ライフサイエンスコーパス: origin of replication

1 recombinase gene and a temperature-sensitive origin of replication.

2 bidirectional replication initiates from an origin of replication.

3 that binds to and nicks the double-stranded origin of replication.

4 ion and anti-correlated with distance to the origin of replication.

5 position relative to the expression site or origin of replication.

6 onserved Sequence Block III and the L-strand origin of replication.

7 directional genome replication from a single origin of replication.

8 ated by DnaA, a AAA+ ATPase that unwinds the origin of replication.

9 may have a specific function at or near the origin of replication.

10 se, mCherry fluorescent protein, and a ColE1 origin of replication.

11 were unexpectedly distant (> 1 Mb) from the origin of replication.

12 and not those originating at the chromosomal origin of replication.

13 eight identified parS sites located near the origin of replication.

14 in with the seven 22-bp iterons of the gamma origin of replication.

15 not only for the gene but also for the local origin of replication.

16 ry cellular replication factors to the viral origin of replication.

17 sence of a centromere-like site close to the origin of replication.

18 ion initiation protein and (ii) the putative origin of replication.

19 g ORC free in solution and bound to the ARS1 origin of replication.

20 trand replication is initiated from a second origin of replication.

21 hosphorylated CtrA binds to and silences the origin of replication.

22 (kanamycin) and an Escherichia coli plasmid origin of replication.

23 in the opposite orientation relative to the origin of replication.

24 vel transcripts derived from the EBV latency origin of replication.

25 oading of viral E1 protein subunits onto the origin of replication.

26 es called parS that are located close to the origin of replication.

27 replication is the removal of primers at the origin of replication.

28 er placed in both orientations near a strong origin of replication.

29 hromosome remain unsegregated at or near the origin of replication.

30 naA and specific DNA elements arrayed at the origin of replication.

31 vary as a function of the distance from the origin of replication.

32 nicks one DNA strand at the double-stranded origin of replication.

33 isomes showed a preference for their cognate origin of replication.

34 TATA-containing cryptic promoter within the origin of replication.

35 in complex with a DNA fragment from the MCV origin of replication.

36 inhibits the ability of DnaA to bind to the origin of replication.

37 ates fluctuate 1.9-fold, peaking towards the origin-of-replication.

38 ld-type cells by inappropriately firing late origins of replication.

39 dictable manner relative to known functional origins of replication.

40 onserved miRNA family arising from the viral origins of replication.

41 ugh the unwinding of R-loops bound to the T4 origins of replication.

42 ent of prereplication complexes (pre-RCs) at origins of replication.

43 ne of five possible ends serving as putative origins of replication.

44 have been noted for transcribed regions and origins of replication.

45 quences and at prokaryotic and mitochondrial origins of replication.

46 aryotes that defines the localization of the origins of replication.

47 , CDC6-dependent mechanism to load MCM2-7 on origins of replication.

48 he dissociation of R-loops located at the T4 origins of replication.

49 tone H3-H4 locus HHT1-HHF1, a centromere and origins of replication.

50 and other proteins that interact with DNA at origins of replication.

51 ut not including, the heavy and light strand origins of replication.

52 hen Mcm2-7 are normally recruited to license origins of replication.

53 sufficient to transform these sequences into origins of replication.

54 utation gradient between the H- and L-strand origins of replication.

55 cules, each with different ends and putative origins of replication.

56 ps to form several key protein assemblies at origins of replication.

57 tive helicase around DNA licenses eukaryotic origins of replication.

58 ition complex (ORC) binding DNA sites called origins of replication.

59 ns provide a unique identifier of eukaryotic origins of replication.

60 nts (ZREs) in target promoters and EBV lytic origins of replication.

61 nce MCM2-7 helicase complex and localizes to origins of replication.

62 sis I but does not lead to the activation of origins of replication.

63 nvolves the replication of DNA from multiple origins of replication.

64 Oribeta, an origin of replication 3' to Chinese hamster dihydrofolat

65 Here, we report an origin of replication adjacent to the FMR1 promoter and

66 insert relative to the unidirectional ColE1 origin of replication affected the amount of instability

67 culture proliferate with intact chromosomal origins of replication after disruption of both alleles

68 nsed in an elongated axial filament with the origins of replication anchored at opposite poles of the

69 n of the genome contains the putative latent origin of replication and 13 additional open reading fra

70 dified in our laboratory to hold an R6Kgamma origin of replication and a marker recombination cassett

71 These plasmids include an origin of replication and a segment of the bacteriophage

72 hange, recombination events cluster near the origin of replication and are localized by tRNAs and sho

73 tiator protein encoded by pT181 nicks at the origin of replication and becomes covalently attached to

74 gulator CtrA, which silences the Caulobacter origin of replication and controls multiple cell cycle e

75 ve positions between a conserved 5'-terminal origin of replication and divergent coding sequences.

76 ds directly to clusters of DnaA boxes at the origin of replication and elsewhere, including the promo

77 tus, ParB binds to sequences adjacent to the origin of replication and is required for the initiation

78 ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell pol

79 with the partitioning protein ParB near the origin of replication and localizes with the duplicated

80 lts provide insights into recognition of the origin of replication and nicking of DNA during bocaviru

81 on the chromosomal position of dnaA near the origin of replication and restriction of CcrM synthesis

82 oth TopBP1 and Brd4 are present at the viral origin of replication and that interaction with E2 is re

83 Since distance between the origin of replication and the (CTG.CAG)n sequence modula

84 ntromere-like element in the vicinity of the origin of replication and the cell pole.

85 LANA binds both the viral latency-associated origin of replication and the host cell chromosome, ther

86 ike DNA sequences (parS) that cluster at the origin of replication and the structural maintenance of

87 It is thought that UL9 binds the origin of replication and unwinds it in the presence of

88 ith DNA containing the early firing lamin B2 origin of replication and, 2 h after release from the bl

89 The origin recognition complex (ORC) defines origins of replication and also interacts with heterochr

90 tones H3, H4, and H2AX occurring at both the origins of replication and at the key lytic regulatory e

91 x (ORC) initiates the assembly of pre-RCs at origins of replication and Cdk phosphorylation of ORC is

92 we show that the alternating arrangement of origins of replication and non-coding RNA in pericentrom

93 g a marker gene and all regulatory elements (origins of replication and promoter-enhancer cassettes)

94 levels revealed that DHX9 is associated with origins of replication and that its suppression leads to

95 duplications and deletions are enriched near origins of replication and their density correlates nega

96 ard to base composition, with exceptions for origins of replication and transcription start sites and

97 initiation of DNA synthesis occurs (known as origins of replication) and subsequently on the lagging

98 proteins E1 and E2 associate with the viral origin of replication, and E2 can also regulate transcri

99 promoter-controlled expression unit, a p15A origin of replication, and genes for rare transfer RNAs

100 s being more negatively supercoiled than the origin of replication, and that such a gradient is absen

101 PR loci, ribosomal RNA genes, rolling circle origins of replication, and areas where plasmids recombi

102 (DDK) is required for the activation of the origins of replication, and DDK phosphorylates Mcm2 in v

103 sion in late G1 phase, affects activation of origins of replication, and inhibits the DNA damage chec

104 tion initiates at specific locations, termed origins of replication, and progresses in a defined temp

105 he single-stranded (ss) DNA of two different origins of replication, and S-CDK phosphorylation of Sld

106 The minimal requirements for a eukaryotic origin of replication are an initiator binding site and

107 rganization, coding potential, and conserved origin of replication are similar to those of members of

108 Origins of replication are activated throughout the S ph

109 Origins of replication are expected to recruit initiatio

110 Eukaryotic origins of replication are licensed upon loading of the

111 s not cleaved from viral DNAs, and the viral origins of replication are not detectably degraded at a

112 We also provide evidence that early origins of replication are preferentially located near h

113 Plasmid origins of replication are rare in bacterial chromosomes

114 Eukaryotic origins of replication are selected by loading a head-to

115 but were able to dimerize and bind the HSV-1 origin of replication as well as wild-type UL9.

116 an essential eukaryotic ATPase that binds to origins of replication as a ring-shaped heterohexamer to

117 the chromatin environment does not regulate origins of replication as a simple binary switch, but ra

118 both H3.1 and H3.3 were enriched on defined origins of replication, as was overall nucleosome densit

119 these pathways leads us to suggest that the origin of replication-associated genome instability shou

120 During late mitosis and early interphase, origins of replication become "licensed" for DNA replica

121 We cotransfected plasmids encoding a common origin of replication but different transcription units

122 e movement of newly replicated loci near the origin of replication but has no qualitative or quantita

123 e perturb replication initiation not only at origins of replication but also during fork repair at ot

124 sites were located within 70 kb of the ChrII origin of replication, but one parS2 site was found in t

125 c DNA replication is initiated from multiple origins of replication, but little is known about the gl

126 large T-antigen of MCV recognizes the viral origin of replication by binding repeating G(A/G)GGC pen

127 d on the circular chromosome near the single origin of replication by ParB proteins bound to parS seq

128 pE, which stimulates initiation at bacterial origins of replication by promoting interactions of init

129 eraction with the viral RNA packaging signal/origin of replication, called epsilon.

130 A plasmid origin of replication can be changed to a different orig

131 The vector contains a bacterial origin of replication (ColE1) to allow circular viral DN

132 -specific inversion, starting 19 kb from the origin of replication, compared to R. prowazekii and R.

133 Here we show that ORC1--a component of ORC (origin of replication complex), which mediates pre-DNA r

134 ntains an orc1 gene flanked by a presumptive origin of replication consisting of 38 tandem repeats of

135 inese hamster dihydrofolate reductase (DHFR) origin of replication consists of a 55-kb zone of potent

136 inese hamster dihydrofolate reductase (DHFR) origin of replication consists of a broad zone of potent

137 Polyomavirus origins of replication contain multiple occurrences of G

138 e data suggest that in Xenopus egg extracts, origins of replication contain multiple, distributed, in

139 ntibiotic resistance transposons and plasmid origins of replication could enable the uptake of insert

140 ruitment of Smc to a large region around the origin of replication depends on the presence of Spo0J.

141 n is eventually completed by initiating late origins of replication despite the presence of hyperphos

142 owledge of herpesvirus genomics, namely, the origins of replication differed from those in the protot

143 Initiation releases polar tethering of the origin of replication, distinction spatially differentia

144 NA synthesis is initiated from at least five origins of replication distributed across the 172 kb chr

145 Eukaryotic genome duplication relies on origins of replication, distributed over multiple chromo

146 Experimental datasets are focused on the origin of replication, DNase I hypersensitivity, chromat

147 Herpesviruses utilize different origins of replication during lytic versus latent infect

148 he eukaryotic MCM2-7 complex is recruited at origins of replication during the G1 phase and acts as t

149 Impaired licensing of origins of replication during the G1 phase of the cell c

150 ly of pre-replicative complexes (pre-RCs) at origins of replication during the G1 phase of the cell c

151 easurements in E. coli demonstrates that the origin of replication exhibits processive motion with a

152 rates, particularly proteins involved in the origin of replication firing.

153 tegrated copy of a tandem repeat of the ACMV origin of replication flanking nonviral sequences that c

154 ix-associated region sequences to provide an origin of replication for long-term mitotic maintenance

155 tes, DNA replication initiates from multiple origins of replication for timely genome duplication.

156 Two studies have shown that multiple origins of replication function in two archaeal species.

157 showed that the noncoding region, containing origins of replication, governs selfish transmission.

158 equence (TRS) relative to the unidirectional origin of replication had a pronounced effect, signaling

159 Recombination substrates lacking a viral origin of replication had similar genetic requirements f

160 s in both orientations relative to a defined origin of replication has been developed.

161 tions, differing in their positioning of the origin of replication, have been constructed.

162 genomes place the major RP cluster near the origin of replication; (iii) the delta genomes possess t

163 cation complex and is recruited to the viral origin of replication in an E1-E2-dependent manner.

164 DNA replication induced by E2 from the viral origin of replication in association with E1.

165 ed association of Cdc45 with the beta-globin origin of replication in BPDE-treated cells.

166 ogression of replication forks formed at the origin of replication in Escherichia coli is challenged

167 NA restriction fragment derived from the M13 origin of replication in plasmid LITMUS 28, and a 476-bp

168 CtrA binds to and silences the origin of replication in swarmer cells.

169 This review summarizes the search for origins of replication in archaea, and our current knowl

170 f the existence of developmentally regulated origins of replication in both cell lines and primary ce

171 where the intra-S-phase checkpoint regulates origins of replication in human chromosomes.

172 nt that targets both cellular and SV40 viral origins of replication in the absence of DNA damage or s

173 One study identified two origins of replication in the archaeon Sulfolobus solfat

174 ins that recognize and melt their respective origins of replication in the initial phase of DNA repli

175 rmatic approach to identify and characterize origins of replication in three distantly related fissio

176 is therefore insufficient to target DmORC to origins of replication in vivo.

177 ts cellular replication proteins to the BPV1 origin of replication, including DNA polymerase alpha-pr

178 One system for origin of replication-independent loading of the DnaB re

179 enrichment of methylated GATC motifs in the origin of replication indicates that DNA methylation may

180 of stable protein-DNA complexes at S. pombe origins of replication involves binary interactions amon

181 the Chinese hamster dihydrofolate reductase origin of replication is a prominent nuclear matrix atta

182 se results also suggest that the KSHV latent origin of replication is a unique chromatin environment

183 e that, in halophilic archaea, a chromosomal origin of replication is physically linked to orc7 homol

184 acter has a single circular chromosome whose origin of replication is positioned at one cell pole.

185 We found that the origin of replication is positioned near midcell prior t

186 E1-E2-containing nuclear foci, and the viral origin of replication is required for the efficient form

187 ion of integration relative to promoters and origins of replication is consistent with group II intro

188 at the association between Cdc45 and Mcm7 at origins of replication is negatively regulated by Chk1 i

189 , and chromosomes with two centromeres or an origin of replication juxtaposed to a centromere rescue

190 t the presence of a TATA site near the viral origin of replication led us to hypothesize that TATA-bi

191 ted COS1 cells under the control of the SV40 origin of replication located at one of five different d

192 cle, based on binding of CRISPR/dCas9 to the origin-of-replication locus.

193 Because Rad53 binds an origin of replication mainly through its kinase domain a

194 g of the Origin Recognition Complex (ORC) to origins of replication marks the first step in the initi

195 nverted repeat sequences (IRs) near probable origins of replication, not at random sites as expected

196 e and potentially bidirectional light-strand origins of replication (O(L)) are present in unionoid F

197 The origin of replication of African cassava mosaic virus (A

198 the E. coli lagging strand as well as in the origin of replication of bacteriophage G4.

199 The origin of replication of chromosome I is similar to that

200 duction of RctB, a protein that binds to the origin of replication of chromosome II, promoted overini

201 a 60-bp region corresponding to the putative origin of replication of pXO2 located immediately downst

202 is responsible for recognition of the viral origin of replication of the double-stranded DNA nature

203 nd heavy strand promoters (LSP, HSP) and the origin of replication of the light strand (OL).

204 The RctB protein binds to the origin of replication of Vibrio cholerae chromosome II (

205 The origins of replication of DNA tumor viruses have a highl

206 es of the three 13-mers are conserved in the origins of replication of enteric bacterial chromosomes.

207 The origins of replication of many different bacteria have b

208 istribution of pentanucleotides found in the origins of replication of polyomaviruses is discussed.

209 The origins of replication of the two chromosomes are simila

210 We defined and characterized the origins of replication of the two Vibrio cholerae chromo

211 ized the localization and segregation of the origins of replication of the V. cholerae chromosomes.

212 faciens strains and five transferred (T)-DNA origins of replication on transformation frequency, tran

213 ntation relative to the unidirectional ColE1 origin of replication or, in the other orientation, 30 o

214 For instance, promoters, origins of replication or homologous recombination sites

215 d E2 regions (nt 2723 to 3826) and the viral origin of replication (ori) (p11Rc).

216 eplication protein E1 assembles on the viral origin of replication (ori) as a series of complexes.

217 ing open reading frame 1 (ORF1) (rep) or the origin of replication (Ori) between PCV1 and PCV2 and co

218 lasmid duplication is the recognition of the origin of replication (ori) by specific Rep proteins tha

219 show that all necessary cis elements for the origin of replication (ori) function are located within

220 ns attributes of a theta-replicating plasmid origin of replication (Ori), namely, an exclusively A+T-

221 We mapped four origins of replication, ori 1-4, using two independent m

222 in, DnaA, binds to 9-bp DNA sites within the origin of replication oriC.

223 DnaA binds to multiple sites in the origin of replication (oriC) and is required for recruit

224 aA protein binds 'DnaA boxes' present in the origin of replication (oriC) and operator sites of sever

225 , initiates DNA synthesis at the chromosomal origin of replication (oriC) and regulates the transcrip

226 arm occupies a separate cell half, with the origin of replication (oriC) at mid-cell.

227 ively analyse the cell cycle dynamics of the origin of replication (oriC) in hundreds of cells.

228 ation of the initiator protein, DnaA, on the origin of replication (oriC) is crucial for initiation o

229 replicating M. tuberculosis, MtrA access to origin of replication (oriC) is enriched in the post-rep

230 ng of the replicative ring helicase onto the origin of replication (oriC) is the final outcome of a w

231 The origin of replication (oriC) region in some clinical str

232 hromosome (8.67 Mb) with a centrally located origin of replication (oriC).

233 nd DNase I footprinting that the chromosomal origin of replication, oriC, and the promoter for the ma

234 methylated GATC sequences and sequesters the origin of replication, oriC, from methylation and premat

235 In Bacillus subtilis, the origin of replication, oriC, is located at 0 degrees /36

236 n initiator protein remodels the chromosomal origin of replication, oriC, to load the replicative hel

237 ound DnaA binds to multiple sequences at the origin of replication, oriC, unwinding the DNA and promo

238 to specific binding sites in the chromosomal origin of replication, oriC.

239 igh-affinity recognition sites in the unique origin of replication, oriC.

240 hat unwind the Escherichia coli chromosome's origin of replication, oriC.

241 iator DnaA and its access to the chromosomal origin of replication, oriC.

242 tion starts with the newly replicated sister origins of replication, oriCs, which move apart to defin

243 ultiple discrete sites in the genome, termed origins of replication (origins).

244 and (ii) the orientation of the heavy-strand origin of replication (OriH) has reversed relative to th

245 binds to the centromeric site parSI near the origin of replication (oriI), and parSI-ParBI complexes

246 BET proteins also localize to the lytic origin of replication (OriLyt) genetic elements, and BET

247 Here we show that the EBV latency origin of replication (oriP) is transcribed bi-direction

248 the EBNA1-dependent enhancer activity of the origin of replication (OriP).

249 The plasmid origin of replication, oriP, of Epstein-Barr Virus (EBV)

250 nt EBNA1 binding to sites in the EBV latency origin of replication, oriP.

251 was noted in specific promoters and putative origins of replication, predicting important functional

252 Origins of replication present a paradox to evolutionary

253 a helper plasmid that contains a conditional origin of replication promotes site-specific recombinati

254 or to a DNA sequence can create a functional origin of replication, providing a robust genetic assay

255 pYA4534 harbors two origins of replication, pSC101 and pUC (low and high cop

256 ducts of six Saccharomyces cerevisiae genes, origin of replication recognition complex (ORC), has sug

257 n A- chromatin immunoprecipitation signal at origins of replication, reduced levels of DDK-phosphoryl

258 -repeats is dependent on the location of the origin of replication relative to the repeat tract, supp

259 on in vitro, synthesis of RNA primers at the origin of replication requires only the viral tumor (T)

260 al plasmids are modular entities composed of origins of replication, selectable markers and other com

261 teractions between initiator protein and the origin of replication should provide insights into the m

262 richment of P-element insertions in putative origins of replication, similar to that seen in D. melan

263 viral genome, which is composed of a minimal origin of replication spanning 67 nucleotides.

264 nants of nuclear pore association, including origins of replication, specific intergenic regions, and

265 is highly enriched in the region around the origin of replication, specifically near parS sites to w

266 e orientation of the repeats relative to the origin of replication strongly influenced the apparent f

267 ncrease in CDC6 occupancy on the beta-globin origin of replication, suggesting increment in origin li

268 M proteins are present in excess relative to origins of replication, suggesting they may serve other

269 d deletion transposon contains a conditional origin of replication that allows deleted chromosomal DN

270 ofermentans that has a resistance marker, an origin of replication that can be selectively lost, and

271 d ea ly S phase, and bracket an early-firing origin of replication that consists of a 55-kb zone of p

272 . coli variant that includes only an ectopic origin of replication that is positioned such that one o

273 Several mutations were found in the origin of replication that quantitatively and qualitativ

274 iation of eukaryotic DNA synthesis occurs at origins of replication that are utilized with characteri

275 omaviruses have repeating sequences at their origins of replication that bind the origin-binding doma

276 ed RRs with variable deletions in either the origin of replication, the 21-bp repeat elements, or the

277 complex (pre-RC) is formed at all potential origins of replication through the action of the origin

278 The two initiators bind in the origin of replication to multiple sites, called iterons

279 o cholerae chromosome 2 (chr2), binds to the origin of replication to specific 12-mer sites both as a

280 ate that the addition of the simian virus 40 origin of replication to the papillomavirus genome incre

281 e factors is sufficient to allow late firing origins of replication to initiate early and together wi

282 S-phase kinase Cdc7-Dbf4 acts at eukaryotic origins of replication to trigger a cascade of protein a

283 en the cosmid carries a conditionally active origin of replication, transductional introduction of th

284 ication assay employing a plasmid based SV40 origin of replication, transfected into cells expressing

285 ed distinctive chromatin motifs for introns, origins of replication, tRNAs, antisense transcripts, do

286 Herpes simplex virus 1 contains three origins of replication; two copies of oriS and one of a

287 ParB/Spo0J partitions the origin of replication using a nucleoprotein complex, ass

288 asymmetry suggest that (i) the light-strand origin of replication was also inverted and is adjacent

289 A functional origin of replication was mapped to the transcriptional

290 Moreover, the proximal c-myc origin of replication was not required to cause orientat

291 th a single psoralen cross-link and the SV40 origin of replication was replicated by HeLa cell-free e

292 tly, the only archaeon for which a bona fide origin of replication was reported was Pyrococcus abyssi

293 ed that only an asymmetric region around the origin of replication was syntenic across the genus.

294 ere bidirectional replication ensues from an origin of replication, we show that translesion synthesi

295 A amplification, which is driven by the oriV origin of replication, we used copy-up mutations in the

296 ecruits the viral helicase E1 to an A/T-rich origin of replication, whereupon a dihexamer forms, resu

297 ins, including DNA polymerase, and the viral origin of replication, which are required for viral DNA

298 mere-like sequences, bordering the wild-type origin of replication, which are used by host mechanisms

299 nosarcina spp. in the region proximal to the origin of replication, with interspecies gene similariti

300 marks, euchromatin and heterochromatin, and origins of replication within the Schizosaccharomyces po