temporal organizer of parasite cell division, a process that appe

183 rt we define a role for Gravin as a temporal organizer of phosphorylation-dependent protein-protein i

184 cytic leukemia protein (PML) is an essential organizer of PML nuclear bodies (NBs), which carry out a

185 us on the actin regulator Cortactin, a major organizer of protrusion, membrane mobility, and invasive

186 Our findings demonstrate that NG2 is a core organizer of Rho GTPase activity and localization in the

187 ndomesodermal lineage represent an embryonic organizer of subsequent development and are causally inv

188 r protein (CDC42EP) signaling pathway, a key organizer of the actin cytoskeleton, was previously repo

189 scaffolding protein ankyrin-G is the master-organizer of the AIS.

190 that the CDK oscillator acts as the primary organizer of the cell cycle, imposing timing and directi

191 enchymal cells (the cumulus) functions as an organizer of the dorsoventral axis.

192 ve suggested that the D quadrant acts as the organizer of the embryonic axes in annelids, although th

193 Epithelial-cadherin (E-cadherin) is a master organizer of the epithelial phenotype.

194 ociation of ERAD machinery components, a key organizer of the ERAD complex.

195 urce in the rostromedial telencephalon as an organizer of the neocortical area map.

196 ch transcript-Z+Agrin-known to be a critical organizer of the NMJ.

197 We show that Arp2/3 complex is an essential organizer of treadmilling actin filament arrays but has

198 anchor cell (AC) of the gonad, the critical organizer of uterine and vulval development.

199 ntal disorder and that SPECC1L is a critical organizer of vertebrate facial morphogenesis.

200 Angptl4 is expressed in the Spemann organizer of Xenopus embryos and acts as a Wnt antagonis

201 nt and demonstrates a role for astrocytes as organizers of active synaptic connections by coordinatin

202 rin-alpha have been identified as two master organizers of AZ assembly.

203 Follicular dendritic cells (FDCs) are key organizers of B cell follicles and germinal centers.

204 tenance of chromosome (SMC) proteins are key organizers of chromosome architecture and are essential

205 e plasma membrane of most cells serve as key organizers of intracellular signalling and tethering poi

206 lgeranyl isoprenoids to Rab GTPases, the key organizers of intracellular vesicular transport, is esse

207 uncover a novel function for neutrophils as organizers of lymphangiogenesis during inflammation.

208 Primary cilia have pivotal roles as organizers of many different signaling pathways, includi

209 In animals, they are known to act as central organizers of membrane complexes and thought to facilita

210 pericentromeric heterochromatin clusters as organizers of nuclear microenvironment required for prop

211 ce provides a list of outstanding women whom organizers of scientific meetings, scientific review pan

212 Neurexins are considered central organizers of synapse architecture that are implicated i

213 Neurexins are recognized as key organizers of synapses that are essential for normal bra

214 in-binding protein filamins (FLNs) are major organizers of the actin cytoskeleton.

215 eLRRon proteins as important components and organizers of the pre-cuticular and cuticular apical ECM

216 CSPGs, acting as central organizers of the tumor microenvironment, dramatically i

217 o whether AnkG functions as an initial nodal organizer or whether it functions as a nodal stabilizer

218 of invited speakers, assembled by conference organizers or committees, is key to achieving these goal

219 ndent transcription factor for NADPH oxidase organizer p47phox, thereby increasing ROS-NFkappaB-VCAM-

220 ates that the proteasome and mitotic spindle organizers participate in discrete aspects of synaptic d

221 The meeting organizers, Patricia Ernst, Hanna Mikkola and Timm Schro

222 atory factor (NHERF1) is a molecular pathway organizer, PDZ-domain protein that recruits membrane, cy

223 Organizers play important roles during the embryonic dev

224 d transcription factors, the Spemann-Mangold organizer, pluripotency genes and the neuromuscular junc

225 e E3 ubiquitin ligase that degrades the ND10 organizer PML and disperses ND10 to alleviate the repres

226 is article grew out of contributions made by organizers, presenters, panelists, and other participant

227 The head organizer produces two signals, the head activator and h

228 stone acetyltransferase p300 is recruited to organizer promoters in a Wnt and Nodal effector-dependen

229 We found that the genome organizer protein Satb1 is highly expressed in mature ne

230 NCC ubiquitination and ERAD, the Hsp70/Hsp90 organizer protein stabilized NCC turnover, indicating th

231 teracting protein (CHIP) and the Hsp70/Hsp90 organizer protein, were associated with NCC.

232 bout WNT interaction with mitotic structural organizer proteins.

233 d rRNA gene subtypes mapped to the nucleolus organizer region (NOR) on chromosome 2 (NOR2).

234 to be a determinant at the Xenopus gastrula organizer region and a segment-polarity determinant in D

235 ome as well as during the formation of a new organizer region in developing buds suggesting they play

236 Nucleolus organizer regions (NORs) are chromosomal loci where hund

237 curred in both the centromeres and nucleolar organizer regions (NORs) in D- and AD-genome species, ye

238 f 45S rRNA gene copies localize in Nucleolus Organizer Regions (NORs), and the activation or repressi

239 localizes with the 45S rDNA at the nucleolar organizer regions (NORs).

240 Dorsoventral patterning is mediated by two organizer regions that extend along the dorsal and ventr

241 ed with altered silver staining of nucleolar organizer regions, coupled to a modest decrease in H3K9

242 regulating cellular dynamics in the Spemann organizer, regulates delamination of neuroblasts in the

243 ctor, has been shown to act as a presynaptic organizer released from the postsynaptic site, it seems

244 Whereas organizers rescued before cleavage properly oriented the

245 Here we show that the cytoskeletal organizer RhoA suppresses neutrophil priming via formins

246 proposed more than a decade ago explain the organizer's region-specific inductions (i.e., head and t

247 T cell-specific deficiency of the genome organizer Satb1 impaired Treg-SE activation and the subs

248 directly regulating expression of the genome organizer Satb1 in progenitor cells.

249 al. (2017) uncover a key role for the genome organizer Satb1 in restraining PD1 expression and promot

250 In March 2016, meeting organizers Sebastian Jessberger and Hongjun Song brought

251 Our findings implicate FGF8 as an organizer signal, and its source in the rostromedial tel

252 e development of all structures that require organizer signaling and ventralizes the embryo.

253 inhibit or promote formation of the Spemann organizer signaling center.

254 the pathway is active in all lineages during organizer signaling, but activation is strongest on the

255 nduce eyes and external shell, which require organizer signaling.

256 Just as its amphibian counterpart in the organizer signals body plan and cell fate during embryog

257 Organizer signals come from a surprisingly limited set o

258 se extended interactome includes the spindle organizer, silencing factors, the proteasome, and key co

259 vocative new studies establish the chromatin organizer special AT-rich binding protein 1 (Satb1) as o

260 We found that the chromatin organizer special AT-rich sequence-binding protein-1 (Sa

261 induce organizer formation and expression of organizer-specific genes, including Goosecoid (Gsc).

262 dorsal-anterior structures and overexpressed organizer-specific genes, indicating that maternal Bicc1

263 rab5ab is essential for nodal signalling and organizer specification in the developing zebrafish embr

264 The Spemann organizer stands out from other signaling centers of the

265 stimulated phosphorylation of p47(phox) (an organizer subunit for nicotinamide adenine dinucleotide

266 ighly expressed in the colon, Nox1 needs the organizer subunit NoxO1 and the activator subunit NoxA1

267 c architectures without benefit of a central organizer, such as a centrosome, to control the location

268 Using these devices, Otx2 and other head organizer TFs (for example, Lim1/Lhx1 (activator) or Goo

269 r Visceral Endoderm (AVE), an extraembryonic organizer that controls the position of the streak.

270 ts presented argue that E202 acts as a water-organizer that creates a proton conduit connecting intra

271 tra-terminal (ET) domain, is a key chromatin organizer that directs gene activation in chromatin thro

272 CTIP2 appears to serve as a transcriptional organizer that integrates input from multiple signaling

273 ted set of interactions operating within the organizer that is critical for embryonic patterning.

274 Satb1 is a nuclear organizer that partitions chromatin through the formatio

275 vated in the cells of the anterior-posterior organizer that produce the region between wing veins 3 a

276 tein 1 (SATB1) is a tissue-restricted genome organizer that provides a key link between DNA loop orga

277 The most famous example is the Spemann organizer that sets up embryonic axes in amphibian embry

278 the PSD-95 MAGUKs serve as critical synaptic organizers that use distinct protein-protein interaction

279 d by a small group of cells, often called an organizer, that signals to other cells to establish the

280 For course organizers, the portal provides opportunities to promote

281 Meeting organizers thus felt the time was right, armed with new

282 Transplantation of Spemann organizer tissue showed that Chordin diffused over long

283 which gives rise to Shh-expressing posterior organizer tissue, caused loss of posterior gene expressi

284 However, a third head organizer tissue, the prechordal plate, fails to express

285 motile and immotile cilia at the left-right organizer to determine laterality, and reveal a novel me

286 rmation, DNA is also an excellent biological organizer to establish well-designed nanostructures in t

287 up, the prechordal plate, from the embryonic organizer to the animal pole.

288 These results connect the spiralian organizer to this general aspect of secondary axis patte

289 ql3, produced by MFs, serve as extracellular organizers to recruit functional postsynaptic KAR comple

290 ar to experiments performed with the Spemann organizer, transplantation of the cumulus is able to ind

291 rsal organizer induction: the primary dorsal organizer was ablated by UV irradiation, and a new organ

292 ordin protein secreted by the dorsal Spemann organizer was found to diffuse along a narrow region tha

293 zer was ablated by UV irradiation, and a new organizer was induced at various locations, either early

294 Late organizers were unable to correctly orient the LR axis e

295 ity is initiated at the embryonic left-right organizer, where motile cilia generate leftward flow tha

296 ls are required for formation of the Spemann organizer, which is essential for germ layer patterning

297 nd its maintenance is controlled by the head organizer, which is located at the apex of the animal.

298 ly characterized as a T cell-specific genome organizer whose aberrant overexpression in breast cancer

299 ssively refined by the activity of secondary organizers within the neuroepithelium that function by r

300 8 is increased at the rostral telencephalic organizer, yet the FGF8 source was unchanged in hem-abla