ライフサイエンスコーパス: organophosphorus

1 Organophosphorus acid anhydride (OP) "nerve agents" are

2 rate that this enzyme (but not a G117H/E197Q organophosphorus acid anhydride hydrolase catalytic vari

3 Organophosphorus acid anhydrolase (OPAA) was spontaneous

4 irst time, a nerve agent detoxifying enzyme, organophosphorus acid anhydrolase (OPAA), has been succe

5 t widely used reactions for the synthesis of organophosphorus acids, is presented.

6 can be used to search for new biomarkers of organophosphorus agent exposure.

7 go self-reactivation after inhibition by the organophosphorus agent paraoxon.

8 suitable for identifying exposure to unknown organophosphorus agents.

9 lticlass pesticide residues (organochlorine, organophosphorus and synthetic pyrethroids) in edible oi

10 wo bacterial enzymes, phosphotriesterase and organophosphorus anhdrolase, are examined for their abil

11 inherent distinction in design criteria for organophosphorus-based catalysts operating via P(III)/P(

12 Terrorist use of organophosphorus-based nerve agents and toxic industrial

13 on the test line was able to recognize both organophosphorus BChE adducts (OP-BChE) and BChE and pro

14 This latter result confirms that the organophosphorus binding site of albumin is a tyrosine.

15 tic cleavage of the N-C and C-S bonds of the organophosphorus bridge leading to the formation of dime

16 ple and suggest additional opportunities for organophosphorus catalysis in a biphilic mode.

17 atalytic bioscavenger countermeasure against organophosphorus chemical warfare agents and pesticides

18 1)R(2)P(O)H are important functionalities in organophosphorus chemistry and display prototropic tauto

19 um ring synthesis, but were soon diverted to organophosphorus chemistry, and that eventually resulted

20 reaction has many potential applications in organophosphorus chemistry.

21 o different concentrations of the prototypic organophosphorus compound chlorpyrifos-oxon.

22 nic crystal sensing material that senses the organophosphorus compound parathion at ultratrace concen

23 iron oxide nanoparticles with a bifunctional organophosphorus compound, N-(phosphonomethyl)iminodiace

24 -component mixture of a ketone, alcohol, and organophosphorus compound, the same level of ion isolati

25 detect the presence of paraoxon, which is an organophosphorus compound, using the layer-by-layer (LbL

26 selectively recognize small model molecules, organophosphorus compounds (OPCs), of high biological im

27 Many organophosphorus compounds (OPs) are potent cholinestera

28 Organophosphorus compounds (OPs) being applied as flame

29 volume) sensitivity to either organoamine or organophosphorus compounds are demonstrated, and their u

30 The pharmacology of weaponized organophosphorus compounds can be investigated using pho

31 A variety of substituted organophosphorus compounds can be obtained in one pot vi

32 se was found to be potently inhibited by the organophosphorus compounds chlorpyrifosmethyl oxon, dich

33 Considering the ubiquity of organophosphorus compounds in organic synthesis, pharmac

34 Organophosphorus compounds include many synthetic, neuro

35 yme acetylcholinesterase (AChE), which binds organophosphorus compounds irreversibly, creating an ani

36 The one-pot synthesis of various important organophosphorus compounds is also demonstrated.

37 useful synthons for the preparation of other organophosphorus compounds is demonstrated.

38 Organophosphorus compounds represent a large class of mo

39 Biologically based extractions of organophosphorus compounds represent a new technique for

40 ped an NMR method that selectively edits for organophosphorus compounds via (31)P-(1)H heteronuclear

41 l agent of meningitis, NmAPN) complexed with organophosphorus compounds were resolved to determine th

42 use such a system to detect the presence of organophosphorus compounds with speed and sensitivity us

43 y efficient catalytic scavenger of poisonous organophosphorus compounds, based on organophosphorus hy

44 ety of toxic acetylcholinesterase-inhibiting organophosphorus compounds, including fluorine-containin

45 on the reactivity of the fluoride ion toward organophosphorus compounds, we established that the extr

46 c metalloenzyme that hydrolyzes a variety of organophosphorus compounds.

47 preparation of H-phosphinic acids and other organophosphorus compounds.

48 r the cognitive-enhancing effects of certain organophosphorus compounds.

49 tion of a previously unrecognized target for organophosphorus compounds.

50 omising candidates for the bioremediation of organophosphorus compounds.

51 N(R)C(=O)N(H)R], a new family of derivatized organophosphorus compounds.

52 on, and allows one-pot conversion to various organophosphorus compounds.

53 icient modification of phenyl substituent in organophosphorus compounds.

54 of aqueous fluoride ions to react with such organophosphorus compounds.

55 Diisopropyl phosphorofluoridate (DFP) is an organophosphorus ester, which produces organophosphorus

56 is an organophosphorus ester, which produces organophosphorus ester-induced delayed neuropathy (OPIDN

57 isopropyl phosphorofluoridate (DFP) produces organophosphorus ester-induced delayed neurotoxicity (OP

58 Organophosphorus esters 9, 10, 14, and 15 prepared via r

59 ntibodies, serum cholinesterase (a marker of organophosphorus exposure), total and specific serum IgE

60 er and an organic phase containing an acidic organophosphorus extractant.

61 ylphosphate) (BPA-BDPP) are two halogen-free organophosphorus flame retardant (PFRs) that are used as

62 esorcinol bis(diphenylphosphate) (RDP) is an organophosphorus flame retardant widely used in electric

63 e new wearable sensors, based on stretchable organophosphorus hydrolase (OPH) enzyme electrodes, are

64 xins posing a threat to human life globally, organophosphorus hydrolase (OPH) has become the enzyme o

65 E. coli cells expressing organophosphorus hydrolase (OPH) on the cell surface wer

66 d layer of Escherichia coli cells expressing organophosphorus hydrolase (OPH) on the cell surface.

67 Organophosphorus hydrolase (OPH) was displayed and ancho

68 Structural changes in the enzyme organophosphorus hydrolase (OPH) were monitored upon ads

69 is study is to immobilize an enzyme, namely, organophosphorus hydrolase (OPH), and to detect the pres

70 n a biosensing scheme by integrating it with organophosphorus hydrolase (OPH), capable of selective O

71 s, mammalian serum paraoxonase and bacterial organophosphorus hydrolase (OPH).

72 isonous organophosphorus compounds, based on organophosphorus hydrolase (OPH, EC 3.1.8.1), is produce

73 Organophosphorus hydrolase (OPH, EC 8.1.3.1) is a dimeri

74 Organophosphorus hydrolase (OPH, EC 8.1.3.1) is a homodi

75 of rabbit serum paraoxonase, suggesting that organophosphorus hydrolase can hydrolyze phosphoryl oxim

76 of ligand recognition and the prolidase and organophosphorus hydrolase catalytic activities of OPAA.

77 h encapsulated seminapthofluorescein (SNAFL)-organophosphorus hydrolase enzyme conjugates.

78 hydrophobicity of CNT was used to immobilize organophosphorus hydrolase mutant with improved catalyti

79 Escherichia coli cells expressing the enzyme organophosphorus hydrolase on the cell surface and the o

80 ns of ClyA to the enzymes beta-lactamase and organophosphorus hydrolase resulted in synthetic OMVs th

81 Inclusion of the organophosphorus hydrolase signal sequence was necessary

82 Organophosphorus hydrolase was covalently immobilized on

83 ered Escherichia coli with surface-expressed organophosphorus hydrolase.

84 Organophosphorus insecticide poisoning is not a single e

85 Each organophosphorus insecticide should be considered as an

86 Although more than 100 organophosphorus insecticides exist, organophosphorus po

87 creased by exposure to dust-mite allergen or organophosphorus insecticides in urban and rural areas o

88 d to determine whether the three most common organophosphorus insecticides used for self-poisoning in

89 ern--including some phenoxy acid herbicides, organophosphorus insecticides, polychlorinated biphenyls

90 anagement protocols developed for particular organophosphorus insecticides.

91 o develop binary prophylactic agents against organophosphorus intoxication.

92 igand in [1H]BF(4) is readily substituted by organophosphorus ligands to afford the substituted deriv

93 marised for the main classes of extractants (organophosphorus ligands, diamides and N-heterocycles),

94 The detection and identification of organophosphorus molecules, particularly in the cases of

95 (ddHRMS/MS) method capable of detecting all organophosphorus nerve agent (OPNA) adducts to human but

96 The technique was characterized using the organophosphorus nerve agent VX.

97 l) methylphosphonothioate) is a highly toxic organophosphorus nerve agent, and even low levels of con

98 Hydrolysis of G- and V-series organophosphorus nerve agents (OPNAs) containing a phosp

99 (IMS) method for diagnosing exposure to the organophosphorus nerve agents (OPNAs) sarin (GB), cycloh

100 method for the simultaneous detection of the organophosphorus nerve agents (OPNAs) tabun (GA), sarin

101 ymes that efficiently hydrolyze highly toxic organophosphorus nerve agents could potentially be used

102 Organophosphorus nerve agents interfere with cholinergic

103 The organophosphorus nerve agents sarin, soman, tabun, and V

104 ich catalyzes the hydrolysis of a variety of organophosphorus nerve agents with high efficiency.

105 synthesized twelve fluorogenic analogues of organophosphorus nerve agents with the 3-chloro-7-oxy-4-

106 ate acetylcholinesterase (AChE) inhibited by organophosphorus nerve agents.

107 used as a medical countermeasure against the organophosphorus nerve agents.

108 meric, bacterial enzyme that detoxifies many organophosphorus neurotoxins by hydrolyzing a variety of

109 e detection of organophosphorus (OP) and non-organophosphorus (non-OP) pesticides.

110 Human albumin or plasma was treated with organophosphorus (OP) agent at alkaline pH, digested wit

111 e neonicotinoids acting as nAChR agonists or organophosphorus (OP) and methylcarbamate (MC) acetylcho

112 on electrode for discriminative detection of organophosphorus (OP) and non-organophosphorus (non-OP)

113 Organophosphorus (OP) compound poisoning is a major glob

114 Soman is an organophosphorus (OP) compound which irreversibly inhibi

115 Insecticide and nerve agent organophosphorus (OP) compounds are potent inhibitors of

116 Organophosphorus (OP) compounds cause toxic symptoms, in

117 gents soman, sarin, VX, and tabun are deadly organophosphorus (OP) compounds chemically related to OP

118 The possibility that organophosphorus (OP) compounds contribute to motor neur

119 Binding of certain organophosphorus (OP) compounds to NTE is believed to ca

120 es lactones, aromatic esters, and neurotoxic organophosphorus (OP) compounds, including insecticide m

121 sters, lactones, oxidized phospholipids, and organophosphorus (OP) compounds.

122 Organophosphorus (OP) insecticides and chemical warfare

123 Organophosphorus (OP) insecticides were the first group

124 Organophosphorus (OP) nerve agents are potent toxins tha

125 been developed for vapor-phase detection of organophosphorus (OP) nerve agents.

126 tor erythrocytes for exposure of patients to organophosphorus (OP) pesticides and chemical warfare ag

127 phorylation for biomonitoring of exposure to organophosphorus (OP) pesticides and nerve agents based

128 Exposure to nerve agents or organophosphorus (OP) pesticides can have life-threateni

129 arget esterase (NTE) is inhibited by several organophosphorus (OP) pesticides, chemical warfare agent

130 As a consequence of organophosphorus (OP) toxins posing a threat to human li

131 Aging of organophosphorus (OP)-compound-inhibited neuropathy targ

132 significantly lower for pyrethroids than for organophosphorus or organochlorine insecticides, which s

133 as shown that the cumulative acute intake of organophosphorus or pyrethroid compounds from the consum

134 plant hormones, decreased residues of common organophosphorus, organochlorine and carbamate pesticide

135 time, we propose a biomimetic biosensor for organophosphorus pesticide detection employing a functio

136 Prenatal organophosphorus pesticide exposure and child neurodevel

137 n, and the substructure classes are standard organophosphorus pesticide groupings.

138 demonstrated a novel sensing strategy for an organophosphorus pesticide namely, malathion, employing

139 ChE biosensor enabled precision detection of organophosphorus pesticides (diazinon(oxon), chlorpyrifo

140 on, pre-concentration, and extraction of six organophosphorus pesticides (malathion, phosalone, dichl

141 Organophosphorus pesticides (OPs) are used in agricultur

142 y of BChE could be irreversibly inhibited by organophosphorus pesticides (OPs), thus, the recovery ef

143 nd cotton farmers with long-term exposure to organophosphorus pesticides (OPs).

144 et for neurodegeneration induced by selected organophosphorus pesticides and chemical warfare agents.

145 resence of other chemical analogues, such as organophosphorus pesticides and herbicides, was investig

146 eric enzyme that catalyzes the hydrolysis of organophosphorus pesticides and nerve agents.

147 dict the toxicity or active substructures of organophosphorus pesticides and then are applied to scre

148 s amide, benzimidazole, methyl carbamate, or organophosphorus pesticides and with increasing numbers

149 Chemically analogous organophosphorus pesticides tested against the sensor ha

150 ng E. coli cells catalyzed the hydrolysis of organophosphorus pesticides to form stoichiometric amoun

151 analytes were seven specific metabolites of organophosphorus pesticides, five metabolites of synthet

152 d the increased potency of oxygen analogs of organophosphorus pesticides.

153 ng methods to measure levels of the ollowing organophosphorus pesticides: chlorpyrifos, azinphos-meth

154 allylic bromides is catalyzed by a biphilic organophosphorus (phosphetane) catalyst.

155 h models for mild, moderate and severe acute organophosphorus poisoning by exposing zebrafish larvae

156 more effective countermeasures against acute organophosphorus poisoning is urgently needed.

157 han 100 organophosphorus insecticides exist, organophosphorus poisoning is usually regarded as a sing

158 r multifunctional drug therapy against acute organophosphorus poisoning.

159 Organophosphorus poisons (OP) bind covalently to the act

160 Overall, a variety of novel organophosphorus reagents and products were synthesized

161 ble enzyme to hydrolyze such a wide range of organophosphorus substrates.

162 thods to measure resistance to inhibition by organophosphorus toxicants (OP) for mutants of butyrylch

163 city from acute exposure to nerve agents and organophosphorus toxicants is due to irreversible inhibi