ライフサイエンスコーパス: organolithium

1 ansfer catalyst, is commonly used to prepare organolithiums.

2 s urea-stabilized, configurationally defined organolithiums.

3 ne of two interconvertible diastereoisomeric organolithiums.

4 A remarkable finding is that for all of the organolithiums a lithium oxyanionic group in the proxima

5 Organolithiums add in an umpolung fashion to the beta-ca

6 ffect of a THF-solvated lithium cation in an organolithium addition to an aldehyde.

7 st merges three simple starting materials-an organolithium, an organoboronic ester, and an organotrif

8 Changing course: While organolithium and Grignard reagents favor addition to C1

9 t yields upon reaction with alkyl/vinyl/aryl organolithium and Grignard reagents, in the absence of a

10 A wide array of nucleophiles, such as organolithium and Grignard reagents, lithium enolates an

11 s the synthesis of ketones from a variety of organolithium and Grignard reagents.

12 oup, resulting in retentive arylation of the organolithium and hence overall addition of an alkyl or

13 occurring with the highly reactive secondary organolithium and in the presence of an allylic oxyanion

14 The synthesis of siloxanes via organolithium and magnesium reagents was limited by the

15 that is thought to occur with the analogous organolithium and organomagnesium cyclizations.

16 g electrophilic functionalities sensitive to organolithium and organomagnesium derivatives.

17 monoperoxyacetals react with sp(3) and sp(2) organolithium and organomagnesium reagents to furnish mo

18 A variety of organolithiums are added to terminal and 2,2-disubstitut

19 (3) Conjugate bases of organolithiums are stable with respect to electron loss

20 dimethyl-substituted phosphine sulfide using organolithium bases in the presence of (-)-sparteine has

21 m by which oxiranes react in the presence of organolithium bases.

22 most general method yet known for preparing organolithiums capable of intramolecular carbometalation

23 This type of reaction is rare in organolithium chemistry and has obvious significant impl

24 Possible benefits of carrying out organolithium chemistry at low ligand concentrations are

25 Shattering the long-held dogma that organolithium chemistry needs to be performed under iner

26 t measurement of ligand-binding constants of organolithium complexes using a (1)H NMR/diffusion-order

27 e most widely used methods of preparation of organolithium compounds is by the reductive lithiation o

28 Organolithium compounds RLi (R = CH(3), CH(3)CH(2), CH(2

29 The organolithium compounds were prepared by tin-lithium exc

30 Like organolithium compounds, they exhibit aggregation phenom

31 ble from 1-azapenta-1,4-dien-3-ones 3a-i and organolithium compounds.

32 uding aldol condensations and reactions with organolithium compounds.

33 and/or undesired homocoupling that has kept organolithium cross-couplings from achieving the same le

34 metallic reagents such as organomagnesium or organolithium derivatives was studied, affording acyl be

35 ive asymmetric deprotonation reactions using organolithium/diamine complexes in THF.

36 in the reactions of chiral heterosubstituted organolithiums, generated by lithiation of alkylideneazi

37 Addition of a variety of organolithium, Grignard, and organozinc reagents (M-R) t

38 between the sp(2)-hybridized bromide and an organolithium initiates the process.

39 one structure and subsequent elaboration via organolithium intermediates.

40 The organolithium is configurationally stable at low tempera

41 ingly analogous reaction of thioketones with organolithiums is a fundamentally different process: suc

42 An array of organolithiums, magnesiates, enolates, and metalated nit

43 In 18 out of 20 examples of the organolithium-mediated conversion of beta-alkoxy aziridi

44 aryl iodides without the need of traditional organolithium or Grignard precursors.

45 nuous flow synthesis of ketones from CO2 and organolithium or Grignard reagents that exhibits signifi

46 The condensation of organolithium or Grignard reagents with nitriles produce

47 One of the diastereoisomeric atropisomeric organolithiums produced by the tin-lithium exchange is d

48 fferent alkenes supports the hypothesis that organolithium-promoted decomposition of precursors to cy

49 athways, (2) the resulting conclusions about organolithium reaction mechanisms, and (3) perspectives

50 d an unprecedented solvent-dependence of the organolithium reactivity, the key factor in governing se

51 2-fold neopentylic coupling reaction with an organolithium reagent derived from the alkyl iodides (R)

52 The title organolithium reagent possesses relatively low basicity

53 l halogen metal exchange and reaction of the organolithium reagent with N-butanoylmorpholine.

54 lic displacement of the 3-methoxy group with organolithium reagents and instead afforded dihydronapht

55 zed asymmetric allylic alkylation (AAA) with organolithium reagents and reductive ozonolysis is prese

56 ctions of [Me(2)Si(Cp(Me(2)))(2)]W(H)Cl with organolithium reagents do not yield simple ansa tungsten

57 The reaction of ketones with organolithium reagents generally proceeds by addition of

58 been achieved that permit the direct use of organolithium reagents in the palladium-catalyzed cross-

59 ls (TEFDDOLs), by addition of perfluorinated organolithium reagents or Ruppert's reagent (TMS-CF(3))

60 ion and arylation of 4-chloroquinoline using organolithium reagents proceed with high regioselectivit

61 and diastereoselective conjugate addition of organolithium reagents to alpha,beta,gamma,delta-unsatur

62 Addition of organolithium reagents to corannulene (1) produces 1-R-1

63 of 1,2 to 1,4 addition of sulfur-substituted organolithium reagents to cyclohexenones and hexenal was

64 Temporarily anchoring Grignard and organolithium reagents to gamma-hydroxy-alpha,beta-alken

65 organic solvents, chemoselective addition of organolithium reagents to non-activated imines and quino

66 These can be intercepted reductively or with organolithium reagents to produce diastereomerically pur

67 or the reaction of methyl boronic ester with organolithium reagents with alpha-leaving groups.

68 olution for intermolecular cross-coupling of organolithium reagents without the problematic lithium-h

69 s, prepared by combining organoboronates and organolithium reagents, engage in palladium-induced meta

70 The influence of organolithium reagents, ratio of organolithium/(-)-spart

71 ontrolled additions with organomagnesium and organolithium reagents.

72 cleanly into epoxy ketones by treatment with organolithium reagents.

73 nfluence of organolithium reagents, ratio of organolithium/(-)-sparteine pair versus N,N-dialkyl aryl

74 Nonstabilized alpha-O-substituted tertiary organolithium species are difficult to generate, and the

75 rational stability of a carbamate-stabilized organolithium species may be enhanced by restrictive geo

76 cleophilic addition of Grignard reagents and organolithium species to a 3-silyloxy-3,4,5,6-tetrahydro

77 The configurational stability of the alpha-S-organolithium species was enhanced by using a less coord

78 e reaction of various sp2- and sp-hybridized organolithium species with bromoketone 1 is presented.

79 sible pathways for inversion of these chiral organolithium species.

80 fers from the configurational instability of organolithiums that are stereogenic at a lithiated carbo

81 Rapid electrophilic trapping of the organolithium therefore generates highly enantiomericall

82 d a variety of products, and addition of the organolithium to carbon of the C horizontal lineS group

83 of ketones and thioketones in reactions with organolithiums, transition states for both the addition

84 The deprotonation to give the organolithium was optimized by in situ IR spectroscopy a

85 e group and for the enantiomerization of the organolithium were determined.

86 It was also found that the cyclized organolithiums, which would have become protonated in th

87 llithiums to give diastereoisomeric benzylic organolithiums whose stereochemistry can be assigned by

88 prehensive investigation of the reactions of organolithiums with a representative alkyl-substituted t